Dottorato in SCIENZE DELLA VITA

email: marco.tripodi@uniroma1.it
telefono: 0649918244
edificio: PL028
stanza: 207

PERSONAL INFORMATION Marco Tripodi
Sapienza University of Rome
Dept of Molecular Medicine,
Viale Regina Elena 324, 00161, Rome, Italy
+39 0649918244

marco.tripodi@uniroma1.it Sex Male | Date of birth 19thAugust 1955 | Nationality Italian

CURRENT POSITION. SSD 05/F1. Full professor SSD BIO/13

RESEARCH TOPICS / EXPERIENCES ▪ ncRNAs compartmentalization, extracellular vesicles structure and function
▪ ncRNAs function and RNA-based translational applications
▪ Proteomic approach for RNA-protein interaction detection
▪ Epitranscriptomic modifications on lncRNA impacting cancer progression.

SCIENTIFIC / TECHNICAL QUALIFICATION
(source: Scopus) ▪ H-index: ▪ 39
▪ No. publications: ▪ Total :133; 2015-2023 :48
▪ No. citations: ▪ 5296
THEMATIC AREA KEYWORDS ▪ Bio-pharma & health: ▪ Cancer, ncRNAs, extracellular vesicles


EDUCATION AND TRAINING
1983-1984 EMBL Post-Doc Fellow: EMBL European Molecular Biology Laboratory Heidelberg, Gene expression programme
1982-1983 EEC Pre-Doc Fellow: EMBL European Molecular Biology Laboratory Heidelberg
1981 Degree: Biology (summa cum laude) Sapienza University of Rome

WORK EXPERIENCE
From 2000- up to date
Full Professor
“Sapienza” University of Rome, Italy; Dept. of Molecular Medicine.
https://web.uniroma1.it/dmm/en/dmm/node/5548/persone-menu-position-rule-12
https://phd.uniroma1.it/web/MARCO-TRIPODI_nC463_IT.aspx
From 2000- 2022
Responsible of U.O.
“Gene Expression” INMI, IRCCS “Lazzaro Spallanzani.
From 1998- to 2000 Associate Professor
University of Cagliari,
From 1985- to 1997 Researcher
“Sapienza” University of Rome; Dept. of Cellular Biotechnologies and Hematology

MAIN ROLES AND RESPONSIBILITIES

From 2015- to 2018 Head of the Dept
Dept. of Cellular Biotechnologies and Hematology “Sapienza” University of Rome;
From 2019- up to date Programme Coordinator (Master degree President)
“Sapienza” University, Master Degree Course in Medical Biotechnology
From 2012- to 2015 Coordinator at Life Science Doctoral Course
“Sapienza” University of Rome,
From 2006- to 2012 Coordinator at Scienze Pasteuriane Doctoral Course
“Sapienza” University of Rome
From 2007- up to date Scientific Board Member
“Pasteur Institute Italia- Cenci Bolognetti Foundation”, https://www.istitutopasteuritalia.it/organigramma-e-statuto/

SERVICE TO NATIONAL AND INTERNATIONAL COMMUNITY
From 2016
To 2018 President of the ASN board SC 05/F1
From 1995 up to date Reviewer for: Gastroenterology, Hepatology, Journal of Hepatology, Digestive and Liver Disease, Proteomic, Cellular and Molecular Life Sciences, Cell Death and Differentiation, Cell Death and Disease, Gut, Journal of Cellular Biochemistry, Oncogene, Stem Cell Research, International Journal of Molecular Sciences, Gene Therapy and Molecular Biology, EMBO Reports, Journal of Proteome Research, Cell Reports

TEACHING EXPERIENCE

From 2017 to 2020
• Life sciences Coordinator SSAS (Scuola superiore di studi avanzati, Sapienza) https://web.uniroma1.it/sssas/en
From 2014 to 2020
• Senior Fellow SSAS life sciences (Scuola superiore di studi avanzati, Sapienza) https://web.uniroma1.it/sssas/en
From 2000 up to date • Full Professor of Biology and Genetics (Medicine and Surgery)
Sapienza University of Rome
From 2000 up to date • Full Professor of Molecular basis of cell function (Medical Biotechnologies)
Sapienza University of Rome
From 1998- to 2000 • Associate Professor of Biology and Genetics (Medicine and Surgery)
University of Cagliari

MAIN RESEARCH EXPERIENCE
From 1996 up to date SAPIENZA UNIVERSITY OF ROME:
• Experimental hepatology: Tumour progression, EMT, liver precursor cells.
• Financial supports: AIRC (from 1996 up to date)
• PRIN (from 1997 to 2011)
• ATENEO
From 2000 to 2022 IRCCS National Institute of Infectious Diseases L. SPALLANZANI, Rome:
• Experimental hepatology: translational research on hepatitis
• Financial supports: Ricerca Corrente e Ricerca Finalizzata (Ministry of
• Health)

HONOURS, AWARDS, MEMBERSHIPS, OTHER QUALIFICATIONS
From 2021 to 2026
• Honorary Fellow SSAS life sciences (Scuola superiore di studi avanzati, Sapienza) https://web.uniroma1.it/sssas/en
From 2007 up to date
• Scientific Board Member “Pasteur Institute Italia- Cenci Bolognetti Foundation”, https://www.istitutopasteuritalia.it/organigramma-e-statuto/

ADDITIONAL INFORMATION

Publications
Number of total publications in peer-review journals in the last ten years (2012-2022). 50 Impact Factor (2020 journal IF wos) of the total papers of last ten years 412.694 Average Impact Factor (IF)/paper of the last ten years 8,253
total number of citations 5299H index 39

Skills and interests
ncRNAs compartmentalization, extracellular vesicles structure and function (see pub 1, 2, 4, 5, 8) ncRNAs function and RNA-based translational applications (see pub 3, 6, 7)
Proteomic approach for RNA-protein interaction detection (see pub. 2)
From the beginning of 2021 the main focus of the research is on epitranscriptomics: on the basis of previous results (see pub. 7) we are dissecting the functional effects of specific RNA modifications on lncRNA impacting cancer progression.

8 recent relevant publications
Parameters of the 8 publications: Total citations 985 Average citations 123 Total IF 121.05 Average IF 15.13
1. 2015. Conigliaro A., Costa V., Lo Dico A., Saieva L., Buccheri S., Dieli F., Manno M., Raccosta S., Mancone C., Tripodi M., De Leo G. and Alessandro R. “CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA”. Mol Cancer. 2015 Aug;14:155.
2. 2016. Santangelo L., Giurato G., Cicchini C., Montaldo C., Mancone C., Tarallo R., Battistelli C., Alonzi T., Weisz A. and Tripodi M. "The RNA binding protein SYNCRIP is a component of the hepatocyte exosomal machinery controlling microRNAs sorting". Cell Rep. 2016 Oct;17(3):799- 808
3. 2017. Battistelli C., Cicchini C., Santangelo L., Tramontano A., Grassi L., Gonzalez F.J., de Nonno V., Grassi G., Amicone L. and Tripodi M. “The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition”. Oncogene. 2017 Feb;36(7):942-955.
4. 2018. Hobor F., Dallmann A., Ball N.J., Cicchini C., Battistelli C., Ogrodowicz R.W., Christodoulou E., Martin S.R., Castello A., Tripodi M., Taylor I.A. and Ramos A. “A cryptic RNA- binding domain mediates Syncrip recognition and exosomal partitioning of miRNAtargets”. Nat Commun. Feb;9(1):831.
5. 2018. Santangelo L., Bordoni V., Montaldo C., Cimini E., Zingoni A.., Battistelli C, D'Offizi G., Capobianchi M.R., Santoni A., Tripodi M. and Agrati C. “Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties”. Liver Int. 2018 Oct;38(10):1741-1750.
6. 2019. Battistelli C., Sabarese G., Santangelo L., Montaldo C., Gonzalez F.J., Tripodi M. and Cicchini C. “The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation”. Cell Death Differ. 2019 May;26(5):890-901.
7. 2021. Battistelli C., Garbo S., Riccioni V,, Montaldo C., Santangelo L., Vandelli A., Strippoli R., Tartaglia G.G., Tripodi M., Cicchini C. Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition. Cancer Res 2021 Jan 1;81(1):103-113. doi: 10.1158/0008-5472.CAN-20-1764
8. 2021 Montaldo C., Terri M., Riccioni V., Battistelli C., Bordoni V., D’Offizi G., Prado G.P., Trionfetti F., Vescovo T., Tartaglia E., Strippoli R., Agrati C. and Tripodi M. Persistence of fibrogenic signals in DAA-treated HCV patients that reached sustained virological response. J Hepatol 2021 Dec;75(6):1301-1311. doi: 10.1016/j.jhep.2021.07.003. Epub 2021 Jul 13.

According to law 679/2016 of the Regulation of the European Parliament of 27th April 2016, I hereby express my consent to process and use my data provided in this CV

Rome, 18/02/2023 Marco Tripodi