MARIANO PONTICO

Dottore di ricerca

ciclo: XXXIV


supervisore: Prof. Roberto Pani

Titolo della tesi: PET and MR Thermometry imaging–guided photothermal therapy assisted by radiolabeled keratin-coated gold nanoparticles for precision anticancer thermoablation

Nanomedicine is an emerging key technology of the 21st century. Gold nanoparticles (AuNPs) have been actively investigated as photothermal converters, drug delivery systems, radiosensitizers, and molecular imaging probes in a wide range of biomedical applications in both cancer diagnostics and therapeutics. The flourishing development of AuNPs applications has led to the opportunity of a new targeted cancer treatment that could be capable of selectively fighting cancerous cells, keeping low harmful side effects suffered by surrounding healthy cells, namely the plasmonic photothermal therapy (PPTT). The PPTT approach should have the following key features: targeted AuNPs delivery to the tumor for effective thermal damage response under NIR laser exposure, aiming to keep the surrounding tissues healthy and accurate thermal dose calculation with non-invasive real-time monitoring of thermometric response profile in the target volume. What constitutes a technological frontier is the application of a novel AuNPs generation properly labeled with a radiotracer which may serve as a nuclear imaging-guided high-precision cancer probe. The topic of this thesis is part of a wider funded project (NANO-TAFT), focused on the development of a novel radiolabeled AuNPs-mediated selective PPPT cancer treatment, supported by the development of a prototypal multimodality PET/MR imaging integration console, using MR Thermometry (MRT) to provide a volumetric "heat map". The aims of my research work were to obtain accurate modeling of PET performance variability in detecting radiolabeled AuNPs and their concentration through a PET imaging phantom study carried out on three different PET systems, and the AuNPs radiolabeling, its further characterization, and nuclear imaging study. The evaluation of the variability of the efficiencies and of the AuNP concentration for each PET machine was done through the study of a phantom model and the standardized uptake value (SUV) calculation, which resulted in PET imaging poor reproducibility in terms of quantitative analysis and determination of concentrations. SPECT is known to be a more versatile and reliable imaging technique, thus it was chosen to use technetium-99m (99mTc) as labeling radionuclide along with SPECT technique, instead of fluorine-18 (18F) with PET imaging. A critical issue must be identified in the achievement of an effective AuNPs radiolabeling, able to demonstrate optimal radiochemical yield and stability performances. A novel bridging molecule, namely keratin, was used to solve the problem of binding AuNPs and radioisotopes. To our knowledge, keratin protein remains still unexplored in the field of PPPT-based applications. A reliable and reproducible procedure for the 99mTc radiolabeling of this novel generation of AuNPs (Ker-AuNPs) was therefore achieved. Optical, spectroscopic, and morphological analysis of the Ker-AuNPs proved their stable bioconjugation. The optimal radiolabeling strategy to obtain 99mTc-KerAuNPs and its relative conditions have been found and validated, leading to an excellent performance in terms of radiolabeling efficiency, that reach over 95% of radiochemical purity (RCP). UV-Vis absorbance test supported the occurrence of a novel Ker-AuNPs configuration. The laser-triggered photothermal test demonstrated a good thermometric response through a significant temperature increase in the site of 99mTc-Ker-AuNPs deposition, while corroborating the successful outcomes of the Ker-AuNPs radiolabeling procedure. SPECT imaging study showed a good performance. The analysis of PET imaging data on phantoms showed that PET is not sufficiently selective in terms of achievable spatial resolution and in the determination of the concentrations, thus its application in the context of this project has proven to be unfeasible. SPECT technique allows a less variable determination of radioisotope concentrations than PET and also a less complex calibration of SPECT equipment. Unfortunately, if reasonably small tumors are considered, both techniques are not able to ensure a proper high spatial resolution, which is a crucial prerequisite for a selective and safe treatment. Despite open issues related to the imaging applications remain unsolved, nuclear imaging techniques will be useful rather to determine the targeted volumes of interest, which subsequently will be more accurately confirmed by MR imaging, which has the absolute advantage of a better spatial resolution. A novel functional and stable AuNPs keratin coating has been provided, leading to a promising novel tool in the field of biocompatible photothermal nanoagents for selective anticancer PPPT treatments.

Produzione scientifica

11573/1674594 - 2023 - 18F-fluorodeoxyglucose (18F-FDG) functionalized gold nanoparticles (GNPs) for plasmonic photothermal ablation of cancer. A review
Pontico, M.; Conte, M.; Petronella, F.; Frantellizzi, V.; De Feo, M. S.; Di Luzio, D.; Pani, R.; De Vincentis, G.; De Sio, L. - 01g Articolo di rassegna (Review)
rivista: PHARMACEUTICS (Basel: MDPI, 2009-) pp. 1-18 - issn: 1999-4923 - wos: WOS:000940916500001 (1) - scopus: 2-s2.0-85149147015 (2)

11573/1652733 - 2022 - 99mTc-labeled keratin gold-nanoparticles in a nephron-like microfluidic chip for photo-thermal therapy applications
Frantellizzi, V.; Verrina, V.; Raso, C.; Pontico, M.; Petronella, F.; Bertana, V.; Ballesio, A.; Marasso, S. L.; Miglietta, S.; Rosa, P.; Scibetta, S.; Petrozza, V.; De Feo, M. S.; De Vincentis, G.; Calogero, A.; Pani, R.; Perotto, G.; De Sio, L. - 01a Articolo in rivista
rivista: MATERIALS TODAY ADVANCES (Oxford: Elsevier Ltd.) pp. - - issn: 2590-0498 - wos: WOS:000856804500003 (19) - scopus: 2-s2.0-85136538653 (18)

11573/1545051 - 2021 - Unexpected detection of abscessualized lung carcinoma on tc-99m-hmpao-labeled leukocytes scintigraphy misdiagnosed on chest computed tomography
Cosma, L.; Frantellizzi, V.; Pontico, M.; De Vincentis, G. - 01i Case report
rivista: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY (Turkey:Galenos Yayinevi Tic. Ltd. Sti.) pp. 60-62 - issn: 2146-1414 - wos: WOS:000617765700011 (1) - scopus: 2-s2.0-85101511647 (1)

11573/1590335 - 2021 - Radium-223 treatment in mcrpc patient with polycythemia vera
De Angelis, C.; Frantellizzi, V.; Pontico, M.; De Feo, M. S.; Lazri, J.; De Vincentis, G. - 01i Case report
rivista: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY (Turkey:Galenos Yayinevi Tic. Ltd. Sti.) pp. 193-196 - issn: 2146-1414 - wos: WOS:000709762600010 (0) - scopus: 2-s2.0-85118807906 (0)

11573/1568718 - 2021 - 89Zr-PET imaging in humans: a systematic review
De Feo, M. S.; Pontico, M.; Frantellizzi, V.; Corica, F.; De Cristofaro, F.; De Vincentis, G. - 01g Articolo di rassegna (Review)
rivista: CLINICAL AND TRANSLATIONAL IMAGING (Springer is part of Springer Science) pp. - - issn: 2281-5872 - wos: WOS:000692497300001 (15) - scopus: 2-s2.0-85114152677 (15)

11573/1545054 - 2021 - Prognostic and theranostic applications of positron emission tomography for a personalized approach to metastatic castration‐resistant prostate cancer
Filippi, L.; Frantellizzi, V.; Chiaravalloti, A.; Pontico, M.; De Feo, M. S.; Corica, F.; Montebello, M.; Schillaci, O.; De Vincentis, G.; Bagni, O. - 01g Articolo di rassegna (Review)
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000645789500001 (7) - scopus: 2-s2.0-85102555703 (8)

11573/1573683 - 2021 - Administrative health claims and laboratory data to identified mCRPC or mCSPC patients: the way to go looks long but promising
Frantellizzi, V.; Pontico, M.; De Vincentis, G. - 01f Lettera, Nota
rivista: CURRENT MEDICAL RESEARCH AND OPINION (Librapharm:Gemini House 162 Craven Road, Newbury RG14 5NR United Kingdom:011 44 1635 522651, EMAIL: enquiries@librapharm.com, INTERNET: http://www.librapharm.com, Fax: 011 44 1635 36294) pp. 1-2 - issn: 0300-7995 - wos: WOS:000700491700001 (0) - scopus: 2-s2.0-85115773341 (0)

11573/1613110 - 2021 - 99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy
Frantellizzi, V.; Pontico, M.; De Vincentis, G.; Civitelli, L.; Petronella, F.; Pani, R.; Calogero, A.; Perotto, G.; De Sio, L. - 04b Atto di convegno in volume
congresso: Biophotonics Congress: Optics in the Life Sciences (Washington, DC; United States)
libro: Optical Molecular Probes, Imaging and Drug Delivery - OTu1E - Molecular Contrast Agents and Probes - ()

11573/1383585 - 2021 - 123I-FP-CIT brain SPECT findings in succinic semialdehyde dehydrogenase (SSADH) deficiency
Frantellizzi, Viviana; Pontico, Mariano; Pani, Arianna; De Feo, Maria Silvia; De Vincentis, Giuseppe - 01i Case report
rivista: CURRENT RADIOPHARMACEUTICALS (Bentham Science Publishers Ltd) pp. 78-83 - issn: 1874-4710 - wos: WOS:000641557600012 (0) - scopus: 2-s2.0-85103993847 (0)

11573/1590328 - 2021 - Potential prognostic value of miR-132 and miR-212 expression in mCRPC patients
Pontico, M.; Frantellizzi, V.; Cindolo, L.; De Vincentis, G. - 01f Lettera, Nota
rivista: ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA (Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. 373-374 - issn: 1124-3562 - wos: WOS:000704501700024 (0) - scopus: 2-s2.0-85117181110 (0)

11573/1476172 - 2021 - The prognostic value of 123I-mIBG SPECT cardiac imaging in heart failure patients: a systematic review
Pontico, Mariano; Brunotti, Gabriele; Conte, Miriam; Corica, Ferdinando; Cosma, Laura; De Angelis, Cristina; De Feo, Maria Silvia; Lazri, Julia; Matto, Antonio; Montebello, Melissa; Di Rocco, Arianna; Frantellizzi, Viviana; Farcomeni, Alessio; De Vincentis, Giuseppe - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF NUCLEAR CARDIOLOGY (Mosby Year Book Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)654-2452, (407)345-4000, EMAIL: hhspcs@harcourt.com, INTERNET: http://www.mosby.com, Fax: (407)363-9661, (314)432-1380) pp. 1-11 - issn: 1071-3581 - wos: WOS:000607483800001 (13) - scopus: 2-s2.0-85099392014 (14)

11573/1364432 - 2020 - New frontiers in molecular imaging with superparamagnetic iron oxide nanoparticles (SPIONs): efficacy, toxicity, and future applications
Frantellizzi, V.; Conte, M.; Pontico, M.; Pani, A.; Pani, R.; De Vincentis, G. - 01g Articolo di rassegna (Review)
rivista: NUCLEAR MEDICINE AND MOLECULAR IMAGING (Heidelberg: Springer) pp. 65-80 - issn: 1869-3474 - wos: WOS:000515985800001 (43) - scopus: 2-s2.0-85079457176 (45)

11573/1364434 - 2020 - Role of nuclear imaging in cardiac amyloidosis management: clinical evidence and review of literature
Frantellizzi, Viviana; Cosma, Laura; Pani, Arianna; Pontico, Mariano; Conte, Miriam; De Angelis, Cristina; De Vincentis, Giuseppe - 01g Articolo di rassegna (Review)
rivista: CURRENT MEDICAL IMAGING REVIEWS (Bentham Science Publishers Ltd) pp. 957-966 - issn: 1573-4056 - wos: WOS:000581851800003 (1) - scopus: 2-s2.0-85094120481 (1)

11573/1364424 - 2020 - Primary radical prostatectomy or ablative radiotherapy as protective factors for patients with mCRPC treated with radium-223 dichloride: an Italian multicenter study
Frantellizzi, Viviana; Costa, Renato; Mascia, Manlio; Spanu, Angela; Farcomeni, Alessio; Licari, Maria; Cindolo, Luca; Nuvoli, Susanna; Pontico, Mariano; De Vincentis, Giuseppe - 01a Articolo in rivista
rivista: CLINICAL GENITOURINARY CANCER (Dallas, Tex. : Cancer Information Group) pp. 185-191 - issn: 1558-7673 - wos: WOS:000540745100024 (6) - scopus: 2-s2.0-85081608183 (9)

11573/1383582 - 2020 - Baseline quality of life predicts overall survival in patients with mCRPC treated with 223Ra-dichloride
Frantellizzi, Viviana; De Feo, Maria Silvia; Di Rocco, Arianna; Pontico, Mariano; Pani, Arianna; Farcomeni, Alessio; Cosma, Laura; Lazri, Julia; De Vincentis, Giuseppe - 01a Articolo in rivista
rivista: HELLENIC JOURNAL OF NUCLEAR MEDICINE (Thessaloniki, Greece : Hellenic Society of Nuclear Medicine, [2004]-) pp. 12-20 - issn: 1790-5427 - wos: WOS:000531067900004 (5) - scopus: 2-s2.0-85084960866 (4)

11573/1441881 - 2020 - Bone pain palliation outcomes and possibility of Radium-223 re-treatment in mCRPC
Frantellizzi, Viviana; Lazri, Julia; Pontico, Mariano; Pani, Arianna; De Vincentis, Giuseppe - 01i Case report
rivista: ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA (Pavia: PagePress Milano: Scripta Manent) pp. 1-4 - issn: 2282-4197 - wos: WOS:000576886000008 (1) - scopus: 2-s2.0-85092598880 (2)

11573/1548008 - 2020 - Radium-223 in mCPRC patients: a large real-life Italian multicenter study
Frantellizzi, Viviana; Monari, Fabio; Mascia, Manlio; Costa, Renato P; Rubini, Giuseppe; Spanu, Angela; Farcomeni, Alessio; Lodi Rizzini, Elisa; Cindolo, Luca; Tripoli, Vincenzo; Lavelli, Valentina; Nuvoli, Susanna; Pontico, Mariano; Dionisi, Valeria; Ferrari, Cristina; De Vincentis, Giuseppe - 01a Articolo in rivista
rivista: MINERVA UROLOGICA E NEFROLOGICA (Torino: Edizioni Minerva Medica) pp. 21-28 - issn: 1827-1758 - wos: WOS:000768297300004 (3) - scopus: 2-s2.0-85126388742 (3)

11573/1336242 - 2020 - Analysis of unusual adverse effects after radium-223 dichloride administration
Frantellizzi, Viviana; Pontico, Mariano; Pani, Arianna; Pani, Roberto; De Vincentis, Giuseppe - 01i Case report
rivista: CURRENT RADIOPHARMACEUTICALS (Bentham Science Publishers Ltd) pp. - - issn: 1874-4710 - wos: WOS:000557550000010 (1) - scopus: 2-s2.0-85087137336 (3)

11573/1364439 - 2020 - Usefulness of 5 minutes 123I-mIBG scan in Parkinson's disease and heart failure
Frantellizzi, Viviana; Ricci, Maria; Farcomeni, Alessio; Pontico, Mariano; Pani, Arianna; Vincentis, Giuseppe De - 01a Articolo in rivista
rivista: CURRENT RADIOPHARMACEUTICALS (Bentham Science Publishers Ltd) pp. - - issn: 1874-4710 - wos: WOS:000557550000006 (5) - scopus: 2-s2.0-85083423140 (5)

11573/1392115 - 2020 - Characterization of monolithic GAGG:Ce coupled to both PMT and SiPM array for gamma imaging in nuclear medicine
Pani, R.; Pergola, A.; Bettiol, M.; Longo, M.; Polito, C.; Falconi, R.; De Sio, L.; Pontico, M.; Pani, P.; Indovina, L.; Vincentis, G. De; Pellegrini, R.; Frantellizzi, V. - 04c Atto di convegno in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. 1-9 - issn: 1748-0221 - wos: WOS:000534740600011 (2) - scopus: 2-s2.0-85085740370 (3)
congresso: 15th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD) (Siena Italy)

11573/1455285 - 2020 - 111In-Octreoscan SPECT/CT hybrid imaging and 68Ga-DOTANOC PET/CT in neuroendocrine adenoma of the middle ear (NAME)
Pontico, M.; Frantellizzi, V.; Cosma, L.; De Vincentis, G. - 01i Case report
rivista: INDIAN JOURNAL OF RADIOLOGY AND IMAGING - NEW SERIES (Mumbai : Medknow Publications) pp. 400-404 - issn: 0971-3026 - wos: WOS:000588082400025 (4) - scopus: 2-s2.0-85095110478 (4)

11573/1145404 - 2018 - Incidental findings in traditional nuclear medicine practice
De Vincentis, Giuseppe; Pontico, Mariano; Ricci, Maria; Frantellizzi, Viviana; Liberatore, Mauro - 01i Case report
rivista: JOURNAL OF RADIOLOGY AND ONCOLOGY (Irving, TX : Heighten Science Publications Corporation, 2017-) pp. 036-040 - issn: 2573-7724 - wos: (0) - scopus: (0)

11573/1105232 - 2018 - 99mTc-HMPAO brain SPECT in the monitoring of cerebral vasculitis therapy
Frantellizzi, V.; Morreale, M.; Pontico, M.; Francia, A.; Drudi, F. M.; Farcomeni, A.; Liberatore, M. - 01a Articolo in rivista
rivista: REVISTA ESPAÑOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR () pp. 211-217 - issn: 2253-654X - wos: WOS:000439013700003 (5) - scopus: 2-s2.0-85044597497 (5)

11573/1336248 - 2018 - Annual Congress of the European Association of Nuclear Medicine October 13 - 17, 2018 Düsseldorf, Germany
Frantellizzi, V.; Sollaku, S.; Pontico, M.; De Vincentis, G. - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (Springer, Heidelberg and Berlin) pp. 1-844- - issn: 1619-7089 - wos: (0) - scopus: 2-s2.0-85056052770 (6)
congresso: European Association of Nuclear Medicine (EANM) 31st Annual Congress (CCD Congress Center Dusseldorf, Dusseldorf, Nordrhein-Westfalen, Germany)
libro: EANM - ()

11573/1355420 - 2018 - 223Ra-dichloride Treatment In mCRPC Patients: Analysis Of An Elderly Population
Frantellizzi, V.; Sollaku, S.; Pontico, M.; De Vincentis, G. - 04d Abstract in atti di convegno
congresso: EAMN 2018 (Dusseldorf)
libro: Eur J Nucl Med Mol Imaging - ()

11573/1159384 - 2018 - Bladder wall paraganglioma located using123I-mIBG SPECT and CT imaging
Frantellizzi, Viviana; Pontico, Mariano; Letizia, Claudio; De Vincentis, Giuseppe - 01a Articolo in rivista
rivista: REVISTA ESPAÑOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR () pp. 253-254 - issn: 2253-654X - wos: WOS:000439013700010 (6) - scopus: 2-s2.0-85032193910 (6)

11573/1253342 - 2018 - Long-term chronic suppressive antibiotic therapy (CSAT) in chronic joint infection evaluated by (99m)Tc-HMPAO radiolabeled leucocytes scintigraphy (LS)
Ricci, M.; Follacchio, G. A.; Pontico, M.; De Feo, M. S.; Monteleone, F.; De Vincentis, G.; Ceccarelli, G.; Liberatore, M. - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. S260-S261 - issn: 1619-7070 - wos: WOS:000449266202122 (0) - scopus: 2-s2.0-85056052770 (6)
congresso: EANM Annual Congress 2018 (Dusseldorf, GE)
libro: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING - ()

11573/1380770 - 2017 - Mixed leukocytes separation for scintigraphic purposes: assessment of red blood cells contamination
Civitelli, L; Pontico, M; Frantellizzi, V; Follacchio, Ga; D'arcangelo, I; Liberatore, M - 04d Abstract in atti di convegno
rivista: CLINICAL AND TRANSLATIONAL IMAGING (Springer is part of Springer Science) pp. 108- - issn: 2281-5872 - wos: (0) - scopus: (0)
congresso: 13° Congresso dell’Associazione Italiana di Medicina Nucleare (AIMN) (Rimini, IT)
libro: CLINICAL AND TRANSLATIONAL IMAGING - ()

11573/1255226 - 2017 - Definition of a Predictive Score to guide therapeutic management in metastatic CRPC patients eligible to Radium-223
Follacchio, Ga; Frantellizzi, V; Pontico, M; De Feo, Maria Silvia; Monteleone, F; Liberatore, M; Farcomeni, A.; Pacilio, M; De Vincentis, G - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. - - issn: 1619-7070 - wos: WOS:000455019402598 (0) - scopus: 2-s2.0-85057137539 (5)
congresso: Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) (Vienna, AUSTRIA)
libro: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING - ()

11573/1255221 - 2017 - 223Radium: analysis of effect of treatment in bone oligo-metastatic CRPC patients
Frantellizzi, V; Follacchio, Ga; Pontico, M; Cosma, Laura; Farcomeni, A; Monteleone, F; Lineratore, M; De Vincentis, G - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. - - issn: 1619-7070 - wos: WOS:000455019402391 (0) - scopus: 2-s2.0-85057137539 (5)
congresso: Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) (Vienna, AUSTRIA)
libro: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING - ()

11573/1255216 - 2017 - Rare paranganglioma localizations caught by MRI and CT hybrid 123I-MIBG SPECT imaging.
Pontico, M; Follacchio, G; Frantellizzi, V; Cosma, L; Ricci, M; Liberatore, M; Monteleone, F; Devincentis, G - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. - - issn: 1619-7070 - wos: WOS:000455019401360 (0) - scopus: 2-s2.0-85057137539 (5)
congresso: Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) (Vienna, AUSTRIA)
libro: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING - ()

11573/1255215 - 2017 - Effectiveness of long-term chronic suppressive antibiotic therapy in chronic joint infection: follow-up by 99mTc-HMPAO-labeled leukocyte scan
Ricci, M; Pontico, M; Follacchio, Ga; De Feo, M; Monteleone, F; De Vincentis, G; Ceccarelli, G; Liberatore, M - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. - - issn: 1619-7070 - wos: WOS:000455019403048 (0) - scopus: 2-s2.0-85057137539 (5)
congresso: Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) (Vienna, AUSTRIA)
libro: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING - ()

11573/1355376 - 2016 - Role of 99mTc-HMPAO brain perfusion SPECT in the clinical management of autoimmune brain vasculitis.
Frantellizzi, V; Pontico, M; Farcomeni, A; Francia, A; Morreale, M; Monteleone, F; De Vincentis, G; Liberatore, M - 04d Abstract in atti di convegno
congresso: EAMN 2016 (Barcellona)
libro: Eur J Nucl Med Mol Imaging - ()

11573/1122133 - 2016 - Use of 123I-MIBG SPECT in association with 123I-FP-CIT in patients with Early Parkinson’s Disease: a new point of view.
Frantellizzi, V; Ullo, M; Follacchio, Ga; Pontico, M; Ricci, M; Sollaku, S; Berloco, B; Filauri, M; Liberatore, M; Monteleone, F; De Vincentis, G - 04d Abstract in atti di convegno
rivista: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. - - issn: 1619-7070 - wos: WOS:000391802500386 (0) - scopus: 2-s2.0-85013695580 (4)
congresso: Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) (Barcelona, SPAIN)
libro: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING - ()

11573/935914 - 2015 - Differential influence of carotid stenosis and white matter disease on motor and cognitive activation
Polidori, M. C; Calistri, Valentina; Mainero, C; Tinelli, Emanuele; Aceti, A; Pontico, Mariano; Tardioli, Stefano; Santini, M; Fiorelli, Marco; Panico, M. A; Speziale, Francesco; Caramia, M. D; Schulz, R. J; Caramia, Francesca - 01a Articolo in rivista
rivista: CURRENT ALZHEIMER RESEARCH (BENTHAM SCIENCE PUBL LTD,) pp. 585-591 - issn: 1567-2050 - wos: WOS:000358302800010 (1) - scopus: 2-s2.0-84938584891 (1)

11573/645668 - 2014 - Non mass-like enhancement categories detected by breast MRI and histological findings
Ballesio, Laura; Di Pastena, Francesca; Gigli, Silvia; D'ambrosio, Ilaria; Antonio, Aceti; M., Pontico; Manganaro, Lucia; Porfiri, Lucio Maria; Tardioli, Stefano - 01a Articolo in rivista
rivista: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES (Roma: Verduci publisher.) pp. 910-917 - issn: 1128-3602 - wos: WOS:000341968400023 (10) - scopus: 2-s2.0-84902096131 (9)

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