MIRKO MININI

Dottore di ricerca

ciclo: XXXIII

Titolo della tesi: Myo-Inositol treatment triggers miR-125a-5p expression reducing metastatic potential of breast cancer cells by IP6K1 inhibition

The acquiring of invasive phenotype for metastatic progression is the main cause of death in tumor patients. The investigation about this process in breast cancer patients allowed to identify PI3K/Akt signaling cascade as the main deregulated pathway in Epithelial-Mesenchymal Transition (EMT) process. For long time, PI3K/Akt pathway has been used as target of several drugs. However, toxicity profiles, mutations in specific genes and multiple pathways activated together with PI3K/Akt pathway hamper these drugs from achieving the optimal inhibitory effects making them less attractive for chemoprevention than natural agents such as myo-Inositol. Previously, we demonstrated how myo-Inositol treatment can block EMT in breast cancer cells by downregulating PI3K/Akt and inducing changes in cytoskeletal architecture. Herein, we go insight the mechanism of action of myo-Inositol administration, using as model both triple negative (MDA-MB-231) and hormone responsive (MCF-7) breast cancer cells. Our results suggest that myo-Inositol triggers early modulation in expression pattern, probably led by miRNAs and methylation remodeling of chromatin. The study has allowed us to identify miR-125a-5p and IP6K1 as a novel axis to inhibit motility and metastasis formation using molecular targeted therapies in breast cancer.

Produzione scientifica

11573/1574470 - 2021 - miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting

Minini, M.; Senni, A.; He, X.; Proietti, S.; Liguoro, D.; Catizone, A.; Giuliani, A.; Mancini, R.; Fuso, A.; Cucina, A.; Cao, Y.; Bizzarri, M. - 01a Articolo in rivista

rivista: CANCER LETTERS (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 48-56 - issn: 0304-3835 - wos: WOS:000696948200001 (9) - scopus: 2-s2.0-85109143153 (12)

11573/1362408 - 2020 - Redifferentiation therapeutic strategies in cancer

Bizzarri, M.; Giuliani, A.; Cucina, A.; Minini, M. - 01g Articolo di rassegna (Review)

rivista: DRUG DISCOVERY TODAY (Elsevier Science Limited Trends Journals:PO Box 331, Haywards Heath RH16 3FG United Kingdom:011 44 1444 475651, EMAIL: ct.subs@rbi.co.uk, Fax: 011 44 1444 445423) pp. 731-738 - issn: 1359-6446 - wos: WOS:000530687600010 (5) - scopus: 2-s2.0-85079071144 (5)

11573/1442522 - 2020 - Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape

Bizzarri, Mariano; Giuliani, Alessandro; Minini, Mirko; Monti, Noemi; Cucina, Alessandra - 01a Articolo in rivista

rivista: BIOESSAYS (-HOBOKEN, USA, NJ: JOHN WILEY & SONS INC -Cambridge : Cambridge University Press, 1984-) pp. 1900108- - issn: 0265-9247 - wos: WOS:000516656800001 (8) - scopus: 2-s2.0-85081231084 (9)

11573/1442520 - 2020 - The Key Role of IP6K: A Novel Target for Anticancer Treatments?

Minini, Mirko; Senni, Alice; Unfer, Vittorio; Bizzarri, Mariano - 01a Articolo in rivista

rivista: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. 4401- - issn: 1420-3049 - wos: WOS:000586589200001 (6) - scopus: 2-s2.0-85092094657 (6)

11573/1340363 - 2019 - Myo-Inositol treatment inhibits motility in triple negative breast cancer via miR-125a-5p/IP6K1 axis

Minini, Mirko; Proietti, Sara; He, Xingkang; Senni, Alice; Monti, Noemi; Fuso, Andrea; Cucina, Alessandra; Cao, Yihai; Bizzarri, Mariano - 04b Atto di convegno in volume

congresso: EMBL CONFERENCE: Cancer Genomics (EMBL Heidelberg, Germany)

libro: EMBL CONFERENCE: Cancer Genomics - ()

11573/1340369 - 2019 - The activation of miR-125a-5p/IP6K1 axis in breast cancer cells upon treatment with myo-Inositol.

Minini, Mirko; Proietti, Sara; Monti, Noemi; Senni, Alice; Fuso, Andrea; Cucina, Alessandra; Bizzarri, Mariano - 04b Atto di convegno in volume

congresso: 16th Horizons in Molecular Biology, International PhD Student Symposium and Career Fair for Life Sciences (MPI, Göttingen, Germany)

libro: 16th Horizons in Molecular Biology, International PhD Student Symposium and Career Fair for Life Sciences - ()

11573/1276721 - 2019 - Active fraction from embryo fish extracts induces reversion of the malignant invasive phenotype in breast cancer through down-regulation of TCTP and modulation of E-cadherin/β-catenin pathway

Proietti, Sara; Cucina, Alessandra; Pensotti, Andrea; Biava, Pier Mario; Minini, Mirko; Monti, Noemi; Catizone, Angela; Ricci, Giulia; Leonetti, Erica; Harrath, Abdel Halim; Alwasel, Saleh H; Bizzarri, Mariano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-18 - issn: 1422-0067 - wos: WOS:000469753500098 (19) - scopus: 2-s2.0-85065656863 (20)

11573/1160997 - 2018 - From implantation to birth: insight into molecular melatonin functions

Carlomagno, Gianfranco; Minini, Mirko; Tilotta, Marco; Unfer, Vittorio - 01g Articolo di rassegna (Review)

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-16 - issn: 1661-6596 - wos: WOS:000449988100338 (53) - scopus: 2-s2.0-85053698312 (55)

11573/1079026 - 2018 - Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation

Proietti, Sara; Catizone, Angela; Masiello, Maria Grazia; Dinicola, Simona; Fabrizi, Gianmarco; Minini, Mirko; Ricci, Giulia; Verna, Roberto; Reiter, Russel J; Cucina, Alessandra; Bizzarri, Mariano; Proietti, Catizone Uguale Contributo - 01a Articolo in rivista

rivista: JOURNAL OF PINEAL RESEARCH (Blackwell Munksgaard:PO Box 2148, Periodicals Department, DK-1016 Copenhagen K Denmark:011 45 33 755913, EMAIL: agentservices@oxon.blackwellpublishing.com, INTERNET: http://www.blackwellmunksgaard.com, Fax: 011 45 77 333377) pp. 1-17 - issn: 0742-3098 - wos: WOS:000430110100002 (33) - scopus: 2-s2.0-85045457158 (37)

11573/1014338 - 2017 - Nutritional and Acquired Deficiencies in Inositol Bioavailability. Correlations with Metabolic Disorders. Dinicola S, Minini M, Unfer V, Verna R, Cucina A, Bizzarri M. IJMSInt J Mol Sci. 2017 Oct 20;18(10). pii: E2187. doi: 10.3390/ijms18102187

Dinicola, Simona; Minini, Mirko; Unfer, Vittorio; Verna, Roberto; Cucina, Alessandra; Bizzarri, Mariano - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000414671800170 (47) - scopus: 2-s2.0-85032024805 (50)

11573/1089134 - 2017 - Melatonin, mitochondria, and the cancer cell

Proietti, Sara; Cucina, Alessandra; Minini, Mirko; Bizzarri, Mariano - 01g Articolo di rassegna (Review)

rivista: CELLULAR AND MOLECULAR LIFE SCIENCES (Birkhaeuser Verlag AG:Viaduktstrasse 42-44, CH 4051 Basel Switzerland:011 41 61 2050707, EMAIL: subscriptions@birkhauser.ch, INTERNET: http://www.birkhauser.ch, Fax: 011 41 61 2050792) pp. 4015-4025 - issn: 1420-682X - wos: WOS:000412754800011 (43) - scopus: 2-s2.0-85026923562 (46)

11573/903648 - 2016 - Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement

Dinicola, Simona; Fabrizi, Gianmarco; Masiello, Maria Grazia; Proietti, Sara; Palombo, Alessandro; Minini, Mirko; Harrath, Abdel Halim; Alwasel, Saleh H.; Ricci, Giulia; Catizone, Angiolina; Cucina, Alessandra; Bizzarri, Mariano - 01a Articolo in rivista

rivista: EXPERIMENTAL CELL RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 37-50 - issn: 0014-4827 - wos: WOS:000378973600005 (55) - scopus: 2-s2.0-84973879574 (56)