MATTEO COSTANZO

Dottore di ricerca

ciclo: XXXVI

Titolo della tesi: Impact of non-motor symptoms on clinical heterogeneity and treatment strategies in patients with cervical dystonia

Cervical dystonia (CD) presents with significant clinical heterogeneity, encompassing a broad spectrum of motor and non-motor symptoms, with pain being a predominant factor contributing to disease-related disability and diminished quality of life. This variability underscores a critical gap in understanding and managing CD, particularly regarding the influence of non-motor symptoms (NMS) on its clinical heterogeneity. Botulinum toxin (BoNT) remains the first-line treatment for motor symptoms in CD; however, its effects on NMS, including psychiatric conditions, sleep disorders, and pain, are not well-understood, necessitating comprehensive studies to elucidate its broader therapeutic impacts. Additionally, the management of pain through neuromodulatory approaches is an area ripe for exploration and advancements. This thesis presents three studies focused on addressing these gaps. The first study aimed to categorize clinical subtypes of CD through a comprehensive, hypothesis-free, data-driven analysis of both motor and non-motor symptoms within a cross-sectional framework. The second study longitudinally evaluated the effects of BoNT-A on NMS in CD, such as cognitive issues, psychiatric conditions, sleep disorders, and pain. The third study investigated the potential of vibrotactile stimulation (VTS) as a non-invasive neuromodulation method targeting the somatosensory system to modulate neck pain in CD patients. This research aimed to explore alternative pain management strategies that could alleviate the significant pain burden in CD, offering new avenues for treatment.

Produzione scientifica

11573/1729658 - 2025 - Neurophysiological Features of Tremor during Walking in Parkinson's Disease

Costanzo, Matteo; Marchet, Francesco; Leodori, Giorgio; Cutrona, Carolina; De Bartolo, Maria Ilenia; Vivacqua, Giorgio; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo; Belvisi, Daniele - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS CLINICAL PRACTICE (Hoboken, NJ : John Wiley & Sons, 2014-) pp. - - issn: 2330-1619 - wos: (0) - scopus: (0)

11573/1716173 - 2024 - Evaluating the Diagnostic Potential of Combined Salivary and Skin Biomarkers in Parkinson's Disease.

Costanzo, M; Galosi, E; De Bartolo, Maria Ilenia; Gallo, G; Leodori, G; Belvisi, D; Conte, A; Fabbrini, G; Truini, A; Berardelli, A; Vivacqua, G. - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001219880700001 (0) - scopus: 2-s2.0-85192740553 (1)

11573/1729096 - 2024 - Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer’s disease progression: a systematic review

Costanzo, Matteo; Cutrona, Carolina; Leodori, Giorgio; Malimpensa, Leonardo; D'antonio, Fabrizia; Conte, Antonella; Belvisi, Daniele - 01d Recensione

rivista: ALZHEIMER'S RESEARCH & THERAPY ([London] : BioMed Central Ltd., c2009-) pp. - - issn: 1758-9193 - wos: WOS:001348655300001 (0) - scopus: 2-s2.0-85208516570 (0)

11573/1722449 - 2024 - Can Repetitive Transcranial Magnetic Stimulation (rTMS) Promote Neurogenesis and Axonogenesis in Subacute Human Ischemic Stroke?

De Michele, Manuela; Piscopo, Paola; Costanzo, Matteo; Lorenzano, Svetlana; Crestini, Alessio; Rivabene, Roberto; Manzini, Valeria; Petraglia, Luca; Iacobucci, Marta; Berto, Irene; Schiavo, Oscar Gaetano; Conte, Antonella; Belvisi, Daniele; Berardelli, Alfredo; Toni, Danilo - 01a Articolo in rivista

rivista: BIOMEDICINES (Basel: MDPI) pp. - - issn: 2227-9059 - wos: WOS:001191878600001 (1) - scopus: 2-s2.0-85188687642 (1)

11573/1716885 - 2024 - Mapping Motor Cortical Network Excitability and Connectivity Changes in De Novo Parkinson's Disease

Leodori, Giorgio; De Bartolo, Maria Ilenia; Piervincenzi, Claudia; Mancuso, Marco; Ojha, Abhineet; Costanzo, Matteo; Aiello, Flavia; Vivacqua, Giorgio; Fabbrini, Giovanni; Conte, Antonella; Pantano, Patrizia; Berardelli, Alfredo; Belvisi, Daniele - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS (-WILEY-LISS, DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, USA, NJ, 07030 -Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 0885-3185 - wos: WOS:001253844100001 (0) - scopus: 2-s2.0-85196653559 (0)

11573/1714176 - 2024 - Understanding the role of cerebellum in early Parkinson’s disease: a structural and functional MRI study

Pietracupa, S.; Ojha, A.; Belvisi, D.; Piervincenzi, C.; Tommasin, S.; Petsas, N.; De Bartolo, M. I.; Costanzo, M.; Fabbrini, A.; Conte, A.; Berardelli, A.; Pantano, P. - 01a Articolo in rivista

rivista: NPJ PARKINSON'S DISEASE ([New York NY] : Nature Publishing Group; Parkinson's Disease Foundation , [2015]-) pp. - - issn: 2373-8057 - wos: WOS:001250364000001 (0) - scopus: 2-s2.0-85196156216 (0)

11573/1722442 - 2024 - Vibro-tactile stimulation of the neck reduces pain in people with cervical dystonia: a proof-of-concept study

Xu, Jiapeng; Costanzo, Matteo; Avanzino, Laura; Martino, Davide; Salehi, Parisa; Standal, Stephanie; Manzo, Nicoletta; Alizadeh, Parisa; Terranova, Sara; Bonassi, Gaia; Oh, Jinseok; Conte, Antonella; Konczak, Jürgen - 01a Articolo in rivista

rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 4847-4856 - issn: 1590-1874 - wos: WOS:001220392300001 (1) - scopus: 2-s2.0-85192724078 (1)

11573/1689138 - 2023 - Distal Upper Limb Tremor during Walking in Parkinson's Disease

Costanzo, Matteo; Cutrona, Carolina; Leodori, Giorgio; De Bartolo, Maria Ilenia; Fabbrini, Andrea; Vivacqua, Giorgio; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo; Belvisi, Daniele - 01a Articolo in rivista

rivista: MOVEMENT DISORDERS CLINICAL PRACTICE (Hoboken, NJ : John Wiley & Sons, 2014-) pp. 1198-1202 - issn: 2330-1619 - wos: WOS:001011839600001 (0) - scopus: 2-s2.0-85162654689 (1)

11573/1689139 - 2023 - Motor Cortical Correlates of Paired Associative Stimulation Induced Plasticity: A TMS-EEG Study

Costanzo, Matteo; Leodori, Giorgio; Cutrona, Carolina; Marchet, Francesco; De Bartolo, Maria Ilenia; Mancuso, Marco; Belvisi, Daniele; Conte, Antonella; Berardelli, Alfredo; Fabbrini, Giovanni - 01a Articolo in rivista

rivista: BRAIN SCIENCES (Basel: Molecular Diversity Preservation International) pp. 921- - issn: 2076-3425 - wos: WOS:001014158300001 (1) - scopus: 2-s2.0-85163714826 (1)

11573/1642015 - 2022 - Relationship between risk and protective factors and clinical features of Parkinson's disease

Belvisi, D.; Pellicciari, R.; Fabbrini, A.; Costanzo, M.; Ressa, G.; Pietracupa, S.; De Lucia, M.; Modugno, N.; Magrinelli, F.; Dallocchio, C.; Ercoli, T.; Nicoletti, A.; Zappia, M.; Solla, P.; Bologna, M.; Fabbrini, G.; Tinazzi, M.; Conte, A.; Berardelli, A.; Defazio, G. - 01d Recensione

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 80-85 - issn: 1353-8020 - wos: WOS:001012146300006 (11) - scopus: 2-s2.0-85129610188 (11)

11573/1660141 - 2022 - A combined panel of salivary biomarkers in de novo Parkinson's Disease

De Bartolo, Maria Ilenia; Vivacqua, Giorgio; Belvisi, Daniele; Mancinelli, Romina; Fabbrini, Andrea; Manzo, Nicoletta; Costanzo, Matteo; Leodori, Giorgio; Conte, Antonella; Fabbrini, Giovanni; Morini, Sergio; Berardelli, Alfredo; Md, - 01a Articolo in rivista

rivista: ANNALS OF NEUROLOGY ([Boston] : American Neurological Association, c1977-) pp. - - issn: 1531-8249 - wos: WOS:000906409600001 (20) - scopus: 2-s2.0-85145367515 (20)

11573/1617756 - 2022 - Longitudinal evaluation of patients with isolated head tremor

Ferrazzano, G.; Belvisi, D.; De Bartolo, M. I.; Baione, V.; Costanzo, M.; Fabbrini, G.; Defazio, G.; Berardelli, A.; Conte, A. - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 10-12 - issn: 1353-8020 - wos: WOS:000725173800002 (8) - scopus: 2-s2.0-85120156084 (12)

11573/1642087 - 2022 - Neurofilament assessment in patients with cervical dystonia

Ferrazzano, G.; Zingaropoli, M. A.; Costanzo, M.; Belvisi, D.; Dominelli, F.; Pasculli, P.; Ciardi, M. R.; Fabbrini, G.; Defazio, G.; Berardelli, A.; Conte, A. - 01f Lettera, Nota

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 70-71 - issn: 1353-8020 - wos: WOS:001012146300003 (4) - scopus: 2-s2.0-85129832646 (4)

11573/1660642 - 2022 - The Role of the Motor Cortex in Tremor Suppression in Parkinson's Disease

Leodori, Giorgio; De Bartolo, Maria Ilenia; Fabbrini, Andrea; Costanzo, Matteo; Mancuso, Marco; Belvisi, Daniele; Conte, Antonella; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista

rivista: JOURNAL OF PARKINSON'S DISEASE (Amsterdam : b IOS Press) pp. 1957-1963 - issn: 1877-7171 - wos: WOS:000852648500016 (3) - scopus: 2-s2.0-85137170562 (5)

11573/1660721 - 2022 - The effect of stimulation frequency on transcranial evoked potentials

Leodori, Giorgio; Rocchi, Lorenzo; Mancuso, Marco; De Bartolo, Maria Ilenia; Baione, Viola; Costanzo, Matteo; Belvisi, Daniele; Conte, Antonella; Defazio, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista

rivista: TRANSLATIONAL NEUROSCIENCE (Warszawa : "Versita") pp. 211-217 - issn: 2081-3856 - wos: WOS:000837049500001 (10) - scopus: 2-s2.0-85135803367 (10)

11573/1617760 - 2021 - The role of frailty in Parkinson’s disease: a cross-sectional study

Belvisi, D.; Canevelli, M.; Costanzo, M.; Giangrosso, M.; Fabbrini, A.; Borraccino, A.; Bruno, G.; Berardelli, A.; Fabbrini, G. - 01a Articolo in rivista

rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:000719696700002 (12) - scopus: 2-s2.0-85119171932 (11)

11573/1570894 - 2021 - Effect of botulinum toxin on non-motor symptoms in cervical dystonia

Costanzo, M.; Belvisi, D.; Berardelli, I.; Maraone, A.; Baione, V.; Ferrazzano, G.; Cutrona, C.; Leodori, G.; Pasquini, M.; Conte, A.; Fabbrini, G.; Defazio, G.; Berardelli, A. - 01a Articolo in rivista

rivista: TOXINS (Basel : Molecular Diversity Preservation International MDPI) pp. 647- - issn: 2072-6651 - wos: WOS:000699824300001 (14) - scopus: 2-s2.0-85115213571 (16)

11573/1634903 - 2021 - Motor and non-motor subtypes of cervical dystonia

Costanzo, M.; Belvisi, D.; Berardelli, I.; Maraone, A.; D'antonio, F.; Baione, V.; Toscano, A.; Ferrazzano, G.; Pasquini, M.; Conte, A.; Fabbrini, G.; Defazio, G.; Berardelli, A. - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 108-113 - issn: 1353-8020 - wos: WOS:000671580100021 (11) - scopus: 2-s2.0-85108447272 (14)

11573/1555359 - 2021 - Salivary caffeine in Parkinson’s disease

Leodori, G.; De Bartolo, M. I.; Belvisi, D.; Ciogli, A.; Fabbrini, A.; Costanzo, M.; Manetto, S.; Conte, A.; Villani, C.; Fabbrini, G.; Berardelli, A. - 01a Articolo in rivista

rivista: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. 9823- - issn: 2045-2322 - wos: WOS:000658740400009 (13) - scopus: 2-s2.0-85105556727 (13)

11573/1579386 - 2021 - Cortical mechanisms underlying variability in intermittent theta-burst stimulation-induced plasticity: A TMS-EEG study

Leodori, G.; Fabbrini, A.; De Bartolo, M. I.; Costanzo, M.; Asci, F.; Palma, V.; Belvisi, D.; Conte, A.; Berardelli, A. - 01a Articolo in rivista

rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 2519-2531 - issn: 1388-2457 - wos: WOS:000704914800024 (14) - scopus: 2-s2.0-85113362527 (16)

11573/1449311 - 2020 - Risk factors of Parkinson’s disease: Simultaneous assessment, interactions and etiological subtypes

Belvisi, Daniele; Pellicciari, Roberta; Fabbrini, Andrea; Costanzo, Matteo; Pietracupa, Sara; Maria, De Lucia; Modugno, Nicola; Magrinelli, Francesca; Dallocchio, Carlo; Ercoli, Tommaso; Terravecchia, Claudio; Nicoletti, Alessandra; Solla, Paolo; Fabbrini, Giovanni; Tinazzi, Michele; Berardelli, Alfredo; Defazio, Giovanni - 01a Articolo in rivista

rivista: NEUROLOGY (Wolters Kluwer Hagerstown MD: Lippincott Williams & Wilkins Cleveland Ohio: Advanstar Communications) pp. 10.1212/WNL.0000000000010813- - issn: 0028-3878 - wos: WOS:000587818100015 (44) - scopus: 2-s2.0-85095461540 (49)

11573/1388981 - 2020 - Re-emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex

Leodori, G.; Belvisi, D.; De Bartolo, M. I.; Fabbrini, A.; Costanzo, M.; Vial, F.; Conte, A.; Hallett, M.; Berardelli, A. - 01a Articolo in rivista

11573/1450448 - 2020 - Efficacy of occupational therapy interventions on quality of life in patients with Parkinson's disease. A systematic review and meta‐analysis

Tofani, Marco; Ranieri, Alessandro; Fabbrini, Giovanni; Berardi, Anna; Pelosin, Elisa; Valente, Donatella; Fabbrini, Andrea; Costanzo, Matteo; Galeoto, Giovanni - 01g Articolo di rassegna (Review)

rivista: MOVEMENT DISORDERS CLINICAL PRACTICE (Hoboken, NJ : John Wiley & Sons, 2014-) pp. 891-901 - issn: 2330-1619 - wos: WOS:000574213400001 (17) - scopus: 2-s2.0-85091757484 (19)

11573/1277191 - 2019 - The clinical correlates of suicidal ideation in Parkinson's disease

Belvisi, Daniele; Berardelli, Isabella; Ferrazzano, Gina; Costanzo, Matteo; Corigliano, Valentina; Fabbrini, Giovanni; Berardelli, Alfredo; Pompili, Maurizio - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. - - issn: 1353-8020 - wos: WOS:000482247500008 (16) - scopus: 2-s2.0-85062374866 (18)

11573/1254380 - 2019 - Salivary alpha-synuclein in the diagnosis of parkinson's disease and progressive supranuclear palsy

Vivacqua, Giorgio; Suppa, Antonio; Mancinelli, Romina; Belvisi, Daniele; Fabbrini, Andrea; Costanzo, Matteo; Formica, Alessandra; Onori, Paolo; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 143-148 - issn: 1353-8020 - wos: WOS:000482247500023 (63) - scopus: 2-s2.0-85061641627 (64)

11573/1225562 - 2018 - Re-emergent tremor in parkinson's disease. the effect of dopaminergic treatment

Belvisi, D.; Conte, A.; Cutrona, C.; Costanzo, M.; Ferrazzano, G.; Fabbrini, G.; Berardelli, A. - 01a Articolo in rivista

rivista: EUROPEAN JOURNAL OF NEUROLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 799-804 - issn: 1351-5101 - wos: WOS:000431989200006 (15) - scopus: 2-s2.0-85044845755 (21)

11573/1190041 - 2018 - Suicidal ideation, perceived disability, hopelessness and affective temperaments in patients affected by Parkinson's disease

Berardelli, Isabella; Belvisi, Daniele; Corigliano, Valentina; Costanzo, Matteo; Innamorati, Marco; Fabbrini, Giovanni; Berardelli, Alfredo; Pompili, Maurizio - 01a Articolo in rivista

rivista: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (Medicom International:42 Avondale Avenue, Hinchley Wood, Esher Surrey KT10 0DA United Kingdom:011 44 20 833090300, EMAIL: michael@mycltd.demon.co.uk, Fax: 011 44 20 83983361) pp. e13287- - issn: 1368-5031 - wos: WOS:000462615600015 (16) - scopus: 2-s2.0-85055945389 (16)

11573/961865 - 2017 - Re-emergent tremor in Parkinson's disease

Belvisi, Daniele; Conte, Antonella; Bologna, Matteo; Bloise, Maria Carmela; Suppa, Antonio; Formica, Alessandra; Costanzo, Matteo; Cardone, Pierluigi; Fabbrini, Giovanni; Berardelli, Alfredo - 01a Articolo in rivista

rivista: PARKINSONISM & RELATED DISORDERS (Elsevier Science:Molenwarf 1, 1014 AG Amsterdam The Netherlands:011 31 20 4853597, EMAIL: p.j.bishop@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 31 20 4853249) pp. 41-46 - issn: 1353-8020 - wos: WOS:000397073000006 (24) - scopus: 2-s2.0-85008414366 (29)