baiocchi marta

Dottoressa di ricerca

ciclo: XXXIII


relatore: Prof F. Cutruzzolà
co-supervisore: Prof F. Cutruzzolà

Titolo della tesi: A colorectal cancer stem cells (CSCs) biobank as a multi-level approach to drug sensitivity studies.

Abstract Cancer stem cells (CSCs), recently identified in the majority of solid tumors, are a subpopulation of slow-replicating cells that drive tumor growth, by generating a cascade of differentiated cells that actually constitutes the bulk of the tumor. CSCs are selectively resistant to antiproliferative and cytotoxic drugs; therefore, it is widely accepted that they represent one main determinant of tumor relapses following chemotherapy. Colorectal CSCs can be isolated from patient’s tumors, and grown in vitro in selective mediums in an undifferentiated state as spheroids. Upon injection into immunocompromised mice, they generate tumor xenografts that closely replicate the original parental tumor, in terms of both antigen expression and histological tissue organization. In the host institution, we have recently established a biobank of frozen colorectal CSCs derived from individual patient’s tumors [1]. Newly established cultures are routinely validated by i) patient-matching verification through STR (Short Tandem Repeats) analysis, ii) assessment of CSC capability to originate phenocopies of the original patient’s tumor upon xenografting into NSG mice, iii) analysis of expression of stem cell markers. CSCs are then molecularly characterized by whole exome sequencing (WES) and banked for future uses. This platform is a powerful tool for the screening of targeted therapies and for drug resistance molecular studies. During the last few years, it has allowed our group to assess and characterize the activity on colorectal CSCs of different antineoplastic agents, including CHK1-targeted therapy [2], novel NHERF1 inhibitors [3], and new chemical derivatives of fenretinide [4, 5]. In addition, it has allowed us to characterize the EMT-related transcription factor ZEB2 in CSCs quiescence and drug resistance [6]. Here in particular I report the results of a study on differential sensitivity to the anti-EGFR MoAb cetuximab, on different classes of Microsatellite Instable (MSI) versus Microsatellite Stable (MSS) colorectal cancer stem cells. MSI tumors represent a distinct group of colorectal cancers, characterized by deficiency in the mismatch repair machinery and by high mutation rate. By analyzing the effect of anti-EGFR MoAb cetuximab on a panel of cCSCs we observed that MSI strains display an increased resistance to anti-EGFR therapy as compared to MSS, irrespective of KRAS mutational status. Gene mutation analysis on MSI versus MSS CSCs revealed that MSI strains carry recurrent mutations within groups of genes coding for proteins with a role in RAS and calcium signaling, highlighting the role of a genomically unstable context in determining anti-EGFR resistance. Altogether, these results indicate a multifactorial origin of anti-EGFR resistance, which emerges as the effect of multiple events further than the KRAS mutation, targeting direct and indirect regulators of the EGFR pathway. Data have been published in [7]. References 1. De Angelis, M.L., et al., Cancer Stem Cell-Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy Resistance. Stem Cells Transl Med, 2016. 5(4): p. 511-23. 2. Manic, G., et al., CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells. Gut, 2018. 67(5): p. 903-917. 3. Coluccia, A., et al., Drug Design and Synthesis of First in Class PDZ1 Targeting NHERF1 Inhibitors as Anticancer Agents. ACS Med Chem Lett, 2019. 10(4): p. 499-503. 4. Orienti, I., et al., A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors. Cell Death Dis, 2019. 10(7): p. 529. 5. Orienti, I., et al., A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells. J Exp Clin Cancer Res, 2019. 38(1): p. 373. 6. Francescangeli, F., et al., A pre-existing population of ZEB2(+) quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer. J Exp Clin Cancer Res, 2020. 39(1): p. 2. 7. De Angelis, M.L., et al., Colorectal cancer spheroid biobanks: multi-level approaches to drug sensitivity studies. Cell Biol Toxicol, 2018. 34(6): p. 459-469.

Produzione scientifica

11573/1494085 - 2020 - COVID-19–Induced Modifications in the Tumor Microenvironment: Do They Affect Cancer Reawakening and Metastatic Relapse?
Francescangeli, F.; De Angelis, M. L.; Baiocchi, M.; Rossi, R.; Biffoni, M.; Zeuner, A. - 01a Articolo in rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. 592891- - issn: 2234-943X - wos: WOS:000587390600001 (20) - scopus: 2-s2.0-85095720800 (23)

11573/1348337 - 2020 - A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer
Francescangeli, Federica; Contavalli, Paola; De Angelis, Maria Laura; Careccia, Silvia; Signore, Michele; Haas, Tobias Longin; Salaris, Federico; Baiocchi, Marta; Boe, Alessandra; Giuliani, Alessandro; Tcheremenskaia, Olga; Pagliuca, Alfredo; Guardiola, Ombretta; Minchiotti, Gabriella; Colace, Lidia; Ciardi, Antonio; D’Andrea, Vito; La Torre, Filippo; Medema, Janpaul; De Maria, Ruggero; Zeuner, Ann - 01a Articolo in rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: WOS:000513537100001 (27) - scopus: 2-s2.0-85077688228 (28)

11573/1223718 - 2019 - Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents
Coluccia, A.; La Regina, G.; Naccarato, V.; Nalli, M.; Orlando, V.; Biagioni, S.; De Angelis, M. L.; Baiocchi, M.; Gautier, C.; Gianni, S.; Di Pastena, F.; Di Magno, L.; Canettieri, G.; Coluccia, A. M. L.; Silvestri, R. - 01a Articolo in rivista
rivista: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 499-503 - issn: 1948-5875 - wos: WOS:000464767700019 (13) - scopus: 2-s2.0-85064264813 (13)

11573/1336625 - 2019 - A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors
Orienti, I.; Francescangeli, F.; De Angelis, M. L.; Fecchi, K.; Bongiorno-Borbone, L.; Signore, M.; Peschiaroli, A.; Boe, A.; Bruselles, A.; Costantino, A.; Eramo, A.; Salvati, V.; Sette, G.; Contavalli, P.; Zolla, L.; Oki, T.; Kitamura, T.; Spada, M.; Giuliani, A.; Baiocchi, M.; La Torre, F.; Melino, G.; Tartaglia, M.; De Maria, R.; Zeuner, A. - 01a Articolo in rivista
rivista: CELL DEATH & DISEASE (Nature Group) pp. 1-19 - issn: 2041-4889 - wos: WOS:000478098700001 (37) - scopus: 2-s2.0-85070321668 (41)

11573/1336618 - 2019 - A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells
Orienti, I.; Salvati, V.; Sette, G.; Zucchetti, M.; Bongiorno-Borbone, L.; Peschiaroli, A.; Zolla, L.; Francescangeli, F.; Ferrari, M.; Matteo, C.; Bello, E.; Di Virgilio, A.; Falchi, M.; De Angelis, M. L.; Baiocchi, M.; Melino, G.; De Maria, R.; Zeuner, A.; Eramo, A. - 01a Articolo in rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: WOS:000483021100006 (24) - scopus: 2-s2.0-85071273770 (29)

11573/1498763 - 2018 - In utero. La scienza e i nuovi modi di diventare madre
Baiocchi, Marta - 03a Saggio, Trattato Scientifico

11573/1212499 - 2018 - Colorectal cancer spheroid biobanks: multi-level approaches to drug sensitivity studies
De Angelis, Maria Laura; Bruselles, Alessandro; Francescangeli, Federica; Pucilli, Flavia; Vitale, Sara; Zeuner, Ann; Tartaglia, Marco; Baiocchi, Marta - 01a Articolo in rivista
rivista: CELL BIOLOGY AND TOXICOLOGY (Princeton Scientific Publishing Company Incorporated:PO Box 2155:Princeton, NJ 08543:(609)683-4750, EMAIL: pspubinc@aol.com, Fax: (609)683-0838) pp. 459-469-469 - issn: 0742-2091 - wos: WOS:000448811600005 (15) - scopus: 2-s2.0-85042412811 (18)

11573/1221902 - 2018 - How to assess drug resistance in cancer stem cells
De Angelis, Maria Laura; De Maria, Ruggero; Baiocchi, Marta - 02a Capitolo o Articolo
libro: Methods in Molecular Biology - (978-1-4939-7400-9; 978-1-4939-7401-6)

11573/1027697 - 2017 - A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer
Viel, Alessandra; Bruselles, Alessandro; Meccia, Ettore; Fornasarig, Mara; Quaia, Michele; Canzonieri, Vincenzo; Policicchio, Eleonora; Urso, Emanuele Damiano; Agostini, Marco; Genuardi, Maurizio; Lucci-Cordisco, Emanuela; Venesio, Tiziana; Martayan, Aline; Diodoro, Maria Grazia; Sanchez-Mete, Lupe; Stigliano, Vittoria; Mazzei, Filomena; Grasso, Francesca; Giuliani, Alessandro; Baiocchi, Marta; Maestro, Roberta; Giannini, Giuseppe; Tartaglia, Marco; Alexandrov, Ludmil B.; Bignami, Margherita - 01a Articolo in rivista
rivista: EBIOMEDICINE (Amsterdam : Elsevier) pp. 39-49 - issn: 2352-3964 - wos: WOS:000405719700012 (134) - scopus: 2-s2.0-85019617591 (141)

11573/869457 - 2016 - Cancer stem cell-based models of colorectal cancer reveal molecular determinants of therapy resistance
De Angelis, Maria Laura; Zeuner, Ann; Policicchio, Eleonora; Russo, Giorgio; Bruselles, Alessandro; Signore, Michele; Vitale, Sara; De Luca, Gabriele; Pilozzi, Emanuela; Boe, Alessandra; Stassi, Giorgio; Ricci Vitiani, Lucia; Amoreo, Carla Azzurra; Pagliuca, Alfredo; Francescangeli, Federica; Tartaglia, Marco; De Maria, Ruggero; Baiocchi, Marta - 01a Articolo in rivista
rivista: STEM CELLS TRANSLATIONAL MEDICINE (New York: AlphaMed Press) pp. 511-523 - issn: 2157-6564 - wos: WOS:000373523700011 (43) - scopus: 2-s2.0-84961257417 (45)

11573/1213106 - 2015 - Dynamic regulation of the cancer stem cell compartment by cripto-1 in colorectal cancer
Francescangeli, F; Contavalli, P; De Angelis, M L; Baiocchi, M; Gambara, G; Pagliuca, Alessandra; Fiorenzano, A; Prezioso, C; Boe, A; Todaro, M; Stassi, G; Castro, N P; Watanabe, K; Salomon, D S; De Maria, R; Minchiotti, G; Zeuner, A - 01a Articolo in rivista
rivista: CELL DEATH AND DIFFERENTIATION (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. 1700-1713 - issn: 1350-9047 - wos: WOS:000360989400012 (46) - scopus: 2-s2.0-84941178069 (49)

11573/1215209 - 2014 - Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines
Calzolari, Alessia; Saulle, Ernestina; De Angelis, Maria Laura; Pasquini, Luca; Boe, Alessandra; Pelacchi, Federica; Ricci-Vitiani, Lucia; Baiocchi, Marta; Testa, Ugo - 01a Articolo in rivista
rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e94438- - issn: 1932-6203 - wos: WOS:000336863900045 (35) - scopus: 2-s2.0-84899743360 (35)

11573/739194 - 2014 - Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XLinhibition in non-small cell lung cancer
Zeuner, ; Francescangeli, Federica; Contavalli, P.; Zapparelli, G.; Apuzzo, Tiziana; Eramo, A.; Baiocchi, M.; De Angelis, M. L.; Biffoni, M.; Sette, G.; Todaro, ; Stassi, G.; R. De Maria S., - 01a Articolo in rivista
rivista: CELL DEATH AND DIFFERENTIATION (Nature Publishing Group:Brunel Road Houndmills, Basingstoke RG21 6XS United Kingdom:011 44 20 78334000, EMAIL: institutions@natureny.com, INTERNET: http://www.nature.com, Fax: 011 44 20 78434640) pp. - - issn: 1350-9047 - wos: (0) - scopus: (0)

11573/751819 - 2012 - Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells
F., Francescangeli; M., Patrizii; M., Signore; Federici, Giulia; S., Di Franco; A., Pagliuca; M., Baiocchi; M., Biffoni; L., Ricci Vitiani; M., Todaro; R., De Maria; A., Zeuner - 01a Articolo in rivista
rivista: STEM CELLS (Dayton, Ohio : AlphaMed Press) pp. - - issn: 1549-4918 - wos: WOS:000307820200005 (52) - scopus: 2-s2.0-84865341013 (50)

11573/1221789 - 2012 - LINE-1 retrotransposon copies are amplified during murine early embryo development
Vitullo, Patrizia; Sciamanna, Ilaria; Baiocchi, Marta; Sinibaldi-Vallebona, Paola; Spadafora, Corrado - 01a Articolo in rivista
rivista: MOLECULAR REPRODUCTION AND DEVELOPMENT (New York N.Y.: Wiley) pp. 118-127 - issn: 1040-452X - wos: WOS:000299156300007 (45) - scopus: 2-s2.0-84855926569 (46)

11573/41273 - 2010 - New models for cancer research: human cancer stem cell xenografts
Baiocchi, Marta; Mauro, Biffoni; Lucia Ricci Vitiani, ; Pilozzi, Emanuela; Ruggero De Maria, - 01a Articolo in rivista
rivista: CURRENT OPINION IN PHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 380-384 - issn: 1471-4892 - wos: WOS:000281138700006 (40) - scopus: 2-s2.0-77955268969 (43)

11573/114432 - 2010 - A novel high resolution, high sensitivity SPECT detector for molecular imaging of cardiovascular diseases
Cusanno, F.; Argentieri, A.; Baiocchi, M.; Colilli, S.; Cisbani, E.; De Vincentis, Giuseppe; Fratoni, R.; Garibaldi, F.; Giuliani, F.; Gricia, M.; Lucentini, M.; Magliozzi, M. L.; Majewski, S.; Marano, G.; Musico, P.; Musumeci, M.; Santavenere, F.; Torrioli, S.; Tsui, B. M. W.; Vitelli, L.; Wang, Y. - 01a Articolo in rivista
rivista: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 217-218 - issn: 0168-9002 - wos: WOS:000279258700064 (9) - scopus: 2-s2.0-79955130369 (9)
congresso: 11th Pisa Meeting on Advanced Detectors (Isola Elba, ITALY)

11573/396169 - 2009 - A powerful readout system for high resolution and high efficiency molecular imaging studies of cardiovascular diseases in mice
Baiocchi, M.; Cisbani, E.; Cusanno, F.; De Vincentis, Giuseppe; Garibaldi, F.; Magliozzi, M. L.; Majewski, S.; Marano, G.; Musico, P.; Musumeci, M.; Torrioli, S.; Tsui, B.; Vitelli, L. - 04b Atto di convegno in volume
congresso: 2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009 (Orlando, FL)
libro: IEEE Nucl. Sci. Symp. Conf. Rec - (9781424439614; 9781424439621)

11573/130893 - 2008 - Isolation and characterization of CD146+ multipotent mesenchymal stromal cells
Sorrentino, A; Ferracin, M; Castelli, G; Biffoni, M; Tomaselli, G; Baiocchi, M; Fatica, Alessandro; Negrini, M; Peschle, C; Valtieri, M. - 01a Articolo in rivista
rivista: EXPERIMENTAL HEMATOLOGY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 1035-1046 - issn: 0301-472X - wos: WOS:000258207200014 (206) - scopus: 2-s2.0-47149093520 (225)

11573/365040 - 2007 - Bisperoxovanadium, a phospho-tyrosine phosphatase inhibitor, reprograms myogenic cells to acquire a pluripotent, circulating phenotype
Castaldi, Laura; Serra, Carlo; Moretti, F.; Messina, Graziella; Paoletti, R.; Sampaolesi, M.; Torgovnick, A.; Baiocchi, M.; Padula, Fabrizio; Pisaniello, A.; Molinaro, Mario; Cossu, G.; Levrero, Massimo; Bouche', Marina - 01a Articolo in rivista
rivista: THE FASEB JOURNAL (Federation of American Societies for Experimental Biology (FASEB):9650 Rockville Pike, Room L-2310:Bethesda, MD 20814:(800)433-2732, (301)530-7027, EMAIL: staff@dues.faseb.org, INTERNET: http://www.faseb.org, Fax: (301)571-5728, (301)530-7001) pp. 3573-3583 - issn: 0892-6638 - wos: WOS:000250517800020 (18) - scopus: 2-s2.0-35948972434 (18)

11573/1221831 - 2004 - Heart infarct in NOD-SCID mice: therapeutic vasculogenesis by transplantation of human CD34+ cells and low dose CD34 +KDR+ cells
Botta, Rosanna; Gao, Erhe; Stassi, Giorgio; Bonci, Desirée; Pelosi, Elvira; Zwas, Donna; Patti, Mariella; Colonna, Lucrezia; Baiocchi, Marta; Coppola, Simona; Ma, Xin; Condorelli, Gianluigi; Peschle, Cesare - 01a Articolo in rivista
rivista: THE FASEB JOURNAL (Federation of American Societies for Experimental Biology (FASEB):9650 Rockville Pike, Room L-2310:Bethesda, MD 20814:(800)433-2732, (301)530-7027, EMAIL: staff@dues.faseb.org, INTERNET: http://www.faseb.org, Fax: (301)571-5728, (301)530-7001) pp. 1392-1394 - issn: 0892-6638 - wos: WOS:000222979200030 (84) - scopus: 2-s2.0-9444260364 (90)

11573/1221419 - 2003 - 5-azacytidine reactivates the erythroid differentiation potential of the myeloid-restricted murine cell line 32D Ro
Baiocchi, Marta; Di Rico, Cristina; Di Pietro, Roberta; Di Baldassarre, Angela; Migliaccio, Anna Rita - 01a Articolo in rivista
rivista: EXPERIMENTAL CELL RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 258-67- - issn: 0014-4827 - wos: WOS:000182507500009 (4) - scopus: 2-s2.0-0037403646 (4)

11573/1221905 - 2003 - Myogenic potential of mouse primordial germ cells
Klinger, Francesca-Gioia; Scaldaferri, Maria-Lucia; Di Carlo, Anna; Baiocchi, Marta; Coletta, Marcello; Cossu, Giulio; De Felici, Massimo - 01a Articolo in rivista
rivista: THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (Universidad del Pais Vasco:Servicio Editorial, Apartado 1397, E-48080 Bilbao Spain:011 34 94 6015126, EMAIL: luxedito@lg.ehu.es, INTERNET: http://www.ehu.es/servicios/se_az/, Fax: 011 34 94 4801314) pp. 303-5- - issn: 0214-6282 - wos: WOS:000182812500008 (1) - scopus: 2-s2.0-0037906395 (1)

11573/80932 - 2002 - The meso-angioblast: a multipotent, self-renewing cell that originates from the dorsal aorta and differentiates into most mesodermal tissues
Minasi, Mg; Riminucci, Mara; De Angelis, Luciana; Borello, U; Berarducci, B; Innocenzi, A; Caprioli, A; Sirabella, D; Baiocchi, M; De Maria, R; Boratto, R; Jaffredo, T; Broccoli, U; Bianco, Paolo; Cossu, G. - 01a Articolo in rivista
rivista: DEVELOPMENT (The Company of Biologists Limited:Bidder Building, 140 Cowley Road, Cambridge CB4 0DL United Kingdom:011 44 1223 420482, EMAIL: mandy@thecob.demon.co.uk, INTERNET: http://www.biologists.com, Fax: 011 44 1223 423353) pp. 2773-2783 - issn: 0950-1991 - wos: WOS:000176471600019 (394) - scopus: 2-s2.0-0036333788 (446)

11573/1221430 - 2000 - An IL-6/IL-6 soluble receptor (IL-6R) hybrid protein (H-IL-6) induces EPO-independent erythroid differentiation in human CD34+cells
Baiocchi, Marta; Marcucci, Isabella; Rose-John, Stefan; Serlupi-Crescenzi, Ottaviano; Biffoni, Mauro - 01a Articolo in rivista
rivista: CYTOKINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1395-1399 - issn: 1043-4666 - wos: WOS:000089536100016 (7) - scopus: 2-s2.0-0033802580 (7)

11573/1221428 - 1999 - Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis
Boe, Alessandra; Baiocchi, Marta; Carbonatto, Michela; Papoian, Ruben; Serlupi-Crescenzi, Ottaviano - 01a Articolo in rivista
rivista: CYTOKINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1057-1064 - issn: 1043-4666 - wos: WOS:000084775700008 (106) - scopus: 2-s2.0-0033393367 (119)

11573/1221618 - 1998 - Mild proteolysis induces a ready-to-fuse state on Sendai virus envelope
Tomasi, M; Baiocchi, M; Moscufo, N; Parolini, I; Squatriti, T; Bellini, T; Dallocchio, F - 01a Articolo in rivista
rivista: FEBS LETTERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 286-90- - issn: 0014-5793 - wos: WOS:000072512800003 (1) - scopus: 2-s2.0-0032570578 (2)

11573/1213103 - 1997 - Human immunodeficiency virus (HIV)-resistant CD4+ UT-7 megakaryocytic human cell line becomes highly HIV-1 and HIV-2 susceptible upon CXCR4 transfection: induction of cell differentiation by HIV-1 infection
Baiocchi, M; Olivetta, E; Chelucci, C; Santarcangelo, A C; Bona, R; D'aloja, P; Testa, U; Komatsu, N; Verani, P; Federico, M - 01a Articolo in rivista
rivista: BLOOD (New York: Elsevier Inc. [Washington DC etc.]: American Society of Hematology) pp. 2670-8- - issn: 0006-4971 - wos: WOS:A1997WV14600006 (20) - scopus: 2-s2.0-0030935027 (19)

11573/1221915 - 1996 - Anti-HIV Viral Interference Induced by Retroviral Vectors Expressing a Nonproducer HIV-1 Variant
Federico, M.; Bona, R.; D'aloja, P.; Baiocchi, M.; Pugliese, K.; Nappi, F.; Chelucci, C.; Mavilio, F.; Verani, P. - 01a Articolo in rivista
rivista: ACTA HAEMATOLOGICA (S Karger AG:Allschwilerstrasse 10, CH-4009 Basel Switzerland:011 41 61 3061111, EMAIL: orders@karger.ch, INTERNET: http://www.karger.com, Fax: 011 41 61 3061234) pp. 199-203 - issn: 0001-5792 - wos: WOS:A1996UM16400009 (8) - scopus: 2-s2.0-0029869815 (10)

11573/1212760 - 1996 - Isolation and biological characterization of two classes of blast-cell colony-forming cells from normal murine marrow
Migliaccio, G; Baiocchi, M; Adamson, J W; Migliaccio, A R - 01a Articolo in rivista
rivista: BLOOD (New York: Elsevier Inc. [Washington DC etc.]: American Society of Hematology) pp. 4091-9- - issn: 0006-4971 - wos: WOS:A1996UK87900009 (5) - scopus: 2-s2.0-0029925268 (6)

11573/1221722 - 1996 - Circulating progenitor cells in human ontogenesis: response to growth factors and replating potential
Migliaccio, G; Baiocchi, M; Hamel, N; Eddleman, K; Migliaccio, A R - 01a Articolo in rivista
rivista: JOURNAL OF HEMATOTHERAPY (Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688) pp. 161-70-170 - issn: 1061-6128 - wos: WOS:000232368700055 (1) - scopus: 2-s2.0-0029962011 (29)

11573/1221925 - 1994 - Stem cell factor and the amplification of progenitor cells from CD34+ cord blood cells
Migliaccio, A R; Baiocchi, M; Durand, B; Eddleman, K; Migliaccio, G; Adamson, J W - 01a Articolo in rivista
rivista: BLOOD CELLS (Springer-Verlag New York Incorporated:175 Fifth Avenue:New York, NY 10010:(212)460-1500, EMAIL: orders@springer-ny.com, INTERNET: http://www.springer-ny.com, Fax: (212)533-3503) pp. 129-38; discussion 138-9- - issn: 0340-4684 - wos: WOS:A1994NX13900011 (10) - scopus: 2-s2.0-0028111535 (9)

11573/1221909 - 1993 - Simple purification and secondary structure evaluation of Sendai virus neuraminidase water soluble fragment
Baiocchi, M; Pescarmona, M; Gallina, A; Dallocchio, F; Tomasi, M - 01a Articolo in rivista
rivista: BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 389-98- - issn: 1039-9712 - wos: WOS:A1993MG02400021 (4) - scopus: 2-s2.0-0027138969 (4)

11573/1221739 - 1993 - Aspects of the biology of the neonatal hematopoietic stem cell
Migliaccio, Anna Rita; Migliaccio, Giovanni; Baiocchi, Marta; Durand, Brigitte; Adamson, John W.; Eddleman, Keith - 01a Articolo in rivista
rivista: STEM CELLS (Alphamed Press Incorporated:1 Prestige Place, Suite 290:Miamisburg, OH 45342:(937)291-2355, EMAIL: alphamedpress@alphamedpress.com, INTERNET: http://www.alphamedpress.com, Fax: (937)291-4229) pp. 56-64 - issn: 1066-5099 - wos: WOS:A1993LP54200010 (9) - scopus: 2-s2.0-0027494734 (7)

11573/1221927 - 1993 - Dependence for the proliferative response to erythropoietin on an established erythroid differentiation program in a human hematopoietic cell line, UT-7
Nicolis, S; Ottolenghi, S; Papayannopoulou, T; Baiocchi, M; Migliaccio, G; Adamson, J; Migliaccio, A R - 01a Articolo in rivista
rivista: EXPERIMENTAL HEMATOLOGY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 665-70- - issn: 0301-472X - wos: WOS:A1993MW61000012 (10) - scopus: 2-s2.0-0027849717 (10)

11573/1221911 - 1991 - Allosteric inhibition of the water-soluble C-terminal fragment of Sendai virus neuraminidase
Dallocchio, F; Bellini, T; Martuscelli, G; Baiocchi, M; Tomasi, M - 01a Articolo in rivista
rivista: BIOCHEMISTRY INTERNATIONAL (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 663-8- - issn: 0158-5231 - wos: WOS:A1991HA61400009 (4) - scopus: 2-s2.0-0026353849 (3)

11573/1213098 - 1991 - Response to erythropoietin in erythroid subclones of the factor-dependent cell line 32D is determined by translocation of the erythropoietin receptor to the cell surface
Migliaccio, A R; Migliaccio, G; D'andrea, A; Baiocchi, M; Crotta, S; Nicolis, S; Ottolenghi, S; Adamson, J W - 01a Articolo in rivista
rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 11086-90- - issn: 0027-8424 - wos: WOS:A1991GV87700022 (55) - scopus: 2-s2.0-0026322997 (55)

11573/1221607 - 1988 - Selective extraction of haemagglutinin and matrix protein from Sendai virions by employing trifluoperazine as a detergent
Baiocchi, M; Pescarmona, M; Bruschi, M L; Montecucco, C; Squatriti, T; Tomasi, M - 01a Articolo in rivista
rivista: FEBS LETTERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 171-4- - issn: 0014-5793 - wos: WOS:A1988Q360500039 (7) - scopus: 2-s2.0-0023814378 (5)

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