Phd in PHARMACEUTICAL SCIENCES

email: maria.carafa@uniroma1.it
phone: +390649913603
building: CU019
room: 211

CURRENT LOCATION
Full Professor of the scientific disciplinary sector CHIM09 (Pharmaceutical Technological Application) at the Faculty of Pharmacy and Medicine of the University of Rome "La Sapienza".


CAREER AND TITLES

EDUCATION and TRAINING
1980 Classical high school diploma
1987 Degree in Pharmaceutical Chemistry and Technology, 110/110 cum laude "New Pd catalyzed synthesis of alpha-ketoacids" Sapienza University-Rome
18/9/1987 - 18/2/1988 Professional internship at the Laboratoires de Pharmacologie Homeopatique DOLISOS Italia S.r.l.
18/2/1988 - 31/3/1988 Head of the Galenic Preparation Laboratory at the Laboratoires de Pharmacologie Homeopatique DOLISOS Italia S.r.l.
11/4/1988 - 31/10/1988 Employee at the Pharmaceutical Development Laboratory, "Pharmaceutical Development and Registration" management at Wellcome Italia S.p.A
1988 Qualification for the Profession of Pharmacist
1988 Winner of the IMI Scholarship for Technological Innovation
1989 Degree in Pharmacy, "Hydrophilic matrices in pharmaceutical forms for oral use" Sapienza University-Rome
1988-1991 PhD in "Pharmaceutical Sciences", Sapienza University - Rome "A polysaccharide matrix for the control of release from oral solid pharmaceutical forms"

CAREER AND TITLES
1991 Researcher-Faculty of Pharmacy, Sapienza University-Rome
2001 Associate Professor of "Technology, socioeconomics and pharmaceutical legislation" Faculty of Pharmacy, University of Annunzio, Chieti-Pescara
November 2008 - February 2020 Associate Professor "Technology, socioeconomics and pharmaceutical legislation" Faculty of Pharmacy and Medicine, Sapienza University, Rome
from March 2020 Full Professor "Technology, socioeconomics and pharmaceutical legislation" (SSD CHIM09 Pharmaceutical Technological Application) Faculty of Pharmacy and Medicine, Sapienza University, Rome

From the 2015/2016 academic year he is director of the II level Master "Magisterial galenic preparations for human and veterinary use" at Sapienza

From the 2020/2021 academic year, President of the Degree in Pharmacy, Faculty of Pharmacy and Medicine, Sapienza University, Rome

From 2011 to 2016 she was a member of the Advisory Commission of Veterinary Drugs, at the Ministry of Health and in the Ethics Committee of the ASL RMD, as an expert in Pharmaceutical Technology.

From 2011 to 2013 he participated as an Expert in Pharmaceutical Technology and Legislation
to the Ethics Committee of the ASL Roma D (RMD)

In 2015 he participated as an external expert in the Technical Table for the launch of the "State pilot project for medical cannabis" at the Ministry of Health

2021-2023 Commissioner ASN SC 03D2 - TECHNOLOGY, SOCIOECONOMICS AND REGULATION OF MEDICINAL PRODUCTS

Prof. Carafa has held numerous refresher courses for Pharmacists, as part of ECM events on various topics relating to the profession.

Editorial Boards:
Dal 2014 Editorial Board Member – International Journal of Medical Nano Research –
ISSN: 2378-3664
Dal 2016 al 2019 Editorial Board Member – Recent Patents on Drug Delivery & Formulation – ISSN: 2212-4039 (Online) ISSN: 1872-2113 (Print)
Dal 2019 Associate Editor – Recent Patents on Drug Delivery & Formulation -ISSN: 2212-4039 (Online) – ISSN: 1872-2113 (Print)
Dal 2019 Editorial Board Member – Pharmaceutics – EISSN 1999-4923

Honors:
2018 - present Board of Directors Divisione di Tecnologia Farmaceutica (SCI)
2017 European Commission mention in: “EU Science Hub”. Nanocarriers for brain cancer therapy, articolo selezionato: C. Ingallina et al.: "Niosomal approach to brain delivery: Development, characterization and in vitro toxicological studies", J. Pharmaceut. 511 (2016) 969–982, doi:10.1016/j.ijpharm.2016.08.002
2017 European Commission mention in: “EU Science Hub”. Nanotechnology for safe drug delivery, articolo selezionato: F. Rinaldi et al., "pH-sensitive Niosomes: Effects on Cytotoxicity and on Inflammation and Pain in Murine Models", J Enzyme Inhib Med Chem 32 (1), 538-546. 12 2017, DOI: 10.1080/14756366.2016.1268607
2016 - present Board of Directors - ADRITELF
2014 - present Member Società Chimica Italiana (SCI) –
Divisione di Chimica Farmaceutica/Divisione di Tecnologia Farmaceutica
2007 - present Member Controlled Release Society (CRS) Italian Chapter
1991 - present Member Associazione Docenti e Ricercatori Italiani di Tecnologie e
Legislazione Farmaceutiche (ADRITELF)

TEACHING ACTIVITY

Prof. Carafa, first as a researcher and later as associate and full professor, has held various courses for the Degree Courses in Pharmacy, CTF, Scientific Information on Drugs, Biotechnologies, Pharmaceutical Biotechnologies, Techniques of Environmental Prevention and of Workplaces at the "Sapienza" University of Rome and "G. D'Annunzio" of Chieti-Pescara

SCIENTIFIC ACTIVITY

Prof. Carafa has been involved since the beginning of her research activity in pharmaceutical technology and more precisely in controlled / prolonged drug release; initially the aim of the research was the definition of new reference formulations and their behavior in different experimental conditions; in particular, some polysaccharides of natural origin have been studied.
Lately his attention has focused on the study and characterization of vesicular systems consisting of both phospholipids and surfactants for their possible use in the release of drugs: vesicular, phospholipid and non-phospholipid, "conventional" structures, coated with polymers or pH-sensitive , in dermal and transdermal, ocular and pulmonary formulations, in cellular interaction studies, in studies relating to the use of liposomes as biological membrane simulators, as systems for the delivery of pro-drugs active on the Central Nervous System; structural characterization studies of non-phospholipid vesicles using in situ Energy Dispersive X-ray Diffraction techniques; structural characterization studies and applications of “multivector” systems from charged vesicles and polyelectrolytes.
Recently it has also approached in-depth studies related to the physico-chemical characterization of nanosystems such as mixed polymer / vesicle systems, nanoemulsions and nanobubbles for various therapeutic and diagnostic applications.
In the last period, thanks to the collaboration with AIFA, it is also approaching regulatory research on the evaluation of nanomedicines, nanocarriers and surfactants in relation to clinical trials.
The researches have been and are currently carried out using a large number of national and international collaborations, evidenced by the works published in common
She is author and co-author of 102 articles (source: Scopus) and about 200 oral and poster presentations; has worked as a peer reviewer for approximately 30 journals (eg J Contr Rel, Pharm, Int J Pharm, Coll Surf B, Colloid Surf A, BBA: biomembranes).

bibliometric indexes (Scopus, 16/04/2023):
pubblications = 109
h-index = 35
n. citation = 3405

SCIENTIFIC PUBLICATIONS 2013-2023 (04/16/2023)

1. Di Marzio Luisa, Esposito Sara, Rinaldi Federica, Marianecci Carlotta, Carafa Maria
“Polysorbate 20 vesicles as oral delivery system: in-vitro characterization”
Colloids and Surfaces B: Biointerfaces 104 200-206 (Amsterdam, The Netherlands, 2013)

2. Carlotta Marianecci, Federica Rinaldi, Luisa Di Marzio, Alessia Ciogli, Sara Esposito, Maria Carafa*
Polysorbate 20 vesicles as multi-drug carriers: in vitro preliminary evaluations
Letters in Drug Design & Discovery 10 (3) 212-218 (Bentham Science Publ., Arab Emirates, 2013)

3. Carlotta Marianecci, Federica Rinaldi, Luisa Di Marzio, Daniela Pozzi, Giulio Caracciolo, Daniela Manno, Luciana Dini, Donatella Paolino,
Christian Celia , Maria Carafa*
Interaction of pH-sensitive non-phospholipid liposomes with cellular mimetic membranes
Biomedical Microdevices 15 299–309 (New York, USA, 2013)

4. Carlotta Marianecci, Federica Rinaldi, Sara Esposito, Luisa Di Marzio, Maria Carafa*
Niosomes Encapsulating Ibuprofen–Cyclodextrin Complexes: Preparation and Characterization
Current Drug Targets, 2013, 14 (9), 107

5. C. Marianecci, F. Rinaldi, C. Ingallina, D. Passeri, A. Sorbo, M. Rossi, M. Carafa
Smart magnetic nanovesicles for theranostic application: preparation and characterization
Nuovo Cimento C (associato all'European Physical Journal), 2013, 36 C (2) 103-110
(Bologna, Italy, 2013)

6. Siddique Akber Ansari, Pietro Matricardi, Claudia Cencetti, Chiara Di Meo, Maria Carafa, Claudia Mazzuca, Antonio Palleschi, Donatella Capitani,
Franco Alhaique, Tommasina Coviello Sonication-Based Improvement of the Physicochemical Properties of Guar Gum as a Potential Substrate for
Modified Drug Delivery Systems
BioMed Research International (già Journal of Biomedicine and Biotechnology), vol. 2013, Article ID 985259, 11 pages, 2013.

7. C. Celia, E. Trapasso, M. Locatelli, M. Navarra, C.A. Ventura, J. Wolfram, M. Carafa, V.M. Morittu, D. Britti, L. Di Marzio, D. Paolino, Anticancer
Activity of Liposomal Bergamot Essential Oil (BEO) on Human Neuroblastoma Cells,
Colloids and Surfaces B: Biointerfaces 112, 548-553 (Amsterdam, The Netherlands, 2013)

8. Roberto Molinaro, Joy Wolfram, Cinzia Federico, Felisa Cilurzo, Luisa Di Marzio, Cinzia A Ventura, Maria Carafa, Christian Celia, Massimo Fresta
Polyethylenimine and chitosan carriers for the delivery of RNA interference effectors
Expert Opinion on Drug Delivery, 10, 1653-1668. (London, UK, 2013).

9. Emanuela Gentile, Felisa Cilurzo, Luisa Di Marzio, Maria Carafa, Cinzia Anna Ventura, Joy Wolfram, Donatella Paolino, Christian Celia
Liposomal chemotherapeutics Future oncology, 9, 1849-1859 (London, UK, 2013)

10. Carlotta Marianecci, Federica Rinaldi, Luisa Di Marzio, Marica Mastriota, Stefano Pieretti, Christian Celia, Donatella Paolino, Michelangelo Iannone, Massimo Fresta, Maria Carafa*
Ammonium glycyrrhizinate-loaded Niosomes as potential nanotherapeutic system for anti- inflammatory activity in murine models
Int. Journal of Nanomedicine, 9(1), 635 – 651 (Aukland, New Zealand, 2014)

11. Carlotta Marianecci, Luisa Di Marzio, Federica Rinaldi, Christian Celia, Donatella Paolino, Franco Alhaique, Sara Esposito, Maria Carafa*
Niosomes from 80s to present: the state of the art
Adv Colloid Interface Sci 205, 187–206 (Amsterdam, The Netherlands, 2014)

12. Donato Cosco, Luisa Di Marzio, Carlotta Marianecci, Elena Trapasso, Donatella Paolino, Christian Celia, Maria Carafa* and Massimo Fresta.
Colloidal Supramolecular Aggregates for Therapeutic Application in Neuromedicine
Curr Med Chem. 21 (36), 4132-4153 (Bussum, The Netherlands, 2014)

13. D. Passeri, C. Dong, M. Reggente, M. Barteri, F. A. Scaramuzzo, F. De Angelis, F. Marinelli, F. Antonelli, F. Rinaldi, C. Marianecci, M. Carafa, A. Sorbo, D. Sordi, I.W.C.E. Arends, M. Rossi
Magnetic force microscopy: quantitative issues in biomaterials Biomatter 4. eLocation ID: e29507 (2014)

14. Ijeoma F. Uchegbu, Marie Christine Jones, Frederica Corrente, Lisa Godfrey, Davide Laghezza, Maria Carafa, Per Holm, Andreas G. Schätzlein
The Oral and Intranasal Delivery of Propofol Using Chitosan Amphiphile Nanoparticles
Pharmaceutical Nanotechnology 2 (2) 65-74 (Bussum, The Netherlands, 2014)

15. Carlotta Marianecci, Federica Rinaldi, Cinzia Ingallina, Patrizia N. Hanieh and Maria Carafa*
Vesicular systems in dairy products: an up to date overview
Advances in Food Safety and Health 6 (2), 22-32 2014

16. Andrea Bettucci, Angelo Biagioni, Adriano Alippi, Carlotta Marianecci, Federica Rinaldi, Maria Carafa
CARATTERIZZAZIONE ACUSTICA DI MICROBOLLE E NANOBOLLE LIPIDICHE - ACOUSTIC CHARACTERIZATION OF LIPID-COATED MICROBUBBLES AND NANOBUBBLES
Rivista Italiana di Acustica 38 (2), 38-55 2014 ISSN 2385-2615 (online)

17. Viviana De Caro, Anna Lisa Scaturro, Flavia Maria Sutera, Giuseppe Avellone, Gabriella Schiera, Evelina Ferrantelli, Maria Carafa, Valerio Rizzo, Fabio Carletti, Pierangelo Sardo and Libero Italo Giannola
N-Valproyl-L-Phenylalanine as New Potential Antiepileptic Drug: Synthesis, Characterization and In Vitro Studies on Stability, Toxicity and Anticonvulsant Efficacy
Medicinal Chemistry 2015;11(1):30-40.

18. D. Passeri, F. Rinaldi, C. Ingallina, M. Carafa, M. Rossi, M. L. Terranova, and C. Marianecci Biomedical Applications of Nanodiamonds: An Overview J. Nanosci. Nanotechnol. 15, 972-988 (2015)

19. T. Coviello, A.M. Trotta, C. Marianecci, M. Carafa*, L. Di Marzio, F. Rinaldi, C. Di Meo, F. Alhaique, P. Matricardi
Gel-embedded niosomes: preparation, characterization and release studies of a new system for topical drug delivery
Colloids and Surfaces B: Biointerfaces 125, 291–299 (Amsterdam, The Netherlands, 2015)

20. Luisa Di Marzio, Marcello Locatelli, Felisa Cilurzo, Donato Cosco, Emanuela Gentile, Daniela Scalise, Maria Carafa, Cinzia Anna Ventura, Mathias Fleury, Christelle Tisserand, Massimo Fresta, Christian Celia, Donatella Paolino
Physicochemical Evaluation of Long Term Stability of Prostacyclin Released from Biomedical Device through Turbiscan Lab® Expert Medicinal Chemistry 2015; 11(4), 391 - 399

21. Donato Cosco, Donatella Paolino, Jessica Maiuolo, Luisa Di Marzio, Maria Carafa, Cinzia A. Ventura, Massimo Fresta Ultradeformable liposomes as multidrug carrier of resveratrol and 5-fluorouracil for their topical delivery
International Journal of Pharmaceutics, Volume 489, Issues 1–2, 1-10 (Amsterdam, The Netherlands, 2015)

22. C. Dong, S. Corsetti, D. Passeri, M. Rossi, M. Carafa, F. Pantanella, F. Rinaldi, C. Ingallina, A. Sorbo and C. Marianecci
Visualization and quantification of magnetic nanoparticles into vesicular systems by combined atomic and magnetic force microscopy AIP Conf. Proc. 1667, 020011 (2015);

23. I. Venditti, T. F. Hassanein, I. Fratoddi, L. Fontana, C. Battocchio, F. Rinaldi, M. Carafa, C. Marianecci, M. Diociaiuti, E. Agostinelli, C. Cametti, M.V. Russo Bioconjugation of Gold-Polymer Core-Shell Nanoparticles with Bovine Serum Amino Oxidase for Biomedical Applications
Colloids and Surfaces B: Biointerfaces 134 (2015) 314–321

24. Federica Rinaldi , Patrizia N. Hanieh , Carlotta Marianecci, Maria Carafa
DLS Characterization of Non-Ionic Surfactant Vesicles for Potential Nose to Brain Application Nanoscience and Nanometrology 2015; 1(1): 8-14

25. Rosita Primavera, Martina Di Francesco, Antonella De Cola, Vincenzo De Laurenzi, Donatella Paolino, Matteo Ciancaioni, Maria Carafa, Christian Celia, Carmine Di Ilio, Antonio Di Stefano, Massimo Fresta, Marcello Locatelli, Luisa Di Marzio
HPLC-FLD and spectrofluorometer apparatus: how to best detect fluorescent probe-loaded niosomes in biological samples
Colloids and Surfaces B: Biointerfaces, Volume 135 (1) 2015, Pages 575-580

26. Carlotta Marianecci, Federica Rinaldi, Patrizia N. Hanieh, Donatella Paolino, Luisa Di Marzio and Maria Carafa* Nose to brain delivery: new trends in amphiphile-based “soft” nanocarriers
Curr Pharm Des. 2015;21:5225-5232

27. Felisa Cilurzo, Maria Chiara Cristiano, Luisa Di Marzio, Donato Cosco, Maria Carafa, Cinzia Anna Ventura, Massimo Fresta and Donatella Paolino
Influence of the Supramolecular Micro-Assembly of Multiple Emulsions on their Biopharmaceutical Features and In vivo Therapeutic Response
Current Drug Targets 2015;16(14), 1612-1622.

28. Carlotta Marianecci; Stefania Petralito; Federica Rinaldi; Patrizia N Hanieh; Maria Carafa*
Some recent advances on liposomal and niosomal vesicular carriers
Journal of Drug Delivery Science and Technology 32 256-269 (Amsterdam, The Netherlands 2016)

29. Carlotta Marianecci, Luisa Di Marzio, Elena Del Favero, Laura Cantù, Paola Brocca, Valeria Rondelli, Federica Rinaldi, Luciana Dini, Antonio Serra, Paolo Decuzzi, Christian Celia, Donatella Paolino, Massimo Fresta and Maria Carafa*
Niosomes as Drug Nanovectors: Multiscale pH-Dependent Structural Response
Langmuir, 2016;32(5):1241-9.

30. C. Ingallina, F. Rinaldi, A. Bogni, J. Ponti, D. Passeri, M. Reggente, M. Rossi, A. Kinsner- Ovaskainen, D. Mehn, F. Rossi, B. Botta, M. Carafa, C. Marianecci
Niosomal approach to brain delivery: Development, characterization and in vitro toxicological studies International Journal of Pharmaceutics 511(2), 969-982 (Amsterdam, The Netherlands 2016)

31. Mohan C. Pereira, Monica Pianella, Da Wei, Anna Moshnikova, Carlotta Marianecci, Maria Carafa, Oleg A. Andreev & Yana K. Reshetnyak pHsensitive pHLIP® coated niosomes
Molecular Membrane Biology, 33:3-5, 51-63 (2016)

32. Federica Rinaldi, Elena Del Favero, Valeria Rondelli, Stefano Pieretti, Alessia Bogni, Jessica Ponti, François Rossi, Luisa Di Marzio, Donatella Paolino, Carlotta Marianecci, Maria Carafa*
pH-sensitive niosomes: effects on cytotoxicity and on inflammation and pain in murine models
Journal of Enzyme Inhibition and Medicinal Chemistry IENZ 2017 VOL. 32, NO. 1, 538–546

33. Carlotta Marianecci, Federica Rinaldi, Patrizia Nadia Hanieh, Luisa Di Marzio, Donatella Paolino, Maria Carafa*
Drug delivery in overcoming the blood–brain barrier: role of nasal mucosal grafting
Drug Design, Development and Therapy 2017:11 325–335

34. Rinaldi, Federica; Hanieh, Patrizia Nadia; Longhi, Catia; Carradori, Simone; Secci, Daniela; Zengin, Gokhan; Ammendolia, Maria Grazia; Mattia, Elena; Del Favero, Elena; Marianecci, Carlotta; Carafa, Maria
NEEM OIL NANOEMULSIONS: CHARACTERIZATION AND ANTIOXIDANT ACTIVITY
Journal of Enzyme Inhibition and Medicinal Chemistry (IENZ) 2017 32(1):1265-1273

35. Rinaldi F, Hanieh PN, Chan LKN, Angeloni L, Passeri D, Rossi M, Wang JT, Imbriano A, Carafa M*, Marianecci C.
Chitosan Glutamate-Coated Niosomes: A Proposal for Nose-to-Brain Delivery.
Pharmaceutics. 2018 Mar 22;10(2).

36. Rosita Primavera, Palumbo Paola, Christian Celia, Felisa Cilurzo, Benedetta Cinque, Elisabetta Carata, Maria Carafa, Donatella Paolino, Maria Grazia Cifone, Luisa Di Marzio
An insight of in vitro transport of PEGylated non-ionic surfactant vesicles (NSVs) across the intestinal polarized enterocyte monolayers
European Journal of Pharmaceutics and Biopharmaceutics Volume 127, 2018, 432-442

37. Federica Rinaldi, Patrizia N. Hanieh, Elena Del Favero, Valeria Rondelli, Paola Brocca, Mohan C. Pereira, Oleg A. Andreev, Yana K. Reshetnyak, Carlotta Marianecci and Maria Carafa*
Decoration of Nanovesicles with pH (Low) Insertion Peptide (pHLIP) for Targeted
Delivery Nanoscale Research Letters (2018) 13:391

38. Rinaldi F., Seguella L., Gigli S., Hanieh P.N., Del Favero E., Cantù L., Pesce M., Sarnelli G., Marianecci C., Esposito G., Carafa M inPentasomes: An innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice Journal of Controlled Release, 294, 2019, 17-26

39. Francesca Marzoli, Carlotta Marianecci, Federica Rinaldi, Paola Minosi, Maria Carafa, Stefano Pieretti Long-lasting, anti-nociceptive effects of ph-sensitive niosome loaded with ibuprofen in acute and chronic models of pain. Pharmaceutics 2019, 11(2), 62;

40. Marianecci C, Carafa M. Smart Nanovesicles for Drug Targeting and Delivery. Pharmaceutics. 2019 Mar 29;11(4). – Editorial

41. Rinaldi F, Del Favero E, Moeller J, Hanieh PN, Passeri D, Rossi M, Angeloni L, Venditti I, Marianecci C, Carafa M, Fratoddi I. Hydrophilic Silver Nanoparticles Loaded into Niosomes: Physical-Chemical Characterization in View of Biological Applications. Nanomaterials (Basel). 2019 Aug 17;9(8).

42. Federica Rinaldi, Patrizia Nadia Hanieh, Anna Imbriano, Daniele Passeri, Elena Del Favero, Marco Rossi, Carlotta Marianecci, Simone De Panfilis, Maria Carafa
Different instrumental approaches to understand the chitosan coated niosomes/mucin interaction.
Journal of Drug Delivery Science and Technology Volume 55, 2020, 101339

43. Seguella, Luisa; Rinaldi, Federica; Marianecci, Carlotta; Pesce, Marcella; Gigli, Stefano; Bassotti, Gabrio; Sidoni, Angelo; Capuano, Riccardo; Pesce, Mirella; Milone, Marco; De Palma, Giovanni; Carafa, Maria; Esposito, Giuseppe; Sarnelli, Giovanni,
Pentamidine niosomes thwart S100B effects in human colon carcinoma biopsies favoringwtp53 rescue J Cell Mol Med. 2020;24:3053–3063.

44. Helder A. Santos, Nicola d’Avanzo, Christian Celia, Antonella Barone, Maria Carafa, Luisa Di Marzio, and Massimo Fresta Immunogenicity of Polyethylene glycol Based Nanomedicines: Mechanisms, Clinical Implications and Systematic Approach
Advanced Therapeutics Article Number: UNSP 1900170 (1 of 18) Volume: 3 Issue: 3 2020

45. Alessandro Maccelli, Luca Vitanza, Anna Imbriano, Caterina Fraschetti, Antonello Filippi, Paola Goldoni, Linda Maurizi, Maria Grazia Ammendolia, Maria Elisa Crestoni, Simonetta Fornarini, Luigi Menghini, Maria Carafa, Carlotta Marianecci, Catia Longhi and Federica Rinaldi
Satureja montana L. Essential Oils: Chemical Profiles/Phytochemical Screening, Antimicrobial Activity and O/W NanoEmulsion Formulations Pharmaceutics 2020, 12(1), 7;

46. Federica Rinaldi, Alessandra Oliva, Manuela Sabatino, Anna Imbriano, Patrizia N. Hanieh, Stefania Garzoli, Claudio M. Mastroianni, Massimiliano De Angelis, Maria Claudia Miele, Marcela Arnaut, Federica Di Timoteo, Carlotta Marianecci, Rino Ragno, Maria Carafa
Antimicrobial Essential Oil Formulation: Chitosan Coated Nanoemulsions for Nose to Delivery
Pharmaceutics 2020, 12, 678;

47. Maria Valeria Giuli, Patrizia Nadia Hanieh, Eugenia Giuliani, Federica Rinaldi,
Carlotta Marianecci, Isabella Screpanti, Saula Checquolo, Maria Carafa
Current Trends in ATRA Delivery for Cancer Therapy Pharmaceutics 2020, 12(8), 707;

48. Rinaldi, F.; Maurizi, L.; Conte, A.L.; Marazzato, M.; Maccelli, A.; Crestoni, M.E.; Hanieh, P.N.; Forte, J.; Conte, M.P.; Zagaglia, C.; Longhi, C.; Marianecci, C.; Ammendolia, M.G.; Carafa, M. Nanoemulsions of Satureja montana Essential Oil: Antimicrobial and Antibiofilm Activity against Avian Escherichia coli Strains. Pharmaceutics 2021, 13, 134.

49. Diego Alejandro Dri, Carlotta Marianecci, Maria Carafa, Elisa Gaucci and Donatella Gramaglia
Surfactants, Nanomedicines and Nanocarriers: a critical evaluation on Clinical Trials
Pharmaceutics 2021, 13, 381.

50. Patrizia N. Hanieh, Jacopo Forte, Chiara Di Meo, Maria Grazia Ammendolia, Elena Del Favero, Laura Cantù, Federica Rinaldi, Carlotta Marianecci, Maria Carafa
Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes Molecules 2021, 26, 3434.

51. Rinaldi F., Maurizi L., Forte J., Marazzato M., Hanieh P.N., Conte A.L., Ammendolia M.G., Marianecci C., Carafa M., Longhi C. Resveratrol-loaded nanoemulsions: In vitro activity on human t24 bladder cancer cells Nanomaterials 2021, 11, 1569.

52. Federica Rinaldi, Patrizia Nadia Hanieh, Simona Sennato, Federica De Santis, Jacopo Forte, Maurizio Fraziano, Stefano Casciardi, Carlotta Marianecci, Federico Bordi, Maria Carafa
Rifampicin-liposomes for Mycobacterium abscessus infection treatment: intracellular uptake and antibacterial activity evaluation.
Pharmaceutics 2021, 13, 1070.

53. Francesca Sciolla, Domenico Truzzolillo, Edouard Chauveau, Silvia Trabalzini, Luisa Di Marzio, Maria Carafa, Carlotta Marianecci, Angelo Sarra, Federico Bordi, Simona Sennato
Influence of drug/lipid interaction on the entrapment efficiency of isoniazid in liposomes for antitubercular therapy: a multi-faced investigation
Colloids and Surfaces B: Biointerfaces 2021, 208, 112054

54. Monica Bartolomei, Paola Bertocchi, Maria Carafa, Lucia Friciello, Carlotta Marianecci, Federica Rinaldi LOTTA AI FARMACI FALSIFICATI ECCO GLI STRUMENTI EUROPEI PER FRONTEGGIARE IL CRIMINE Dicembre 2021|Gennaio 2022 Numero 194 www.aboutpharma.com ISSN 2282-6491

55. Maria Carafa, Maurizio Cini, Anna Maria Fadda, Massimo Fresta, Paola Minghetti, Rosario Pignatello, Nicola Realdon L’ALLESTIMENTO DEI MEDICINALI IN FARMACIA
IN LABORATORIO SEPARATO: ANALISI DELLA NORMATIVA E DELLA GIURISPRUDENZA
Rassegna di diritto farmaceutico e della salute Anno LII Numero 6 2021

56. Federica Rinaldi, Jacopo Forte, Giada Pontecorvi, Patrizia Nadia Hanieh, Alessandra Carè, Maria Bellenghi, Valentina Tirelli, Maria Grazia Ammendolia, Gianfranco Mattia, Carlotta Marianeccia, Rossella Puglisi, Maria Carafa
pH-responsive oleic acid based nanocarriers: Melanoma treatment strategies International Journal of Pharmaceutics, 2022, 613,121391

57. Patrizia Nadia Hanieh, Sara Consalvi, Jacopo Forte, Gianluigi Cabiddu, Alessandro De Logu, Giovanna Poce, Federica Rinaldi, Mariangela Biava, Maria Carafa, Carlotta Marianecci Nano-Based Drug Delivery Systems of Potent MmpL3 Inhibitors for Tuberculosis Treatment
Pharmaceutics 2022, 14, 610. https://doi.org/10.3390/pharmaceutics14030610

58. Patrizia Nadia Hanieh, Angela Bonaccorso, Elide Zingale, Silvia Cimarelli, Eliana B. Souto Federica Rinaldi, Carlotta Marianecci, Rosario Pignatello, Maria Carafa
Almond oil O/W nanoemulsions: potential application for ocular drug delivery Journal of Drug Delivery Science and Technology, 2022, 72 103424

59. Diego Alejandro Dri, Elisa Gaucci, Ilaria Torrieri, Maria Carafa, Carlotta Marianecci, Donatella Gramaglia
Critical Analysis and Quality Assessment of Nanomedicines and Nanocarriers in Clinical Trials: Three Years of Activity at the Clinical Trials Office
Pharmaceutics 2022, 14, 1438.

60. Patrizia N. Hanieh, Caterina Ricci, Roberto Marotta, Andrea Bettucci, Carmel M. Moran, Laura Cantù, Maria Carafa, Federica Rinaldi, Elena Del Favero, Carlotta Marianecci Ultrastable shelled PFC nanobubbles: a platform for ultrasound-assisted diagnostics, and therapy.
Nanomedicine: Nanotechnology, Biology, and Medicine, 2022, 46, 102611

61. Linda Maurizi, Jacopo Forte, Maria Grazia Ammendolia, Patrizia Nadia Hanieh, Antonietta Lucia Conte, Michela Relucenti, Orlando Donfrancesco, Caterina Ricci, Federica Rinaldi, Carlotta Marianecci, Maria Carafa, Catia Longhi
Effect of Ciprofloxacin-Loaded Niosomes on Escherichia coli and Staphylococcus aureus Biofilm Formation
Pharmaceutics 2022, 14, 2662.

62. Federica Rinaldi, Patrizia Nadia Hanieh, Linda Maurizi, Catia Longhi, Daniela Uccelletti, Emily Schifano, Elena Del Favero, Laura Cantù, Caterina Ricci, Maria Grazia Ammendolia, Donatella Paolino, Francesca Froiio, Carlotta Marianecci, Maria Carafa*
Neem oil or Almond oil nanoemulsions for Vitamin E delivery: From structural evaluation to in vivo assessment of antioxidant and anti-inflammatory activity
International Journal of Nanomedicine 2022:17 6447–6465

63. Diego Alejandro Dri, Federica Rinaldi, Maria Carafa and Carlotta Marianecci
Nanomedicines and Nanocarriers in Clinical Trials: Surfing through Regulatory Requirements and Physicochemical Critical Quality Attributes
Drug Deliv. and Transl. Res. 2023:13(3),757-769

64. Maria Carafa*, Paola Minghetti (Editorial)
New trends in drug delivery: The contribution of young European researchers
Journal of Drug Delivery Science and Technology 2023:81, 104287

Brevetti

2010 Maria Carafa, Franco Alhaique, Carlotta Marianecci, Donatella Paolino, Massimo Fresta:
“Niosomi, polvere liofilizzata di essi e loro uso in terapia”
RM/2010/A000002
2011 Maria Carafa, Franco Alhaique, Carlotta Marianecci, Donatella Paolino, Massimo Fresta:
“Niosomes, lyophilized powder thereof and their uses in therapy”
PCT/IB2011/050041
WO2011/083428 A1
2016 Maria Carafa, Andrea Bettucci, Carlotta Marianecci, Federica Rinaldi, Angelo Biagioni
“Nanobolle e relative impieghi” IT102016000037062
2017 Maria Carafa, Andrea Bettucci, Carlotta Marianecci, Federica Rinaldi, Angelo Biagioni
“Nanobubbles and uses thereof”
PCT/IB2017/052060 WO2017/178954

CAPITOLI di LIBRI
F. Alhaique, C. Marianecci, E. Santucci, S. Petralito, A. Memoli, L. Di Marzio, M. Carafa “Veicoli cosmetici” in Manuale di Scienze e Tecnologie Cosmetologiche
Maurizio Giuliani e Ferdinando Di Iorio ARACNE Editrice S.r.l. Roma pp. 345-384 (2005)

M. Carafa, C. Marianecci, P. Donatella, L. Di Marzio, C. Celia, M. Fresta, F. Alhaique
“Novel concept in pulmonary delivery”
Chronic Obstructive Pulmonary Disease, ISBN 979-953-307-038-3 InTech - Open Access Publisher in press (2011)

Carlotta Marianecci, Luisa Di Marzio, Federica Rinaldi, Sara Esposito, Maria Carafa
“Niosomes” In Fundamentals of Pharmaceutical Nanoscience, ISBN 978-1-4614-9163-7
Eds.Uchegbu, I.F.; Schätzlein, A.; Cheng, W.P.; Lalatsa, A.
Springer Science + Business Media New York (2013)

Maria C. Cristiano, Felisa Cilurzo, Maria Carafa, Donatella Paolino
“Innovative vesicles for dermal and transdermal drug delivery”
in Lipid Nanocarriers for Drug Targeting Series: Pharmaceutical Nanotechnology
eBook ISBN: 9780128136881 ISBN: 9780128136874
Ed. Alexandru Grumezescu,
Elsevier (2018)