MARIA ROSA LOFFREDO

Dottoressa di ricerca

ciclo: XXXII


supervisore: Maria Luisa Mangoni
relatore: Maria Luisa Mangoni

Titolo della tesi: INSIGHTS INTO THE MECHANISM(S) OF ACTION AND THERAPEUTIC APPLICATIONS OF ESCULENTIN-1a-DERIVED ANTIMICROBIAL PEPTIDES


Produzione scientifica

11573/1705181 - 2024 - The antimicrobial potential of adarotene derivatives against Staphylococcus aureus strains
Princiotto, Salvatore; Casciaro, Bruno; G Temprano, Alvaro; Musso, Loana; Sacchi, Francesca; Loffredo, Maria Rosa; Cappiello, Floriana; Sacco, Federica; Raponi, Giammarco; Fernandez, Virginia Perez; Iucci, Teresa; Mangoni, Maria Luisa; Mori, Mattia; Dallavalle, Sabrina; Pisano, Claudio - 01a Articolo in rivista
rivista: BIOORGANIC CHEMISTRY (San Diego CA: Elsevier Orlando Fla.: Academic Press) pp. - - issn: 1090-2120 - wos: (0) - scopus: 2-s2.0-85186099210 (0)

11573/1695543 - 2023 - The antimicrobial peptide Esc(1-21)-1c increases susceptibility of Pseudomonas aeruginosa to conventional antibiotics by decreasing the expression of the MexAB-OprM efflux pump
Canè, Carolina; Casciaro, Bruno; Di Somma, Angela; Loffredo, Maria Rosa; Puglisi, Elena; Battaglia, Gennaro; Mellini, Marta; Cappiello, Floriana; Rampioni, Giordano; Leoni, Livia; Amoresano, Angela; Duilio, Angela; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: FRONTIERS IN CHEMISTRY (Lausanne : Frontiers Media S.A., 2013-) pp. 1271153- - issn: 2296-2646 - wos: WOS:001099168300001 (0) - scopus: 2-s2.0-85175794441 (0)

11573/1686382 - 2023 - Antimicrobial peptides for novel antiviral strategies in the current post-COVID-19 pandemic
Loffredo, Maria Rosa; Nencioni, Lucia; Mangoni, Maria Luisa; Casciaro, Bruno - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF PEPTIDE SCIENCE (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 1-28 - issn: 1075-2617 - wos: WOS:001037365800001 (0) - scopus: 2-s2.0-85165904409 (0)

11573/1686381 - 2023 - Effects of antimicrobial peptides on membrane dynamics: A comparison of fluorescence and NMR experiments
Roversi, Daniela; Troiano, Cassandra; Salnikov, Evgeniy; Giordano, Lorenzo; Riccitelli, Francesco; De Zotti, Marta; Casciaro, Bruno; Loffredo, Maria Rosa; Park, Yoonkyung; Formaggio, Fernando; Mangoni, Maria Luisa; Bechinger, Burkhard; Stella, Lorenzo - 01a Articolo in rivista
rivista: BIOPHYSICAL CHEMISTRY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 107060- - issn: 0301-4622 - wos: WOS:001026542400001 (1) - scopus: 2-s2.0-85161986256 (4)

11573/1658024 - 2022 - Pulmonary safety profile of Esc peptides and Esc-peptide-loaded poly(lactide-co-glycolide) nanoparticles: A promising therapeutic approach for local treatment of lung infectious diseases
Cappiello, Floriana; Casciaro, Bruno; Loffredo, Maria Rosa; Puglisi, Elena; Lin, Qiao; Yang, Dandan; Conte, Gemma; D’Angelo, Ivana; Ungaro, Francesca; Ferrera, Loretta; Barbieri, Raffaella; Cresti, Laura; Pini, Alessandro; Di, Yuanpu Peter; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: PHARMACEUTICS (Basel: MDPI, 2009-) pp. 2297- - issn: 1999-4923 - wos: WOS:000881548700001 (3) - scopus: 2-s2.0-85141838111 (4)

11573/1610047 - 2022 - The triprenylated anthranoid Ferruginin A, a promising scaffold for the development of novel antibiotics against Gram-positive bacteria
Casciaro, B.; Ghirga, F.; Cappiello, F.; Vergine, V.; Loffredo, M. R.; Cammarone, S.; Puglisi, E.; Tortora, C.; Quaglio, D.; Mori, M.; Botta, B.; Mangoni, M. L. - 01a Articolo in rivista
rivista: ANTIBIOTICS (Basel : MDPI) pp. 84- - issn: 2079-6382 - wos: WOS:000759095500001 (0) - scopus: 2-s2.0-85123232642 (0)

11573/1664251 - 2022 - KDEON WK-11: A short antipseudomonal peptide with promising potential
Casciaro, Bruno; Loffredo, Maria Rosa; Cappiello, Floriana; O'sullivan, Niamh; Tortora, Carola; Manzer, Rizwan; Karmakar, Sougata; Haskell, Alan; Hasan, Syed K; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: FRONTIERS IN CHEMISTRY (Lausanne : Frontiers Media S.A., 2013-) pp. 1000765- - issn: 2296-2646 - wos: WOS:000892758200001 (3) - scopus: 2-s2.0-85143365692 (3)

11573/1610735 - 2022 - Esc peptides as novel potentiators of defective cystic fibrosis transmembrane conductance regulator: an unprecedented property of antimicrobial peptides
Ferrera, L.; Cappiello, F.; Loffredo, M. R.; Puglisi, E.; Casciaro, B.; Botta, B.; Galietta, L. J. V.; Mori, M.; Mangoni, M. L. - 01a Articolo in rivista
rivista: CELLULAR AND MOLECULAR LIFE SCIENCES (Birkhaeuser Verlag AG:Viaduktstrasse 42-44, CH 4051 Basel Switzerland:011 41 61 2050707, EMAIL: subscriptions@birkhauser.ch, INTERNET: http://www.birkhauser.ch, Fax: 011 41 61 2050792) pp. 67- - issn: 1420-682X - wos: WOS:000736790100005 (5) - scopus: 2-s2.0-85122505018 (4)

11573/1667866 - 2022 - Esculentin-1a Derived Peptide Diastereomers to Target Pseudomonas aeruginosa Lung Infection in Cystic Fibrosis: From Nature to Bench towards Therapeutic Application
Mangoni, Maria Luisa; Casciaro, Bruno; Cappiello, Floriana; Loffredo, Maria Rosa; Puglisi, Elena; Ungaro, Francesca; D’Angelo, Ivana; Mori, Mattia; Ferrera, Loretta; Galietta, Luis; Peter Di, Y. - 04b Atto di convegno in volume
congresso: 36th European Peptide Symposium (Sitges)
libro: Proceedings of the 36th European Peptide Symposium - ()

11573/1623736 - 2022 - The antimicrobial peptide Esc(1-21) synergizes with colistin in inhibiting the growth and in killing multidrug resistant Acinetobacter baumannii strains
Sacco, F.; Bitossi, C.; Casciaro, B.; Loffredo, M. R.; Fabiano, G.; Torrini, L.; Raponi, F.; Raponi, G.; Mangoni, M. L. - 01a Articolo in rivista
rivista: ANTIBIOTICS (Basel : MDPI) pp. 234- - issn: 2079-6382 - wos: WOS:000770865100001 (7) - scopus: 2-s2.0-85124818216 (9)

11573/1552375 - 2021 - Inoculum effect of antimicrobial peptides
Loffredo, M. R.; Savini, F.; Bobone, S.; Casciaro, B.; Franzyk, H.; Mangoni, M. L.; Stella, L. - 01a Articolo in rivista
rivista: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (Editore National Academy of Sciences a Washington, DC) pp. e2014364118- - issn: 1091-6490 - wos: WOS:000659437300003 (29) - scopus: 2-s2.0-85106690389 (40)

11573/1415624 - 2020 - The revaluation of plant-derived terpenes to fight antibiotic-resistant Infections
Cappiello, Floriana; Loffredo, Maria Rosa; Del Plato, Cristina; Cammarone, Silvia; Casciaro, Bruno; Quaglio, Deborah; Mangoni, Maria Luisa; Botta, Bruno; Ghirga, Francesca - 01g Articolo di rassegna (Review)
rivista: ANTIBIOTICS (Basel : MDPI) pp. - - issn: 2079-6382 - wos: WOS:000551698400001 (32) - scopus: 2-s2.0-85089713938 (37)

11573/1471977 - 2020 - The antimicrobial peptide temporin G: Anti-biofilm, anti-persister activities, and potentiator effect of tobramycin efficacy against Staphylococcus aureus
Casciaro, B.; Loffredo, M. R.; Cappiello, F.; Fabiano, G.; Torrini, L.; Mangoni, M. L. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. 1-13 - issn: 1661-6596 - wos: WOS:000602751000001 (16) - scopus: 2-s2.0-85097557403 (16)

11573/1443570 - 2020 - Frog skin-derived peptides against corynebacterium jeikeium: correlation between antibacterial and cytotoxic activities
Casciaro, B.; Loffredo, M. R.; Cappiello, F.; Verrusio, W.; Corleto, V. D.; Mangoni, M. L. - 01a Articolo in rivista
rivista: ANTIBIOTICS (Basel : MDPI) pp. 1-13 - issn: 2079-6382 - wos: WOS:000564227400001 (7) - scopus: 2-s2.0-85088977950 (10)

11573/1443574 - 2020 - Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections
Casciaro, B.; Mangiardi, L.; Cappiello, F.; Romeo, I.; Loffredo, M. R.; Iazzetti, A.; Calcaterra, A.; Goggiamani, A.; Ghirga, F.; Mangoni, M. L.; Botta, B.; Quaglio, D. - 01g Articolo di rassegna (Review)
rivista: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. 3619- - issn: 1420-3049 - wos: WOS:000578849300001 (36) - scopus: 2-s2.0-85089407877 (38)

11573/1321306 - 2020 - The potential of frog skin peptides for anti-infective therapies: the case of esculentin-1a(1-21)nh2
Casciaro, Bruno; Cappiello, Floriana; Loffredo, Maria Rosa; Ghirga, Francesca; Mangoni, Maria Luisa - 01g Articolo di rassegna (Review)
rivista: CURRENT MEDICINAL CHEMISTRY (Bentham Science Publishers BV:PO Box 7917, Exec Ste Y 26, Saif Zone Sharjah Uae:011 971 6 5571132, EMAIL: benthams@emirates.net.ae, INTERNET: http://www.bentham.org, Fax: 011 971 6 5571134) pp. 1405-1419 - issn: 0929-8673 - wos: WOS:000522393100003 (18) - scopus: 2-s2.0-85082746751 (21)

11573/1381291 - 2020 - Methods for the In vitro examination of the antibacterial and cytotoxic activities of antimicrobial peptides
Casciaro, Bruno; Cappiello, Floriana; Loffredo, Maria Rosa; Mangoni, Maria Luisa - 02a Capitolo o Articolo
libro: Immunity in Insects - ()

11573/1433609 - 2020 - A novel colistin adjuvant identified by virtual screening for ArnT inhibitors
Ghirga, Francesca; Stefanelli, Roberta; Cavinato, Luca; Lo Sciuto, Alessandra; Corradi, Silvia; Quaglio, Deborah; Calcaterra, Andrea; Casciaro, Bruno; Loffredo, Maria Rosa; Cappiello, Floriana; Morelli, Patrizia; Antonelli, Alberto; Rossolini, Gian Maria; Mangoni, Marialuisa; Mancone, Carmine; Botta, Bruno; Mori, Mattia; Ascenzioni, Fiorentina; Imperi, Francesco - 01a Articolo in rivista
rivista: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. 2564-2572 - issn: 0305-7453 - wos: WOS:000574367100026 (14) - scopus: 2-s2.0-85089713563 (15)

11573/1444335 - 2020 - Ent-beyerane diterpenes as a key platform for the development of arnt-mediated colistin resistance inhibitors
Quaglio, D.; Mangoni, M. L.; Stefanelli, R.; Corradi, S.; Casciaro, B.; Vergine, V.; Lucantoni, F.; Cavinato, L.; Cammarone, S.; Loffredo, M. R.; Cappiello, F.; Calcaterra, A.; Erazo, S.; Ghirga, F.; Mori, M.; Imperi, F.; Ascenzioni, F.; Botta, B. - 01a Articolo in rivista
rivista: JOURNAL OF ORGANIC CHEMISTRY ([Washington, D.C: American Chemical Society) pp. 10891-10901 - issn: 0022-3263 - wos: WOS:000563754800052 (13) - scopus: 2-s2.0-85091138745 (16)

11573/1403738 - 2020 - Structural elucidation and antimicrobial characterization of novel diterpenoids from Fabiana densa var. ramulosa
Quaglio, Deborah; Corradi, Silvia; Erazo, Silvia; Vergine, Valeria; Berardozzi, Simone; Sciubba, Fabio; Cappiello, Floriana; Crestoni, Maria Elisa; Ascenzioni, Fiorentina; Imperi, Francesco; Delle Monache, Franco; Mori, Mattia; Loffredo, Maria Rosa; Ghirga, Francesca; Casciaro, Bruno; Botta, Bruno; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: ACS MEDICINAL CHEMISTRY LETTERS (USA: ACS Publications) pp. 760-765-765 - issn: 1948-5875 - wos: WOS:000535281200024 (11) - scopus: 2-s2.0-85088470709 (12)

11573/1396537 - 2020 - Binding of an antimicrobial peptide to bacterial cells: Interaction with different species, strains and cellular components
Savini, F.; Loffredo, M. R.; Troiano, C.; Bobone, S.; Malanovic, N.; Eichmann, T. O.; Caprio, L.; Canale, V. C.; Park, Y.; Mangoni, M. L.; Stella, L. - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 183291- - issn: 0005-2736 - wos: WOS:000537573200018 (49) - scopus: 2-s2.0-85084060443 (58)

11573/1296445 - 2019 - The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L
Buommino, E.; Carotenuto, A.; Antignano, I.; Bellavita, R.; Casciaro, B.; Loffredo, M. R.; Merlino, F.; Novellino, E.; Mangoni, M. L.; Nocera, F. P.; Brancaccio, D.; Punzi, P.; Roversi, D.; Ingenito, R.; Bianchi, E.; Grieco, P. - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. 1283-1290 - issn: 1860-7179 - wos: WOS:000473984900007 (22) - scopus: 2-s2.0-85067024264 (22)

11573/1321304 - 2019 - Nigritanine as a new potential antimicrobial alkaloid for the treatment of Staphylococcus aureus-induced infections
Casciaro, B.; Calcaterra, A.; Cappiello, F.; Mori, M.; Loffredo, M. R.; Ghirga, F.; Mangoni, M. L.; Botta, B.; Quaglio, D. - 01a Articolo in rivista
rivista: TOXINS (Basel : Molecular Diversity Preservation International MDPI) pp. 511- - issn: 2072-6651 - wos: WOS:000487968300054 (34) - scopus: 2-s2.0-85071737488 (37)

11573/1272160 - 2019 - Poly(lactide- co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies
Casciaro, Bruno; D'angelo, Ivana; Zhang, Xiaoping; Loffredo, Maria Rosa; Conte, Gemma; Cappiello, Floriana; Quaglia, Fabiana; Di, Yuan-Pu Peter; Ungaro, Francesca; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: BIOMACROMOLECULES (Washington DC: American Chemical Society, ©2000-) pp. 1876-1888 - issn: 1525-7797 - wos: WOS:000468120800005 (77) - scopus: 2-s2.0-85065439562 (80)

11573/1280915 - 2019 - Inhibition of pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide esculentin-1a(1-21)NH2
Casciaro, Bruno; Lin, Qiao; Afonin, Sergii; Loffredo, Maria Rosa; De Turris, Valeria; Middel, Volker; Ulrich, Anne S; Di, Y Peter; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: THE FEBS JOURNAL (Blackwell Pub., Oxford, UK) pp. 3874-3890 - issn: 1742-464X - wos: WOS:000491274500011 (35) - scopus: 2-s2.0-85067390189 (41)

11573/1336203 - 2019 - Esculentin-1a derivatives as new antipseudomonal agents: limited induction of resistance and inhibition of biofilm formation
Casciaro, Bruno; Loffredo, Maria Rosa; Lin, Qiao; Afonin, Sergei; De Turris, Valeria; Ulrich, A. S.; Di Yuan, Pu; Mangoni, Maria Luisa - 04f Poster
congresso: 9th International Meeting on Antimicrobial Peptides (Utrecht University, The Netherlands)
libro: Abstracts book - ()

11573/1070778 - 2018 - Esculentin-1a derived peptides kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface
Casciaro, Bruno; Dutta, Debarun; Loffredo, Maria Rosa; Marcheggiani, Stefania; Mcdermott, Alison M; Willcox, Mark Dp; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: PEPTIDE SCIENCE (Hoboken NJ: John Wiley & Sons) pp. e23074- - issn: 2475-8817 - wos: WOS:000450664700002 (18) - scopus: 2-s2.0-85033234654 (22)

11573/1244254 - 2018 - Esculentin-1 aderived antipseudomonal peptides. limited induction of resistance and synergy with aztreonam
Casciaro, Bruno; Loffredo, Maria Rosa; Luca, Vincenzo; Verrusio, Walter; Cacciafesta, Mauro; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: PROTEIN & PEPTIDE LETTERS (Hilversum : Bentham Science Publishers) pp. 1155-1162 - issn: 1875-5305 - wos: WOS:000456082200011 (24) - scopus: 2-s2.0-85060943380 (22)

11573/953510 - 2017 - Derivatives of esculentin-1a: promising frog-skin peptides for the development of new antipseudomonal drugs with expanding properties
Casciaro, Bruno; Loffredo, Maria Rosa; Luca, Vincenzo; Mangoni, Maria Luisa - 04f Poster
congresso: 14th ECFS Basic Science Conference (Albufeira, Portugal)
libro: European Cystic Fibrosis Society, 14th ECFS Basic Science Conference - Conference Programme & Abstract Book - ()

11573/1014114 - 2017 - Membrane perturbing activities and structural properties of the frog-skin derived peptide esculentin-1a(1-21)NH2 and its diastereomer esc(1-21)-1c: correlation with their antipseudomonal and cytotoxic activity
Loffredo, Maria Rosa; Ghosh, Anirban; Harmouche, Nicole; Casciaro, Bruno; Luca, Vincenzo; Bortolotti, Annalisa; Cappiello, Floriana; Stella, Lorenzo; Bhunia, Anirban; Bechinger, Burkhard; Mangoni, Maria Luisa - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 2327-2339 - issn: 0005-2736 - wos: WOS:000415770900006 (26) - scopus: 2-s2.0-85029699709 (27)

11573/1014113 - 2017 - Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: evaluation of antimicrobial, cytotoxic and hemolytic activities
Merlino, Francesco; Carotenuto, Alfonso; Casciaro, Bruno; Martora, Francesca; Loffredo, Maria Rosa; Di Grazia, Antonio; Yousif, Ali M.; Brancaccio, Diego; Palomba, Luciana; Novellino, Ettore; Galdiero, Massimiliano; Iovene, Maria Rosaria; Mangoni, Maria Luisa; Grieco, Paolo - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (Editions Scientifique & Medical Elsevier:23 Rue Linois, F 75724 Paris Cedex 15 France:011 33 1 71724646, INTERNET: http://www.elsevier.fr, Fax: 011 33 1 71724664) pp. 750-761 - issn: 0223-5234 - wos: WOS:000412788200057 (31) - scopus: 2-s2.0-85028413843 (32)

11573/954661 - 2016 - Novel analogues of Temporin L and their potential therapeutic application
Berrino, E.; Martora, F.; Merlino, F.; Loffredo, Maria Rosa; Casciaro, Bruno; Di Grazia, Antonio; Yousif, A. M.; Di Carluccio, N.; Carotenuto, A.; Galdiero, M.; Novellino, E.; Iovene, M. R.; Mangoni, Maria Luisa; Grieco, P. - 04f Poster
congresso: 15th Naples Workshop on Bioactive Peptide (Centro Congressi d’Ateneo “Federico II” – Via Partenope, Napoli)
libro: Book Of Abstracts - ()

11573/953513 - 2016 - Effects of the conjugation of the antimicrobial peptide Esc(1-21) to gold-nanoparticles
Casciaro, Bruno; Loffredo, Maria Rosa; Bellelli, Andrea; Mangoni, Maria Luisa - 04f Poster
congresso: 15th Naples Workshop on Bioactive Peptides (Centro Congressi d’Ateneo “Federico II” – Via Partenope, Napoli)
libro: PEPTIDES: RECENT DEVELOPMENTS AND FUTURE DIRECTIONS - BOOK OF ABSTRACTS - ()

11573/954653 - 2016 - Effetti della coniugazione del peptide antimicrobico Esc(1-21) a nanoparticelle di oro
Casciaro, Bruno; Moros, Maria; Rivera Fernandez, Sara; Loffredo, Maria Rosa; Bellelli, Andrea; La Fuente, Jesus M. De; Mangoni, Maria Luisa - 04a Atto di comunicazione a congresso
congresso: Prima Conferenza della Società Italiana Peptidi (Napoli, Centro Congressi “Federico II”)

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