February 2024
Curriculum Vitae
Natalia A. Riobo-Del Galdo, PhD
Associate Professor
University of Leeds
Date of Birth: 15th of May, 1974
Citizenship: Argentina and USA
Address:
University of Leeds
School of Molecular and Cellular Biology
LC Miall Building, 7.19b
Clarendon Way
Leeds, LS2 9JT
United Kingdom
Phone: (+44) 01133439184
Email: n.a.riobo-delgaldo@leeds.ac.uk; natalia.riobo@gmail.com
Education:
1992-1997 M.Sc. (Biological Sciences), School of Natural Sciences, University of Buenos Aires, Argentina.
1998-2001 Ph.D. (Human Biochemistry), School of Medicine, University of Buenos Aires, Argentina
2001-2006 Postdoctoral fellowship, University of Pennsylvania School of Medicine, Department of Cell and Developmental Biology (2001-2003) and Department of Pharmacology (2004-2006).
Teaching activity:
1996-2000 Teaching Assistant-Instructor, Department of Biology, School of Natural Sciences, University of Buenos Aires, Argentina
1998-2000 Teaching Assistant, Department of Biological Chemistry, School of Natural Sciences, University of Buenos Aires, Argentina
1999-2000 Teaching Assistant, Department of Genetics and Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
2000 Lecturer, “Biology of the Neutrophil”, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
2006 Lecturer, Phrm560 “Principles in Cancer Signaling and Therapeutics”, School of Medicine, University of Pennsylvania
2007 Lecturer, Phrm640 “Topics in Cancer Pharmacology”, School of Medicine, University of Pennsylvania
2008 Lecturer, Developmental Biology Course, University of Medicine and Dentistry of New Jersey
2009-2015 Lecturer, PHRM520 “Molecular and Cell Biology”, Pharmacy, Thomas Jefferson University
2009 Lecturer, “Developmental Biology” Course, University of Medicine and Dentistry of New Jersey
2009-2010 Lecturer, PR680 “Molecular Pharmacology”, Jefferson Graduate College of Biomedical Sciences, Thomas Jefferson University
2010-2015 Lecturer, MCBM “Molecular and Cellular Basis of Medicine”, SIDNEY Kimmel Medical College, Thomas Jefferson University
2011-2015 Lecturer, GC665 “Cell Signaling”, Jefferson Graduate College of Biomedical Sciences, Thomas Jefferson University
2011-2015 Lecturer, GC550 “Fundamentals of Biology”, Jefferson Graduate College of Biomedical Sciences, Thomas Jefferson University
2014-2015 Lecturer, GB625 “Mechanisms of Development”, Jefferson Graduate College of Biomedical Sciences, Thomas Jefferson University
2014-2015 Lecturer, BI612 “Advanced Topics in Protein Function and Dysfunction”, Jefferson Graduate College of Biomedical Sciences, Thomas Jefferson University
2015 Co-director, BI725 “Current Literature in Biochemistry and Molecular Pharmacology”, Jefferson Graduate College of Biomedical Sciences, Thomas Jefferson University
2016-present Lecturer, BIOC3232 Advanced Topic Units “Signal Transduction in Cancer and Cardiovascular Disease”, University of Leeds
2017-present Lecturer, BIOL2211 “Human Diseases”, University of Leeds
2017-present Tutor, BIOL1305 “Introductory Skills for the Biological Sciences”, University of Leeds
2017-present Module Manager, lecturer and tutor, BIOL3305 “Advanced Skills for the Biological Sciences”, University of Leeds
2021-present Lecturer, MICR2120 “Cell biology of disease”, University of Leeds
2021-present Tutor, BIOL2305 “Intermediate Skills for the Biological Sciences”, University of Leeds
2021-present Tutor, BIOL3215 “Cancer biology”, University of Leeds
Research positions:
1994-1996 Lab technician, Laboratory of Oxygen Metabolism, School of Medicine, University of Buenos Aires, Argentina
1996-1998 Undergraduate Student Fellow, Laboratory of Oxygen Metabolism, School of Medicine, University of Buenos Aires, Argentina.
1998-2001 Graduate Student Fellow, Laboratory of Oxygen Metabolism, School of Medicine, University of Buenos Aires, Argentina.
2001 Visiting Scholar, Department of Cell & Developmental Biology, University of Pennsylvania
2002-2004 Postdoctoral Researcher, Department of Cell & Developmental Biology, University of Pennsylvania
2004-2006 Postdoctoral Fellow (American Heart Association), Department of Pharmacology, University of Pennsylvania
2006-2008 Assistant Professor of Emergency Medicine, University of Pennsylvania
2008-2014 Assistant Professor of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University
2015-2018 Associate Professor of Biochemistry and Molecular Biology, Sidney Kimmel Medical College, Thomas Jefferson University
2015-2019 Group Leader, University of Leeds
2019-present Associate Professor, University of Leeds
2019-2023 Director of Research and Innovation, School of Molecular and Cellular Biology, University of Leeds
2023-present Cancer and Cell Signalling Pillar Lead, School of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Leeds
2024-present Discovery Bioscience Committee Chair, Leeds Centre for Cancer Research, University of Leeds
Organizer activities
2006-2008 Organizer of the CRS Journal Club series
2007 Co-organizer of the “Resuscitation Science Retreat”, a one-day symposium held at the Inn at Penn on October 15th
2011 Organizer of regional “Hedgehog Club” series
2023-present Organizer of the Cancer and Cell Signalling seminar series (monthly)
Study sections-grant review activities
2007 Reviewer of the Department of Defense Prostate Cancer Research Program panel “Pathobiology 1” (PBY-1)
2007 Reviewer for National Science Foundation’s Merit Award
2007 Reviewer of the Agency for Science, Technology and Research’s (A*STAR) Biomedical Research Council (BMRC) of Singapore
2008 Reviewer of the Department of Defense Breast Cancer Research Training panel
2008 Reviewer of the Department of Defense Prostate Cancer Research Program panel “Pathobiology 3” (PBY-3), ad-hoc reviewer of panel “Cell Biology 2” (CBY-2)
2008 Editorial Board, American Journal of Pathology
2009 Reviewer of the Department of Defense Prostate Cancer Research Program panel “Pathobiology 2” (PREPBY-2)
2009 Reviewer of the American Heart Association Cell Signaling panel.
2009 Editorial Board, Journal of Molecular Signaling
2011 Reviewer of the Department of Defense Pediatric Brain Tumor Program and Prostate Cancer Research Program
2010-11 Reviewer of the American Heart Association “Molecular Signaling I” panel
2012 Reviewer of the Department of Defense Visionary Postdoctoral Program (VP-1)
2012-2015 Member of the American Heart Association Research Committee, Great Rivers Affiliate
2012-present External reviewer of the Agencia Nacional de Promoción Científica y Tecnológica, Ministry of Science and Technology, Argentina
2014-present External referee for the National Research Agency (ANR), France
2016-2021 Foreign expert, NZ3 panel, National Science Centre, Poland
2013-present Expert reviewer, Medical Research Council, UK
2016-present Expert reviewer, Biotechnology and Biological Sciences Research Council, UK
2022-present Chair, NZ3 panel, National Science Centre, Poland
PUBLICATIONS
1. JJ Poderoso, MC Carreras, C Lisdero, NA Riobo, F Schöpfer, and A Boveris. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 328: 85-92 (1996).
2. EM Gatto, MC Carreras, GA Pargament, NA Riobo, C Reides, M Repetto, MM Fernández Pardal, S Llesuy, and JJ Poderoso. Neutrophil function, nitric oxide and blood oxidative stress in Parkinson’s disease. Mov. Disord. 11: 261-267 (1996).
3. MC Carreras, NA Riobo, A Boveris and JJ Poderoso. Effects of respiratory burst inhibitors on nitric oxide production by human neutrophils. Free Radic. Res. 26: 325-331 (1997).
4. JJ Poderoso, MC Carreras, FJ Schöpfer, CL Lisdero, NA Riobo, C Giulivi, A Boveris, P Evelson, A Boveris, and E Cadenas. The reaction of nitric oxide with ubiquinol; kinetic properties and biological implicances. Free Radic. Biol. & Med. 26: 925-935 (1999).
5. EM Gatto, NA Riobo, MC Carreras, FJ Schöpfer, GA Pargament, and JJ Poderoso. Circulating plasma factors increase nitric oxide production by neutrophils in Parkinson’s disease. J. Neurol. Sci. 165: 66-70 (1999).
6. JJ Poderoso, MC Carreras, CL Lisdero, FJ Schöpfer, NA Riobo, and J Peralta. Shock: concepts for a definition. Medicina (Argentina) 58: 341-349 (1999).
7. JJ Poderoso, CL Lisdero, FJ Schopfer, NA Riobo, MC Carreras, E Cadenas, and A Boveris. The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol. J. Biol. Chem. 274: 37709-37716 (1999).
8. EM Gatto, NA Riobo, MC Carreras, A Cherñavsky, A Rubio, L Satz, and JJ Poderoso. Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson’s disease. Nitric oxide 4: 534-539 (2000).
9. FJ Schopfer, NA Riobo, MC Carreras, B Alvarez, R Radi, A Boveris, E Cadenas, and JJ Poderoso. Oxidation of ubiquinol by peroxynitrite: implications for nitrosative damage in mitochondria. Biochem. J. 349: 35-42 (2000).
10. MC Carreras, FJ Schopfer, CL Lisdero, NA Riobo, and Poderoso JJ. Mitochondrial function and nitric oxide utilization. Biol. Res. 33: 177-183 (2000).
11. NA Riobo, E Clementi, M Melani, S Moncada, E Cadenas, A Boveris, and JJ Poderoso. Nitric oxide inhibits mitochondrial NADH-ubiquinone reductase activity through the formation of peroxynitrite. Biochem. J. 359: 139-145 (2001).
12. NA Riobo, FJ Schopfer, A Boveris, E Cadenas, and JJ Poderoso. The reaction of nitric oxide and 6-hydroxydopamine: implications for Parkinson’s disease. Free Radic. Biol. & Med. 32(2): 115-121 (2002).
13. EM Gatto, NA Riobo, MC Carreras, JJ Poderoso, and F Micheli. Neuroprotection in Parkinson's disease: a commentary. Neurotox. Res. 4(2): 141-145 (2002).
14. NA Riobo, M Melani, N Sanjuan, ML Fiszman, MC Gravrielle, MC Carreras, E Cadenas, and JJ Poderoso. The Modulation of mitochondrial nitric-oxide synthase activity in rat brain development. J. Biol. Chem. 277(45): 42447-42455 (2002).
15. MC Carreras, M Melani, NA Riobo, DP Converso, EM Gatto, and JJ Poderoso. Neuronal nitric oxide synthases in brain and extraneural tissues. Methods Enzymol. 359: 413-423 (2002).
16. NA Riobo and DR Manning. Receptors coupled to heterotrimeric G proteins to the G12 family. Trends Pharmacol. Sci. 26(3):146-154 (2005).
17. NA Riobo, GM Haines, and CP Emerson. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control Gli activation in Hedgehog signaling. Cancer Res. 66(2): 839-845 (2006).
18. NA Riobo, X Ai, K Lu, GM Haines, and CP Emerson. PI3 kinase and Akt are essential for Sonic Hedgehog signaling. Proc. Natl. Acad. Sci. USA 103(12): 4505-4510 (2006).
19. NA Riobo and CP Emerson. Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle 5(15): 1612-1615 (2006).
20. NA Riobo, B Saucy, C DiLizio, and DR Manning. Activation of heterotrimeric G proteins by Smoothened. Proc. Natl. Acad. Sci. USA 103(33): 12607-12612 (2006).
21. MV Gavrielides, A Gonzalez-Guerrico, NA Riobo, and MG Kazanietz. Androgens transcriptionally regulate PKC expression in prostate cancer cells and modulate its apoptotic function. Cancer Res. 66(24): 11792-11801 (2006).
22. NA Riobo* and DR Manning*. Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem. J. 403: 369-379 (2007). (*)
23. MP Chinchilla and NA Riobo. Purification and bioassay of Hedgehog ligands for the study of cell death and survival. Methods Enzymol. 446: 189-204 (2008).
24. F Han, T Da, NA Riobo* and LB Becker*. Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation following cardiac arrest. Crit. Care Med. 36(11) S447-S453 (2008) (*)
25. MP Chinchilla, L Xia, MG Kazanietz and NA Riobo. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle 9(3): 59-68 (2010)
26. AH Polizio, MP Chinchilla, X Chen, S Kim, DR Manning and NA Riobo. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho- small GTPases to promote fibroblast migration. J. Biol. Chem. 286(22): 19589-96 (2011)
27. A Douglas, JA Heim, F Shen, NA Riobo, ME Fernández-Zapico and DR Manning. The heterotrimeric G protein G13 regulates the activity of one or more Gli transcription factors independently of Smoothened. J. Biol. Chem. 286(35): 30714-22 (2011)
28. AH Polizio, P Chinchilla, X Chen, DR Manning and NA Riobo. Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner via coupling of Smoothened to Gi proteins. Sci. Signal. 7(pt4) (2011)
29. DR Robbins, F Seng, and NA Riobo. The Hedgehog signaling network. Sci. Signal. 5(246): re6 (2012)
30. NA Riobo. Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr. Opin. Pharmacol. 12(6): 736-41 (2012)
31. DM Brennan, X Chen, L Cheng, M Mahoney and NA Riobo. Noncanonical Hedgehog signaling. Vitam. Horm. 88: 55-72 (2012)
32. F Shen, L Cheng, AE Douglas, NA Riobo, and DR Manning. Smoothened is a fully competent activator of the heterotrimeric G protein (Gi). Mol. Pharm. 83(3): 691-7 (2013)
33. NA Riobo and F Del Galdo. Hedgehog Dysfunction in Fibrosis: Insights in the Pathogenesis of Scleroderma. Biochem. & Pharmacol. 2:e141 (2013)
34. C Carbe, L Cheng, S Addya, J Gold, E Gao, WJ Koch and NA Riobo. Gi proteins mediate activation of the canonical Hedgehog pathway in the myocardium. A.J.P. Heart and Circ. Physiol. 307(1): H66-72 (2014)
35. R Teperino, F Aberger, H Esterbauer, NA Riobo, A Pospisilik. Canonical and non-canonical Hedgehog signalling and the control of metabolism. Sem. Cell. Dev. Biol. 33C: 81-92 (2014)
36. XL Chen, P Chinchilla, J Fombonne, L Ho, C Guix, J Keen, P Mehlen and NA Riobo. Patched-1 pro-apoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. Mol. Cell. Biol. 34(20): 3855-66 (2014)
37. DM Brennan, C Hossain, J Sahu, M Brady, NA Riobo*, and MG Mahoney*. Crosstalk between Desmoglein 2 and Patched1 enhances chemical-induced skin tumorigenesis. Oncotarget 6(11):8593-605 (2015) * co-corresponding authors
38. A Gupta, D Nitoiu, D Brennan-Crispi, S Addya, NA Riobo, DP Kelsell, and MG Mahoney. Cell cycle- and cancer-associated gene networks activated by Dsg2: evidence of cystatin A deregulation and a potential role in cell-cell adhesion. PLoS One 10(3):e0120091 (2015)
39. L Ho and NA Riobo. Canonical and noncanonical Hedgehog signaling. Hedgehog Signaling Protocols (Ed. NA Riobo, Springer) Methods Mol Biol 1322:v-xi (2015)
40. DR Manning, F Shen, and NA Riobo. Evaluating the activity of Smoothened toward G proteins using [35S]Guanosine 5’-(3-O-thio)triphosphate ([35S]GTPγS). Hedgehog Signaling Protocols (Ed. NA Riobo, Springer) Methods Mol Biol 1322:35-44 (2015)
41. D Brennan-Crispi, MG Mahoney, and NA Riobo. Methods for detection of Patched1-driven lacZ expression in adult mouse skin. Hedgehog Signaling Protocols (Ed. NA Riobo, Springer) Methods Mol Biol 1322: 167-85 (2015)
42. M Trerotola, KK Ganguly, L Fazli, H Lu, A Dutta, Q Liu, T De Angelis, LW Riddell, NA Riobo, ME Gleave, A Zoubeidi, DC Altieri, LR Languino. Trop-2 is upregulated in aggressive prostate cancer and interacts with 51 integrin. Oncotarget 6:14318-28 (2015)
43. V Papadopoulos, K Tsapakidis, NA Riobo-Del Galdo, CN Papandreou, F Del Galdo, A Anthoney, N Sakellaridis, K Dimas, K Kamposioras. The prognostic significance of the Hedgehog signaling pathway in colorectal cancer. Clin. Colorectal Cancer 15:116-27 (2016)
44. X Chen, CC Morales-Alcala, NA Riobo-Del Galdo Autophagic flux is regulated by interaction between the C-terminal domain of PATCHED1 and ATG101. Mol. Cancer Res. 16(5):909-19 (2018)
45. X Guo, NA Riobo-Del Galdo, EJ Kim, GR Grant, DR Manning. Overlap in signalling between Smoothened and the subunit of the heterotrimeric G protein G13. PLoS One 13(5):e0197442 (2018)
46. L Cheng L, M Al-Owais, ML Covarrubias, WJ Koch, DR Manning, C Peers, NA Riobo-Del Galdo. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. J. Biol. Chem. 293(28):11022-32 (2018)
47. L Ho Wei, M Arastoo, I Georgiou, DR Manning, NA Riobo-Del Galdo. Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signalling is independent of primary cilia. PLoS One 13(8):e0203170 (2018)
48. F Cooper, A Overmiller, A Loder, D Brennan-Crispi, K McGuinn, M Marous, T Freeman, NA Riobo-Del Galdo, L Siracusa, J Wahl 3rd, MG Mahoney. Enhancement of cutaneous wound healing by Dsg2 augmentation of uPAR secretion. J. Invest. Dermatol. 138:2470-79 (2018)
49. DM Brennan-Crispi, AM Overmiller, L Tamayo-Orrego, MR Marous, J Sahu, KP McGuinn, F Cooper, I Georgiou, M Frankfurter, JC Salas-Alanis, F Charron, SE Millar, MG Mahoney, NA Riobo-Del Galdo. Overexpression of Desmoglein2 in a mouse model of Gorlin syndrome enhances spontaneous basal cell carcinoma formation through STAT3-mediated Gli1 expression. J. Invest. Dermatol. 139(2): 300-7 (2019)
50. NA Riobo-Del Galdo, A Lara Montero, EV Wertheirmer. Role of Hedgehog signalling in breast cancer: pathogenesis and therapeutics. Cells 8(4) pii: E375 (2019)
51. AJ Timmis, NA Riobo-Del Galdo. Another twist to the GLI code. Biochem. J. 477(22): 4343-4347 (2020)
52. CW Wasson, RL Ross, R Wells, C Corinaldesi, Ich Georgiou, NA Riobo-Del Galdo, F Del Galdo. Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblasts. Arth. Res. & Ther. 22(1): 286 (2020)
53. D Mellis, KA Staines, S Peluso, Ich Georgiou, N Dora, M Kubiak, M Grillo, C Farquharson, E Kinsella, A Thronburn, SH Ralston, DM Salter, NA Riobo-Del Galdo*, RE Hill*, M Ditzel*. Ubiquitin-protein ligase Ubr5 cooperates with Hedgehog signalling to promote skeletal tissue homeostasis. PLoS Genetics 17(4);e1009275 (2021) *co-corresponding authors.
54. A Urdiciain, E Erausquin, MV Zelaya, I Zazpe, JL Lanciego, B Melendez, JA Rey, MA Idoate, NA Riobo-Del Galdo, JS Castresana. Silencing of Histone Deacetylase 6 decreases cellular malignancy and contributes to primary cilium restoration, epithelial-to-mesenchymal transition reversion, and autophagy inhibition in glioblastoma cell lines. Biology (Basel) 10(6):467 (2021)
55. CC Morales-Alcala, Ich Georgiou, AJ Timmis, NA Riobo-Del Galdo. Integral Membrane Protein 2A is a negative regulator of canonical and non-canonical Hedgehog signalling. Cells 10(8):2003 (2021)
56. CW Wasson, B Caballero-Ruiz, J Gillespie, E Derrett-Smith, J Mankouri, CP Denton, G Canettieri, NA Riobo-Del Galdo, F Del Galdo. Induction of pro-fibrotic CLIC4 in dermal fibroblasts by TGF-b/Wnt3a is mediated by GLI2 upregulation. Cells 11(3):530 (2022)
57. FI Ghuloum, CA Johnson, NA Riobo-Del Galdo, MH Amer. From mesenchymal niches to engineered in vitro model systems: exploring and exploiting biomechanical regulation of vertebrate Hedgehog signalling. Material Bio Today 17, 100502 (2022)
58. B Caballero-Ruiz, DS Gkotsi, H Ollerton, CC Morales-Alcala, R Bordone, GML Jenkins, L Di Magno, G Canettieri, NA Riobo-Del Galdo. Partial truncation of the C-terminal domain of PTCH1 in cancer enhances autophagy and metabolic adaptability. Cancers 15, 369 (2023)
59. MK Hiltunen, AJ Timmis, M Thomsen, DS Gkotsi, H Iwai, OM Ribeiro, A Goldman, NA Riobo-Del Galdo NA. PTCHD1 binds cholesterol but not Sonic Hedgehog, suggesting a distinct cellular function. Int. J. Mol. Sci. 24:2682 (2023)
60. N Pitesa, M Kurtovic, N Bartonicek, DS Gkotsi, J Conkas, T Petric, V Musani, P Ozretic, NA Riobo-Del Galdo, M Sabol. Signaling switching from Hedgehog-GLI to MAPK signaling potentially serves as a compensatory mechanism in melanoma cell lines resistant to GANT-61. Biomedicines 11:1353 (2023)
61. FI Ghuloum, LA Stevens, CA Johnson, NA Riobo-Del Galdo, MH Amer. Towards modular engineering of cell signalling: topographically-textured microparticles induce osteogenesis via activation of canonical hedgehog signalling. Biomater. Adv. 154:213652 (2023)
62. CW Wasson, E De Lorenzis, EM Clavane, RL Ross, KA Walker, B Caballero-Ruiz, A Antinozzi, R Wells, G Migneco, JMY Brown, NA Riobo-Del Galdo, L Di Luigi, CS McKimmie, F Del Galdo, P Meakin. The beta-secretase BACE1 drives fibroblasts activation in Systemic Sclerosis through the APP/b-catenin/Notch signalling axis. BioRxiv 2022.12.521579 (preprint)
63. AJ Timmis, F Cross, DS Gkotsi, H Ollerton, CA Johnson, NA Riobo-Del Galdo. The Hedgehog receptors PTCH1 and PTCH2 exist as active homomeric and heteromeric complexes. BioRvix 2023.08.08.54932 (preprint)
64. P Verma, B Yalavarthi, S Bhattacharyya, D Khanna, JE Gudjonsson, LC Tsoi, R Wells, RL Ross, NA Riobo-Del Galdo, F Del Galdo, SM Frtier, ME Teves, J Varga, D Bhattacharyya. Morphological reprogramming of primary cilia length mitigates the fibrotic phenotype in fibroblasts across diverse fibrotic conditions. BioRvix 2024.01.06.574461 (preprint)
65. M Peckham, O Umney, J Leng, G Canettieri, NA Riobo-Del Galdo, H Slaney, P Quirke, A Curd. Annotation and automated segmentation of single-molecule localization microscopy data on cell membrane receptors. (under review)
NON-INDEXED REVIEWS AND CHAPTERS
J Bustamante, MC Carreras, NA Riobo, A Tovar, G Montero, JJ Poderoso and A Boveris. Nitric oxide and hydrogen peroxide production during human neutrophils apoptosis. Oxidative Stress in Cancer, AIDS and Neurodegenerative Diseases. Chp. 20 (1998). Eds: L Montagnier-R Olivier-C Pasquier.
EM Gatto, NA Riobo, MC Carreras and JJ Poderoso. Oxidative stress and nitric oxide overproduction in Parkinson’s disease. Free radicals in brain pathology Chp. 11 (2000). Eds: E. Cadenas-L. Packer, Marcel Dekker, Inc., New York.
MC Carreras, NA Riobo, CL Lisdero and JJ Poderoso. Nitric oxide and nitric oxide synthases. (1999) Antioxidantes y calidad de vida (Argentina).
NA Riobo. PKCs as mediators of the Hedgehog and Wnt signaling pathways. (2010) PKC in cancer signaling and therapy. Current Cancer Research series. Ed: M. Kazanietz, Springer, NY.
NA Riobo. Canonical and non-canonical Hedgehog signaling pathways: role of G proteins. (2014) In “The Smoothened receptor in cancer and regenerative medicine” Topics in Medicinal Chemistry, Ed. Martial Ruat, Springer, NY.
BOOKS
Hedgehog Signaling Protocols. Methods in Molecular Biology. Ed. NA Riobo, Springer, NY. (In press, 2015)
http://www.springer.com/us/book/9781493927715
PAST and CURRENT MEMBERS of the LAB
Pilar Chinchilla (PhD student) – graduated in 2011 – currently postdoc in Mülberg University, Germany
Donna Brennan-Crispi, PhD) – currently Basic Research Director at UPenn Dermatology
Lan Ho Wei, PhD – currently Technical Services Leader at Perkin Elmer, Inc
Ariel Polizio, PhD– currently Research Associate at University of Virginia
Christian Carbe, PhD (postdoc) – currently Professor at Misericordia University
Xiaole Chen, PhD (postdoc) – current
Lan Cheng, MD PhD (postdoc) – currently Instructor at Thomas Jefferson University
Mohammad Arastoo, PhD – Researcher, University of Aberdeen
Ioanna Georgiou (technician) – currently PhD student at University of Liverpool
Alex Timmis, PhD – currently Senior Specialist at Cellomatics
Dominic Lowen, PhD – currently Senior Scientist at Inaphaea BioLabs
Cintli Morales-Alcala, PhD – currently Research Technician at the Unviersity of Leeds
Danai Gkotsi, PhD – postdoctoral fellow at University of Nottingham
Begoña Caballero-Ruiz, PhD – currently postdoctoral fellow at University of Leeds
Felix Cross – awaiting thesis examination
Hattie Ollerton – 4th year PhD student
Esther Perez-Barreiro – 3rd year PhD student
Fatmah Ghuloum – 3rd year PhD student
Nan Zhang – 3rd year PhD student
Rosa Cassidy – 2nd year PhD student
Rana Alhusayan – 1st year PhD student
FUNDING
Completed:
NIH-NIGMS 1R01GM088256 (08/05/10-08/04/15)
Role: PI
Mechanism of cell cycle and survival regulation by Hedgehog signaling
Total direct cost $928,627
NIH-NIGMS 2RO1GM080396 (02/01/14-01/31/18)
Role: co-PI
Engagement of heterotrimeric G proteins by Sonic Hedgehog
Direct cost of sub-award corresponding to NA Riobo $409,816
AHA - Scientist Development Grant (07/01/06-6/30/10)
Role: PI
Hedgehog signaling in angiogenesis
Total direct cost $ 240,000
WW Smith Charitable Foundation – Cancer Research (01/01/09-12/31/10)
Role: PI
Dissecting the role of Patched-1 in gastric cancer
Total direct cost $ 200,000
NIH-NIGMS 2RO1GM080396-05 (10/01/07-09/30/11)
Role: co-I
Engagement of heterotrimeric G proteins by Sonic Hedgehog
Total direct cost of sub-award corresponding to NA Riobo $ 309,000
AHA-Innovative Research Grant (07/01/10-06/30/12)
Role: PI
Mimicking Hedgehog: identification of novel mechanisms for PTCH-1 regulation
Total direct cost $ 150,000
BBSRC (2019-2023)
Role: PI
Autophagic flux regulation by the cholesterol/H+ antiporter PTCH1
Total direct cost £577,047
British Heart Foundation (2020-2023)
Role: co-PI
The CXCL2 chemokine promotes VEGF-A regulated angiogenesis
Total direct cost: £253,313
BBSRC ALERT2020 (2021-2023)
Role: co-PI
Lattice light sheet microscopy for the biosciences
Total direct cost: £651,012
Active:
Impact Accelerator Account/ Dark Blue Tx (2023-2024)
Role: PI
Assay development for testing efficacy of oncological non-canonical HH inhibitors
Total direct cost: £52,000
BBSRC International Partnering Award (2022-2026)
Role: PI
Italy-Croatia-Poland- UK partnership: The GLI transcription factors: from upstream regulators to downstream targets”
Total direct cost: £25,400