Marco Bettiol

Dottore di ricerca

ciclo: XXXIV


supervisore: prof. Roberto Pani

Titolo della tesi: Body K-Tomography

The biological issue addressed The potassium (K) monitoring is crucial to diagnose the serious manifestations of hypokalemia and hyperkalaemia, which can involve several diseases, often life-threatening, such as muscle weakness or paralysis, cardiac conduction abnormalities or arrhythmias. Covid-19 has recently been found to cause hypokalemia, too. Unfortunately, the currently available methods for K monitoring are based on in vitro measurements, and so a real-time monitoring is not allowed. Herein the first non-invasive wearable detector, which measures in vivo potassium, is proposed. It uses the intrinsic radioactivity of one K isotope, the 40K, in equilibrium with stable isotopes 39K and 41K. Therefore neither invasive nor additional radiation are needed, only the one already present in human body. Moreover, it performs a direct in-vivo measurement on intracellular K, ensuring a higher accuracy and allowing a continuous monitoring of patient potassium, remotely too. Results The proposed detector is composed by five NaI scintillators (diameter 2.5cm, length 10cm) optionally coupled to 5 Silicon Photo Multiplier arrays. A feasibility study of such detector, placed close to human liver, was carried out. First, the radiation background was estimated, both with theoretical evaluation (520 gamma/s) and with experimental measurements (220 gamma/s). Then, detection and geometrical efficiency were assessed. The geometrical efficiency estimation was obtained with the computational human phantoms (also known as voxel phantoms), from CTs of real patients. In the CT images of these patients, the segmentation of organs with not negligible potassium amount was carried out. With a statistical method, based on the isotropic generation of 1k gamma events and on the count of photons impinging on the detector, it was possible to assess geometrical efficiency. The detector position relative to patient was finally selected, in order to maximize geometrical efficiency. The overall efficiency resulted 0.2%. The comparison of the amount of K used for detection, between the proposed method and the standard method based on the blood sampling, was reported. In the first case the detector gets information from 8.3g of K, mainly present in the liver and in muscles, which lead to a concentration of 0.54 mg of K per Kg, taking into account the detector efficiency. In the latter case, the information comes from the sample (5ml) of serum, where the K concentration is 120 mg/l. Assuming a 100% efficiency, the K used in this electrochemical measurement is 0.6mg. Since the project goal is the early hypokalemia diagnosis, as required for the quick treatment of the covid patient, the detector has been tested for the detection of pathological potassium reduction (for moderate hypokalemia the reduction is above 25%). To test the discrimination between the measurements with and without K reduction, the parametric Z test was used. The minimum detectable activity as a function of measuring time, pathological potassium reduction and confidence level has finally been obtained. Conclusions Herein a proposal of the first non invasive wearable in vivo intracelullar potassium measuring detector is reported. It has been designed overcoming many experimental challenges, first of all low counts 40K activity, thanks to a trade off for several problems as cheapness, weight and signal (human 40K radioactive emissions) to noise (background radiation) ratio. It will be particularly useful for territorial health structures, because they will be able to monitor the bedridden patient from their home. Costly and unnecessary mass hospitalizations will therefore be avoided.

Produzione scientifica

11573/1392115 - 2020 - Characterization of monolithic GAGG:Ce coupled to both PMT and SiPM array for gamma imaging in nuclear medicine
Pani, R.; Pergola, A.; Bettiol, M.; Longo, M.; Polito, C.; Falconi, R.; De Sio, L.; Pontico, M.; Pani, P.; Indovina, L.; Vincentis, G. De; Pellegrini, R.; Frantellizzi, V. - 04c Atto di convegno in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. 1-9 - issn: 1748-0221 - wos: WOS:000534740600011 (2) - scopus: 2-s2.0-85085740370 (3)
congresso: 15th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD) (Siena Italy)

11573/1416860 - 2020 - Imaging performance dependence on crystal absorption properties: the CRY018 and CRY019 comparison
Pellegrini, R.; Camera, F.; Polito, C.; Falconi, R.; Bettiol, M.; Longo, M.; De Vincentis, G.; Indovina, L.; Pani, R.; Frantellizzi, V. - 04c Atto di convegno in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. 1-11 - issn: 1748-0221 - wos: WOS:000545343400014 (2) - scopus: 2-s2.0-85086015681 (1)
congresso: 15th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD) (Siena, ITALY)

11573/1389744 - 2019 - Novel Gamma Tracker for Rapid Radiation Direction Detection for UAV Drone Use
Pani, R.; Camera, F.; Pergola, A.; Polito, C.; Falconi, R.; Franciosini, G.; Longo, M.; Bettiol, M.; Frantellizzi, V.; De Vincentis, G.; Pani, A. - 01a Articolo in rivista
rivista: IEEE TRANSACTIONS ON NUCLEAR SCIENCE (IEEE / Institute of Electrical and Electronics Engineers Incorporated:445 Hoes Lane:Piscataway, NJ 08854:(800)701-4333, (732)981-0060, EMAIL: subscription-service@ieee.org, INTERNET: http://www.ieee.org, Fax: (732)981-9667) pp. 1-3 - issn: 0018-9499 - wos: WOS:000569982800235 (0) - scopus: 2-s2.0-85083593438 (0)

11573/1041617 - 2017 - LaBr3:Ce and NaI:Tl performance comparison for single photon emission detector
Bettiol, Marco; Preziosi, Enrico; Borrazzo, Cristian; Polito, Claudia; Aria Nerina Cinti, M.; Pellegrini, Rosanna; Pani, Roberto - 01a Articolo in rivista
rivista: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0168-9002 - wos: WOS:000453717200040 (2) - scopus: 2-s2.0-85037044189 (3)

11573/1071458 - 2017 - Monte carlo simulation to evaluate factors affecting imaging performances of compact scintillation gamma camer
Borrazzo, Cristian; Bettiol, Marco; Bennati, Paolo; Preziosi, Enrico; Fabbri, Andrea; Scafe, Raffaele; Pellegrini, Rosanna; Pani, Roberto - 04b Atto di convegno in volume
congresso: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 (Strasbourg, France)
libro: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 - (9781509016426)

11573/1071460 - 2017 - PET and MRI-guided focused ultrasound surgery for neurological applications
Borrazzo, Cristian; Preziosi, Enrico; Borasi, Giovanni; Bettiol, Marco; Sanchez, Sebastian; Carn, Marco; Castro, Elisabetta Di; Gonzalez, Antonio J.; Bennati, Paolo; Gonzalez-Montoro, Andrea; Napoli, Alessandro; Pellegrini, Rosanna; Pani, Roberto - 04b Atto di convegno in volume
congresso: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 (Strasbourg, France)
libro: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 - (9781509016426)

11573/1071461 - 2017 - Performance evaluation of the MindView PET using GATE and STIR
Sanchez, Sebastian; Preziosi, Enrico; González, Antonio J.; Conde, Pablo; Iborra, Amadeo; Moliner, Laura; Borrazzo, Cristian; Aguilar, Albert; Bellido, Pablo; Díaz-Caballero, Elena; García-Garrigos, Juan J.; Grau-Ruiz, Daniel; González-Montoro, Andrea; Rigla, Juan P.; Rodríguez-Álvarez, María J.; Seimetz, Michael; Sánchez, Filomeno; Bettiol, Marco; Soriano, Antonio; Pani, Roberto; Correcher, Carlos; Benlloch, José M. - 04b Atto di convegno in volume
congresso: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 (Strasbourg, France)
libro: 2016 IEEE Nuclear Science Symposium, Medical Imaging Conference and Room-Temperature Semiconductor Detector Workshop, NSS/MIC/RTSD 2016 - (9781509016426)

11573/923227 - 2016 - A Depth-of-Interaction encoding method for SPECT monolithic scintillation detectors
Bettiol, Marco; Preziosi, Enrico; Borrazzo, Cristian; Cassano, Bartolomeo; Polito, Claudia; Pellegrini, Rosanna; Pani, Roberto; Maria Nerina, Cinti; Andrea, Fabbri - 04c Atto di convegno in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. - - issn: 1748-0221 - wos: WOS:000395731900054 (3) - scopus: 2-s2.0-85008428227 (5)
congresso: 18th International Workshop on Radiation Imaging Detectors (Barcellona)

11573/874841 - 2016 - Depth-of-interaction discrimination to correct parallax error in high resolution PET
Bettiol, Marco; Preziosi, Enrico; Borrazzo, Cristian; Cinti, Maria Nerina; Gonzalez, A. J.; Pani, Roberto - 01a Articolo in rivista
rivista: PHYSICA MEDICA (UK: Elsevier Pisa: Istituti Editoriali e Poligrafici Internazionali. Pisa Italy: Giardini Editori Stampatori) pp. 98- - issn: 1120-1797 - wos: (0) - scopus: (0)

11573/1071359 - 2016 - The MINDView brain PET detector, feasibility study based on SiPM arrays
González, Antonio J.; Majewski, Stan; Sánchez, Filomeno; Aussenhofer, Sebastian; Aguilar, Albert; Conde, Pablo; Hernández, Liczandro; Vidal, Luis F.; Pani, Roberto; Bettiol, Marco; Fabbri, Andrea; Bert, Julien; Visvikis, Dimitris; Jackson, Carl; Murphy, John; O'neill, Kevin; Benlloch, Jose M. - 01a Articolo in rivista
rivista: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 82-90 - issn: 0168-9002 - wos: WOS:000371768400013 (53) - scopus: 2-s2.0-84959562136 (57)

11573/856702 - 2016 - Position algorithm for monolithic scintillation crystals based on charge projection readout
Pani, Roberto; Bettiol, Marco; Preziosi, Enrico; Cinti, Maria Nerina; Borrazzo, Cristian; Pellegrini, Rosanna; Castro, E. Di; Fabbri, Andrea - 01a Articolo in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. C01061-C01061 - issn: 1748-0221 - wos: WOS:000371469800061 (15) - scopus: 2-s2.0-84957017483 (15)

11573/922221 - 2016 - A crystal identification method for mo- nolithic phoswich detectors based on scintillation light distribution
Preziosi, Enrico; Polito, Claudia; Bettiol, Marco; Borrazzo, Cristian; Pellegrini, Rosanna; Pani, Roberto - 01a Articolo in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. - - issn: 1748-0221 - wos: WOS:000395732500009 (2) - scopus: 2-s2.0-85008239837 (2)

11573/935757 - 2016 - Performance study of a PET scanner based on monolithic scintillators for different DoI-dependent methods
Preziosi, Enrico; Sánchez, S.; González, A. J.; Pani, Roberto; Borrazzo, Cristian; Bettiol, Marco; Rodriguez Alvarez, M. J.; González Montoro, A.; Moliner, L.; Benlloch, J. M. - 01a Articolo in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. C12076-C12076 - issn: 1748-0221 - wos: WOS:000395731900076 (3) - scopus: 2-s2.0-85008168846 (4)

11573/856753 - 2015 - A Novel Method for Y Photons Depth of Interaction Discrimination on Monolithic LYSO Crystals for Brain PET/MRI
Pani, Roberto; Bettiol, Marco; Preziosi, E.; Borrazzo, Cristian; Pellegrini, Rosanna; Gonzalez, A. J.; Conde, P.; Cint, M. N.; Fabbri, Andrea; Di Castro, Elisabetta; Majewski, S. - 04f Poster
congresso: PSMR 2015: 4th Conference on PET/MR and SPECT/MR (La Biodola, Isola d ’ Elba, Italy.)

11573/856707 - 2015 - A novel method for γ photons depth of interaction discrimination on monolithic LYSO crystals for brain PET/MRI
Pani, Roberto; Bettiol, Marco; Preziosi, Enrico; Borrazzo, Christian; Pellegrini, Rosanna; Gonzalez, Antonio; Conde, Pablo; Cinti, Maria Nerina; Fabbri, Andrea; Di Castro, Elisabetta; Majewski, Stan - 04c Atto di convegno in rivista
rivista: EJNMMI RESEARCH (Heidelberg ; Berlin : Springer) pp. A11- - issn: 2191-219X - wos: (0) - scopus: (0)
congresso: PSMR 2015: 4th Conference on PET/MR and SPECT/MR (La Biodola, Isola d ’ Elba, Italy.)

11573/856706 - 2015 - Preliminary evaluation of a monolithic detector module for integrated PET/MRI scanner with high spatial resolution
Pani, Roberto; Gonzalez, A. J.; Bettiol, Marco; Fabbri, Andrea; Cinti, Maria Nerina; Preziosi, Enrico; Borrazzo, Cristian; Conde, P.; Pellegrini, Rosanna; Castro, E. Di; Majewski, S. - 01a Articolo in rivista
rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. C06006-C06006 - issn: 1748-0221 - wos: WOS:000358004200006 (21) - scopus: 2-s2.0-84936971971 (26)

11573/1071394 - 2014 - A novel brain PET insert for the MINDView project
Gonzalez, Antonio J.; Sanchez, Filomeno; Conde, Pablo; Aussenhofer, Sebastian; Gareis, Daniel; Pani, Roberto; Pellegrini, Rossana; Bettiol, Marco; Fabbri, Andrea; Majewski, Stan; Bauer, Christian; Stolin, Alexander; Martone, Peter; Bert, Julien; Visvikis, Dimitris; Jackson, Carl; Murphy, John; O'neill, Kevin; Benlloch, Jose M. - 01a Articolo in rivista
rivista: IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD (Piscataway, NJ : IEEE Service Center, c1997-) pp. 1-4 - issn: 1095-7863 - wos: WOS:000392917500141 (0) - scopus: 2-s2.0-84965060867 (7)

11573/460855 - 2012 - New position arithmetic for scintillation camera based on floating weight system
Pani, Roberto; Cinti, Maria Nerina; Paolo, Bennati; Pellegrini, Rosanna; Raffaele, Scafe; Bettiol, Marco; Chiara, Marchioni; Sergio Lo Meo, ; Fabbri, Andrea - 04b Atto di convegno in volume
congresso: 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 (Valencia, SPAIN)

11573/460776 - 2012 - Continuous DoI determination by gaussian modelling of linear and non-linear scintillation light distributions
Pani, Roberto; Nourbakhsh, Shervin; Priscilla, Pani; Bennati, Paolo; Sergio Lo Meo, ; Cinti, Maria Nerina; Pellegrini, Rosanna; Bartolomeo, Cassano; Bettiol, Marco; Raffaele, Scafe - 04b Atto di convegno in volume
congresso: 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 (Valencia, SPAIN)

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