MARIANA DI FELICE

PhD Student

PhD program:: XXXVIII
email: mariana.difelice@uniroma1.it
phone: 0649910879
building: Alessandro Rossi Fanelli CU027
room: 217




supervisor: Prof. Stefano Gianni
co-supervisor: Prof. Stefano Gianni

Research: Comparison of the folding and the binding features of domains in isolation and in a multidomain construct

EDUCATION AND TRAINING:
-November 2022-2025
PhD in Biochemistry
November 2022-2025
Sapienza University of Rome

-October 2022
Master`s Degree in Pharmaceutical Biotechnology
Sapienza University of Rome
Title thesis: "Development and optimization of non-invasive diagnostic tests to detect pathological protein aggregates in protein misfolding diseases"

-July 2022
Bachelor's Degree in Biological Science
University of L' Aquila
Title thesis: "The mechanisms of cardiac aging"


LANGUAGES:
Italian (Native language)
English

Research products

11573/1706810 - 2024 - The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain
Di Felice, Mariana; Pagano, Livia; Pennacchietti, Valeria; Diop, Awa; Pietrangeli, Paola; Marcocci, Lucia; Di Matteo, Sara; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista
paper: THE JOURNAL OF BIOLOGICAL CHEMISTRY (American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: asbmb@asbmb.faseb.org, INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824) pp. - - issn: 0021-9258 - wos: (0) - scopus: 2-s2.0-85188713900 (2)

11573/1711822 - 2024 - Folding and binding kinetics of the tandem of SH2 domains from SHP2
Pagano, Livia; Pennacchietti, Valeria; Malagrinò, Francesca; Di Felice, Mariana; Toso, Julian; Puglisi, Elena; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001255961100001 (0) - scopus: (0)

11573/1726961 - 2024 - A PDZ tandem repeat folds and unfolds via different pathways
Pennacchietti, Valeria; Di Matteo, Sara; Pagano, Livia; Toplek, Fran Bačić; Stegani, Bruno; Toto, Angelo; Toso, Julian; Puglisi, Elena; Capelli, Riccardo; Di Felice, Mariana; Malagrinò, Francesca; Camilloni, Carlo; Gianni, Stefano - 01a Articolo in rivista
paper: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: (0) - scopus: (0)

11573/1707732 - 2024 - The mechanism of folding of human frataxin in comparison to the yeast homologue – broad energy barriers and the general properties of the transition state
Pietrangeli, Paola; Marcocci, Lucia; Pennacchietti, Valeria; Diop, Awa; Di Felice, Mariana; Pagano, Livia; Malagrinò, Francesca; Toto, Angelo; Brunori, Maurizio; Gianni, Stefano - 01a Articolo in rivista
paper: JOURNAL OF MOLECULAR BIOLOGY (-LONDON, ENGLAND: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, -London; New York: Academic Press.) pp. - - issn: 0022-2836 - wos: WOS:001223623100001 (0) - scopus: 2-s2.0-85189293931 (0)

11573/1683686 - 2023 - Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners
Diop, Awa; Pietrangeli, Paola; Nardella, Caterina; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 10138- - issn: 1422-0067 - wos: WOS:001017317000001 (2) - scopus: 2-s2.0-85163977385 (2)

11573/1695759 - 2023 - Addressing the binding mechanism of the Meprin and TRAF-C hmology domain of the Speckle-Type POZ protein using protein engineering
Diop, Awa; Pietrangeli, Paola; Pennacchietti, Valeria; Pagano, Livia; Toto, Angelo; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Malagrinò, Francesca; Gianni, Stefano - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001131010700001 (0) - scopus: 2-s2.0-85180652606 (1)

11573/1685968 - 2023 - An intramolecular energetic network regulates ligand recognition in a SH2 domain
Nardella, Caterina; Pagano, Livia; Pennacchietti, Valeria; Felice, Mariana Di; Matteo, Sara Di; Diop, Awa; Malagrinò, Francesca; Marcocci, Lucia; Pietrangeli, Paola; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista
paper: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: WOS:001040354200001 (2) - scopus: 2-s2.0-85166371265 (3)

11573/1686025 - 2023 - Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands
Pennacchietti, Valeria; Pagano, Livia; Malagrinò, Francesca; Diop, Awa; Di Felice, Mariana; Di Matteo, Sara; Marcocci, Lucia; Pietrangeli, Paola; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista
paper: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (Attuale:ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, USA, NY, 10010-1710 Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 109703- - issn: 0003-9861 - wos: WOS:001053305400001 (0) - scopus: 2-s2.0-85166633882 (0)

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma