MERVE ARPACIOGLU

PhD Student

PhD program:: XXXVIII
email: merve.arpacioglu@uniroma1.it
phone: 0649913965
building: CU032
room: 5B




supervisor: Roberta Costi
advisor: Roberta Costi

Thematic area: Pharmaceutical chemistry.
SSD: CHIM/08.

Brief resume: Having graduated from the Department of Chemistry with a BSc and the Department of Biotechnology with an MSc from Izmir Institute of Technology, I found the chance of first-hand experience on the subjects of synthesis of organic, small-molecule fluorescent probes, and inorganic compounds, metal-organic frameworks, both in Izmir Institute of Technology and Christian-Albrechts-University zu Kiel with IAESTE, respectively. Additionally, I worked in the development of multicomponent crystal forms such as co-crystal and salt as well as polymorphic screening of antibiotics throughout my Erasmus+ mobility program at Instituto Superior Tecnico, Lisbon, Portugal. At the same time, I have contributed to the development/synthesis of carbonic anhydrase inhibitors at La Sapienza, University of Rome. Most recently, inspired by the encouraging internship I had at Sapienza Università di Roma and the excellent opportunity offered by the Life Sciences Ph.D. program, I aim to enrich my scientific understanding in the subject of drug discovery and make my contribution to the field.


Brief description of my project: The severe and acute respiratory syndrome coronavirus 2 (SARS-CoV 2) has caused to pandemic with considerably great socioeconomical impact worldwide Throughout the global pandemic, vaccine development has been prioritized. Despite the outstanding job done in the development of vaccines, there are various downsides when it comes to lacking antiviral drugs active on SARS CoV 2: first and foremost, the short-term vaccine induced immunity, and obscurity of vaccines among new variants. These reasons rightfully highlight the pivotal importance of having broad-spectrum antiviral inhibitors. Among those therapeutical targets, my project aims at unveiling nsp13 inhibitors for the treatment of SARS-CoV-2. In this sense, within my project, novel analogous are designed, synthesized, purified and their inhibitory profile is examined.

Attendance:
PhD Courses: From Ramon y Cajal to CryoEM Course for Advanced Microscopy, Introduction to Immunology, Preparing artwork for scientific papers.

Poster presentations: “Novel nsp13 Inhibitors Capable of Blocking Viral Replication of SARS-CoV-2” in European School of Medicinal Chemistry (ESMEC), 42 nd Advanced Course of Medicinal Chemistry and "E. Duranti" Seminar for PhD Students and “New Blood- brain Barrier Permeable Compounds as naegleria fowleri CYP51 Inhibitors” in XXVIII National Meeting on Medicinal Chemistry (NMMC28)

Seminars: Exploring the allosteric mechanism of oncogenic phosphatase SHP2 for the design of peptide inhibitors of its protein-protein interactions by Prof. Lorenzo Stella, Regulation of enzymatic activity mediated by liquid-liquid phase separation by Dott. Mirco Dindo, Engineering Proteins To Boost LTP And Memory by Prof. Cristian Ripoli, Application of deep learning to the protein structure prediction: the tale of a “gigantic leap” by Prof. Anna Marabotti, Deciphering self-renewal traits in epidermal stem cells by Dott. Elena Enzo, Insulin Signaling in Alzheimer’s Disease Brain and Models Thereof by Prof. Eugenio Barone, Educating tutor-associate macrophages under metabolic stress by Dr. Ping-Chih Ho, Synthetic Biology: what, why and how by Dott.ssa Velia Siciliano, Protecting our genome: mechanisms to maintain DNA repeats stability in human cells by Prof. Simona Giunta, The chaperonin GroEL nano-machine: allostery and function by Prof. Amnon Horowitz, Enzymes by the point of view of a computational chemist by Prof. Massimiliano Aschi, Riboregulation from bacteria to eukaryotes: mechanisms and challenges by Matthias Hentze & Ina Huppertz & Ben Luisi & Gian Gaetano Tartaglia & Francesca Cutruzzola.

Research products

11573/1697149 - 2023 - New blood-brain-barrier permeable compounds as Naegleria Fowleri CYP51 inhibitors.
Arpacioglu, M.; Madia, V. N.; Ialongo, D.; Patacchini, E.; Messore, A.; Tudino, V.; Sharma, V.; Nguyen, J.; Debnath, A.; Podust, L.; Palenca, I.; Basili Franzin, S.; Seguella, L.; Esposito, G.; Petrucci, R.; Di Matteo, P.; Bortolami, M.; Scipione, L.; Costi, R.; Di Santo, R. - 04f Poster
conference: XXVIII edition of the National Meeting on Medicinal Chemistry (Chieti; Italy)
book: XXVIII edition of the National Meeting on Medicinal Chemistry - ()

11573/1697156 - 2023 - Novel nsp13 inhibitors capable of blocking viral replication of SARS-CoV-2.
Arpacioglu, M.; Madia, V. N.; Messore, A.; Patacchini, E.; Ialongo, D.; Tudino, V.; Scipione, L.; Corona, A.; Esposito, F.; Artico, M.; Amatore, D.; Faggioni, G.; De Santis, R.; Lista, F.; Tramontano, E.; Costi, R.; Di Santo, R. - 04f Poster
conference: ESMEC 2023 - European School of Medicinal Chemistry – 42nd Edition (Urbino; Italy)
book: ESMEC 2023 - European School of Medicinal Chemistry – 42nd Edition - ()

11573/1697165 - 2023 - Aminopyrimidine derivatives as new protein kinase inhibitors endowed with anticancer activity.
Ialongo, D.; Madia, V. N.; Messore, A.; Patacchini, E.; Arpacioglu, M.; Scipione, L.; Scarpa, S.; Rauh, D; Di Santo, R.; Costi, R. - 04f Poster
conference: 10th EFMC Young Medicinal Chemists' Symposium (Zagreb; Croatia.)
book: 10th EFMC Young Medicinal Chemists' Symposium - ()

11573/1697174 - 2023 - Pyrimidine-based compounds as new promising protein kinase inhibitors for cancer treatment.
Ialongo, D.; Madia, V. N.; Messore, A.; Patacchini, E.; Arpacioglu, M.; Scipione, L.; Scarpa, S.; Rauh, D; Di Santo, R.; Costi, R. - 04f Poster
conference: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (Zagreb; Croatia.)
book: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry - ()

11573/1697175 - 2023 - Diketo acid heterocyclic derivatives as new SARS-CoV-2 nsp13 inhibitors blocking viral replication.
Ialongo, D.; Madia, V. N.; Messore, A.; Patacchini, E.; Arpacioglu, M.; Tudino, V.; Scipione, L.; Corona, A.; Esposito, F.; Artico, M.; Amatore, D.; Faggioni, G.; De Santis, R.; Lista, F.; Tramontano, E.; Costi, R.; Di Santo, R. - 04f Poster
conference: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (Zagreb; Croatia.)
book: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry - ()

11573/1697147 - 2023 - Identification of novel aminopyrimidine derivatives as protein kinase inhibitors blocking cell growth.
Ialongo, Davide; Madia, Valentina Noemi; Messore, Antonella; Patacchini, Elisa; Arpacioglu, Merve; Scipione, Luigi; Scarpa, S.; Rauh, D.; Di Santo, R.; Costi, R. - 04f Poster
conference: XXVIII edition of the National Meeting on Medicinal Chemistry (Chieti; Italy)
book: XXVIII edition of the National Meeting on Medicinal Chemistry - ()

11573/1697162 - 2023 - New diketo acid derivatives as dual SARS-CoV-2 nsp13 inhibitors active against viral replication.
Ialongo, Davide; Madia, Valentina Noemi; Messore, Antonella; Patacchini, Elisa; Arpacioglu, Merve; Tudino, Valeria; Scipione, Luigi; Corona, Angela; Esposito, Francesca; Artico, Marco; Amatore, Donatella; Faggioni, Giovanni; De Santis, Riccardo; Lista, Florigio; Tramontano, Enzo; Costi, Roberta; Di Santo, Roberto - 04f Poster
conference: 10th EFMC Young Medicinal Chemists' Symposium (Zagreb; Croatia.)
book: 10th EFMC Young Medicinal Chemists' Symposium - ()

11573/1684012 - 2023 - Synergistic Effects of Caffeine in Combination with Conventional Drugs: Perspectives of a Drug That Never Ages
Ialongo, Davide; Tudino, Valeria; Arpacioglu, Merve; Messore, Antonella; Patacchini, Elisa; Costi, Roberta; Di Santo, Roberto; Madia, Valentina Noemi - 01g Articolo di rassegna (Review)
paper: PHARMACEUTICALS (Basel : MDPI, Molecular Diversity Preservation International, 2004-) pp. 730- - issn: 1424-8247 - wos: WOS:000997931100001 (2) - scopus: 2-s2.0-85160675541 (4)

11573/1697142 - 2023 - Discovery of new small molecules as anti-SARS-CoV-2 agents inhibiting ACE2-spike binding.
Madia, V. N.; Ialongo, D.; Messore, A.; Patacchini, E.; Arpacioglu, M.; Scipione, L.; Di Santo, R.; Costi, R. - 04f Poster
conference: XXVIII edition of the National Meeting on Medicinal Chemistry (Chieti; Italy)
book: XXVIII edition of the National Meeting on Medicinal Chemistry - ()

11573/1697168 - 2023 - Dual HIV-1 integrase catalytic site and integrase-RNA interaction inhibitors.
Madia, V. N.; Ialongo, D.; Messore, A.; Patacchini, E.; Arpacioglu, M.; Scipione, L.; Kvaratskhelia, M.; Di Santo, R.; Costi, R. - 04f Poster
conference: 10th EFMC Young Medicinal Chemists' Symposium (Zagreb; Croatia.)
book: 10th EFMC Young Medicinal Chemists' Symposium - ()

11573/1697179 - 2023 - Quinolinonyl derivatives as dual inhibitors of the HIV-1 integrase catalytic site and integrase-RNA interactions.
Madia, V. N.; Ialongo, D.; Messore, A.; Patacchini, E.; Arpacioglu, M.; Scipione, L.; Kvaratskhelia, M.; Di Santo, R.; Costi, R. - 04f Poster
conference: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (Zagreb; Croatia.)
book: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry - ()

11573/1697181 - 2023 - Design and synthesis of brain permeable anti-Naegleria fowleri agents targeting CYP51 for primary amoebic meningoencephalitis treatment.
Madia, V. N.; Ialongo, D.; Messore, A.; Patacchini, E.; Arpacioglu, M.; Tudino, V.; Sharma, V.; Nguyen, J.; Debnath, A.; Podust, L.; Palenca, I.; Basili Franzin, S.; Seguella, L.; Esposito, G.; Petrucci, R.; Di Matteo, P.; Bortolami, M.; Scipione, L.; Costi, R.; Di Santo, R. - 04f Poster
conference: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (Zagreb; Croatia.)
book: IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry - ()

11573/1697153 - 2023 - Small molecule derivatives as dual inhibitors of SARS-CoV-2 nsp13 blocking viral replication.
Madia, V. N.; Ialongo, D.; Patacchini, E.; Arpacioglu, M.; Messore, A.; Tramontano, E.; De Santis, R.; Lista, F.; Costi, R.; Di Santo, R. - 04f Poster
conference: 3rd Synthesis in Drug Discovery and Development (Virtual meeting)
book: 3rd Synthesis in Drug Discovery and Development - ()

11573/1697146 - 2023 - Discovery of quinolinonyl derivatives as anti-HIV-1 inhibitors endowed with an innovative mechanism of action.
Madia, Valentina Noemi; Ialongo, Davide; Messore, Antonella; Patacchini, Elisa; Arpacioglu, Merve; Scipione, Luigi; Di Santo, Roberto; And Costi, Roberta. - 04f Poster
conference: XXVIII edition of the National Meeting on Medicinal Chemistry (Chieti; Italy)
book: XXVIII edition of the National Meeting on Medicinal Chemistry - ()

11573/1697172 - 2023 - Miconazole-like compounds as brain permeable anti-Naegleria Fowleri agents targeting CYP51.
Madia, Valentina Noemi; Ialongo, Davide; Patacchini, Elisa; Messore, Antonella; Arpacioglu, Merve; Tudino, V.; Sharma, V.; Nguyen, J.; Debnath, A.; Podust, L.; Palenca, I.; Basili Franzin, S.; Seguella, L.; Esposito, G.; Petrucci, R.; Di Matteo, P.; Bortolami, M.; Scipione, L.; Costi, Roberta; Di Santo, Roberto. - 04f Poster
conference: 10th EFMC Young Medicinal Chemists' Symposium (Zagreb; Croatia.)
book: 10th EFMC Young Medicinal Chemists' Symposium - ()

11573/1697140 - 2023 - Design and synthesis of tetrahydro-β-carbolines derivatives as PDIA inhibitors.
Messore, A.; Madia, V. N.; Ialongo, D.; Patacchini, E.; Arpacioglu, M.; Scipione, L.; Altieri, F.; Paglia, G.; Meschiari, G.; Di Santo, R.; Costi, R. - 04f Poster
conference: XXVIII edition of the National Meeting on Medicinal Chemistry (Chieti; Italy)
book: XXVIII edition of the National Meeting on Medicinal Chemistry - ()

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma