Research: Study of the role of RNA-binding proteins in Amyotrophic Lateral Sclerosis using human iPS cells
PERSONAL INFORMATION
Michela Mochi
Date of birth 18/08/1997
Place of living Rome, via Francesco Ripandelli 45
Nationality Italian
Phone number +393467298184
E-mail address michela.mochi@uniroma1.it
EDUCATION AND QUALIFICATIONS
2019-2021 Master Degree in Genetics and Molecular Biology
Università degli Studi di Roma “La Sapienza”
Final grade 110/110 cum laude
2016-2019 Bachelor Degree in Biological Sciences
Università degli Studi di Roma “La Sapienza”
Final grade 110/110 cum laude
2011-2016 High School “G.B.Morgagni”
Final grade 92/100
INTERNSHIPS
November 2019-July 2021 Master Internship
Supervisor: prof. Alessandro Rosa
Università degli Studi di Roma “La Sapienza”
Project Study of the RNA-binding proteins in Amyotrophic
Lateral Sclerosis (ALS): their implications in the axonal
morphology and the molecular mechanism of the network
between FUS, HuD and FMRP.
Model system: hiPSC-derived motoneurons.
March 2019-July 2019 Supervisor: prof. Alessandro Rosa
Università degli Studi di Roma “La Sapienza”
Project Study of the axonal sprouting in human motoneurons:
implications in Amyotrophic Lateral Sclerosis (ALS).
Model system: hiPSC-derived motoneurons carrying the
P525L mutation of the FUS gene.
WORK EXPERIENCES
2021–Ongoing PhD in Life Science
Università degli Studi di Roma “La Sapienza”
Supervisor: prof. Alessandro Rosa
February 2021-July 2021 Scholarship: laboratory assistant (Cellular Biology Lab and
Deveolpmental Biology lab) at Department of Biology
and Biotechnology “Charles Darwin”
Università degli Studi di Roma “La Sapienza”
October 2019-January 2021 Scholarship: laboratory assistant (Cellular Biology Lab) at
Department of Biology and Biotechnology “Charles Darwin”,
Università degli Studi di Roma “La Sapienza”
SKILLS
Cell culture (iPSCs, motoneurons, HeLa cells)
Motoneuron differentiation protocol
RT-qPCR
Immunofluorescence
Luciferase Assay
Western Blot
Cloning
DIGITAL COMPETENCE
Microsoft Office (Word, Powerpoint, Excel)
Sequence analysis software (Serial Cloner, Snapgene Viewer)
Data analysis (R, Python)
Molecular visualization system (PyMOL)
PUBLICATIONS
Garone MG, Birsa N, Rosito M, Salaris F, Mochi M, de Turris V, Nair RR, Cunningham TJ, Fisher EMC, Morlando M, Fratta P, Rosa A. ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity. Commun Biol. 2021 Sep 1;4(1):1025. doi: 10.1038/s42003-021-02538-8. PMID: 34471224; PMCID: PMC8410767.
AWARDS
October 2020 Win of the 6th edition of “PriSLA – Premi di laurea per la
ricerca sulla SLA” (“Io corro con Giovanni” company)
March 2021-July 2021 Path of Excellence in Genetics and Molecular Biology
Master Course
Department of Biology and Biotechnology “Charles Darwin”