MARTINA CAPPONI

PhD Graduate

PhD program:: XXXVIII

Thesis title: Sindrome Neuropsichiatrica Pediatrica ad esordio Acuto (PANS) e Disturbi Neuropsichiatrici Autoimmuni Pediatrici Associati a infezioni Streptococciche (PANDAS): un’analisi approfondita dello stress ossidativo e dell’endotossiemia di basso grado.

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), unlike pediatric acute-onset neuropsychiatric syndrome (PANS), is triggered by infections. This study aimed to assess the differences in low-grade endotoxemia and oxidative stress between these conditions. A cross-sectional study compared serum levels of soluble NOX2-dp (sNOX-2-dp), isoprostanes, lipopolysaccharide (LPS), and zonulin in 30 PANDAS, 21 PANS, and 30 control (CT) children matched for age and gender. Zonulin was used to assess gut permeability. Patients with PANDAS showed significantly higher serum levels of sNOX2-dp, isoprostanes, LPS, and zonulin than PANS and controls, while no significant differences were found between PANS and controls. sNOX2-dp correlated with isoprostanes (Rs = 0.708; p < 0.001), LPS (Rs = 0.584; p < 0.001), and zonulin (Rs = 0.662; p < 0.001). Multiple regression identified isoprostanes (β = 0.599; p < 0.001) and zonulin (β = 0.295; p = 0.01) as independent predictors of sNOX2-dp (R2 = 81%). PANDAS and PANS showed distinct profiles of LPS, zonulin, NOX2, and isoprostanes. Future research should explore therapies targeting endotoxemia and oxidative stress for potential clinical benefits.

Research products

11573/1733792 - 2025 - Nickel-induced labial angioedema in a pediatric patient with orthodontic braces: a case report

Leone, Fabrizio; Gori, Alessandra; Cinicola, Bianca Laura; Coletti, Giorgio; Pignataro, Elia; Capponi, Martina; Brindisi, Giulia; Anania, Caterina; Zicari, Anna Maria - 01i Case report

paper: THE ITALIAN JOURNAL OF PEDIATRICS (London : BioMed Central Ospedaletto : Pacini Editore) pp. - - issn: 1824-7288 - wos: WOS:001390557600003 (2) - scopus: 2-s2.0-85214221563 (1)

11573/1707250 - 2024 - SARS-CoV-2–specific mucosal immune response in vaccinated versus infected children

Conti, Maria Giulia; Piano Mortari, Eva; Nenna, Raffaella; Pierangeli, Alessandra; Sorrentino, Leonardo; Frasca, Federica; Petrarca, Laura; Mancino, Enrica; Di Mattia, Greta; Matera, Luigi; Fracella, Matteo; Albano, Christian; Scagnolari, Carolina; Capponi, Martina; Cinicola, Bianca; Carsetti, Rita; Midulla, Fabio - 01a Articolo in rivista

paper: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (Lausanne : Frontiers Media SA, 2011-) pp. - - issn: 2235-2988 - wos: WOS:001198831600001 (5) - scopus: 2-s2.0-85190147720 (5)

11573/1706005 - 2024 - Impact of heat-not-burn cigarette passive smoking on children's oxidative stress, endothelial and platelet function

Loffredo, Lorenzo; Carnevale, Roberto; Pannunzio, Arianna; Cinicola, Bianca Laura; Palumbo, Ilaria Maria; Bartimoccia, Simona; Nocella, Cristina; Cammisotto, Vittoria; Violi, Francesco; Biondi-Zoccai, Giuseppe; Frati, Giacomo; Zicari, Anna Maria; Magna, Arianna; Izzo, Raffaella; Capponi, Martina; Brindisi, Giulia; Salvatori, Francesca; Castellani, Valentina; Amico, Alessandra D’; Trivigno, Chiara; Totè, Chiara; Maggio, Enrico; Miraldi, Fabio; Duse, Marzia; Pignatelli, Pasquale; Spalice, Alberto; Antonucci, Flavia - 01a Articolo in rivista

paper: ENVIRONMENTAL POLLUTION (United Kingdom: Elsevier Science Limited Barking: Elsevier Applied Science Publishers, 1987-) pp. - - issn: 0269-7491 - wos: WOS:001181590900001 (5) - scopus: 2-s2.0-85184600359 (6)

11573/1722840 - 2024 - Impaired arterial dilation and increased NOX2 generated oxidative stress in subjects with ataxia-telangiectasia mutated (ATM) kinase

Loffredo, Lorenzo; Soresina, Annarosa; Cinicola, Bianca Laura; Capponi, Martina; Salvatori, Francesca; Bartimoccia, Simona; Picchio, Vittorio; Forte, Maurizio; Caputi, Caterina; Poscia, Roberto; Leuzzi, Vincenzo; Spalice, Alberto; Pignatelli, Pasquale; Badolato, Raffaele; Duse, Marzia; Violi, Francesco; Carnevale, Roberto; Zicari, Anna Maria; Palumbo, Ilaria Maria; Magna, Arianna; Fallarino, Alessia; Pannunzio, Arianna; Maggio, Enrico; Bagnato, Chiara; Cammisotto, Vittoria; Castellani, Valentina - 01a Articolo in rivista

paper: REDOX BIOLOGY (Amsterdam : Elsevier) pp. - - issn: 2213-2317 - wos: WOS:001327234400001 (3) - scopus: 2-s2.0-85204788231 (3)

11573/1654182 - 2022 - Covid-19, anosmia, and allergies. is there a relationship? a pediatric perspective

Brindisi, Giulia; Spalice, Alberto; Anania, Caterina; Bonci, Flaminia; Gori, Alessandra; Capponi, Martina; Cinicola, Bianca Laura; De Castro, Giovanna; Martinelli, Ivana; Pulvirenti, Federica; Matera, Luigi; Mancino, Enrica; Guido, Cristiana Alessia; Zicari, Anna Maria - 01a Articolo in rivista

paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. 1-13 - issn: 2077-0383 - wos: WOS:000851119500001 (3) - scopus: 2-s2.0-85137776409 (3)

11573/1654189 - 2022 - COVID-19 and abducens nerve palsy in a 9-year-old girl—case report

Capponi, Martina; Cinicola, Bianca Laura; Brindisi, Giulia; Guido, Cristiana Alessia; Cristina Torcé, Maria; Zicari, Anna Maria; Spalice, Alberto - 01a Articolo in rivista

paper: THE ITALIAN JOURNAL OF PEDIATRICS (London : BioMed Central Ospedaletto : Pacini Editore) pp. - - issn: 1824-7288 - wos: WOS:000812634900001 (6) - scopus: 2-s2.0-85132183012 (6)

11573/1654188 - 2022 - (R)Evolution in allergic rhinitis add-on therapy. from probiotics to postbiotics and parabiotics

Capponi, Martina; Gori, Alessandra; De Castro, Giovanna; Ciprandi, Giorgio; Anania, Caterina; Brindisi, Giulia; Loffredo, Lorenzo; Tosca, Mariangela; Cinicola, Bianca Laura; Salvatori, Alessandra; Spalice, Alberto; Zicari, Anna Maria - 01g Articolo di rassegna (Review)

paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. - - issn: 2077-0383 - wos: WOS:000852011100001 (13) - scopus: 2-s2.0-85137747907 (18)

11573/1652359 - 2022 - Short-Term Side Effects and SARS-CoV-2 Infection after COVID-19 Pfizer–BioNTech Vaccine in Children Aged 5–11 Years: An Italian Real-World Study

Capponi, Martina; Pulvirenti, Federica; Cinicola, Bianca Laura; Brindisi, Giulia; Conti, Maria Giulia; Colaiocco, Giovanni; De Castro, Giovanna; Guido, Cristiana Alessia; Duse, Marzia; Midulla, Fabio; Zicari, Anna Maria; Spalice, Alberto - 01a Articolo in rivista

paper: VACCINES (Basel: MDPI) pp. 1056- - issn: 2076-393X - wos: WOS:000831912900001 (17) - scopus: 2-s2.0-85133520289 (18)

11573/1679033 - 2022 - The bnt162b2 vaccine induces humoral and cellular immune memory to sars-cov-2 Wuhan strain and the Omicron variant in children 5 to 11 years of age

Cinicola, Bianca Laura; Piano Mortari, E; Zicari, Anna Maria; Agrati, Chiara; Bordoni, Veronica; Albano, Christian; Fedele, Giorgio; Schiavoni, Ilaria; Leone, Pasqualina; Fiore, Stefano; Capponi, Martina; Conti, Maria Giulia; Petrarca, Laura; Stefanelli, Paola; Spalice, Alberto; Midulla, Fabio; Palamara, Anna Teresa; Quinti, Isabella; Locatelli, Franco; Carsetti, Rita - 01a Articolo in rivista

paper: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. 1-11 - issn: 1664-3224 - wos: WOS:000904860400001 (14) - scopus: 2-s2.0-85145205356 (15)

11573/1610395 - 2022 - Selective iga deficiency and allergy. a fresh look to an old story

Cinicola, Bianca Laura; Pulvirenti, Federica; Capponi, Martina; Bonetti, Marta; Brindisi, Giulia; Gori, Alessandra; De Castro, Giovanna; Anania, Caterina; Duse, Marzia; Zicari, Anna Maria - 01g Articolo di rassegna (Review)

paper: MEDICINA (Basel: MDPI, 2018- Kaunas: Lithuanian University of Health Sciences Kaunas: Lithuanian University of Health Sciences, 2011-2013 Kaunas: Kauno medicinos draugija; Gydytojų sekcija prie Lietuvių mokslo draugijos, 1920-1940 1990-) pp. 1-15 - issn: 1010-660X - wos: WOS:000758471300001 (23) - scopus: 2-s2.0-85123092496 (26)

11573/1655361 - 2022 - Neurological and psychological effects of long covid in a young population. a cross-sectional study

Guido, C. A.; Lucidi, F.; Midulla, F.; Zicari, A. M.; Bove, E.; Avenoso, F.; Amedeo, I.; Mancino, E.; Nenna, R.; De Castro, G.; Capponi, M.; Cinicola, B. L.; Brindisi, G.; Grisoni, F.; Murciano, M.; Spalice, A. - 01a Articolo in rivista

paper: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. 1-10 - issn: 1664-2295 - wos: WOS:000848138100001 (21) - scopus: 2-s2.0-85137997770 (23)

11573/1642753 - 2021 - Assessment of disease activity using a whole-body MRI derived radiological activity index in chronic nonbacterial osteomyelitis

Capponi, M.; Pires Marafon, D.; Rivosecchi, F.; Zhao, Y.; Pardeo, M.; Messia, V.; Tanturri De Horatio, L.; Toma, P.; De Benedetti, F.; Insalaco, A. - 01a Articolo in rivista

paper: PEDIATRIC RHEUMATOLOGY ONLINE JOURNAL ([Chicago. Ill. : University of Chicago, 2003]-) pp. - - issn: 1546-0096 - wos: WOS:000686647800002 (19) - scopus: 2-s2.0-85112463665 (21)

11573/1642745 - 2021 - Chronic nonbacterial osteomyelitis — clinical and magnetic resonance imaging features

D'angelo, P.; De Horatio, L. T.; Toma, P.; Ording Muller, L. -S.; Avenarius, D.; Von Brandis, E.; Zadig, P.; Casazza, I.; Pardeo, M.; Pires-Marafon, D.; Capponi, M.; Insalaco, A.; Fabrizio, B.; Rosendahl, K. - 01a Articolo in rivista

paper: PEDIATRIC RADIOLOGY (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 282-288 - issn: 0301-0449 - wos: WOS:000576369400001 (39) - scopus: 2-s2.0-85092244810 (43)

11573/1346552 - 2018 - When a recurrent fever does not only depend on a rheumatic carditis

Capponi, Martina; Del Giudice, Emanuela; Di Coste, Annalisa; Iacobini, Metello; Ventriglia, Flavia; Passarelli, Chiara; De Benedetti, Fabrizio; Duse, Marzia - 04d Abstract in atti di convegno

conference: PReS (Lisbon)

book: Pediatric Rheumatology - ()

11573/1346556 - 2018 - Autoinflammatory diseases: identified two variants of the NLRC4 gene

Del Giudice, E.; Di Coste, A.; Capponi, M.; Romeo, Eleonora; Battagliere, I.; Passarelli, C.; De Benedetti, F.; Duse, M. - 04d Abstract in atti di convegno

conference: PRes (Lisbon)

book: Pediatric Rheumatology - ()

11573/1346564 - 2018 - Descrizione di una nuova mutazione del gene NLRP12 associata con la PFAPA

Di Coste, A.; Del Giudice, E.; Capponi, M.; Imondi, C.; Passarelli, C.; De Benedetti, F.; Duse, M. - 04f Poster

conference: X Congresso Nazionale Società Italiana di Allergologia e Immunologia Pediatrica (Milano)

book: XX Congresso Nazionale Società Italiana di Allergologia e Immunologia Pediatrica - ()

11573/783275 - 2015 - Managing paediatric acute severe ulcerative colitis according to the 2011 ECCO-ESPGHAN guidelines: efficacy of infliximab as a rescue therapy

Aloi, Marina; D'arcangelo, G; Capponi, M; Nuti, Federica Lilia Nicoletta Maria; Vassallo, F; Civitelli, Fortunata; Oliva, Salvatore; Pagliaro, G; Cucchiara, Salvatore - 01l Trial clinico

paper: DIGESTIVE AND LIVER DISEASE (-Roma: Editrice Gastroenterologica Italiana; Milano: Elsevier -Roma: Editrice Gastroenterologica Italiana. -Ospedaletto Pisa: Pacini) pp. 455-459 - issn: 1590-8658 - wos: WOS:000354875000005 (16) - scopus: 2-s2.0-84930181999 (22)