MIRKO MININI

Dottore

ciclo: XXXIII



Titolo della tesi: Myo-Inositol treatment triggers miR-125a-5p expression reducing metastatic potential of breast cancer cells by IP6K1 inhibition

The acquiring of invasive phenotype for metastatic progression is the main cause of death in tumor patients. The investigation about this process in breast cancer patients allowed to identify PI3K/Akt signaling cascade as the main deregulated pathway in Epithelial-Mesenchymal Transition (EMT) process. For long time, PI3K/Akt pathway has been used as target of several drugs. However, toxicity profiles, mutations in specific genes and multiple pathways activated together with PI3K/Akt pathway hamper these drugs from achieving the optimal inhibitory effects making them less attractive for chemoprevention than natural agents such as myo-Inositol. Previously, we demonstrated how myo-Inositol treatment can block EMT in breast cancer cells by downregulating PI3K/Akt and inducing changes in cytoskeletal architecture. Herein, we go insight the mechanism of action of myo-Inositol administration, using as model both triple negative (MDA-MB-231) and hormone responsive (MCF-7) breast cancer cells. Our results suggest that myo-Inositol triggers early modulation in expression pattern, probably led by miRNAs and methylation remodeling of chromatin. The study has allowed us to identify miR-125a-5p and IP6K1 as a novel axis to inhibit motility and metastasis formation using molecular targeted therapies in breast cancer.

Produzione scientifica

  • 11573/1079026 - 2018 - Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation (01a Articolo in rivista)
    PROIETTI, SARA; CATIZONE, ANGIOLINA; MASIELLO, MARIA GRAZIA; DINICOLA, SIMONA; FABRIZI, GIANMARCO; MININI, MIRKO; VERNA, ROBERTO; CUCINA, ALESSANDRA; BIZZARRI, MARIANO
  • 11573/1089134 - 2017 - Melatonin, mitochondria, and the cancer cell (01g Articolo di rassegna (Review))
    CUCINA, ALESSANDRA; MININI, MIRKO; BIZZARRI, MARIANO
  • 11573/903648 - 2016 - Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement (01a Articolo in rivista)
    MININI, MIRKO; CATIZONE, ANGIOLINA; CUCINA, ALESSANDRA; BIZZARRI, MARIANO
  • 11573/1160997 - 2018 - From implantation to birth: insight into molecular melatonin functions (01g Articolo di rassegna (Review))
    CARLOMAGNO, GIANFRANCO; MININI, MIRKO; TILOTTA, MARCO; UNFER, VITTORIO
  • 11573/1014338 - 2017 - Nutritional and Acquired Deficiencies in Inositol Bioavailability. Correlations with Metabolic Disorders. Dinicola S, Minini M, Unfer V, Verna R, Cucina A, Bizzarri M. IJMSInt J Mol Sci. 2017 Oct 20;18(10). pii: E2187. doi: 10.3390/ijms18102187 (01a Articolo in rivista)
    DINICOLA, SIMONA; MININI, MIRKO; UNFER, VITTORIO; VERNA, ROBERTO; CUCINA, ALESSANDRA; BIZZARRI, MARIANO
  • 11573/1276721 - 2019 - Active fraction from embryo fish extracts induces reversion of the malignant invasive phenotype in breast cancer through down-regulation of TCTP and modulation of E-cadherin/β-catenin pathway (01a Articolo in rivista)
    PROIETTI, SARA; CUCINA, ALESSANDRA; MININI, MIRKO; MONTI, NOEMI; CATIZONE, ANGIOLINA; LEONETTI, ERICA; BIZZARRI, MARIANO
  • 11573/1340363 - 2019 - Myo-Inositol treatment inhibits motility in triple negative breast cancer via miR-125a-5p/IP6K1 axis (04b Atto di convegno in volume)
    MININI, MIRKO; PROIETTI, SARA; SENNI, ALICE; MONTI, NOEMI; FUSO, ANDREA; CUCINA, ALESSANDRA; BIZZARRI, MARIANO
  • 11573/1340369 - 2019 - The activation of miR-125a-5p/IP6K1 axis in breast cancer cells upon treatment with myo-Inositol. (04b Atto di convegno in volume)
    MININI, MIRKO; PROIETTI, SARA; MONTI, NOEMI; SENNI, ALICE; FUSO, ANDREA; CUCINA, ALESSANDRA; BIZZARRI, MARIANO
  • 11573/1362408 - 2020 - Redifferentiation therapeutic strategies in cancer (01g Articolo di rassegna (Review))
    BIZZARRI, MARIANO; CUCINA, ALESSANDRA; MININI, MIRKO
  • 11573/1442522 - 2020 - Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path along the Waddington's Landscape (01a Articolo in rivista)
    BIZZARRI, MARIANO; MININI, MIRKO; MONTI, NOEMI; CUCINA, ALESSANDRA
  • 11573/1574470 - 2021 - miR-125a-5p impairs the metastatic potential in breast cancer via IP6K1 targeting (01a Articolo in rivista)
    MININI, MIRKO; SENNI, ALICE; PROIETTI, SARA; LIGUORO, DOMENICO; CATIZONE, ANGIOLINA; GIULIANI, ALESSANDRO; MANCINI, RITA; FUSO, ANDREA; CUCINA, ALESSANDRA; BIZZARRI, MARIANO
  • 11573/1442520 - 2020 - The Key Role of IP6K: A Novel Target for Anticancer Treatments? (01a Articolo in rivista)
    MININI, MIRKO; SENNI, ALICE; UNFER, VITTORIO; BIZZARRI, MARIANO

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