Michele Bombardieri

Professore associato


email: m.bombardieri@qmul.ac.uk




Michele Bombardieri is Professor of Immuno-Rheumatology (HCC) at the Centre for Experimental Medicine and Rheumatology. Professor Bombardieri graduated at Catholic University of Rome and completed his specialist Rheumatology training with Prof Valesini at University of Rome “La Sapienza”. Since 2003 he joined Prof Pitzalis’ group at Kings College London where he completed his PhD in Experimental Rheumatology in 2007 with support from a Clinical Research Fellowship from the Arthritis Research Campaign (now Arthritis Research UK). In 2007 he relocated to the William Harvey Research Institute at Queen Mary University of London as part of the Centre for Experimental Medicine and Rheumatology. He held an ARUK Clinician Scientist Fellowship until 2010 when he was awarded an NIHR “new blood” senior clinical lectureship. Group members Post-Doctoral Fellows: Dr Elisa Astorri, Dr Emanuela Carlotti, Dr Elisa Corsiero, Dr Cristina Croia, Dr Nikola Lepse, Dr Davide Lucchesi, Dr William Murray-Brown, Dr Vidalba Rocher-Ros PhD Students: Dr Sophia Grigoriadou, Dr Alessandra Nerviani, Ms Elena Pontarini Visiting Research Fellows: Mr Edoardo Prediletto Summary Professor Bombardieri leads the Immuno-Rheumatology Research group at EMR (10 researchers) and the Sjogren’s Clinical Research Team (1 clinical trial coordinator, 1 specialist nurse, 2 clinical research fellows). His major research interests focus on the elucidation of the cellular and molecular mechanisms regulating autoreactive B cell activation, breach of self-tolerance and perpetuation of autoimmunity in Sjogren’s syndrome and rheumatoid arthritis. In addition, he has significant interest in translational research with the aim to identify new therapeutic targets and novel biomarkers in order to develop early phase clinical trials based on patients’ stratification and target validation in Sjogren’s syndrome and inflammatory arthritis. Furthermore, Dr Bombardieri is currently investigating the cellular and molecular mechanisms involved in the response/relapse/resistance to B cell depleting agents in rheumatic diseases. Professor Bombardieri seats on the International Scientific Committee for the International Symposia in Sjogren’s syndrome and the Medical Council of the British Sjogren’s Syndrome Association (BSSA). He serves as a regular reviewer for UK and International Research Funding Bodies and several International Scientific Journals including top speciality Journals such as Arthritis and Rheumatology, Annals of the Rheumatic Diseases and the Journal of Immunology. He has authored over 60 peer-reviewed publications in International Journals in the field of autoimmunity, Sjogren’s syndrome and inflammatory arthritis and attracted £2.4million in research income since he joined QMUL. Evolution of TLS in response to viral infection in the SGs and development of autoimmunity (A) Viral infection of the SG mucosa induces activation of epithelial and stromal cells and resident macrophages, triggering the production of inflammatory chemokines and the expression of adhesion molecules on blood vessels, leading to the recruitment of innate immune cells from the peripheral compartment to the SGs. Inflammatory chemokines attract inflammatory monocytes and within the first week from infection, T cells leading to the secretion of inflammatory cytokines (e.g., IFN-γ, TNF-α, IL-1β) that in turn, activate resident NK cells and drive macrophage polarization and a Th1-mediated antiviral response. (B) Despite potent antiviral immune responses, several viruses (e.g., CMV, EBV, and Coxsackie) can escape immune surveillance, leading to lack of viral clearance and persistent infection, preferentially within ductal epithelial cells. Chronic antigen stimulation promotes the lymphoneogenetic program through the interaction between inducer and organizer cells. This triggers the activation of the LTβ pathway and the production of lymphoid chemokines CXCL13, CCL19, and CCL21 by stromal cells and monocyte-derived cells with the accumulation of B and T cells in the gland. (C) In the context of persistent chronic stimulation, the LTβ condition vessels to acquire a HEV phenotype with expression of PNAd, whereas CCL19 and CCL21 facilitate T lymphocyte influx and organize the T cell area of the ectopic follicle. Similarly, stromal cells via CXCL13 production promote the organization of the ectopic B cell follicle and favor the ingress of Tfh cells into the B cell area. Further differentiation of stromal cells into FDCs leads to the GC response, which is sustained by the production of B cell-activating cytokines, such as BAFF and IL-21, leading to in situ activation and proliferation of B cells. TLS fail to exclude autoreactive B cells from entering the ectopic GC, leading to breach of self-tolerance and development of autoimmunity. In this context, immune-modulating viruses, such as HTLV-1 in T cells and EBV in B cells, further promote autoreactive T and B cell survival in the periphery and their preferential recruitment in the ectopic B cell follicles, whereby autoreactive EBV-infected B cells undergo plasma cell differentiation and autoantibody production.


 

 
 
Autonomic symptoms are common and are associated with overall symptom burden and disease activity in primary Sjogren's syndrome.
Newton JL, Frith J, Powell D, Hackett K, Wilton K, Bowman S, Price E, Pease C, Andrews J, Emery P, Hunter J, Gupta M, Vadivelu S, Giles I, Isenberg D, Lanyon P, Jones A, Regan M, Cooper A, Moots R, Sutcliffe N, Bombardieri M, Pitzalis C, McLaren J, Young-Min S, Dasgupta B, Griffiths B, Lendrem D, Mitchell S, Ng WF; UK primary Sjögren's syndrome registry. Ann Rheum Dis. 2012 Dec;71(12):1973-9. doi: 10.1136/annrheumdis-2011-201009. Epub 2012 May 5. PMID: 22562982 Free PMC article.
 
 
 
Association of genes in the NF-κB pathway with antibody-positive primary Sjögren's syndrome.
Nordmark G, Wang C, Vasaitis L, Eriksson P, Theander E, Kvarnström M, Forsblad-d'Elia H, Jazebi H, Sjöwall C, Reksten TR, Brun JG, Jonsson MV, Johnsen SJ, Wahren-Herlenius M, Omdal R, Jonsson R, Bowman S, Ng WF, Eloranta ML, Syvänen AC; UK Primary Sjögren’s Syndrome Registry. Scand J Immunol. 2013 Nov;78(5):447-54. doi: 10.1111/sji.12101. PMID: 23944604 Free article.
 
 
 
The TRACTISS protocol: a randomised double blind placebo controlled clinical trial of anti-B-cell therapy in patients with primary Sjögren's Syndrome.
Brown S, Navarro Coy N, Pitzalis C, Emery P, Pavitt S, Gray J, Hulme C, Hall F, Busch R, Smith P, Dawson L, Bombardieri M, Wan-Fai N, Pease C, Price E, Sutcliffe N, Woods C, Ruddock S, Everett C, Reynolds C, Skinner E, Poveda-Gallego A, Rout J, Macleod I, Rauz S, Bowman S; TRACTISS trial team. BMC Musculoskelet Disord. 2014 Jan 17;15:21. doi: 10.1186/1471-2474-15-21. PMID: 24438039 Free PMC article. Clinical Trial.
 
 
 
Health-related utility values of patients with primary Sjögren's syndrome and its predictors.
Lendrem D, Mitchell S, McMeekin P, Bowman S, Price E, Pease CT, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Vadivelu S, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Ng WF; UK primary Sjögren's Syndrome Registry. Ann Rheum Dis. 2014 Jul;73(7):1362-8. doi: 10.1136/annrheumdis-2012-202863. Epub 2013 Jun 12. PMID: 23761688
 
 
 
Do the EULAR Sjögren's syndrome outcome measures correlate with health status in primary Sjögren's syndrome?
Lendrem D, Mitchell S, McMeekin P, Gompels L, Hackett K, Bowman S, Price E, Pease CT, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Ng WF; UK primary Sjögren’s Syndrome Registry. Rheumatology (Oxford). 2015 Apr;54(4):655-9. doi: 10.1093/rheumatology/keu361. Epub 2014 Sep 19. PMID: 25240612 Free article.
 
 
 
IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.
Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, Zhang Y, Fouser L, Fisher B, Bowman S, Rangel-Moreno J, Garcia-Hernandez Mde L, Randall TD, Lucchesi D, Bombardieri M, Pitzalis C, Luther SA, Buckley CD. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11024-9. doi: 10.1073/pnas.1503315112. Epub 2015 Aug 18. PMID: 26286991 Free PMC article.
 
 
 
A Transcriptional Signature of Fatigue Derived from Patients with Primary Sjögren's Syndrome.
James K, Al-Ali S, Tarn J, Cockell SJ, Gillespie CS, Hindmarsh V, Locke J, Mitchell S, Lendrem D, Bowman S, Price E, Pease CT, Emery P, Lanyon P, Hunter JA, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B; UK Primary Sjögren’s Syndrome registry; Wipat A, Newton J, Jones DE, Isaacs J, Hallinan J, Ng WF. PLoS One. 2015 Dec 22;10(12):e0143970. doi: 10.1371/journal.pone.0143970. eCollection 2015. PMID: 26694930 Free PMC article.
 
 
 
Eligibility for clinical trials in primary Sjögren's syndrome: lessons from the UK Primary Sjögren's Syndrome Registry.
Oni C, Mitchell S, James K, Ng WF, Griffiths B, Hindmarsh V, Price E, Pease CT, Emery P, Lanyon P, Jones A, Bombardieri M, Sutcliffe N, Pitzalis C, Hunter J, Gupta M, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Barone F, Fisher B, Rauz S, Richards A, Bowman SJ; UK Primary Sjögren’s Syndrome Registry. Rheumatology (Oxford). 2016 Mar;55(3):544-52. doi: 10.1093/rheumatology/kev373. Epub 2015 Oct 27. PMID: 26510429 Free PMC article.
 
 
 
Fatigue in primary Sjögren's syndrome is associated with lower levels of proinflammatory cytokines.
Howard Tripp N, Tarn J, Natasari A, Gillespie C, Mitchell S, Hackett KL, Bowman SJ, Price E, Pease CT, Emery P, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg DA, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Lendrem DW, Ng WF. RMD Open. 2016 Jul 19;2(2):e000282. doi: 10.1136/rmdopen-2016-000282. eCollection 2016. PMID: 27493792 Free PMC article.
 
 
 
Physical activity but not sedentary activity is reduced in primary Sjögren's syndrome.
Ng WF, Miller A, Bowman SJ, Price EJ, Kitas GD, Pease C, Emery P, Lanyon P, Hunter J, Gupta M, Giles I, Isenberg D, McLaren J, Regan M, Cooper A, Young-Min SA, McHugh N, Vadivelu S, Moots RJ, Coady D, MacKay K, Dasgupta B, Sutcliffe N, Bombardieri M, Pitzalis C, Griffiths B, Mitchell S, Miyamoto ST, Trenell M; UK Primary Sjögren’s Syndrome Registry. Rheumatol Int. 2017 Apr;37(4):623-631. doi: 10.1007/s00296-016-3637-6. Epub 2016 Dec 24. PMID: 28013357 Free PMC article.
 
 
 
Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium.
Brito-Zerón P, Acar-Denizli N, Zeher M, Rasmussen A, Seror R, Theander E, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Kruize AA, Valim V, Kvarnstrom M, Sene D, Gerli R, Praprotnik S, Isenberg D, Solans R, Rischmueller M, Kwok SK, Nordmark G, Suzuki Y, Giacomelli R, Devauchelle-Pensec V, Bombardieri M, Hofauer B, Bootsma H, Brun JG, Fraile G, Carsons SE, Gheita TA, Morel J, Vollenveider C, Atzeni F, Retamozo S, Horvath IF, Sivils K, Mandl T, Sandhya P, De Vita S, Sanchez-Guerrero J, van der Heijden E, Trevisani VFM, Wahren-Herlenius M, Mariette X, Ramos-Casals M; EULAR-SS Task Force Big Data Consortium. Ann Rheum Dis. 2017 Jun;76(6):1042-1050. doi: 10.1136/annrheumdis-2016-209952. Epub 2016 Nov 29. PMID: 27899373
 
 
 
Standardisation of labial salivary gland histopathology in clinical trials in primary Sjögren's syndrome.
Fisher BA, Jonsson R, Daniels T, Bombardieri M, Brown RM, Morgan P, Bombardieri S, Ng WF, Tzioufas AG, Vitali C, Shirlaw P, Haacke E, Costa S, Bootsma H, Devauchelle-Pensec V, Radstake TR, Mariette X, Richards A, Stack R, Bowman SJ, Barone F; Sjögren's histopathology workshop group (appendix) from ESSENTIAL (EULAR Sjögren's syndrome study group). Ann Rheum Dis. 2017 Jul;76(7):1161-1168. doi: 10.1136/annrheumdis-2016-210448. Epub 2016 Dec 13. PMID: 27965259 Free PMC article.
 
 
 
Randomized Controlled Trial of Rituximab and Cost-Effectiveness Analysis in Treating Fatigue and Oral Dryness in Primary Sjögren's Syndrome.
Bowman SJ, Everett CC, O'Dwyer JL, Emery P, Pitzalis C, Ng WF, Pease CT, Price EJ, Sutcliffe N, Gendi NST, Hall FC, Ruddock SP, Fernandez C, Reynolds C, Hulme CT, Davies KA, Edwards CJ, Lanyon PC, Moots RJ, Roussou E, Giles IP, Sharples LD, Bombardieri M. Arthritis Rheumatol. 2017 Jul;69(7):1440-1450. doi: 10.1002/art.40093. Epub 2017 Jun 5. PMID: 28296257 Free article. Clinical Trial.
 
 
 
Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy.
Bezzina OM, Gallagher P, Mitchell S, Bowman SJ, Griffiths B, Hindmarsh V, Hargreaves B, Price EJ, Pease CT, Emery P, Lanyon P, Bombardieri M, Sutcliffe N, Pitzalis C, Hunter J, Gupta M, McLaren J, Cooper AM, Regan M, Giles IP, Isenberg DA, Saravanan V, Coady D, Dasgupta B, McHugh NJ, Young-Min SA, Moots RJ, Gendi N, Akil M, MacKay K, Ng WF, Robinson LJ; UK Primary Sjögren's Syndrome Registry. Arthritis Care Res (Hoboken). 2017 Nov;69(11):1714-1723. doi: 10.1002/acr.23165. Epub 2017 Oct 9. PMID: 27992710 Free PMC article.
 
 
 
Eligibility for clinical trials in primary Sjögren's syndrome: lessons from the UK Primary Sjögren's Syndrome Registry.
Oni C, Mitchell S, James K, Ng WF, Griffiths B, Hindmarsh V, Price E, Pease CT, Emery P, Lanyon P, Jones A, Bombardieri M, Sutcliffe N, Pitzalis C, Hunter J, Gupta M, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Barone F, Fisher B, Rauz S, Richards A, Bowman SJ. Rheumatology (Oxford). 2017 Dec 1;56(12):2255. doi: 10.1093/rheumatology/kex331. PMID: 28968900 Free PMC article. No abstract available.
 
 
 
Comparison of ESSDAI and ClinESSDAI in potential optimisation of trial outcomes in primary Sjögren's syndrome: examination of data from the UK Primary Sjögren's Syndrome Registry.
Dumusc A, Ng WF, James K, Griffiths B, Price E, Pease C, Emery P, Lanyon P, Jones A, Bombardieri M, Sutcliffe N, Pitzalis C, Gupta M, McLaren J, Cooper A, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Barone F, Fisher B, Rauz S, Richards A, Bowman S. Swiss Med Wkly. 2018 Feb 7;148:w14588. doi: 10.4414/smw.2018.14588. eCollection 2018. PMID: 29442344 Free article.
 
 
 
Effect of rituximab on a salivary gland ultrasound score in primary Sjögren's syndrome: results of the TRACTISS randomised double-blind multicentre substudy.
Fisher BA, Everett CC, Rout J, O'Dwyer JL, Emery P, Pitzalis C, Ng WF, Carr A, Pease CT, Price EJ, Sutcliffe N, Makdissi J, Tappuni AR, Gendi NST, Hall FC, Ruddock SP, Fernandez C, Hulme CT, Davies KA, Edwards CJ, Lanyon PC, Moots RJ, Roussou E, Richards A, Sharples LD, Bombardieri M, Bowman SJ. Ann Rheum Dis. 2018 Mar;77(3):412-416. doi: 10.1136/annrheumdis-2017-212268. Epub 2017 Dec 23. PMID: 29275334 Free PMC article. Clinical Trial.
 
 
 
How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project).
Brito-Zerón P, Acar-Denizli N, Ng WF, Zeher M, Rasmussen A, Mandl T, Seror R, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Armagan B, Kruize AA, Kwok SK, Kvarnström M, Praprotnik S, Sène D, Bartoloni E, Solans R, Rischmueller M, Suzuki Y, Isenberg DA, Valim V, Wiland P, Nordmark G, Fraile G, Bootsma H, Nakamura T, Giacomelli R, Devauchelle-Pensec V, Knopf A, Bombardieri M, Trevisani VF, Hammenfors D, Pasoto SG, Retamozo S, Gheita TA, Atzeni F, Morel J, Vollenveider C, Horvath IF, Sivils KL, Olsson P, De Vita S, Sánchez-Guerrero J, Kilic L, Wahren-Herlenius M, Mariette X, Ramos-Casals M; Sjögren Big Data Consortium. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):102-112. Epub 2018 Aug 14. PMID: 30156539 Free article.
 
 
 
Guidelines for biomarkers in autoimmune rheumatic diseases - evidence based analysis.
Giacomelli R, Afeltra A, Alunno A, Bartoloni-Bocci E, Berardicurti O, Bombardieri M, Bortoluzzi A, Caporali R, Caso F, Cervera R, Chimenti MS, Cipriani P, Coloma E, Conti F, D'Angelo S, De Vita S, Di Bartolomeo S, Distler O, Doria A, Feist E, Fisher BA, Gerosa M, Gilio M, Guggino G, Liakouli V, Margiotta DPE, Meroni P, Moroncini G, Perosa F, Prete M, Priori R, Rebuffi C, Ruscitti P, Scarpa R, Shoenfeld Y, Todoerti M, Ursini F, Valesini G, Vettori S, Vitali C, Tzioufas AG. Autoimmun Rev. 2019 Jan;18(1):93-106. doi: 10.1016/j.autrev.2018.08.003. Epub 2018 Nov 5. PMID: 30408582 Review.
 
 
 
Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren's syndrome.
Hackett KL, Davies K, Tarn J, Bragg R, Hargreaves B, Miyamoto S, McMeekin P, Mitchell S, Bowman S, Price EJ, Pease C, Emery P, Andrews J, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Vadivelu S, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Lendrem DW, Ng WF. RMD Open. 2019 Apr 24;5(1):e000885. doi: 10.1136/rmdopen-2018-000885. eCollection 2019. PMID: 31168409 Free PMC article.
 
 
 
PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes.
Bottini A, Wu DJ, Ai R, Le Roux M, Bartok B, Bombardieri M, Doody KM, Zhang V, Sacchetti C, Zoccheddu M, Lonic A, Li X, Boyle DL, Hammaker D, Meng TC, Liu L, Corr M, Stanford SM, Lewis M, Wang W, Firestein GS, Khew-Goodall Y, Pitzalis C, Bottini N. Ann Rheum Dis. 2019 May;78(5):600-609. doi: 10.1136/annrheumdis-2018-213799. Epub 2019 Feb 26. PMID: 30808624 Free PMC article.
 
 
 
Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients.
Humby F, Lewis M, Ramamoorthi N, Hackney JA, Barnes MR, Bombardieri M, Setiadi AF, Kelly S, Bene F, DiCicco M, Riahi S, Rocher V, Ng N, Lazarou I, Hands R, van der Heijde D, Landewé RBM, van der Helm-van Mil A, Cauli A, McInnes I, Buckley CD, Choy EH, Taylor PC, Townsend MJ, Pitzalis C. Ann Rheum Dis. 2019 Jun;78(6):761-772. doi: 10.1136/annrheumdis-2018-214539. Epub 2019 Mar 16. PMID: 30878974 Free PMC article.
 
 
 
Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes.
Lewis MJ, Barnes MR, Blighe K, Goldmann K, Rana S, Hackney JA, Ramamoorthi N, John CR, Watson DS, Kummerfeld SK, Hands R, Riahi S, Rocher-Ros V, Rivellese F, Humby F, Kelly S, Bombardieri M, Ng N, DiCicco M, van der Heijde D, Landewé R, van der Helm-van Mil A, Cauli A, McInnes IB, Buckley CD, Choy E, Taylor PC, Townsend MJ, Pitzalis C. Cell Rep. 2019 Aug 27;28(9):2455-2470.e5. doi: 10.1016/j.celrep.2019.07.091. PMID: 31461658 Free PMC article.
 
 
 
Symptom-based stratification of patients with primary Sjögren's syndrome: multi-dimensional characterisation of international observational cohorts and reanalyses of randomised clinical trials.
Tarn JR, Howard-Tripp N, Lendrem DW, Mariette X, Saraux A, Devauchelle-Pensec V, Seror R, Skelton AJ, James K, McMeekin P, Al-Ali S, Hackett KL, Lendrem BC, Hargreaves B, Casement J, Mitchell S, Bowman SJ, Price E, Pease CT, Emery P, Lanyon P, Hunter J, Gupta M, Bombardieri M, Sutcliffe N, Pitzalis C, McLaren J, Cooper A, Regan M, Giles I, Isenberg D, Saravanan V, Coady D, Dasgupta B, McHugh N, Young-Min S, Moots R, Gendi N, Akil M, Griffiths B, Johnsen SJA, Norheim KB, Omdal R, Stocken D, Everett C, Fernandez C; Leeds CTRU; Isaacs JD, Gottenberg JE; French ASSESS cohort; Ng WF; UK Primary Sjögren's Syndrome Registry. Lancet Rheumatol. 2019 Oct;1(2):e85-e94. doi: 10.1016/S2665-9913(19)30042-6. Epub 2019 Sep 25. PMID: 38229348 Free PMC article.
 
 
 
CXCL13 as biomarker for histological involvement in Sjögren's syndrome.
Colafrancesco S, Priori R, Smith CG, Minniti A, Iannizzotto V, Pipi E, Lucchesi D, Pontarini E, Nayar S, Campos J, Arienzo F, Fusconi M, Cerbelli B, Giordano C, Valesini G, Bombardieri M, Fisher BA, Barone F. Rheumatology (Oxford). 2020 Jan 1;59(1):165-170. doi: 10.1093/rheumatology/kez255. PMID: 31274159
 
 
 
EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.
Ramos-Casals M, Brito-Zerón P, Bombardieri S, Bootsma H, De Vita S, Dörner T, Fisher BA, Gottenberg JE, Hernandez-Molina G, Kocher A, Kostov B, Kruize AA, Mandl T, Ng WF, Retamozo S, Seror R, Shoenfeld Y, Sisó-Almirall A, Tzioufas AG, Vitali C, Bowman S, Mariette X; EULAR-Sjögren Syndrome Task Force Group. Ann Rheum Dis. 2020 Jan;79(1):3-18. doi: 10.1136/annrheumdis-2019-216114. Epub 2019 Oct 31. PMID: 31672775
 
 
 
Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren's syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study.
Fisher BA, Szanto A, Ng WF, Bombardieri M, Posch MG, Papas AS, Farag AM, Daikeler T, Bannert B, Kyburz D, Kivitz AJ, Carsons SE, Isenberg DA, Barone F, Bowman SJ, Espié P, Floch D, Dupuy C, Ren X, Faerber PM, Wright AM, Hockey HU, Rotte M, Milojevic J, Avrameas A, Valentin MA, Rush JS, Gergely P. Lancet Rheumatol. 2020 Mar;2(3):e142-e152. doi: 10.1016/S2665-9913(19)30135-3. Epub 2020 Jan 23. PMID: 38263652
 
 
 
Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjögren's syndrome.
Brito-Zerón P, Acar-Denizli N, Ng WF, Horváth IF, Rasmussen A, Seror R, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Armagan B, Kruize AA, Kwok SK, Kvarnstrom M, Praprotnik S, Sene D, Gerli R, Solans R, Rischmueller M, Mandl T, Suzuki Y, Isenberg D, Valim V, Wiland P, Nordmark G, Fraile G, Bootsma H, Nakamura H, Giacomelli R, Devauchelle-Pensec V, Hofauer B, Bombardieri M, Trevisani VFM, Hammenfors D, Pasoto SG, Retamozo S, Gheita TA, Atzeni F, Morel J, Vollenweider C, Zeher M, Sivils K, Xu B, Bombardieri S, Sandhya P, De Vita S, Minniti A, Sánchez-Guerrero J, Kilic L, van der Heijden E, Park SH, Wahren-Herlenius M, Mariette X, Ramos-Casals M; Sjögren Big Data Consortium. Rheumatology (Oxford). 2020 Sep 1;59(9):2350-2359. doi: 10.1093/rheumatology/kez578. PMID: 31873754 Free article.
 
 
 
Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma.
Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E, Prediletto E, Corsiero E, Romana Delvecchio F, Coleby R, Gelbhardt E, Bono A, Baldini C, Puxeddu I, Ruscitti P, Giacomelli R, Barone F, Fisher B, Bowman SJ, Colafrancesco S, Priori R, Sutcliffe N, Challacombe S, Carlesso G, Tappuni A, Pitzalis C, Bombardieri M. Ann Rheum Dis. 2020 Dec;79(12):1588-1599. doi: 10.1136/annrheumdis-2020-217646. Epub 2020 Sep 22. PMID: 32963045 Free PMC article.
 
 
 
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial.
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G, Mahto A, Montecucco C, Lauwerys B, Ng N, Ho P, Bombardieri M, Romão VC, Verschueren P, Kelly S, Sainaghi PP, Gendi N, Dasgupta B, Cauli A, Reynolds P, Cañete JD, Moots R, Taylor PC, Edwards CJ, Isaacs J, Sasieni P, Choy E, Pitzalis C; R4RA collaborative group. Lancet. 2021 Jan 23;397(10271):305-317. doi: 10.1016/S0140-6736(20)32341-2. PMID: 33485455 Free PMC article. Clinical Trial.
 
 
 
The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts' Consensus.
Giacomelli R, Afeltra A, Bartoloni E, Berardicurti O, Bombardieri M, Bortoluzzi A, Carubbi F, Caso F, Cervera R, Ciccia F, Cipriani P, Coloma-Bazán E, Conti F, Costa L, D'Angelo S, Distler O, Feist E, Foulquier N, Gabini M, Gerber V, Gerli R, Grembiale RD, Guggino G, Hoxha A, Iagnocco A, Jordan S, Kahaleh B, Lauper K, Liakouli V, Lubrano E, Margiotta D, Naty S, Navarini L, Perosa F, Perricone C, Perricone R, Prete M, Pers JO, Pitzalis C, Priori R, Rivellese F, Ruffatti A, Ruscitti P, Scarpa R, Shoenfeld Y, Triolo G, Tzioufas A. Autoimmun Rev. 2021 Feb;20(2):102738. doi: 10.1016/j.autrev.2020.102738. Epub 2020 Dec 14. PMID: 33326854
 
 
 
PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.
Fanelli G, Romano M, Nova-Lamperti E, Werner Sunderland M, Nerviani A, Scottà C, Bombardieri M, Quezada SA, Sacks SH, Noelle RJ, Pitzalis C, Lechler RI, Lombardi G, Becker PD. PLoS Biol. 2021 Apr 26;19(4):e3001199. doi: 10.1371/journal.pbio.3001199. eCollection 2021 Apr. PMID: 33901179 Free PMC article.
 
 
 
Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren's syndrome.
Jimenez-Royo P, Bombardieri M, Ciurtin C, Kostapanos M, Tappuni AR, Jordan N, Saleem A, Fuller T, Port K, Pontarini E, Lucchesi D, Janiczek R, Galette P, Searle G, Patel N, Kershaw L, Gray C, Ratia N, van Maurik A, de Groot M, Wisniacki N, Bergstrom M, Tarzi R. Rheumatology (Oxford). 2021 May 14;60(5):2396-2408. doi: 10.1093/rheumatology/keaa624. PMID: 33221921 Free PMC article.
 
 
 
Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network.
Deonaraine KK, Carlucci PM, Fava A, Li J, Wofsy D, James JA, Putterman C, Diamond B, Davidson A, Fine DM, Monroy-Trujillo J, Atta MG, Haag K, Rao DA, Apruzzese W, Belmont HM, Izmirly PM, Wu M, Connery S, Payan-Schober F, Furie RA, Berthier CC, Dall'Era M, Cho K, Kamen DL, Kalunian K, Anolik J, Ishimori M, Weisman MH; Accelerating Medicines Partnership RA/SLE network; Petri MA, Buyon JP. Lupus Sci Med. 2021 Aug;8(1):e000522. doi: 10.1136/lupus-2021-000522. PMID: 34389634 Free PMC article.
 
 
 
NKp30 Receptor Upregulation in Salivary Glands of Sjögren's Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment.
Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F, Calcaterra F, Tappuni A, Lewis MJ, Fabris M, Quartuccio L, Bella SD, Bowman S, Pitzalis C, Mavilio D, De Vita S, Bombardieri M. Front Immunol. 2021 Sep 14;12:706737. doi: 10.3389/fimmu.2021.706737. eCollection 2021. PMID: 34594326 Free PMC article.
 
 
 
Influence of the age at diagnosis in the disease expression of primary Sjögren syndrome. Analysis of 12,753 patients from the Sjögren Big Data Consortium.
Retamozo S, Acar-Denizli N, Horváth IF, Ng WF, Rasmussen A, Dong X, Li X, Baldini C, Olsson P, Priori R, Seror R, Gottenberg JE, Kruize AA, Hernandez-Molina G, Vissink A, Sandhya P, Armagan B, Quartuccio L, Sebastian A, Praprotnik S, Bartoloni E, Kwok SK, Kvarnstrom M, Rischmueller M, Soláns-Laqué R, Sene D, Pasoto SG, Suzuki Y, Isenberg DA, Valim V, Nordmark G, Nakamura H, Fernandes Moça Trevisani V, Hofauer B, Sisó-Almirall A, Giacomelli R, Devauchelle-Pensec V, Bombardieri M, Atzeni F, Hammenfors D, Maure B, Carsons SE, Gheita T, Sánchez-Berná I, López-Dupla M, Morel J, Inanç N, Fonseca-Aizpuru E, Morcillo C, Vollenweider C, Melchor S, Vázquez M, Díaz-Cuiza E, Consani-Fernández S, de-Miguel-Campo B, Szántó A, Bombardieri S, Gattamelata A, Hinrichs A, Sánchez-Guerrero J, Danda D, Kilic L, De Vita S, Wiland P, Gerli R, Park SH, Wahren-Herlenius M, Bootsma H, Mariette X, Ramos-Casals M, Brito-Zerón P; Sjögren Big Data Consortium. Clin Exp Rheumatol. 2021 Nov-Dec;39 Suppl 133(6):166-174. doi: 10.55563/clinexprheumatol/egnd1i. Epub 2021 Dec 16. PMID: 34919044 Free article.
 
 
 
Addressing the clinical unmet needs in primary Sjögren's Syndrome through the sharing, harmonization and federated analysis of 21 European cohorts.
Pezoulas VC, Goules A, Kalatzis F, Chatzis L, Kourou KD, Venetsanopoulou A, Exarchos TP, Gandolfo S, Votis K, Zampeli E, Burmeister J, May T, Marcelino Pérez M, Lishchuk I, Chondrogiannis T, Andronikou V, Varvarigou T, Filipovic N, Tsiknakis M, Baldini C, Bombardieri M, Bootsma H, Bowman SJ, Soyfoo MS, Parisis D, Delporte C, Devauchelle-Pensec V, Pers JO, Dörner T, Bartoloni E, Gerli R, Giacomelli R, Jonsson R, Ng WF, Priori R, Ramos-Casals M, Sivils K, Skopouli F, Torsten W, A G van Roon J, Xavier M, De Vita S, Tzioufas AG, Fotiadis DI. Comput Struct Biotechnol J. 2022 Jan 7;20:471-484. doi: 10.1016/j.csbj.2022.01.002. eCollection 2022. PMID: 35070169 Free PMC article.
 
 
 
Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression.
Meednu N, Rangel-Moreno J, Zhang F, Escalera-Rivera K, Corsiero E, Prediletto E, DiCarlo E, Goodman S, Donlin LT, Raychauduri S, Bombardieri M, Pitzalis C, Orange DE; Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Consortium; McDavid A, Anolik JH. Cell Rep. 2022 May 3;39(5):110766. doi: 10.1016/j.celrep.2022.110766. PMID: 35508128 Free PMC article.
 
 
 
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial.
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A, Fossati-Jimack L, Thorborn G, Ahmed M, Prediletto E, Church SE, Hudson BM, Warren SE, McKeigue PM, Humby F, Bombardieri M, Barnes MR, Lewis MJ, Pitzalis C; R4RA collaborative group. Nat Med. 2022 Jun;28(6):1256-1268. doi: 10.1038/s41591-022-01789-0. Epub 2022 May 19. PMID: 35589854 Free PMC article. Clinical Trial.
 
 
 
Development and preliminary validation of the Sjögren's Tool for Assessing Response (STAR): a consensual composite score for assessing treatment effect in primary Sjögren's syndrome.
Seror R, Baron G, Camus M, Cornec D, Perrodeau E, Bowman SJ, Bombardieri M, Bootsma H, Gottenberg JE, Fisher B, Hueber W, van Roon JA, Devauchelle-Pensec V, Gergely P, Mariette X, Porcher R; NECESSITY WP5 - STAR development working group; NECESSITY WP5- STAR development working group. Ann Rheum Dis. 2022 Jul;81(7):979-989. doi: 10.1136/annrheumdis-2021-222054. Epub 2022 Apr 7. PMID: 35393271 Free PMC article.
 
 
 
High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership.
Carlucci PM, Li J, Fava A, Deonaraine KK, Wofsy D, James JA, Putterman C, Diamond B, Davidson A, Fine DM, Monroy-Trujillo J, Atta MG, DeJager W, Guthridge JM, Haag K, Rao DA, Brenner MB, Lederer JA, Apruzzese W, Belmont HM, Izmirly PM, Zaminski D, Wu M, Connery S, Payan-Schober F, Furie R, Dall'Era M, Cho K, Kamen D, Kalunian K, Anolik J, Barnas J, Ishimori M, Weisman MH; Accelerating Medicines Partnership (AMP) RA/SLE Network; Buyon JP, Petri M. Rheumatology (Oxford). 2022 Nov 2;61(11):4335-4343. doi: 10.1093/rheumatology/keac067. PMID: 35212719 Free PMC article.
 
 
 
Circulating c-Met-Expressing Memory T Cells Define Cardiac Autoimmunity.
Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS, Dyer C, Pontarini E, Asimaki A, Bueno-Beti C, De Gaspari M, Rizzo S, Basso C, Bombardieri M, Coe D, Wang G, Harding D, Gallagher I, Solito E, Elliott P, Heymans S, Sikking M, Savvatis K, Mohiddin SA, Marelli-Berg FM. Circulation. 2022 Dec 20;146(25):1930-1945. doi: 10.1161/CIRCULATIONAHA.121.055610. Epub 2022 Nov 23. PMID: 36417924 Free PMC article.
 
 
 
The glucose transporter 2 regulates CD8+ T cell function via environment sensing.
Fu H, Vuononvirta J, Fanti S, Bonacina F, D'Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi MP, Grevitt P, Sheikh MH, Solito E, Godinho SA, Bombardieri M, Smith DM, Cooper D, Iqbal AJ, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD, Marelli-Berg FM. Nat Metab. 2023 Nov;5(11):1969-1985. doi: 10.1038/s42255-023-00913-9. Epub 2023 Oct 26. PMID: 37884694 Free PMC article.
 
 
 
Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials.
Rivellese F, Nerviani A, Giorli G, Warren L, Jaworska E, Bombardieri M, Lewis MJ, Humby F, Pratt AG, Filer A, Gendi N, Cauli A, Choy E, McInnes I, Durez P, Edwards CJ, Buch MH, Gremese E, Taylor PC, Ng N, Cañete JD, Raizada S, McKay ND, Jadon D, Sainaghi PP, Stratton R, Ehrenstein MR, Ho P, Pereira JP, Dasgupta B, Gorman C, Galloway J, Chinoy H, van der Heijde D, Sasieni P, Barton A, Pitzalis C; STRAP collaborative group. Lancet Rheumatol. 2023 Nov;5(11):e648-e659. doi: 10.1016/S2665-9913(23)00241-2. PMID: 38251532 Free article. Clinical Trial.
 
 
 
Exposure to air pollution as an environmental determinant of how Sjögren's disease is expressed at diagnosis.
Brito-Zerón P, Flores-Chávez A, Ng WF, Fanny Horváth I, Rasmussen A, Priori R, Baldini C, Armagan B, Özkiziltaş B, Praprotnik S, Suzuki Y, Quartuccio L, Hernandez-Molina G, Abacar K, Bartoloni E, Rischmueller M, Reis-de Oliveira F, Fernandes Moça Trevisani V, Jurcut C, Fugmann C, Carubbi F, Hofauer B, Valim V, Pasoto SG, Retamozo S, Atzeni F, Fonseca-Aizpuru E, López-Dupla M, Giacomelli R, Nakamura H, Akasbi M, Thompson K, Szántó A, Farris AD, Villa M, Bombardieri S, Kilic L, Tufan A, Perdan Pirkmajer K, Fujisawa Y, de Vita S, Inanc N, Ramos-Casals M; Sjögren Big Data Consortium. Clin Exp Rheumatol. 2023 Dec;41(12):2448-2457. doi: 10.55563/clinexprheumatol/p1r1j4. Epub 2023 Nov 29. PMID: 38019154 Free article.
 
 
 
Influence of exposure to climate-related hazards in the phenotypic expression of primary Sjögren's syndrome.
Flores-Chávez A, Brito-Zerón P, Ng WF, Szántó A, Rasmussen A, Priori R, Baldini C, Armagan B, Özkiziltaş B, Praprotnik S, Suzuki Y, Quartuccio L, Hernández-Molina G, Inanc N, Bartoloni E, Rischmueller M, Reis-de Oliveira F, Fernandes Moça Trevisani V, Jurcut C, Nordmark G, Carubbi F, Hofauer B, Valim V, Pasoto SG, Retamozo S, Atzeni F, Fonseca-Aizpuru E, López-Dupla M, Giacomelli R, Nakamura H, Akasbi M, Thompson K, Fanny Horváth I, Farris AD, Simoncelli E, Bombardieri S, Kilic L, Tufan A, Perdan Pirkmajer K, Fujisawa Y, De Vita S, Abacar K, Ramos-Casals M; Sjögren Big Data Consortium. Clin Exp Rheumatol. 2023 Dec;41(12):2437-2447. doi: 10.55563/clinexprheumatol/pmbay6. Epub 2023 Nov 27. PMID: 38019164 Free article.
 
 
 
Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell-Targeted Therapy in the Trial of Anti-B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS).
Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray-Brown WJ, Lucchesi D, Fossati-Jimack L, Nerviani A, Jaworska E, Ghirardi GM, Giacomassi C, Emery P, Ng WF, Sutcliffe N, Everett C, Fernandez C, Tappuni A, Seror R, Mariette X, Porcher R, Cavallaro G, Pulvirenti A, Verstappen GM, de Wolff L, Arends S, Bootsma H, Lewis MJ, Pitzalis C, Bowman SJ, Bombardieri M; Trial for Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome Study Research Group. Arthritis Rheumatol. 2024 May;76(5):763-776. doi: 10.1002/art.42772. Epub 2024 Feb 15. PMID: 38073013 Clinical Trial.
 
 
 
Tailoring the treatment of inflammatory rheumatic diseases by a better stratification and characterization of the clinical patient heterogeneity. Findings from a systematic literature review and experts' consensus.
Ruscitti P, Allanore Y, Baldini C, Barilaro G, Bartoloni Bocci E, Bearzi P, Bellis E, Berardicurti O, Biaggi A, Bombardieri M, Cantarini L, Cantatore FP, Caporali R, Caso F, Cervera R, Ciccia F, Cipriani P, Chatzis L, Colafrancesco S, Conti F, Corberi E, Costa L, Currado D, Cutolo M, D'Angelo S, Del Galdo F, Di Cola I, Di Donato S, Distler O, D'Onofrio B, Doria A, Fautrel B, Fasano S, Feist E, Fisher BA, Gabini M, Gandolfo S, Gatto M, Genovali I, Gerli R, Grembiale RD, Guggino G, Hoffmann-Vold AM, Iagnocco A, Iaquinta FS, Liakouli V, Manoussakis MN, Marino A, Mauro D, Montecucco C, Mosca M, Naty S, Navarini L, Occhialini D, Orefice V, Perosa F, Perricone C, Pilato A, Pitzalis C, Pontarini E, Prete M, Priori R, Rivellese F, Sarzi-Puttini P, Scarpa R, Sebastiani G, Selmi C, Shoenfeld Y, Triolo G, Trunfio F, Yan Q, Tzioufas AG, Giacomelli R. Autoimmun Rev. 2024 Jul-Aug;23(7-8):103581. doi: 10.1016/j.autrev.2024.103581. Epub 2024 Jul 26. PMID: 39069240 Free article.
 
 
 
Precision medicine in Sjögren's disease.
Gandolfo S, Bombardieri M, Pers JO, Mariette X, Ciccia F. Lancet Rheumatol. 2024 Sep;6(9):e636-e647. doi: 10.1016/S2665-9913(24)00039-0. Epub 2024 May 6. PMID: 38723653 Review.
 
 
 
CD8+ tissue-resident memory T cells are expanded in primary Sjögren's disease and can be therapeutically targeted by CD103 blockade.
Mauro D, Lin X, Pontarini E, Wehr P, Guggino G, Tang Y, Deng C, Gandolfo S, Xiao F, Rui K, Huang E, Tian J, Raimondo S, Rischmueller M, Boroky J, Downie-Doyle S, Nel H, Baz-Morelli A, Hsu A, Maraskovsky E, Barr A, Hemon P, Chatzis L, Boschetti CE, Colella G, Alessandro R, Rizzo A, Pers JO, Bombardieri M, Thomas R, Lu L, Ciccia F. Ann Rheum Dis. 2024 Sep 30;83(10):1345-1357. doi: 10.1136/ard-2023-225069. PMID: 38777379
 
 
 
Executive summary: British Society for Rheumatology guideline on management of adult and juvenile onset Sjögren disease.
Price EJ, Benjamin S, Bombardieri M, Bowman S, Carty S, Ciurtin C, Crampton B, Dawson A, Fisher BA, Giles I, Glennon P, Gupta M, Hackett KL, Larkin G, Ng WF, Ramanan AV, Rassam S, Rauz S, Smith G, Sutcliffe N, Tappuni A, Walsh SB. Rheumatology (Oxford). 2025 Feb 1;64(2):396-408. doi: 10.1093/rheumatology/keae218. PMID: 38785300 Free PMC article. No abstract available.
 
 
 
Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing.
Fu H, Vuononvirta J, Fanti S, Bonacina F, D'Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi MP, Grevitt P, Sheikh MH, Solito E, Godinho SA, Bombardieri M, Smith DM, Cooper D, Iqbal AJ, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD, Marelli-Berg FM. Nat Metab. 2025 Mar;7(3):634. doi: 10.1038/s42255-025-01256-3. PMID: 40000839 Free PMC article. No abstract available.
 
 
 
2023 International Rome consensus for the nomenclature of Sjögren disease.
Ramos-Casals M, Baer AN, Brito-Zerón MDP, Hammitt KM, Bouillot C, Retamozo S, Mackey A, Yarowsky D, Turner B, Blanck J, Fisher BA, Akpek EK, Baldini C, Bootsma H, Bowman SJ, Dörner T, Laing L, Lieberman SM, Mariette X, Pflugfelder SC, Sankar V, Sisó-Almirall A, Tzioufas AG, Anaya JM, Armağan B, Bombardieri M, Carsons S, de Vita S, Fox RI, Gerli R, Giacomelli R, Gottenberg JE, Hernández-Molina G, Jonsson R, Kruize A, Kwok SK, Li X, McCoy SS, Ng WF, Olsson P, Rischmueller M, Saraux A, Scofield RH, Valim V, Vitali C, Vivino F, Wahren-Herlenius M, Moutsopoulos HM; International Task Force on Nomenclature of Sjögren Disease. Nat Rev Rheumatol. 2025 Jul;21(7):426-437. doi: 10.1038/s41584-025-01268-z. Epub 2025 Jun 10. PMID: 40494962
 
 
 
Primary Sjögren's Disease: a review of unmet need, outcome measures, therapeutic advances and health economic impacts. Lessons from the NEw Clinical Endpoints in primary Sjögren's Syndrome: an Interventional Trial based on stratifYing patients (NECESSITY) Innovative Health Initiative (IHI).
Bowman SJ, Seror R, Porcher R, Arends S, de Wolff L, Verstappen G, Devauchelle-Pensec V, Jousse-Joulin S, Baldini C, Bombardieri M, Pontarini E, Hueber W, Marvel J, Goswami P, Cornec D, Fisher BA, Nayar S, Barone F, Ng WF, Gottenberg JE, Bootsma H, Dörner T, Pincemin M, Bouillot C, Hammitt KM, Wahren-Herlenius M, van Roon J, Nocturne G, Laigle L, Moingeon P, Christodoulou A, Sreih AG, van Maurik A, Chen WH, Wisniacki N, Piatrova A, Jonsson R, Gergely P, Mariette X. Ann Rheum Dis. 2025 Jul;84(7):1068-1089. doi: 10.1016/j.ard.2025.05.004. Epub 2025 Jun 17. PMID: 40527714 Free article. Review.
 
 
 
Comparative Analysis of Circulating and Synovial Immune Cells in Early Untreated Rheumatoid Arthritis and Their Relationship With Molecular Pathology and Disease Outcomes.
Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Çubuk C, Goldmann K, Giorli G, Lewis M, Bombardieri M, Pitzalis C; Pathobiology of Early Arthritis Cohort (PEAC) investigators. Arthritis Rheumatol. 2025 Oct;77(10):1349-1361. doi: 10.1002/art.43194. Epub 2025 Jul 7. PMID: 40289062 Free PMC article.
 
 
 
Transcriptomic profiling of Sjögren's disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity.
Pontarini E, Lucchesi D, Sciacca E, Cavallaro G, Song Q, Galbraith D, Thomas E, Marino A, Sutcliffe N, Tappuni AR, Giacomelli R, Pulvirenti A, Bowman SJ, Hao LY, Sivils K, Pitzalis C, Lewis MJ, Bombardieri M. Ann Rheum Dis. 2025 Nov;84(11):1822-1835. doi: 10.1016/j.ard.2025.07.021. Epub 2025 Aug 21. PMID: 40846589 Free article.
 
 
 
Machine learning to classify the focus score and Sjögren's disease using digitalised salivary gland biopsies: a retrospective cohort study.
Duquesne J, Basseto L, Claye C, Barnes M, Pontarini E, Gallagher-Syed A, Bombardieri M, Fisher BA, Nayar S, Brown R, Tzioufas A, Goules A, Chatzis L, Thompson K, Berry J, Ng WF, Bandeira M, Romão VC, López-Presa MD, Nocturne G, Ouerdane W, Molina T, Lazure T, Adam C, Mariette X, Bouget V, Bitoun S. Lancet Rheumatol. 2025 Dec;7(12):e864-e872. doi: 10.1016/S2665-9913(25)00181-X. Epub 2025 Sep 29. PMID: 41038216
 
 
 
Transcriptomic stratification predicts response to rituximab, abatacept, or the association of hydroxychloroquine and leflunomide in 3 randomised controlled clinical trials of Sjögren's disease.
Chevet B, Devauchelle-Pensec V, Pontarini E, Baloche V, Bombardieri M, Bowman SJ, Barnes M, Sreih AG, Liu J, Kelly S, Christodoulou A, Moingeon P, Laigle L, Soret P, Le Dantec C, Pers JO, Alarcon-Riquelme ME, Barturen G, Mariette X, van Roon J, Seror R, Nocturne G, Cornec D, Foulquier N; PRECISEADS Clinical Consortium, NECESSITY consortium. Ann Rheum Dis. 2025 Dec 24:S0003-4967(25)04549-2. doi: 10.1016/j.ard.2025.11.017. Online ahead of print. PMID: 41448992
 
 
 
Pragmatic, open-label, multicentre, randomised controlled trial to guide initial therapy for immune checkpoint inhibitor-induced inflammatory arthritis comparing standard of care (prednisolone) to adalimumab without glucocorticoids: REACT trial protocol.
Fisher BA, Rowe A, Hodson C, Wilkhu M, Williams E, Turner E, Allard A, Blake T, Bombardieri M, Cope AP, Dubey S, Mankia K, Malley T, Moore O, Payne M, Plummer R, Tilby M, Tillett T, Wong E, Wu Y, Filer A, Pratt A, Pallan L, Homer V. BMJ Open. 2026 Mar 3;16(3):e116847. doi: 10.1136/bmjopen-2026-116847. PMID: 41775469 Free PMC article.
 
 


© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma