MARTINA SPAZIANO

Dottoranda

ciclo: XXXIX
email:




supervisore: Ferdinando Nicoletti
relatore: Ferdinando Nicoletti

Classe di laurea LM-9 Biotecnologie mediche, veterinarie e farmaceutiche
Università UNIVERSITA' DEGLI STUDI di FIRENZE
Data di conseguimento 28/06/2022
Elenco cronologico di Borse di studio, Assegni di ricerca (et similia) percepiti: May 2023 – to date Fellowship – I.R.C.C.S. NEUROMED, Laboratory of Neuropharmacology Responsible: Prof. F. Nicoletti Laboratory activity based on the principal methodics applied to molecular biology (DNA extraction, PCR, and others).
Attestati di partecipazione a stage: September 2020 – March 2021 Internship – Department of Experimental and Clinical Biomedical Sciences “Mario Serio” - Laboratory for the study of Protein Misfolding Diseases, University of Florence (Italy) Coordinator: Prof. F. Chiti Laboratory activity based on the study of the affinity of misfolded aggregates of the model protein HypF-N for lipid bilayer and the protective role played by trodusquemine, by related experimental methods among which: biochemical analysis techniques for the purification of proteins, such as chromatography, electrophoresis, centrifugation, extruder for the production of liposomes, fluorimetry, and DLS for the analysis of oligomers-LUVs interaction. The work carried out resulted in the publication of the following article: Errico S, Ramshini H, Capitini C, Canale C, Spaziano M, Barbut D, Calamai M, Zasloff M, Oropesa-Nuñez R, Vendruscolo M, Chiti F “Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine”. ACS Chem Neurosci. 2021, 12:3189-3202 August 2016 – October 2016 Internship – I.R.C.C.S. NEUROMED, Laboratory of Neuropathology, Pozzilli (Italy) Responsible: Dott.ssa A. Arcella Laboratory activity based on the effect of natural substances in the treatment of brain tumor (glioblastoma), by related experimental methods among which: cell cultures, PCR, electrophoresis, volumetric calculation of the tumor, and others.
Altri riconoscimenti (p. es.: premiazione in concorsi, seconda laurea): November 17, 2022 Qualification for biologist profession practice (Section A), University of Bari “Aldo Moro” (Italy) September 10, 2020 Acquisition of 24 credits in anthropo-psycho-pedagogical disciplines and didactic methodologies and technologies, University of Florence (Italy)
Conoscenze informatiche: Good knowledge of Microsoft Office, including Word, Excel, PowerPoint, and Outlook; Advanced skills in creating and formatting complex documents in Microsoft Word.


Produzione scientifica

11573/1724771 - 2021 - Quantitative measurement of the affinity of toxic and nontoxic misfolded protein oligomers for lipid bilayers and of its modulation by lipid composition and trodusquemine
Errico, S.; Ramshini, H.; Capitini, C.; Canale, C.; Spaziano, M.; Barbut, D.; Calamai, M.; Zasloff, M.; Oropesa-Nunez, R.; Vendruscolo, M.; Chiti, F. - 01a Articolo in rivista
rivista: ACS CHEMICAL NEUROSCIENCE (Washington, D.C. : American Chemical Society) pp. 3189-3202 - issn: 1948-7193 - wos: WOS:000693044200005 (17) - scopus: 2-s2.0-85113889250 (16)

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