MARCO CECCANTI

Dottore

ciclo: XXXIII



Titolo della tesi: Non motor neuron involvement in ALS

Background: Amyotrophic lateral sclerosis (ALS) is considered the main model for motor neuron disease. Increasing evidences highlight non motor neuron involvement in ALS, such as a cognitive and sensory fibres impairment. Aim of this project was to demonstrate the involvement of sensory-motor networks in ALS and the possibility to modulate them through the skin tactile stimulation. Second aim of the project was to describe kinematic patterns of finger tapping in an ALS sample, looking for extrapyramidal features and relationships between neurophysiological and kinematic parameters. Material and methods: for the first aim of the project, PAS was used to detect differences between 24 newly-diagnosed ALS patients and 25 age-matched healthy controls. MEP amplitude from the abductor pollicis brevis was considered before PAS, immediately after (T0) and after 10 (T10), 20 (T20), 30 (T30) and 60 (T60) minutes. To demonstrate a possible modulation of sensory-motor networks through skin stimulation, 15 healthy subjects underwent to the same PAS protocol administered to the ALS cohort; the same healthy subjects underwent to the PAS protocol following a 10-minutes skin stimulation, in a different day. Differences between the trend of MEP amplitude after PAS in the two sessions were analysed. For the second aim of the project, 14 ALS patients underwent a complete neurophysiological (motor NCS from ulnar and median nerves, repetitive nerve stimulation -RNS-, needle EMG from FDI, central motor conduction time -CMCT- from ADM and FDI) and kinematic assessment during a 15-seconds finger tapping trial (total number of movement, coefficient of variation -CV-, amplitude, amplitude slope, velocity and velocity slope were detected), compared to the data from healthy controls. Results: In healthy controls, PAS significantly increased MEP amplitude at T10, T20 and T30 compared to the baseline. In ALS patients, a significant increase in MEP amplitude was also observed after 60 minutes, thus demonstrating NMDA-mediated enhanced facilitatory plasticity. In the healthy volunteers’ cohort, skin stimulation significantly enhanced the MEP amplitude increase after PAS at T30 and showed a trend to significancy at T60 (p=0.07), thus demonstrating an increased sensory-motor networks excitability. In the kinematic study, ALS patients showed a reduction in the total number of movement and angular velocity compared to healthy controls, with an increased CV, demonstrating a low rhythmic movement. Nevertheless, amplitude, amplitude slope and velocity slope did not differ from healthy control sample, thus demonstrating a different behaviour from Parkinson patients. Finally, the reduction in the number of movement correlated with cMAP amplitude from median nerve and denervation from FDI, while the angular velocity correlated with cMAP amplitude from ulnar nerve and denervation from FDI, thus underlining a key-role for peripheral nervous system in determining these kinematic features. Conclusions: this project demonstrated an involvement of sensory-motor networks in ALS; the same networks can be hyper-excited by sensory skin stimulation, that should be avoided in ALS rehabilitation. No extrapyramidal feature can be described in the kinematic study, which demonstrated a slow and arhythmic finger tapping, which mainly correlated to peripheral nervous system involvement.

Produzione scientifica

  • 11573/515912 - 2012 - Chronic treatment with rivastigmine in patients with Alzheimer's disease: a study on primary motor cortex excitability tested by 5 Hz-repetitive transcranial magnetic stimulation. (01a Articolo in rivista)
    TREBBASTONI, ALESSANDRO; D'ANTONIO, FABRIZIA; CAMBIERI, CHIARA; CECCANTI, MARCO; DE LENA, CARLO; INGHILLERI, MAURIZIO
  • 11573/434661 - 2012 - Effects of intermittent theta burst stimulation on cerebral blood flow and cerebral vasomotor reactivit (01a Articolo in rivista)
    PICHIORRI, FLORIANA; GIACOMELLI, ELENA; FRASCA, VITTORIO; CAMBIERI, CHIARA; CECCANTI, MARCO; DI PIERO, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/780984 - 2015 - Small-fibre neuropathy related to bulbar and spinal-onset in patients with ALS (01a Articolo in rivista)
    TRUINI, ANDREA; BIASIOTTA, ANTONELLA; ONESTI, EMANUELA; DI STEFANO, GIULIA; CECCANTI, MARCO; LA CESA, SILVIA; PEPE, ALESSIA; GIORDANO, CARLA; CRUCCU, GIORGIO; INGHILLERI, MAURIZIO
  • 11573/785120 - 2016 - Paternal alcohol exposure in mice alters brain NGF and BDNF and increases ethanol-elicited preference in male offspring (01a Articolo in rivista)
    CECCANTI, MAURO; FERRAGUTI, GIAMPIERO; PASCALE, ESTERINA; CECCANTI, MARCO
  • 11573/561335 - 2014 - Prognostic factors of Bell's palsy: multivariate analysis of electrophysiological findings. (01a Articolo in rivista)
    MANCINI, PATRIZIA; DE SETA, DANIELE; PROSPERINI, LUCA; CECCANTI, MARCO; SEMENTILLI, GIULIO; TERELLA, MARIA CONCETTA; BERTOLI, GIAN ANTONIO; FILIPO, ROBERTO; INGHILLERI, MAURIZIO
  • 11573/856260 - 2016 - Altered cortical synaptic plasticity in response to 5 hz repetitive transcranial magnetic stimulation as a new electrophysiological finding in amnestic mild cognitive impairment converting to alzheimer’s disease. results from a four-year prospective cohort study (01a Articolo in rivista)
    TREBBASTONI, ALESSANDRO; PICHIORRI, FLORIANA; D'ANTONIO, FABRIZIA; CAMPANELLI, ALESSANDRA; ONESTI, EMANUELA; CECCANTI, MARCO; INGHILLERI, MAURIZIO
  • 11573/854499 - 2015 - TNF-α and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation (01a Articolo in rivista)
    TARANI, LUIGI; CECCANTI, MAURO; IANNITELLI, ANGELA; CECCANTI, MARCO; BOCCARDO, CHIARA
  • 11573/525629 - 2013 - H-coil repetitive transcranial magnetic stimulation for pain relief in patients with diabetic neuropathy (01a Articolo in rivista)
    ONESTI, EMANUELA; CAMBIERI, CHIARA; CECCANTI, MARCO; DI STEFANO, GIULIA; BIASIOTTA, ANTONELLA; TRUINI, ANDREA; INGHILLERI, MAURIZIO
  • 11573/902955 - 2016 - A Novel Mutation in ABCA1 Gene Causing Tangier Disease in an Italian Family with Uncommon Neurological Presentation (01a Articolo in rivista)
    CECCANTI, MARCO; CAMBIERI, CHIARA; FRASCA, VITTORIO; ONESTI, EMANUELA; BIASIOTTA, ANTONELLA; GIORDANO, CARLA; BRUNO, SABINA MARIA; TESTINO, GIANCARLO; LUCARELLI, MARCO; ARCA, MARCELLO; INGHILLERI, MAURIZIO
  • 11573/877211 - 2016 - Glutamate-mediated blood-brain barrier opening. implications for neuroprotection and drug delivery (01a Articolo in rivista)
    ONESTI, EMANUELA; CECCANTI, MARCO; COLONNESE, CLAUDIO; SANTORO, ANTONIO; SALVATI, MAURIZIO; D'ELIA, ALESSANDRO; INGHILLERI, MAURIZIO
  • 11573/913615 - 2016 - Laryngeal sensitivity in patients with amyotrophic lateral sclerosis (01a Articolo in rivista)
    RUOPPOLO, GIOVANNI; ONESTI, EMANUELA; GORI, MARIA CRISTINA; SCHETTINO, ILENIA; FRASCA, VITTORIO; BIASIOTTA, ANTONELLA; GIORDANO, CARLA; CECCANTI, MARCO; CAMBIERI, CHIARA; GRECO, ANTONIO; CRUCCU, GIORGIO; DE VINCENTIIS, MARCO; INGHILLERI, MAURIZIO
  • 11573/980701 - 2017 - Atypical case of diaphragmatic pseudo myoclonus (01a Articolo in rivista)
    ONESTI, EMANUELA; CECCANTI, MARCO; FRASCA, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/989068 - 2016 - Central Sensitization in the Bladder Pain Syndrome (01a Articolo in rivista)
    ONESTI, EMANUELA; CECCANTI, MARCO; CAMBIERI, CHIARA; INGHILLERI, MAURIZIO
  • 11573/989069 - 2016 - The Compound Muscle Action Potential as Neurophysiological Marker for Amyotrophic Lateral Sclerosis. (01a Articolo in rivista)
    ONESTI, EMANUELA; CECCANTI, MARCO; FRASCA, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/1018425 - 2017 - Acute flaccid paralysis by enterovirus D68 infection: first Italian description on adult patient and role of electrophysiology (01a Articolo in rivista)
    CECCANTI, MARCO; LETTERI, FEDERICA; DE MICHELE, MANUELA; FALCOU, ANNE ALBERTINE; ROMANZI, FEDERICA; ONESTI, EMANUELA; INGHILLERI, MAURIZIO
  • 11573/1029914 - 2015 - Spatial learning in men undergoing alcohol detoxification (01a Articolo in rivista)
    CECCANTI, MAURO; ROMEO, MARINA; CECCANTI, MARCO; IANNITELLI, ANGELA
  • 11573/1066134 - 2018 - Modulation of human corticospinal excitability by paired associative stimulation in patients with amyotrophic lateral sclerosis and effects of Riluzole (01a Articolo in rivista)
    CECCANTI, MARCO; ONESTI, EMANUELA; CAMBIERI, CHIARA; TARTAGLIA, GIORGIO; FRASCA, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/832991 - 2013 - Predictive role of neurophysiological features on Bell’s palsy (04f Poster)
    MANCINI, PATRIZIA; CECCANTI, MARCO; CAMBIERI, CHIARA; FRASCA, VITTORIO; CAPUA, GELSOMINA; INGHILLERI, MAURIZIO
  • 11573/416943 - 2011 - BRAIN NGF AND BDNF ALTERATIONS IN AN FASD MOUSE MODEL (04d Abstract in atti di convegno)
    CECCANTI, MAURO; CECCANTI, MARCO
  • 11573/505970 - 2011 - Deep Repetitive transcranial magnetic stimulation (DRTMS): Effects on different lifetime Drinking-histories. (04c Atto di convegno in rivista)
    CECCANTI, MAURO; ROMEO, MARINA; ATTILIA, MARIA LUISA; CAMBIERI, CHIARA; CECCANTI, MARCO
  • 11573/556121 - 2013 - NGF and BDNF long-term variations in the thyroid, testis and adrenal glands of a mouse model of fetal alcohol spectrum disorders (01a Articolo in rivista)
    CECCANTI, MAURO; CECCANTI, MARCO
  • 11573/477202 - 2011 - Increased NGF and BDNF in the thyroid of aged male mice exposed in fetus and during lactation to ethanol (04d Abstract in atti di convegno)
    ROMEO, MARINA; CECCANTI, MAURO; CECCANTI, MARCO
  • 11573/629318 - 2014 - Cutaneous silent period recordings in demyelinating and axonal polyneuropathies (01a Articolo in rivista)
    ONESTI, EMANUELA; CECCANTI, MARCO; FIONDA, LAURA; BIASIOTTA, ANTONELLA; DI STEFANO, GIULIA; LA CESA, SILVIA; FRASCA, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/477218 - 2011 - Behavioral and brain neurotrophin alterations in a FASD mouse model (04d Abstract in atti di convegno)
    ROMEO, MARINA; CECCANTI, MAURO; CECCANTI, MARCO
  • 11573/1172572 - 2018 - Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome/interstitial cystitis (01a Articolo in rivista)
    ONESTI, EMANUELA; CECCANTI, MARCO; GORI, MARIA CRISTINA; TARTAGLIA, GIORGIO; PANICO, GIANLUCA; CAMBIERI, CHIARA; LIBONATI, LAURA; INGHILLERI, MAURIZIO
  • 11573/872092 - 2015 - Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal (01a Articolo in rivista)
    CECCANTI, MAURO; VITALI, MARIO; IANNUZZI, SILVIA; TARANI, LUIGI; CECCANTI, MARCO; IANNITELLI, ANGELA
  • 11573/656941 - 2015 - Deep TMS on alcoholics: effects on cortisolemia and dopamine pathway modulation. A pilot study (01a Articolo in rivista)
    CECCANTI, MARCO; INGHILLERI, MAURIZIO; ATTILIA, MARIA LUISA; CECCANTI, MAURO
  • 11573/989067 - 2017 - Dysphagia in amyotrophic lateral sclerosis: impact on patient behavior, diet adaptation, and riluzole management (01a Articolo in rivista)
    ONESTI, EMANUELA; SCHETTINO, ILENIA; FRASCA, VITTORIO; CECCANTI, MARCO; CAMBIERI, CHIARA; RUOPPOLO, GIOVANNI; INGHILLERI, MAURIZIO
  • 11573/1219606 - 2019 - Nerve high resolution ultrasonography in Tangier disease (01a Articolo in rivista)
    DI PASQUALE, ANTONELLA; LEONARDI, LUCA; FIONDA, LAURA; VANOLI, FIAMMETTA; GARIBALDI, MATTEO; INGHILLERI, MAURIZIO; CECCANTI, MARCO; CAMBIERI, CHIARA; ONESTI, EMANUELA; ANTONINI, GIOVANNI
  • 11573/1227689 - 2019 - Short-Term Ultramicronized Palmitoylethanolamide Therapy in Patients with Myasthenia Gravis: a Pilot Study to Possible Future Implications of Treatment. (01a Articolo in rivista)
    ONESTI, EMANUELA; FRASCA, VITTORIO; CECCANTI, MARCO; TARTAGLIA, GIORGIO; GORI, MARIA CRISTINA; CAMBIERI, CHIARA; LIBONATI, LAURA; PALMA, ELEONORA; INGHILLERI, MAURIZIO
  • 11573/1227049 - 2019 - Neuromuscular magnetic stimulation counteracts muscle decline in ALS patients: results of a randomized, double-blind, controlled study (01a Articolo in rivista)
    MUSARO', ANTONIO; DOBROWOLNY, GABRIELLA; CAMBIERI, CHIARA; ONESTI, EMANUELA; CECCANTI, MARCO; FRASCA, VITTORIO; PISANO, ANNALINDA; CERBELLI, BRUNA; LEPORE, ELISA; RUFFOLO, GABRIELE; GIORDANO, CARLA; PALMA, ELEONORA; INGHILLERI, MAURIZIO
  • 11573/1268228 - 2019 - HETERONYMOUS H REFLEX IN TEMPORAL MUSCLE AS SIGN OF HYPEREXCITABILITY IN ALS PATIENTS (01a Articolo in rivista)
    LIBONATI, LAURA; CECCANTI, MARCO; CAMBIERI, CHIARA; TARTAGLIA, GIORGIO; ONESTI, EMANUELA; FRASCA, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/1327965 - 2019 - A case of motor neuron involvement in Gaucher disease (01i Case report)
    POZZILLI, VALERIA; GIONA, FIORINA; CECCANTI, MARCO; CAMBIERI, CHIARA; FRASCA, VITTORIO; ONESTI, EMANUELA; LIBONATI, LAURA; DI BARI, SILVIA; FIORINI, IRENE; SANTOPIETRO, MICHELINA; INGHILLERI, MAURIZIO
  • 11573/853615 - 2015 - Afferent nerve ending density in the human laryngeal mucosa: potential implications on endoscopic evaluation of laryngeal sensitivity (01a Articolo in rivista)
    RUOPPOLO, GIOVANNI; SCHETTINO, ILENIA; BIASIOTTA, ANTONELLA; GRECO, ANTONIO; SOLDO, PIETRO; MARCOTULLIO, DARIO; ONESTI, EMANUELA; CECCANTI, MARCO; GIORDANO, CARLA; TRUINI, ANDREA; DE VINCENTIIS, MARCO; INGHILLERI, MAURIZIO
  • 11573/1396999 - 2020 - Muscle involvement in myasthenia gravis: Expanding the clinical spectrum of Myasthenia-Myositis association from a large cohort of patients (01g Articolo di rassegna (Review))
    GARIBALDI, MATTEO; FIONDA, LAURA; VANOLI, FIAMMETTA; LEONARDI, LUCA; LORETI, SIMONA; BUCCI, ELISABETTA; DI PASQUALE, ANTONELLA; MORINO, STEFANIA; MERLONGHI, GIOIA; CECCANTI, MARCO; SALVETTI, MARCO; ANTONINI, GIOVANNI
  • 11573/1397002 - 2020 - Immune checkpoint inhibitors (ICIs)-related ocular myositis (01a Articolo in rivista)
    GARIBALDI, MATTEO; MERLONGHI, GIOIA; CECCANTI, MARCO
  • 11573/1392645 - 2020 - Creatine kinase and progression rate in amyotrophic lateral sclerosis (01a Articolo in rivista)
    CECCANTI, MARCO; POZZILLI, VALERIA; CAMBIERI, CHIARA; LIBONATI, LAURA; ONESTI, EMANUELA; FRASCA, VITTORIO; FIORINI, ILENIA; GARIBALDI, MATTEO; PALMA, ELEONORA; INGHILLERI, MAURIZIO
  • 11573/942739 - 2017 - Effects of visual deprivation on primary motor cortex excitability: a study on healthy subjects based on repetitive transcranial magnetic stimulation. (01a Articolo in rivista)
    CAMBIERI, CHIARA; ONESTI, EMANUELA; CECCANTI, MARCO; FRASCA, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/889938 - 2017 - Vitamina D in Amyotorphic Lateral Sclerosis (01a Articolo in rivista)
    LIBONATI, LAURA; ONESTI, EMANUELA; GORI, MARIA CRISTINA; CECCANTI, MARCO; CAMBIERI, CHIARA; FRASCA, VITTORIO; INGHILLERI, MAURIZIO
  • 11573/1477877 - 2021 - A case of acute motor and sensory axonal neuropathy mimicking brain death (01i Case report)
    LIBONATI, LAURA; FIORINI, ILENIA; CAMBIERI, CHIARA; CECCANTI, MARCO; INGHILLERI, MAURIZIO
  • 11573/1462070 - 2020 - Myoclonic epilepsy, parkinsonism, schizophrenia and left-handedness as common neuropsychiatric features in 22q11.2 deletion syndrome (01a Articolo in rivista)
    FANELLA, MARTINA; FRASCARELLI, MARIANNA; LAMBIASE, CATERINA; MORANO, ALESSANDRA; UNOLT, MARTA; LIBERATI, NATASCIA; FATTOUCH, JINANE; BUZZANCA, ANTONINO; ACCINNI, TOMMASO; CECCANTI, MARCO; VIGANO', ALESSANDRO; BIONDI, MASSIMO; COLONNESE, CLAUDIO; GIALLONARDO, ANNA TERESA; PIZZUTI, ANTONIO; BERARDELLI, ALFREDO
  • 11573/1573092 - 2021 - Bradykinesia in motoneuron diseases (01a Articolo in rivista)
    PAPARELLA, GIULIA; CECCANTI, MARCO; COLELLA, DONATO; CANNAVACCIUOLO, ANTONIO; GUERRA, ANDREA; INGHILLERI, MAURIZIO; BERARDELLI, ALFREDO; BOLOGNA, MATTEO
  • 11573/1571602 - 2021 - Progression of oropharyngeal dysphagia in amyotrophic lateral sclerosis: a retrospective cohort study (01a Articolo in rivista)
    MARIANI, LAURA; RUOPPOLO, GIOVANNI; CILFONE, ARMANDO; COCCHI, CHIARA; LONGO, LUCIA; CECCANTI, MARCO; GRECO, ANTONIO; INGHILLERI, MAURIZIO
  • 11573/1549526 - 2021 - Attrv in lazio-italy: A high-prevalence region in a non-endemic country (01a Articolo in rivista)
    GUGLIELMINO, VALENTINA; ANTONINI, GIOVANNI; CASALI, CARLO; CECCANTI, MARCO; DE GIGLIO, LAURA; GOGLIA, MARTA; INGHILLERI, MAURIZIO; LEONARDI, LUCA; SABATELLI, MARINA
  • 11573/1606399 - 2022 - A novel homozygous mutation in TBK1 gene causing ALS-FTD (01f Lettera, Nota)
    LIBONATI, LAURA; CECCANTI, MARCO; CAMBIERI, CHIARA; MORET, FEDERICA; FIORINI, ILENIA; INGHILLERI, MAURIZIO
  • 11573/1655525 - 2022 - Validation of the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients (01a Articolo in rivista)
    INGHILLERI, MAURIZIO; SICILIANO, GABRIELE; CECCANTI, MARCO; CAMBIERI, CHIARA; LIBONATI, LAURA; FANELLA, GAIA
  • 11573/1652690 - 2022 - Effects of 3,4-diaminopyridine on myasthenia gravis: Preliminary results of an open-label study (01a Articolo in rivista)
    CECCANTI, MARCO; LIBONATI, LAURA; RUFFOLO, GABRIELE; CIFELLI, PIERANGELO; MORET, FEDERICA; FRASCA, VITTORIO; PALMA, ELEONORA; INGHILLERI, MAURIZIO; CAMBIERI, CHIARA
  • 11573/1652602 - 2022 - The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis (01a Articolo in rivista)
    CAMBIERI, CHIARA; LIBONATI, LAURA; MORET, FEDERICA; TARTAGLIA, GIORGIO; GARIBALDI, MATTEO; CHIMENTI, CRISTINA; INGHILLERI, MAURIZIO; CECCANTI, MARCO
  • 11573/1639962 - 2022 - Classical and Unexpected Effects of Ultra-Micronized {PEA} in Neuromuscular Function (01g Articolo di rassegna (Review))
    RUFFOLO, GABRIELE; CECCANTI, MARCO; CAMBIERI, CHIARA; LIBONATI, LAURA; PALMA, ELEONORA; INGHILLERI, MAURIZIO
  • 11573/1656009 - 2020 - TMS nel trattamento della dipendenza da alcool (02a Capitolo o Articolo)
    CECCANTI, MARCO; RIVA, GIUSEPPE; SCARPINO, MAENIA
  • 11573/1655523 - 2022 - Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial (01l Trial clinico)
    INGHILLERI, MAURIZIO; RUSSO, MASSIMO; SICILIANO, GABRIELE; CECCANTI, MARCO; CAMBIERI, CHIARA; LIBONATI, LAURA; MORET, FEDERICA; FRASCA, VITTORIO
  • 11573/1649904 - 2022 - Effects of Skin Stimulation on Sensory-Motor Networks Excitability: Possible Implications for Physical Training in Amyotrophic Lateral Sclerosis (01a Articolo in rivista)
    CECCANTI, MARCO; CAMBIERI, CHIARA; LIBONATI, LAURA; TARTAGLIA, GIORGIO; MORET, FEDERICA; GARIBALDI, MATTEO; INGHILLERI, MAURIZIO
  • 11573/1357062 - 2020 - Isolated Bilateral Tapia’s syndrome after several oro-tracheal intubations: anatomical and pathophysiological considerations (01a Articolo in rivista)
    DE MICHELE, MANUELA; LETTERI, FEDERICA; SPAGNOLELLO, ORNELLA; CECCANTI, MARCO; CAMBIERI, CHIARA; INGHILLERI, MAURIZIO; FALCOU, ANNE ALBERTINE; ANTONIOZZI, ANGELO; TONI, DANILO
  • 11573/1582785 - 2021 - PREVALENCE OF AMYOTROPHIC LATERAL SCLEROSIS IN LATIUM REGION (ITALY) (01a Articolo in rivista)
    DI PUCCHIO, ALESSANDRA; INGHILLERI, MAURIZIO; LIBONATI, LAURA; CECCANTI, MARCO; VANACORE, NICOLA

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