MEDHI HASSANI

Dottore di ricerca

ciclo: XXXII


supervisore: Sergio Adamo
relatore: Antonio Musaro
co-supervisore: Dario Coletti

Titolo della tesi: Serum Response Factor is required for the therapeutic effects of physical activity in cancer-cachexia

Cachexia is a multifactorial and complex syndrome associated with chronic diseases such as cancer, which leads to an involuntary and progressive loss of body weight. Cachexia is characterized by an increased level of pro-inflammatory cytokines and other humoral factors, which induce autophagy and proteolysis mediating muscle fiber atrophy. Muscle wasting interferes with the therapy of the primary disease and is a negative prognostic factor for cancer patients. Physical activity has been proposed to counteract cachexia since it improves muscle metabolism and decreases systemic inflammation by regulating the balance between anti- and pro-inflammatory cytokines. Physical activity is thought to promote the release of beneficial myokines from the exercised muscle. Exercise is associated with an improvement in the quality of life and survival in cancer patients. However, the mechanisms underlying the response to physical exercise in cancer cachexia are not known. We hypothesized that the effects of exercise are mediated by a mechano-transduction response in muscle, involving Serum Response Factor (SRF), which is a gene transcription factor induced by mechanical cues mediated by actin polymerization. Since the broad involvement of SRF in muscle homeostasis includes a pivotal role in satellite cell proliferation and recruitment to myotubes, we also hypothesized that SRF beneficial effects are extended to the satellite cell niche. To verify our hypothesis, we used an in vivo model consisting of mice injected or not with C26 tumor cells, to induce cancer cachexia. The animals were further divided into two groups, which performed or not voluntary exercise. In this way, we had four experimental groups allowing us to test any interaction between exercise and cancer cachexia. To specifically address the SRF role in the rescue of muscle mass by physical exercise in cancer cachexia, we used an SRF loss of function models, consisting of inducible, muscle-specific SRF KO mice with the Cre loxP system activated by tamoxifen injections For these mice, a different tumor, i.e., the Lewis Lung Carcinoma (LLC) was used to induce cachexia, due to immune incompatibility resulting in tumor rejection in these non-immunoexpressed mouse lines. Our results showed that the C26 tumor induces loss of body weight, muscle wasting, protein degradation, including a decrease of SRF protein, which resulted from the downregulation of its transcriptional activity. We observed that the effects of C26 tumors were counteracted by physical activity, suggesting that voluntary exercise is an effective means to counteract cachexia; we also observed that the beneficial exercise effects are linearly correlated to the SRF protein levels in muscle, suggesting a pivotal role for SRF as a mediator of the response to exercise. To demonstrate that SRF is necessary to transduce exercise effects, we applied the same exercise protocol as above to LLC tumor-bearing SRF KO mice and observed that exercise could no longer rescue cachexia, thereby indicating that SRF is essential for the organismal response to exercise. Additionally, we observed opposite effects of the tumor and exercise on Pax7+ cells, i.e., the satellite cells which are responsible for muscle regeneration and homeostasis. Since we also observed the recruitment of nuclei within the muscle fibers in response to exercise, we concluded that the myogenic program is activated by exercise, resulting in stem cell recruitment to muscle fibers, which could contribute to muscle homeostasis. Overall, our data demonstrate that the positive effects of exercise on cancer cachexia are due to an SRF-mediated mechanical response of muscle fibers, resulting in transcriptional changes activating pro-myogenic genes and in the recruitment of muscle stem cells which ultimately result in the rescue of muscle mass.

Produzione scientifica

11573/1025452 - 9999 - Displaced myonuclei in cancer cachexia suggest altered innervation
Coletti, Dario; Hassani, Medhi; Daou, Nissrine; Matos, Emidio; Galvao Figueredo, Raquel; Salim De Castro, Gabriela; Moresi, Viviana; Adamo, Sergio; Li, Zhenlin; Seelaender, Marilia - 04c Atto di convegno in rivista
rivista: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE (Heidelberg ; Berlin : Springer) pp. - - issn: 2190-6009 - wos: (0) - scopus: (0)
congresso: Cachexia Conference (Rome)

11573/1610438 - 2021 - Displaced Myonuclei in Cachexia Suggest the Occurrence of Altered Innervation
Hassani, Medhi; Daou, Nissrine; Rocchi, Marco; Matos, Emidio; Salim De Castro, Gabriela; Galvao Figueredo Costa, Raquel; Seelaender, Marilia; Moresi, Viviana; Adamo, Sergio; Li, Zhenlin; Agbulut, Onnik; Coletti, Dario - 04d Abstract in atti di convegno
rivista: ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY (Firenze : Firenze university press) pp. - - issn: 2038-5129 - wos: (0) - scopus: (0)
congresso: 74th Meeting of the italian Society of Anatomy and Histology (Bologna)
libro: 125 - ()

11573/1409224 - 2020 - Displaced myonuclei in cancer cachexia suggest altered innervation
Daou, N.; Hassani, M.; Matos, E.; De Castro, G. S.; Costa, R. G. F.; Seelaender, M.; Moresi, V.; Rocchi, M.; Adamo, S.; Li, Z.; Agbulut, O.; Coletti, D. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-17 - issn: 1661-6596 - wos: WOS:000522551607019 (25) - scopus: 2-s2.0-85079231259 (25)

11573/1575308 - 2020 - Central myonuclei and denervation markers in cancer cachexia
Daou, N; Hassani, M; Matos, E; Salim De Castro, G; Figueredo Costa, Rg; Seelaender, M; Moresi, V; Rocchi, M; Adamo, S; Li, Z; Agbulut, O; Coletti, D - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (- Padova : Pagepress -Padova : Unipress) pp. 17-18 - issn: 2037-7460 - wos: WOS:000608394500003 (11) - scopus: 2-s2.0-85100238841 (11)
congresso: 2020 Padua Muscle Days (Padova)
libro: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY - ()

11573/1485967 - 2020 - SRF-mediated mechanotransduction is essential for the response to exercise in cancer patients and animal models
Hassani, M; Baccam, A; Benoni, A; Gargano, C; Salim De Castro, G; Alves, J; Chiappalupi, S; Moresi, V; Adamo, S; Riuzzi, F; Sorci, G; Muscaritoli, M; Seelaender, M; Xue, Z; Li, Z; Agbulut, O; Coletti, D - 04d Abstract in atti di convegno
congresso: Virtual Cancer Cachexia Conference 2020 (online)
libro: Virtual Cancer Cachexia Conference 2020 - ()

11573/1609214 - 2019 - Performance & metabolism in mice: SRF knockout and wild-type mice similarly adapt to endurance exercise
Djemai, Haidar; Hassani, Medhi Samy; Daou, Nissrine; Li, Zhenlin; Sotiropoulos, Athanassia; Noirez, Philippe; Coletti, Dario - 04f Poster
rivista: ACTA PHYSIOLOGICA (Oxford: Blackwell Publishing, 2006-) pp. 29-29 - issn: 1748-1708 - wos: WOS:000494719400066 (0) - scopus: (0)
congresso: 3rd Congress of Physiology and Integrative Biology (CPBI) and 86th Congress of French Physiological Society (SFP), Nouvelle Faculté de Médecine (Montpellier)
libro: ACTA PHYSIOLOGICA - ()

11573/1341024 - 2019 - Srf KO and wild-type mice similarly adapt to endurance exercise
Djemai, Haidar; Hassani, Medhi; Daou, Nissrine; Li, Zhenlin; Sotiropoulos, Athanassia; Noirez, Philippe; Coletti, Dario - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (- Padova : Pagepress -Padova : Unipress) pp. 97-105 - issn: 2037-7460 - wos: WOS:000478762600004 (3) - scopus: 2-s2.0-85091006385 (3)

11573/1485945 - 2019 - SRF role as a mechano-transductor in response to exercise in cancer cachexia
Hassani, M; Benoni, A; Xue, Z; Sotiropoulos, A; Parlakian, A; Li, Z; Adamo, S; Coletti, D - 04d Abstract in atti di convegno
rivista: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE (Heidelberg ; Berlin : Springer) pp. 1394-1394 - issn: 2190-6009 - wos: (0) - scopus: (0)
congresso: 12th Cachexia Conference (Berlin)
libro: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE - ()

11573/1282660 - 2018 - Opposite effects of tumor-derived cytokines and mechanical stimulation on muscle stem cell activity and muscle homeostasis
Baccam, Alexandra; Benoni, Alexandra Auriane Patricia; Parlakian, Ara; Hassani, Medhi Samy; Ramella, Martina; Boccafoschi, Francesca; Sotiropoulos (D), Athanassia; Xue, Zhigang; Moresi, Viviana; Li, Zhenlin; Adamo, Sergio; Coletti, Dario - 01h Abstract in rivista
rivista: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (- Padova : Pagepress -Padova : Unipress) pp. 51-52 - issn: 2037-7460 - wos: (0) - scopus: (0)

11573/1485901 - 2018 - Endurance training induces apoptosis in the tumor mass in the C26-bearing mouse model
Barone, Rosario; Macaluso, Filippo; D’Amico, Daniela; Gargano, Caterina; Hassani, Medhi Samy; Xue, Zhigang; Cappello, Francesco; Zummo, Giovanni; Adamo, Sergio; Farina, Felicia; Coletti, Dario; Di Felice, Valentina - 04d Abstract in atti di convegno
rivista: ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY (Firenze : Firenze university press) pp. 8-8 - issn: 2038-5129 - wos: (0) - scopus: (0)
congresso: 72th Meetingof the Italian Society of Anatomy and Histology (Parma)
libro: ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY - ()

11573/1485924 - 2018 - Effect of muscle activity on tumor cell growth and survival
Hassani, M; Xue, Z; Li, Z; Parlakian, A; Adamo, S; Coletti, D - 04c Atto di convegno in rivista
rivista: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (- Padova : Pagepress -Padova : Unipress) pp. 434-434 - issn: 2037-7460 - wos: WOS:000455715500011 (0) - scopus: (0)
congresso: 15th IIM Meeting (Assisi (PG))

11573/1013914 - 2017 - Basking in their niche: stem cells with myogenic potential as a target to combat cachexia
Baccam, Alexandra; Hassani, Medhi Samy; Alexandra, Sviercovich Benoni; Adamo, Sergio; Moresi, Viviana - 01g Articolo di rassegna (Review)
rivista: Current Updates in Stem Cell Research and Therapy (OPR Science) pp. 1-12 - issn: - wos: (0) - scopus: (0)

11573/1025448 - 2017 - Mechanisms involved in the cross-talk between humoral and mechanical cues underlying muscle wasting in cachexia
Baccam, Alexandra; Hassani, Medhi; Benoni, Alexandra Auriane Patricia; Ramella, Martina; Boccafoschi, Francesca; Parlakian, Ara; Li, Zhenlin; Xue, Zhigang; Adamo, Sergio; Coletti, Dario - 04d Abstract in atti di convegno
rivista: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE (Heidelberg ; Berlin : Springer) pp. 1066-1066 - issn: 2190-6009 - wos: (0) - scopus: (0)
congresso: 10th International Conference onCachexia, Sarcopenia and Muscle Wasting (Rome)
libro: JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE - ()

11573/890666 - 2016 - Serum response factor in muscle tissues: from development to ageing
Coletti, Dario; Daou, Nissrine; Hassani, Medhi; Li, Zhenlin; Parlakian, Ara - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY (Padova : Unipress) pp. 87-92 - issn: 2037-7452 - wos: WOS:000378590200004 (41) - scopus: (0)

11573/1655976 - 2015 - Measurement of the branching ratio Gamma(Lambda(0)(b) -> Psi(2S)Lambda(0))/Gamma(Lambda(0.)(b) -> J/Psi Lambda(0)) with the ATLAS detector
Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Aben, R; Abolins, M; Abouzeid, Os; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, Bs; Adamczyk, L; Adams, Dl; Adelman, J; Adomeit, S; Adye, T; Affolder, Aa; Agatonovic-Jovin, T; Agricola, J; Aguilar-Saavedra, Ja; Ahlen, Sp; Ahmadov, F; Aielli, G; Akerstedt, H; Akesson, Tpa; Akimov, Av; Alberghi, Gl; Albert, J; Albrand, S; Verzini, Mja; Aleksa, M; Aleksandrov, In; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Alkire, Sp; Allbrooke, Bmm; Allport, Pp; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Gonzalez, Ba; Piqueras, Da; Alviggi, Mg; Amadio, Bt; Amako, K; Coutinho, Ya; Amelung, C; Amidei, D; Dos Santos, Spa; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, Ls; Andari, N; Andeen, T; Anders, Cf; Anders, G; Anders, Jk; Anderson, Kj; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, Av; Anjos, N; Annovi, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Bella, La; Arabidze, G; Arai, Y; Araque, Jp; Arce, Ath; Arduh, Fa; Arguin, Jf; Argyropoulos, S; Arik, M; Armbruster, Aj; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Asman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, Nb; Augsten, K; Aurousseau, M; Avolio, G; Axen, B; Ayoub, Mk; Azuelos, G; Baak, Ma; Baas, Ae; Baca, Mj; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, Jt; Baker, Ok; Baldin, Em; Balek, P; Balestri, T; Balli, F; Banas, E; Banerjee, S; Bannoura, Aae; Bansil, Hs; Barak, L; Barberio, El; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnes, Sl; Barnett, Bm; Barnett, Rm; Barnovska, Z; Baroncelli, A; Barone, G; Barr, Aj; Barreiro, F; Da Costa, Jbg; Bartoldus, R; Barton, Ae; Bartos, P; Basalaev, A; Bassalat, A; Basye, A; Bates, Rl; Batista, Sj; Batley, Jr; Battaglia, M; Bauce, M; Bauer, F; Bawa, Hs; Beacham, Jb; Beattie, Md; Beau, T; Beauchemin, Ph; Beccherle, R; Bechtle, P; Beck, Hp; Becker, K; Becker, M; Becker, S; Beckingham, M; Becot, C; Beddall, Aj; Beddall, A; Bednyakov, Va; Bee, Cp; Beemster, Lj; Beermann, Ta; Begel, M; Behr, Jk; Belanger-Champagne, C; Bell, Wh; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, Eb; Garcia, Jab; Benjamin, Dp; Bensinger, Jr; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, Eb; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernard, Nr; Bernius, C; Bernlochner, Fu; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, Mi; Besjes, Gj; Bylund, Ob; Bessner, M; Besson, N; Betancourt, C; Bethke, S; Bevan, Aj; Bhimji, W; Bianchi, Rm; Bianchini, L; Bianco, M; Biebel, O; Biedermann, D; Bieniek, Sp; Biglietti, M; De Mendizabal, Jb; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Biondi, S; Black, Cw; Black, Je; Black, Km; Blackburn, D; Blair, Re; Blanchard, Jb; Blanco, Je; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, Gj; Bobrovnikov, Vs; Bocchetta, Ss; Bocci, A; Bock, C; Boehler, M; Bogaerts, Ja; Bogavac, D; Bogdanchikov, Ag; Bohm, C; Boisvert, V; Bold, T; Boldea, V; Boldyrev, As; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boudreau, J; Bouffard, J; Bouhova-Thacker, Ev; Boumediene, D; Bourdarios, C; Bousson, N; Boveia, A; Boyd, J; Boyko, Ir; Bozic, I; Bracinik, J; Brandt, A; Brandt, G; Brandta, O; Bratzler, U; Brau, B; Brau, Je; Braun, Hm; Brazzale, Sf; Madden, Wdb; Brendlinger, K; Brennan, Aj; Brenner, L; Brenner, R; Bressler, S; Bristow, K; Bristow, Tm; Britton, D; Britzger, D; Brochu, Fm; Brock, I; Brock, R; Bronner, J; Brooijmans, G; Brooks, T; Brooks, Wk; Brosamer, J; Brost, E; Brown, J; De Renstrom - 01a Articolo in rivista
rivista: PHYSICS LETTERS. SECTION B (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 63-80 - issn: 0370-2693 - wos: WOS:000365384600013 (13) - scopus: 2-s2.0-85042517730 (17)

11573/1656042 - 2015 - Search for high-mass diboson resonances with boson-tagged jets in proton-proton collisions at root s = TeV with the ATLAS detector
Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Aben, R; Abolins, M; Abouzeid, Os; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, Bs; Adamczyk, L; Adams, Dl; Adelman, J; Adomeit, S; Adye, T; Affolder, Aa; Agatonovic-Jovin, T; Aguilar-Saavedra, Ja; Ahlen, Sp; Ahmadov, F; Aielli, G; Akerstedt, H; Akesson, Tpa; Akimoto, G; Akimov, Av; Alberghi, Gl; Albert, J; Albrand, S; Verzini, Mja; Aleksa, M; Aleksandrov, In; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Alkire, Sp; Allbrooke, Bmm; Allport, Pp; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Gonzalez, Ba; Piqueras, Da; Alviggi, Mg; Amadio, Bt; Amako, K; Coutinho, Ya; Amelung, C; Amidei, D; Dos Santos, Spa; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, Ls; Andari, N; Andeen, T; Anders, Cf; Anders, G; Anders, Jk; Anderson, Kj; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, V; Anjos, N; Annovi, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Bella, La; Arabidze, G; Arai, Y; Araque, Jp; Arce, Ath; Arduh, Fa; Arguin, Jf; Argyropoulos, S; Arik, M; Armbruster, Aj; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Asman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, Nb; Auerbach, B; Augsten, K; Aurousseau, M; Avolio, G; Axen, B; Ayoub, Mk; Azuelos, G; Baak, Ma; Baas, Ae; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, Jt; Baker, Ok; Balek, P; Balestri, T; Balli, F; Banas, E; Banerjee, S; Bannoura, Aae; Bansil, Hs; Barak, L; Barberio, El; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnes, Sl; Barnett, Bm; Barnett, Rm; Barnovska, Z; Baroncelli, A; Barone, G; Barr, Aj; Barreiro, F; Da Costa, Jbg; Bartoldus, R; Barton, Ae; Bartos, P; Basalaev, A; Bassalat, A; Basye, A; Bates, Rl; Batista, Sj; Batley, Jr; Battaglia, M; Bauce, M; Bauer, F; Bawa, Hs; Beacham, Jb; Beattie, Md; Beau, T; Beauchemin, Ph; Beccherle, R; Bechtle, P; Beck, Hp; Becker, K; Becker, M; Becker, S; Beckingham, M; Becot, C; Beddall, Aj; Beddall, A; Bednyakov, Va; Bee, Cp; Beemster, Lj; Beermann, Ta; Begel, M; Behr, Jk; Belanger-Champagne, C; Bell, Wh; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, Eb; Garcia, Jab; Benjamin, Dp; Bensinger, Jr; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, Eb; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernard, Nr; Bernius, C; Bernlochner, Fu; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, Mi; Besjes, Gj; Bylund, Ob; Bessner, M; Besson, N; Betancourt, C; Bethke, S; Bevan, Aj; Bhimji, W; Bianchi, Rm; Bianchini, L; Bianco, M; Biebel, O; Biedermann, D; Bieniek, Sp; Biglietti, M; De Mendizabal, Jb; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Black, Cw; Black, Je; Black, Km; Blackburn, D; Blair, Re; Blanchard, Jb; Blanco, Je; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, Gj; Bobrovnikov, Vs; Bocchetta, Ss; Bocci, A; Bock, C; Boehler, M; Bogaerts, Ja; Bogavac, D; Bogdanchikov, Ag; Bohm, C; Boisvert, V; Bold, T; Boldea, V; Boldyrev, As; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boudreau, J; Bouffard, J; Bouhova-Thacker, Ev; Boumediene, D; Bourdarios, C; Bousson, N; Boveia, A; Boyd, J; Boyko, Ir; Bozic, I; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, Je; Braun, Hm; Brazzale, Sf; Madden, Wdb; Brendlinger, K; Brennan, Aj; Brenner, L; Brenner, R; Bressler, S; Bristow, K; Bristow, Tm; Britton, D; Britzger, D; Brochu, Fm; Brock, I; Brock, R; Bronner, J; Brooijmans, G; Brooks, T; Brooks, Wk; Brosamer, J; Brost, E; Brown, J; De Renstrom, Pab; Bruncko, D; Brun - 01a Articolo in rivista
rivista: JOURNAL OF HIGH ENERGY PHYSICS (Societa Italiana di Fisica:Via Saragozza 12 Subs Service, I 40123 Bologna Italy:011 39 051 331554, EMAIL: sif@sif.it, INTERNET: http://www.sif.it, Fax: 011 39 051 581340 SISSA, Scuola internazionale superiore di studi avanzati) pp. 1-39 - issn: 1029-8479 - wos: WOS:000366831400001 (146) - scopus: 2-s2.0-84950325294 (122)

11573/1656041 - 2015 - Measurement of four-jet differential cross sections in √s=8 TeV proton-proton collisions using the ATLAS detector
Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Aben, R; Abolins, M; Abouzeid, Os; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, Bs; Adamczyk, L; Adams, Dl; Adelman, J; Adomeit, S; Adye, T; Older, Aa; Agatonovic-Jovin, T; Agricola, J; Aguilar-Saavedra, Ja; Ahlen, Sp; Ahmadov, F; Aielli, G; Akerstedt, H; Akesson, Tpa; Akimov, Av; Alberghi, Gl; Albert, J; Albrand, S; Verzini, Mja; Aleksa, M; Aleksandrov, In; Alexa, G; Alexander, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Alkire, Sp; Allbrooke, Bmm; Allport, Pp; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Gonzalez, Ba; Piqueras, Da; Alviggi, Mg; Amadio, Bt; Amako, K; Coutinho, Ya; Amelung, C; Amidei, D; Dos Santos, Spa; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, Ls; Andari, N; Andeen, T; Anders, Cf; Anders, G; Anders, Jk; Anderson, Kj; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, Av; Anjos, N; Annovi, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Bella, La; Arabidze, G; Arai, Y; Araque, Jp; Arce, Ath; Arduh, Fa; Arguin, Jf; Argyropoulos, S; Arik, M; Armbruster, Aj; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Asman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, Nb; Augsten, K; Aurousseau, M; Avolio, G; Axen, B; Ayoub, Mk; Azuelos, G; Baak, Ma; Baas, Ae; Baca, Mj; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, Jt; Baker, Ok; Baldin, Em; Balek, P; Balestri, T; Balli, F; Banas, E; Banerjee, S; Bannoura, Aae; Bansil, Hs; Barak, L; Barberio, El; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnes, Sl; Barnett, Bm; Barnett, Rm; Barnovska, Z; Baroncelli, A; Barone, G; Barr, Aj; Da Costa, Fbg; Bartoldus, R; Barton, Ae; Bartos, P; Basalaev, A; Bassalat, A; Basye, A; Bates, Rl; Batista, Sj; Batley, Jr; Battaglia, M; Bauce, M; Bauer, F; Bawa, Hs; Beacham, Jb; Beattie, Md; Beau, T; Beauchemin, Ph; Beccherle, R; Bechtle, P; Beck, Hp; Becker, K; Becker, M; Beckingham, M; Becot, C; Beddall, Aj; Beddall, A; Bednyakov, Va; Bee, Cp; Beemster, Lj; Beermann, Ta; Begel, M; Behr, Jk; Belanger-Champagne, C; Bell, Wh; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, Eb; Garcia, Jab; Benjamin, Dp; Bensinger, Jr; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, Eb; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernard, Nr; Bernius, C; Bernlochner, Fu; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, Mi; Besjes, Gj; Bylund, Ob; Bessner, M; Besson, N; Betancourt, C; Bethke, S; Bevan, Aj; Bhimji, W; Bianchi, Rm; Bianchini, L; Bianco, M; Biebel, O; Biedermann, D; Bieniek, Sp; Biglietti, M; De Mendizabal, Jb; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Biondi, S; Black, Cw; Black, Je; Black, Km; Blackburn, D; Blair, Re; Blanchard, Jb; Blanco, Je; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, Gj; Bobrovnikov, Vs; Bocchetta, Ss; Bocci, A; Bock, C; Boehler, M; Bogaerts, Ja; Bogavac, D; Bogdanchikov, Ag; Bohm, C; Boisvert, V; Bold, T; Boldea, V; Boldyrev, As; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boudreau, J; Bou, J; Bouhova-Thacker, Ev; Boumediene, D; Bourdarios, C; Bousson, N; Boveia, A; Boyd, J; Boyko, Ir; Bozic, I; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, Je; Braun, Hm; Brazzale, Sf; Madden, Wdb; Brendlinger, K; Brennan, Aj; Brenner, L; Brenner, R; Bressler, S; Bristow, K; Bristow, Tm; Britton, D; Britzger, D; Brochu, Fm; Brock, I; Brock, R; Bronner, J; Brooijmans, G; Brooks, T; Brooks, Wk; Brosamer, J; Brost, E; Brown, J; De Renstrom, Pab; Bruncko, D; Bruneliere, R; - 01a Articolo in rivista
rivista: JOURNAL OF HIGH ENERGY PHYSICS (Societa Italiana di Fisica:Via Saragozza 12 Subs Service, I 40123 Bologna Italy:011 39 051 331554, EMAIL: sif@sif.it, INTERNET: http://www.sif.it, Fax: 011 39 051 581340 SISSA, Scuola internazionale superiore di studi avanzati) pp. 1-76 - issn: 1029-8479 - wos: WOS:000367475300001 (9) - scopus: 2-s2.0-84953240771 (12)

11573/1656044 - 2015 - Constraints on new phenomena via Higgs boson couplings and invisible decays with the ATLAS detector
Aad, G; Abbott, B; Abdallah, J; Abdinov, O; Aben, R; Abolins, M; Abouzeid, Os; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Adye, T; Affolder, Aa; Agatonovic-Jovin, T; Agricola, J; Aguiar-Saavedra, Ja; Ahlen, Sp; Ahmadov, F; Aielli, G; Akerstedt, H; Akesson, Tpa; Akimov, Av; Alberghi, Gl; Albert, J; Albrand, S; Verzini, Mja; Akimov, Av; Alberghi, Gl; Albert, J; Albrand, S; Verzini, Mja; Aleksa, M; Aleksandrov, In; Alexa, C; Alexander, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Alkire, Sp; Allbrooke, Bmm; Allport, Pp; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Gonzalez, Ba; Piqueras, Da; Alviggi, Mg; Amadio, Bt; Amako, K; Coutinho, Ya; Amelung, C; Amidei, D; Dos Santos, Spa; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, Ls; Andari, N; Andeen, T; Anders, Cf; Anders, G; Anders, Jk; Anderson, Kj; Andreazza, A; Andrei, V; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, Av; Anjos, N; Annovi, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Bella, La; Arabidze, G; Arai, Y; Araque, Jp; Arce, Ath; Arduh, Fa; Arguin, Jf; Argyropoulos, S; Arik, M; Armbruster, Aj; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Aring, ; Sman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, Nb; Augsten, K; Aurousseau, M; Avolio, G; Axen, B; Ayoub, Mk; Azuelos, G; Baak, Ma; Baas, Ae; Baca, Mj; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, Jt; Baker, Ok; Baldin, Em; Balek, P; Balestri, T; Balli, F; Balunas, Wk; Banas, E; Banerjee, S; Bannoura, Aae; Bansil, Hs; Barak, L; Barberio, El; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnes, Sl; Barnett, Bm; Barnett, Rm; Barnovska, Z; Baroncelli, A; Barone, G; Barr, Aj; Barreiro, F; Da Costa, Jbg; Bartoldus, R; Barton, Ae; Bartos, P; Basalaev, A; Bassalat, A; Basye, A; Bates, Rl; Batista, Sj; Batley, Jr; Battaglia, M; Bauce, M; Bauer, F; Bawa, Hs; Beacham, Jb; Beattie, Md; Beau, T; Beauchemin, Ph; Beccherle, R; Bechtle, P; Beck, Hp; Becker, K; Becker, M; Beckingham, M; Becot, C; Beddall, Aj; Beddall, A; Bednyakov, Va; Bee, Cp; Beemster, Lj; Beermann, Ta; Begel, M; Behr, Jk; Belanger-Champagne, C; Bell, Wh; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bender, M; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, Eb; Garcia, Jab; Benjamin, Dp; Bensinger, Jr; Bentvelsen, S; Beresford, L; Beretta, M; Berge, D; Kuutmann, Eb; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernard, Nr; Bernius, C; Bernlochner, Fu; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, Mi; Besjes, Gj; Bylund, Ob; Bessner, M; Besson, N; Betancourt, C; Bethke, S; Bevan, Aj; Bhimji, W; Bianchi, Rm; Bianchini, L; Bianco, M; Biebel, O; Biedermann, D; Bieniek, Sp; Biglietti, M; De Mendizabal, Jb; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Biondi, S; Bjergaard, Dm; Black, Cw; Black, Je; Black, Km; Blackburn, D; Blair, Re; Blanchard, Jb; Blanco, Je; Blazek, T; Boch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, Gj; Bobrovnikov, Vs; Bocchetta, Ss; Bocci, A; Bock, C; Boehler, M; Bogaerts, Ja; Bogavac, D; Bogdanchikov, Ag; Bohm, C; Boisvert, V; Bold, T; Boldea, V; Boldyrev, As; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boudreau, J; Bouffard, J; Bouhova-Thacker, Ev; Boumediene, D; Bourdarios, C; Bousson, N; Boutle, Sk; Boveia, A; Boyd, J; Boyko, Ir; Bozic, I; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, Je; Braun, Hm; Brazzale, Sf; Madden, Wdb; Brendlinger, K; Brennan, Aj; Brenner, L; Brenner, R; Bressler, S; Bristow, K; Bristow, Tm; Britton, D; Britzger, D; Brochu, Fm; Brock, I; Brock, R; Bronner, J; Brooijmans, G; Brooks, T; Brooks, Wk; Brosamer - 01a Articolo in rivista
rivista: JOURNAL OF HIGH ENERGY PHYSICS (Societa Italiana di Fisica:Via Saragozza 12 Subs Service, I 40123 Bologna Italy:011 39 051 331554, EMAIL: sif@sif.it, INTERNET: http://www.sif.it, Fax: 011 39 051 581340 SISSA, Scuola internazionale superiore di studi avanzati) pp. 1-52 - issn: 1029-8479 - wos: WOS:000366625100001 (200) - scopus: 2-s2.0-84949684350 (174)

11573/1656040 - 2015 - Measurement of the production of neighbouring jets in lead-lead collisions at root s(NN)=2.76TeV with the ATLAS detector
Aad, G; Abbott, B; Abdallah, J; Khalek, Sa; Abdinov, O; Aben, R; Abi, B; Abolins, M; Abouzeid, Os; Abramowicz, H; Abreu, H; Abreu, R; Abulaiti, Y; Acharya, Bs; Adamczyk, L; Adams, Dl; Adelman, J; Adomeit, S; Adye, T; Agatonovic-Jovin, T; Aguilar-Saavedra, Ja; Agustoni, M; Ahlen, Sp; Ahmadov, F; Aielli, G; Akerstedt, H; Akesson, Tpa; Akimoto, G; Akimov, Av; Alberghi, Gl; Albert, J; Albrand, S; Verzini, Mja; Aleksa, M; Aleksandrov, In; Alexa, C; Alexander, G; Alexandre, G; Alexopoulos, T; Alhroob, M; Alimonti, G; Alio, L; Alison, J; Allbrooke, Bmm; Allison, Lj; Allport, Pp; Almond, J; Aloisio, A; Alonso, A; Alonso, F; Alpigiani, C; Altheimer, A; Gonzalez, Ba; Alviggi, Mg; Amako, K; Coutinho, Ya; Amelung, C; Amidei, D; Dos Santos, Spa; Amorim, A; Amoroso, S; Amram, N; Amundsen, G; Anastopoulos, C; Ancu, Ls; Andari, N; Andeen, T; Anders, Cf; Anders, G; Anderson, Kj; Andreazza, A; Andrei, V; Anduaga, Xs; Angelidakis, S; Angelozzi, I; Anger, P; Angerami, A; Anghinolfi, F; Anisenkov, Av; Anjos, N; Annovi, A; Antonaki, A; Antonelli, M; Antonov, A; Antos, J; Anulli, F; Aoki, M; Bella, La; Apolle, R; Arabidze, G; Aracena, I; Arai, Y; Araque, Jp; Arce, Ath; Arguin, Jf; Argyropoulos, S; Arik, M; Armbruster, Aj; Arnaez, O; Arnal, V; Arnold, H; Arratia, M; Arslan, O; Artamonov, A; Artoni, G; Asai, S; Asbah, N; Ashkenazi, A; Asman, B; Asquith, L; Assamagan, K; Astalos, R; Atkinson, M; Atlay, Nb; Auerbach, B; Augsten, K; Aurousseau, M; Avolio, G; Azuelos, G; Azuma, Y; Baak, Ma; Baas, Ae; Bacci, C; Bachacou, H; Bachas, K; Backes, M; Backhaus, M; Mayes, Jb; Badescu, E; Bagiacchi, P; Bagnaia, P; Bai, Y; Bain, T; Baines, Jt; Baker, Ok; Balek, P; Balli, F; Banas, E; Banerjee, S; Bannoura, Aae; Bansal, V; Bansil, Hs; Barak, L; Barberio, L; Barberis, D; Barbero, M; Barillari, T; Barisonzi, M; Barklow, T; Barlow, N; Barnett, Bm; Barnett, Rm; Barnovska, Z; Baroncelli, A; Barone, G; Barr, Aj; Barreiro, F; Da Costa, Jbg; Bartoldus, R; Barton, Ae; Bartos, P; Bartsch, V; Bassalat, A; Basye, A; Bates, Rl; Batley, Jr; Battaglia, M; Battistin, M; Bauer, F; Bawa, Hs; Beattie, Md; Beau, T; Beauchemin, Ph; Beccherle, R; Bechtle, P; Beck, Hp; Becker, K; Becker, S; Beckingham, M; Becot, C; Beddall, Aj; Beddall, A; Bedikian, S; Bednyakov, Va; Bee, Cp; Beemster, Lj; Beermann, Ta; Begel, M; Behr, Jk; Belanger-Champagne, C; Bell, Pj; Bell, Wh; Bella, G; Bellagamba, L; Bellerive, A; Bellomo, M; Belotskiy, K; Beltramello, O; Benary, O; Benchekroun, D; Bendtz, K; Benekos, N; Benhammou, Y; Noccioli, Eb; Garcia, Jab; Benjamin, Dp; Bensinger, Jr; Benslama, K; Bentvelsen, S; Berge, D; Kuutmann, Eb; Berger, N; Berghaus, F; Beringer, J; Bernard, C; Bernat, P; Bernius, C; Bernlochner, Fu; Berry, T; Berta, P; Bertella, C; Bertoli, G; Bertolucci, F; Bertsche, C; Bertsche, D; Besana, Mi; Besjes, Gj; Bylund, Ob; Bessner, M; Besson, N; Betancourt, C; Bethke, S; Bhimji, W; Bianchi, Rm; Bianchini, L; Bianco, M; Biebel, O; Bieniek, Sp; Bierwagen, K; Biesiada, J; Biglietti, M; De Mendizabal, Jb; Bilokon, H; Bindi, M; Binet, S; Bingul, A; Bini, C; Black, Cw; Black, Je; Black, Km; Blackburn, D; Blair, Re; Blanchard, Jb; Blazek, T; Bloch, I; Blocker, C; Blum, W; Blumenschein, U; Bobbink, Gj; Bobrovnikov, Vs; Bocchetta, Ss; Bocci, A; Bock, C; Boddy, Cr; Boehler, M; Boek, Tt; Bogaerts, Ja; Bogdanchikov, Ag; Bogouch, A; Bohm, C; Bohm, J; Boisvert, V; Bold, T; Boldea, V; Boldyrev, As; Bomben, M; Bona, M; Boonekamp, M; Borisov, A; Borissov, G; Borri, M; Borroni, S; Bortfeldt, J; Bortolotto, V; Bos, K; Boscherini, D; Bosman, M; Boterenbrood, H; Boudreau, J; Bouffard, J; Bouhova-Thacker, Ev; Boumediene, D; Bourdarios, C; Bousson, N; Boutouil, S; Boveia, A; Boyd, J; Boyko, Ir; Bracinik, J; Brandt, A; Brandt, G; Brandt, O; Bratzler, U; Brau, B; Brau, Je; Braun, Hm; Brazzale, Sf; Brelier, B; Brendlinger, K; Brennan, Aj; Brenner, R; Bressler, S; Bristow, K; Bristow, Tm; Britton, D; Brochu, Fm; Brock, I; Brock, R; Bromberg, C; Bronner, J; Brooijmans, G; Brooks, T; Brooks, Wk; Brosamer, J; Brost, E; B - 01a Articolo in rivista
rivista: PHYSICS LETTERS. SECTION B (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 376-395 - issn: 0370-2693 - wos: WOS:000365384600061 (16) - scopus: 2-s2.0-84946912808 (20)

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