Phd in MOLECULAR MEDICINE

Research: Non-canonical HedgeHog activation of Fusobacterium Nucleatum-mediated tumorigenesis in Colorectal Cancer stem cells

WORKPLACE:
Department of Molecular Medicine – Molecular Oncology Laboratory – Viale Regina Elena, 291, Building B
Supervisor: Gianluca Canettieri
PREVIOUS RESEARCH EXPERIENCE:
Internship at the Molecular Medicine Laboratory, Department of Molecular Oncology,
Sapienza University of Rome
Tutor: Professor Gianluca Canettieri [01/2023 – 03/2024]
City:Rome
Country: Italy

- Study of the upstream region (UR) of MYC in response to PI3K inhibitors.
- Investigation of MYC G4 structure in colorectal cancer.

EDUCATION:
Master’s Degree in Genetics and Molecular Biology
Sapienza University of Rome [10/2021 – 03/2024]
City: Rome
Country: Italy
Field of study: Molecular Oncology
Final grade:110/110 with honors

Thesis: The upstream region of MYC dictates resistance to PI3K inhibitors in cancer cells by regulating MEK1-mediated autophagic adaptation.
Tutor: Professor Gianluca Canettieri

Bachelor’s Degree in Biological Sciences
University of Salento [10/2017 – 07/2021]
City: Lecce
Country: Italy
Field of study: Molecular Biology
Final grade: 110/110 with honors

Thesis: Role of epigenetic modifications in the alteration of gene expression in cancer.
Tutor: Professor Fabrizio Damiano

Scientific High School Diploma
Liceo Scientifico Giulietta Banzi Bazoli [09/2012 – 07/2017]
City: Lecce
Country: Italy
Final grade:96/100

SKILLS:

- Molecular Biology Techniques: CRISPR-Cas9, cloning, plasmid DNA extraction, genomic DNA and RNA extraction, reverse transcription, PCR, genotyping, RT-qPCR, luciferase activity assays, Ch-IP, Co-IP.
- Protein Analysis: Western blot, EMSA.
- Cell Biology: Cell cultures, DNA transfection, MTT assays and cell proliferation assays, tumor organoid cultures.