MEDHI HASSANI

Dottore

ciclo: XXXII


tutor: Sergio Adamo
relatore: Antonio Musaro
supervisore: Dario Coletti

Titolo della tesi: Serum Response Factor is required for the therapeutic effects of physical activity in cancer-cachexia

Cachexia is a multifactorial and complex syndrome associated with chronic diseases such as cancer, which leads to an involuntary and progressive loss of body weight. Cachexia is characterized by an increased level of pro-inflammatory cytokines and other humoral factors, which induce autophagy and proteolysis mediating muscle fiber atrophy. Muscle wasting interferes with the therapy of the primary disease and is a negative prognostic factor for cancer patients. Physical activity has been proposed to counteract cachexia since it improves muscle metabolism and decreases systemic inflammation by regulating the balance between anti- and pro-inflammatory cytokines. Physical activity is thought to promote the release of beneficial myokines from the exercised muscle. Exercise is associated with an improvement in the quality of life and survival in cancer patients. However, the mechanisms underlying the response to physical exercise in cancer cachexia are not known. We hypothesized that the effects of exercise are mediated by a mechano-transduction response in muscle, involving Serum Response Factor (SRF), which is a gene transcription factor induced by mechanical cues mediated by actin polymerization. Since the broad involvement of SRF in muscle homeostasis includes a pivotal role in satellite cell proliferation and recruitment to myotubes, we also hypothesized that SRF beneficial effects are extended to the satellite cell niche. To verify our hypothesis, we used an in vivo model consisting of mice injected or not with C26 tumor cells, to induce cancer cachexia. The animals were further divided into two groups, which performed or not voluntary exercise. In this way, we had four experimental groups allowing us to test any interaction between exercise and cancer cachexia. To specifically address the SRF role in the rescue of muscle mass by physical exercise in cancer cachexia, we used an SRF loss of function models, consisting of inducible, muscle-specific SRF KO mice with the Cre loxP system activated by tamoxifen injections For these mice, a different tumor, i.e., the Lewis Lung Carcinoma (LLC) was used to induce cachexia, due to immune incompatibility resulting in tumor rejection in these non-immunoexpressed mouse lines. Our results showed that the C26 tumor induces loss of body weight, muscle wasting, protein degradation, including a decrease of SRF protein, which resulted from the downregulation of its transcriptional activity. We observed that the effects of C26 tumors were counteracted by physical activity, suggesting that voluntary exercise is an effective means to counteract cachexia; we also observed that the beneficial exercise effects are linearly correlated to the SRF protein levels in muscle, suggesting a pivotal role for SRF as a mediator of the response to exercise. To demonstrate that SRF is necessary to transduce exercise effects, we applied the same exercise protocol as above to LLC tumor-bearing SRF KO mice and observed that exercise could no longer rescue cachexia, thereby indicating that SRF is essential for the organismal response to exercise. Additionally, we observed opposite effects of the tumor and exercise on Pax7+ cells, i.e., the satellite cells which are responsible for muscle regeneration and homeostasis. Since we also observed the recruitment of nuclei within the muscle fibers in response to exercise, we concluded that the myogenic program is activated by exercise, resulting in stem cell recruitment to muscle fibers, which could contribute to muscle homeostasis. Overall, our data demonstrate that the positive effects of exercise on cancer cachexia are due to an SRF-mediated mechanical response of muscle fibers, resulting in transcriptional changes activating pro-myogenic genes and in the recruitment of muscle stem cells which ultimately result in the rescue of muscle mass.

Produzione scientifica

  • 11573/1025448 - 2017 - Mechanisms involved in the cross-talk between humoral and mechanical cues underlying muscle wasting in cachexia (04d Abstract in atti di convegno)
    BACCAM, ALEXANDRA; HASSANI, MEDHI SAMY; BENONI, ALEXANDRA AURIANE PATRICIA; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1025452 - in press - Displaced myonuclei in cancer cachexia suggest altered innervation (04c Atto di convegno in rivista)
    COLETTI, DARIO; HASSANI, MEDHI SAMY; MORESI, VIVIANA; ADAMO, SERGIO
  • 11573/890666 - 2016 - Serum response factor in muscle tissues: from development to ageing (01a Articolo in rivista)
    COLETTI, DARIO; HASSANI, MEDHI SAMY
  • 11573/1013914 - 2017 - Basking in their niche: stem cells with myogenic potential as a target to combat cachexia (01g Articolo di rassegna (Review))
    BACCAM, ALEXANDRA; HASSANI, MEDHI SAMY; ADAMO, SERGIO; MORESI, VIVIANA
  • 11573/1282660 - 2018 - Opposite effects of tumor-derived cytokines and mechanical stimulation on muscle stem cell activity and muscle homeostasis (01h Abstract in rivista)
    BACCAM, ALEXANDRA; BENONI, ALEXANDRA AURIANE PATRICIA; HASSANI, MEDHI SAMY; MORESI, VIVIANA; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1341024 - 2019 - Srf KO and wild-type mice similarly adapt to endurance exercise (01a Articolo in rivista)
    HASSANI, MEDHI SAMY; COLETTI, DARIO
  • 11573/1409224 - 2020 - Displaced myonuclei in cancer cachexia suggest altered innervation (01a Articolo in rivista)
    HASSANI, MEDHI SAMY; DE ALMEIDA E SOUSA ALBUQUERQUE MATOS, MARIA SALOME'; MORESI, VIVIANA; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1485901 - 2018 - Endurance training induces apoptosis in the tumor mass in the C26-bearing mouse model (04d Abstract in atti di convegno)
    HASSANI, MEDHI SAMY; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1485945 - 2019 - SRF role as a mechano-transductor in response to exercise in cancer cachexia (04d Abstract in atti di convegno)
    HASSANI, MEDHI SAMY; BENONI, ALEXANDRA AURIANE PATRICIA; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1485924 - 2018 - Effect of muscle activity on tumor cell growth and survival (04c Atto di convegno in rivista)
    HASSANI, MEDHI SAMY; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1485967 - 2020 - SRF-mediated mechanotransduction is essential for the response to exercise in cancer patients and animal models (04d Abstract in atti di convegno)
    HASSANI, MEDHI SAMY; BACCAM, ALEXANDRA; BENONI, ALEXANDRA AURIANE PATRICIA; GARGANO, ANTONELLA; MORESI, VIVIANA; ADAMO, SERGIO; SORCI, GUGLIELMO; MUSCARITOLI, MAURIZIO; LI, ZHI; COLETTI, DARIO
  • 11573/1609214 - 2019 - Performance & metabolism in mice: SRF knockout and wild-type mice similarly adapt to endurance exercise (04f Poster)
    HASSANI, MEDHI SAMY; COLETTI, DARIO
  • 11573/1575308 - 2020 - Central myonuclei and denervation markers in cancer cachexia (04d Abstract in atti di convegno)
    HASSANI, MEDHI SAMY; MORESI, VIVIANA; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1656041 - 2015 - Measurement of four-jet differential cross sections in √s=8 TeV proton-proton collisions using the ATLAS detector (01a Articolo in rivista)
    AMOROSO, STEFANO; ARTONI, GIACOMO; AVOLIO, GIUSEPPE; BAGIACCHI, PAOLO; BAGNAIA, PAOLO; BAUCE, MATTEO; BERETTA, MAURIZIO; LURASCHI, BERNARD STEPHANE C.; BIGLIETTI, MICHELA; BINI, CESARE; BORRONI, SARA; GARGANO, ANTONELLA; GARGANO, ANTONELLA; CALACE, NICOLETTA; CALANDRI, ANTONELLA; CANALE, VITTORIO; CARLINO, MICHELE GIULIANO; CERUTTI, FRANCESCO; CERVELLI, PIERLUIGI; CHEN, XI; CHIARELLA, VITO; CIAPETTI, GUIDO; CORRADI, MANUELA; DA COSTA ESTEVES, MARCOS JOSUÉ; DA VIA, CINZIA; DE ASMUNDIS, ROBERTA; DE BENEDETTI, ALESSANDRA; DE CECCO, SANDRO; DE PEDIS, DANIELE; DE SANTO, ARIANNA; DELL'ACQUA, ANTONIO; DELLA PIETRA, MAURO; DI CIACCIO, LUCIO; DI DOMENICO, ANTONIO; DI MATTIA, ALESSANDRO; IANNICELLI, ELSA; DIAZ, MARTA ELENA ANGELA; DOGLIONI, CARLO; ERDMANN, JORIS; FANG, YERONG; FRANCHINI, MARCO; FRANCONI, LUIGI; GAUZZI, PAOLO; ZAHRA, ANDLEEB; GENTILE, SIMONETTA; GIAGU, STEFANO; GIANNETTI, PAOLO; GOMES, DAYANE APARECIDA; GRANCAGNOLO, SIMONE; GUSTAVINO, GIULIANO; HAAS, ANNA; HAMILTON, ANTONIA FELICITY; HASSANI, MEDHI SAMY; HOWARTH, PAULA JANE; HSU, CHING YU; HU, DAVID LITE; IPPOLITO, VALERIO; JI, HAO; KADO, MARUMI MARCELLO; KAGAN, ABRAM MEIR; KAPLAN, MICHELE BENNETT; KAWAMOTO, TATSURO; KIMURA, NOBUHIRO; KUNA, MARINE; LACAVA, FRANCESCO; SICLARI, DOMENICO; CHEN, HSUEH LI; LIBERTI, BARBARA; LIE, ANNE KVEIM; LIU, LUCIA; LOU, XIAOFAN; LUBATTI, HENRY JOSEPH; MAIANI, CAMILLA; MAIO, ANDREA; MANDELLI, BIANCAMARIA; MASSA, ILARIA; MASSA, LUIGI; MAZZAFERRO, MARIA LUCIA; MEHTA, ANITA; MENNEA, LUCIA MIR; MONZANI, SIMONE; MORI, DANILO; MUELLER, JOHANNES ANDREAS; NEMETHY, PETER; RIDOLA, PAOLO; POLICICCHIO, ANTONIO; PONTECORVO, MARIA LUISA; PRASAD, SARAJ; RAGUSA, FRANCESCA MARTINA; RUBBO, FILOMENA; SABATO, GABRIELE; SAKURAI, YOSHIO; SALAMANNA, GIUSEPPE; SALAMON, ANDREA; SANTONI, CHRISTIAN; SCARCELLA, MARIAPAOLA; SCHNEIDER, BARRY HOWARD; SCHULZ, HANS-JORG; SHRESTHA, SUJAN; SLATER, MELVYN; TUDORACHE, ALEXANDRU; URBAN, JESSICA MICHELLE; VANGURI, RAJESH; VIEL, STEPHANE; WAGNER, WOLFGANG; WANG, CONG; WANG, RUI; WHITE, STEPHEN ALLAN; WILLIAMS, CAROLYN S.; WU, MENGRAN; WU, MENGRAN; XU, DIYU; YE, JIANFENG; YOUNG, CHRISTOPHER MARK; SORRENTINO, LUCIA; ZHANG, DENGCHENG; ZHANG, LI; ZHAO, XIAOXI; ZHOU, LEI; ZHOU, LEI; ZHU, HANDONG
  • 11573/1656040 - 2015 - Measurement of the production of neighbouring jets in lead-lead collisions at root s(NN)=2.76TeV with the ATLAS detector (01a Articolo in rivista)
    AMOROSO, STEFANO; ARTONI, GIACOMO; AVOLIO, GIUSEPPE; BAGIACCHI, PAOLO; BAGNAIA, PAOLO; BANSAL, VIKAS; LURASCHI, BERNARD STEPHANE C.; BIGLIETTI, MICHELA; BINI, CESARE; BORRI, MATTEO; BORRONI, SARA; GARGANO, ANTONELLA; GARGANO, ANTONELLA; CALANDRI, ANTONELLA; CANALE, VITTORIO; CARLINO, MICHELE GIULIANO; CERUTTI, FRANCESCO; CERVELLI, PIERLUIGI; CHEN, XI; CHIARELLA, VITO; CIAPETTI, GUIDO; CORRADI, MANUELA; DA COSTA ESTEVES, MARCOS JOSUÉ; DA VIA, CINZIA; DE ASMUNDIS, ROBERTA; DE CECCO, SANDRO; DE PEDIS, DANIELE; DE SANTO, ARIANNA; DELL'ACQUA, ANTONIO; DELLA PIETRA, MAURO; DI CIACCIO, LUCIO; DI DOMENICO, ANTONIO; DI MATTIA, ALESSANDRO; IANNICELLI, ELSA; DIAZ, MARTA ELENA ANGELA; DOGLIONI, CARLO; ERDMANN, JORIS; FANG, YERONG; FRANCHINI, MARCO; FRANCONI, LUIGI; FRANZ, SILVIO; GAUZZI, PAOLO; ZAHRA, ANDLEEB; GENTILE, SIMONETTA; GIAGU, STEFANO; GIANNETTI, PAOLO; GOMES, DAYANE APARECIDA; GRANCAGNOLO, SIMONE; GRASSI, VALENTINA; HAAS, ANNA; HAMILTON, ANTONIA FELICITY; HASSANI, MEDHI SAMY; HOWARTH, PAULA JANE; HSU, CHING YU; HU, DAVID LITE; IPPOLITO, VALERIO; JI, HAO; JONES, AMELIA GWEN; KADO, MARUMI MARCELLO; KAGAN, ABRAM MEIR; KAPLAN, MICHELE BENNETT; KAWAMOTO, TATSURO; KIMURA, NOBUHIRO; KUNA, MARINE; LACAVA, FRANCESCO; SICLARI, DOMENICO; CHEN, HSUEH LI; LIBERTI, BARBARA; LIE, ANNE KVEIM; LIU, LUCIA; LOU, XIAOFAN; LUBATTI, HENRY JOSEPH; MAIANI, CAMILLA; MAIO, ANDREA; MANDELLI, BIANCAMARIA; MASSA, ILARIA; MASSA, LUIGI; MAZZAFERRO, MARIA LUCIA; MEHTA, ANITA; MENNEA, LUCIA MIR; MONZANI, SIMONE; MUELLER, JOHANNES ANDREAS; NEMETHY, PETER; RIDOLA, PAOLO; POHL, MARTIN; POLICICCHIO, ANTONIO; PONTECORVO, MARIA LUISA; PRASAD, SARAJ; QURESHI, MANTHAR ALI; RAGUSA, FRANCESCA MARTINA; RUBBO, FILOMENA; SAKURAI, YOSHIO; SALAMANNA, GIUSEPPE; SALAMON, ANDREA; SANTONI, CHRISTIAN; SCARCELLA, MARIAPAOLA; SCHMIDT, ESTHER RUTH; SCHNEIDER, BARRY HOWARD; SCHROEDER, CAROLINE THERESA; SCHULZ, HANS-JORG; SCIOLLA, GIANNICARLO; SHRESTHA, SUJAN; SLATER, MELVYN; TUDORACHE, ALEXANDRU; UCHIDA, KEIICHI; VANGURI, RAJESH; VIEL, STEPHANE; WAGNER, WOLFGANG; WANG, CONG; WANG, CONG; WANG, RUI; WHITE, STEPHEN ALLAN; WILLIAMS, CAROLYN S.; WU, MENGRAN; XU, DIYU; YE, JIANFENG; YILMAZ, MELTEM; YOUNG, CHRISTOPHER MARK; SORRENTINO, LUCIA; ZHANG, DENGCHENG; ZHANG, LI; ZHOU, LEI; ZHU, HANDONG
  • 11573/1655976 - 2015 - Measurement of the branching ratio Gamma(Lambda(0)(b) -> Psi(2S)Lambda(0))/Gamma(Lambda(0.)(b) -> J/Psi Lambda(0)) with the ATLAS detector (01a Articolo in rivista)
    AMOROSO, STEFANO; ARTONI, GIACOMO; AVOLIO, GIUSEPPE; BAGIACCHI, PAOLO; BAGNAIA, PAOLO; BAUCE, MATTEO; BERETTA, MAURIZIO; LURASCHI, BERNARD STEPHANE C.; BIGLIETTI, MICHELA; BINI, CESARE; BORRONI, SARA; GARGANO, ANTONELLA; GARGANO, ANTONELLA; CALACE, NICOLETTA; CALANDRI, ANTONELLA; CANALE, VITTORIO; CARLINO, MICHELE GIULIANO; CERUTTI, FRANCESCO; CERVELLI, PIERLUIGI; CHEN, XI; CHIARELLA, VITO; CIAPETTI, GUIDO; CORRADI, MANUELA; DA COSTA ESTEVES, MARCOS JOSUÉ; DA VIA, CINZIA; DE ASMUNDIS, ROBERTA; DE BENEDETTI, ALESSANDRA; DE CECCO, SANDRO; DE PEDIS, DANIELE; DE SANTO, ARIANNA; DELL'ACQUA, ANTONIO; DELLA PIETRA, MAURO; DI CIACCIO, LUCIO; DI DOMENICO, ANTONIO; DI MATTIA, ALESSANDRO; IANNICELLI, ELSA; DIAZ, MARTA ELENA ANGELA; DOGLIONI, CARLO; ERDMANN, JORIS; FANG, YERONG; FRANCHINI, MARCO; FRANCONI, LUIGI; GAUZZI, PAOLO; ZAHRA, ANDLEEB; GIAGU, STEFANO; GIANNETTI, PAOLO; GOMES, DAYANE APARECIDA; GRANCAGNOLO, SIMONE; GUSTAVINO, GIULIANO; HAAS, ANNA; HAMILTON, ANTONIA FELICITY; HASSANI, MEDHI SAMY; HOWARTH, PAULA JANE; HSU, CHING YU; HU, DAVID LITE; IPPOLITO, VALERIO; JI, HAO; JONES, AMELIA GWEN; KADO, MARUMI MARCELLO; KAGAN, ABRAM MEIR; KAPLAN, MICHELE BENNETT; KAWAMOTO, TATSURO; KIMURA, NOBUHIRO; KUNA, MARINE; LACAVA, FRANCESCO; SICLARI, DOMENICO; CHEN, HSUEH LI; LIBERTI, BARBARA; LIE, ANNE KVEIM; LIU, LUCIA; LOU, XIAOFAN; LUBATTI, HENRY JOSEPH; MAIANI, CAMILLA; MAIO, ANDREA; MANDELLI, BIANCAMARIA; MASSA, ILARIA; MASSA, LUIGI; MAZZAFERRO, MARIA LUCIA; MEHTA, ANITA; MENNEA, LUCIA MIR; MONZANI, SIMONE; MORI, DANILO; MUELLER, JOHANNES ANDREAS; NEMETHY, PETER; RIDOLA, PAOLO; POLICICCHIO, ANTONIO; PRASAD, SARAJ; RAGUSA, FRANCESCA MARTINA; RUBBO, FILOMENA; SABATO, GABRIELE; SAKURAI, YOSHIO; SALAMANNA, GIUSEPPE; SALAMON, ANDREA; SANTONI, CHRISTIAN; SCARCELLA, MARIAPAOLA; SCHNEIDER, BARRY HOWARD; SCHROEDER, CAROLINE THERESA; SCHULZ, HANS-JORG; SCIOLLA, GIANNICARLO; SHRESTHA, SUJAN; SLATER, MELVYN; TUDORACHE, ALEXANDRU; URBAN, JESSICA MICHELLE; VANGURI, RAJESH; VIEL, STEPHANE; WAGNER, WOLFGANG; WANG, CONG; WANG, RUI; WHITE, STEPHEN ALLAN; WILLIAMS, CAROLYN S.; WU, MENGRAN; XU, DIYU; YE, JIANFENG; YOUNG, CHRISTOPHER MARK; SORRENTINO, LUCIA; ZHANG, DENGCHENG; ZHANG, LI; ZHAO, XIAOXI; ZHOU, LEI; ZHU, HANDONG
  • 11573/1610438 - 2021 - Displaced Myonuclei in Cachexia Suggest the Occurrence of Altered Innervation (04d Abstract in atti di convegno)
    HASSANI, MEDHI SAMY; MORESI, VIVIANA; ADAMO, SERGIO; COLETTI, DARIO
  • 11573/1656042 - 2015 - Search for high-mass diboson resonances with boson-tagged jets in proton-proton collisions at root s = TeV with the ATLAS detector (01a Articolo in rivista)
    AMOROSO, STEFANO; ARTONI, GIACOMO; AVOLIO, GIUSEPPE; BAGIACCHI, PAOLO; BAGNAIA, PAOLO; BAUCE, MATTEO; BERETTA, MAURIZIO; LURASCHI, BERNARD STEPHANE C.; BIGLIETTI, MICHELA; BINI, CESARE; BORRONI, SARA; GARGANO, ANTONELLA; GARGANO, ANTONELLA; CALANDRI, ANTONELLA; CANALE, VITTORIO; CARLINO, MICHELE GIULIANO; CERUTTI, FRANCESCO; CERVELLI, PIERLUIGI; CHEN, XI; CHIARELLA, VITO; CIAPETTI, GUIDO; CORRADI, MANUELA; DA COSTA ESTEVES, MARCOS JOSUÉ; DA VIA, CINZIA; DE ASMUNDIS, ROBERTA; DE CECCO, SANDRO; DE PEDIS, DANIELE; DE SANTO, ARIANNA; DELL'ACQUA, ANTONIO; DELLA PIETRA, MAURO; DI CIACCIO, LUCIO; DI DOMENICO, ANTONIO; DI MATTIA, ALESSANDRO; IANNICELLI, ELSA; DIAZ, MARTA ELENA ANGELA; DOGLIONI, CARLO; ERDMANN, JORIS; FANG, YERONG; FRANCHINI, MARCO; FRANCONI, LUIGI; GAUZZI, PAOLO; ZAHRA, ANDLEEB; GENTILE, SIMONETTA; GIAGU, STEFANO; GIANNETTI, PAOLO; GOMES, DAYANE APARECIDA; GRANCAGNOLO, SIMONE; GRASSI, VALENTINA; GUSTAVINO, GIULIANO; HAAS, ANNA; HAMILTON, ANTONIA FELICITY; HASSANI, MEDHI SAMY; HOWARTH, PAULA JANE; HSU, CHING YU; HU, DAVID LITE; IPPOLITO, VALERIO; JI, HAO; KADO, MARUMI MARCELLO; KAGAN, ABRAM MEIR; KAPLAN, MICHELE BENNETT; KAWAMOTO, TATSURO; KIMURA, NOBUHIRO; KUNA, MARINE; LACAVA, FRANCESCO; SICLARI, DOMENICO; CHEN, HSUEH LI; LIBERTI, BARBARA; LIE, ANNE KVEIM; LIU, LUCIA; LOU, XIAOFAN; LUBATTI, HENRY JOSEPH; MAIANI, CAMILLA; MAIO, ANDREA; MANDELLI, BIANCAMARIA; MASSA, ILARIA; MASSA, LUIGI; MAZZAFERRO, MARIA LUCIA; MEHTA, ANITA; MENNEA, LUCIA MIR; MONZANI, SIMONE; MUELLER, JOHANNES ANDREAS; NEMETHY, PETER; RIDOLA, PAOLO; POLICICCHIO, ANTONIO; PONTECORVO, MARIA LUISA; PRASAD, SARAJ; RAGUSA, FRANCESCA MARTINA; RUBBO, FILOMENA; SABATO, GABRIELE; SAKURAI, YOSHIO; SALAMANNA, GIUSEPPE; SALAMON, ANDREA; SANTONI, CHRISTIAN; SCARCELLA, MARIAPAOLA; SCHMIDT, ESTHER RUTH; SCHNEIDER, BARRY HOWARD; SCHROEDER, CAROLINE THERESA; SCHULZ, HANS-JORG; SHRESTHA, SUJAN; SLATER, MELVYN; TUDORACHE, ALEXANDRU; TUPPUTI, ANNAMARIA; URBAN, JESSICA MICHELLE; VANGURI, RAJESH; VIEL, STEPHANE; WAGNER, WOLFGANG; WANG, CONG; WANG, RUI; WHITE, STEPHEN ALLAN; WILLIAMS, CAROLYN S.; WU, MENGRAN; WU, MENGRAN; XU, DIYU; YE, JIANFENG; YOUNG, CHRISTOPHER MARK; SORRENTINO, LUCIA; ZHANG, DENGCHENG; ZHANG, LI; ZHAO, XIAOXI; ZHOU, LEI; ZHOU, LEI; ZHU, HANDONG
  • 11573/1656044 - 2015 - Constraints on new phenomena via Higgs boson couplings and invisible decays with the ATLAS detector (01a Articolo in rivista)
    AMOROSO, STEFANO; ARTONI, GIACOMO; AVOLIO, GIUSEPPE; BAGIACCHI, PAOLO; BAGNAIA, PAOLO; BAUCE, MATTEO; BERETTA, MAURIZIO; LURASCHI, BERNARD STEPHANE C.; BIGLIETTI, MICHELA; BINI, CESARE; BORRONI, SARA; GARGANO, ANTONELLA; GARGANO, ANTONELLA; CALACE, NICOLETTA; CALANDRI, ANTONELLA; CANALE, VITTORIO; CARLINO, MICHELE GIULIANO; CERUTTI, FRANCESCO; CERVELLI, PIERLUIGI; CHEN, XI; CHIARELLA, VITO; CIAPETTI, GUIDO; CORRADI, MANUELA; DA COSTA ESTEVES, MARCOS JOSUÉ; DA VIA, CINZIA; DE ASMUNDIS, ROBERTA; DE BENEDETTI, ALESSANDRA; DE CECCO, SANDRO; DE PEDIS, DANIELE; DE SANTO, ARIANNA; DELL'ACQUA, ANTONIO; DELLA PIETRA, MAURO; DI CIACCIO, LUCIO; DI DOMENICO, ANTONIO; DI MATTIA, ALESSANDRO; IANNICELLI, ELSA; DIAZ, MARTA ELENA ANGELA; DOGLIONI, CARLO; ERDMANN, JORIS; FANG, YERONG; FRANCHINI, MARCO; FRANCONI, LUIGI; GAUZZI, PAOLO; ZAHRA, ANDLEEB; GENTILE, SIMONETTA; GIAGU, STEFANO; GIANNETTI, PAOLO; GOMES, DAYANE APARECIDA; GRANCAGNOLO, SIMONE; GUSTAVINO, GIULIANO; HAAS, ANNA; HAMILTON, ANTONIA FELICITY; HASSANI, MEDHI SAMY; HOWARTH, PAULA JANE; HSU, CHING YU; HU, DAVID LITE; IPPOLITO, VALERIO; JI, HAO; KADO, MARUMI MARCELLO; KAGAN, ABRAM MEIR; KAPLAN, MICHELE BENNETT; KAWAMOTO, TATSURO; KIMURA, NOBUHIRO; KUNA, MARINE; LACAVA, FRANCESCO; SICLARI, DOMENICO; CHEN, HSUEH LI; LIBERTI, BARBARA; LIE, ANNE KVEIM; LIU, LUCIA; LOU, XIAOFAN; LUBATTI, HENRY JOSEPH; MAIANI, CAMILLA; MAIO, ANDREA; MANDELLI, BIANCAMARIA; MASSA, ILARIA; MASSA, LUIGI; MAZZAFERRO, MARIA LUCIA; MEHTA, ANITA; MENNEA, LUCIA MIR; MONZANI, SIMONE; MORI, DANILO; MUELLER, JOHANNES ANDREAS; NEMETHY, PETER; RIDOLA, PAOLO; POLICICCHIO, ANTONIO; PONTECORVO, MARIA LUISA; PRASAD, SARAJ; RAGUSA, FRANCESCA MARTINA; RUBBO, FILOMENA; SABATO, GABRIELE; SAKURAI, YOSHIO; SALAMANNA, GIUSEPPE; SALAMON, ANDREA; SANTONI, CHRISTIAN; SCARCELLA, MARIAPAOLA; SCHNEIDER, BARRY HOWARD; SCHROEDER, CAROLINE THERESA; SCHULZ, HANS-JORG; SHRESTHA, SUJAN; SLATER, MELVYN; TUDORACHE, ALEXANDRU; URBAN, JESSICA MICHELLE; VANGURI, RAJESH; VIEL, STEPHANE; WAGNER, WOLFGANG; WANG, CONG; WANG, RUI; WHITE, STEPHEN ALLAN; WILLIAMS, CAROLYN S.; WU, MENGRAN; WU, MENGRAN; XU, DIYU; YE, JIANFENG; YOUNG, CHRISTOPHER MARK; SORRENTINO, LUCIA; ZHANG, DENGCHENG; ZHANG, LI; ZHAO, XIAOXI; ZHOU, LEI; ZHOU, LEI; ZHU, HANDONG

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