LUISA SEGUELLA

PhD Graduate

PhD program:: XXXIII



Thesis title: Enteric glia: a heterogeneous population of peripheral neuroglia that link the “gut wellness to brain wellness”

The enteric nervous system (ENS) is an integrative neural network that provides local control over essential gastrointestinal (GI) functions, i.e. motility, secretion, nutrients absorption, and blood flow, along with other critically relevant processes, as immune and endocrine responses, host-microbes interaction, and epithelial barrier integrity. This vast repertoire of homeostatic functions is fulfilled through “brain-like” neural circuitry composed of neurons and glia. New data showed that bi-directional communication between enteric neurons and enteric glia influences the output of enteric neurocircuits in the ENS. This is beginning to transform the view of normal enteric circuits function, regulatory mechanisms implicate in gut health and disease, as well as of the gut-brain axis signaling. Enteric glia are a large and heterogeneous population of peripheral neuroglia that are associated with the cell bodies and processes of enteric neurons throughout the digestive tract. The antiquated concept of glia as supportive passive cells has been overtaken by unveiling enteric glia as one of the most dynamic components in the ENS. Enteric glia regulate all major GI functions via multiple bi-directional crosstalks with neurons and other cell types present in the intestinal wall. Furthermore, enteric glia are recently emerged as an active player in gut-brain signaling, suggesting that they might impact even on brain functions. Likewise, enteric glia display phenotypic changes that contribute to diverse disease processes including neuroinflammation, cancer, and infection, where glia acquire pro-inflammatory or pro-tumorigenic phenotypes. Alterations of the glial network occur in several GI pathologies and various extragastrointestinal diseases, whereby both losses and gains of glial functions contribute to altering ENS homeostasis and gut-brain signaling. The aim of the present thesis is to highlight the glial heterogeneity and plasticity that should be considered when investigating enteric glia involvement in controlling GI homeostasis and functions and, also, in the pathophysiology of intestinal diseases. Furthermore, to confirm the effect of enteric glia on central and peripheral neuroinflammatory events, I reported the effects of how reactive gliosis mitigation in the intestine improves neuropathological changes both in the ENS and central nervous system (CNS), as well as the mood dysfunction in a murine model of a high-fat diet (HFD)-induced leaky gut.

Research products

11573/1717257 - 2024 - Clinical and nutritional correlates associated with weight changes in achalasia patients and the impact of laparoscopic Heller myotomy
Aurino, Laura; Pesce, Marcella; Rurgo, Sara; Giovanna Puoti, Maria; Polese, Barbara; Capuano, Marianna; Palomba, Giuseppe; Aprea, Giovanni; Seguella, Luisa; Esposito, Giuseppe; Palenca, Irene; Efficie, Eleonora; Sarnelli, Giovanni - 01a Articolo in rivista
paper: DIGESTIVE AND LIVER DISEASE (Roma: Editrice Gastroenterologica Italiana; Milano: Elsevier) pp. - - issn: 1878-3562 - wos: (0) - scopus: (0)

11573/1712241 - 2024 - Gut-directed therapy in Parkinson’s disease
Benvenuti, Laura; Di Salvo, Clelia; Bellini, Gabriele; Seguella, Luisa; Rettura, Francesco; Esposito, Giuseppe; Antonioli, Luca; Ceravolo, Roberto; Bernardini, Nunzia; Pellegrini, Carolina; Fornai, Matteo - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. 1-22 - issn: 1663-9812 - wos: (0) - scopus: (0)

11573/1706611 - 2024 - Intranasal delivery of PEA-producing Lactobacillus paracasei F19 alleviates SARSCoV- 2 spike protein-induced lung injury in mice
Del Re, Alessandro; Basili Franzin, Silvia; Lu, Jie; Palenca, Irene; Zilli, Aurora; Pepi, Federico; Troiani, Anna; Seguella, Luisa; Pesce, Marcella; Esposito, Giovanni; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: TRANSLATIONAL MEDICINE COMMUNICATIONS (London : BioMed Central) pp. - - issn: 2396-832X - wos: (0) - scopus: (0)

11573/1718046 - 2024 - N-palmitoyl-D-glucosamine limits mucosal damage and VEGFmediated angiogenesis by PPARα-dependent suppression of pAkt/mTOR/HIF1α pathway and increase in PEA levels in AOM/DSS colorectal carcinoma in mice
Palenca, Irene; Basili Franzin, Silvia; Zilli, Aurora; Seguella, Luisa; Troiani, Anna; Pepi, Federico; Vincenzi, Martina; Giugliano, Giuseppe; Catapano, Viviana; Di Filippo, Italia; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: PHYTOTHERAPY RESEARCH (New York : J. Wiley) pp. - - issn: 1099-1573 - wos: (0) - scopus: (0)

11573/1706612 - 2024 - Intranasal administration of Escherichia coli Nissle expressing the spike protein of SARS-CoV-2 induces long-term immunization and prevents spike protein-mediated lung injury in mice
Sarnelli, Giovanni; Del Re, Alessandro; Palenca, Irene; Basili Franzin, Silvia; Lu, Jie; Seguella, Luisa; Zilli, Aurora; Pesce, Marcella; Rurgo, Sara; Esposito, Giovanni; Sanseverino, Walter; Esposito, Giuseppe - 01a Articolo in rivista
paper: BIOMEDICINE & PHARMACOTHERAPY (Paris: Elsevier, 2002-) pp. - - issn: 1950-6007 - wos: WOS:001217302100001 (0) - scopus: (0)

11573/1697149 - 2023 - New blood-brain-barrier permeable compounds as Naegleria Fowleri CYP51 inhibitors.
Arpacioglu, M.; Madia, V. N.; Ialongo, D.; Patacchini, E.; Messore, A.; Tudino, V.; Sharma, V.; Nguyen, J.; Debnath, A.; Podust, L.; Palenca, I.; Basili Franzin, S.; Seguella, L.; Esposito, G.; Petrucci, R.; Di Matteo, P.; Bortolami, M.; Scipione, L.; Costi, R.; Di Santo, R. - 04f Poster
conference: XXVIII edition of the National Meeting on Medicinal Chemistry (Chieti; Italy)
book: XXVIII edition of the National Meeting on Medicinal Chemistry - ()

11573/1683625 - 2023 - BQ788 Reveals Glial ETBR Modulation of Neuronal Cholinergic and Nitrergic Pathways to Inhibit Intestinal Motility: ETBR Signaling is Linked to POI
Mazzotta, E; Grants, I; Villalobos-Hernandez, E; Chaudhuri, S; Mcclain, J L; Seguella, L; Kendig, D M; Blakeney, B A; Murthy, K S; Schneider, Reiner; Leven, Patrick; Wehner, Sven; Harzman, A; Grider, J R; Gulbransen, B D; Christofi, F L - 01a Articolo in rivista
paper: BRITISH JOURNAL OF PHARMACOLOGY (Basingstoke: Nature Publishing Group London: Macmillan, 1968-) pp. - - issn: 0007-1188 - wos: WOS:001015963200001 (3) - scopus: 2-s2.0-85162876250 (3)

11573/1697513 - 2023 - Intrarectal Administration of Adelmidrol plus Hyaluronic Acid Gel Ameliorates Experimental Colitis in Mice and Inhibits Pro-Inflammatory Response in Ex Vivo Cultured Biopsies Derived from Ulcerative Colitis-Affected Patients
Palenca, Irene; Seguella, Luisa; Zilli, Aurora; Basili Franzin, Silvia; Del Re, Alessandro; Pepi, Federico; Troiani, Anna; Pesce, Marcella; Rurgo, Sara; Domenica Elisa De Palma, Fatima; Luglio, Gaetano; Paola Tropeano, Francesca; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001140546600001 (0) - scopus: 2-s2.0-85181903361 (0)

11573/1666934 - 2023 - S100B Affects Gut Microbiota Biodiversity
Romano Spica, Vincenzo; Valeriani, Federica; Orsini, Massimiliano; Elisabetta Clementi, Maria; Seguella, Luisa; Gianfranceschi, Gianluca; Di Liddo, Rosa; Di Sante, Gabriele; Ubaldi, Francesca; Ria, Francesco; Esposito, Giuseppe; Michetti, Fabrizio - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000932876700001 (8) - scopus: 2-s2.0-85147894603 (7)

11573/1675662 - 2023 - Oral Immunization with Escherichia coli Nissle 1917 Expressing SARS-CoV-2 Spike Protein Induces Mucosal and Systemic Antibody Responses in Mice
Sarnelli, Giovanni; Del Re, Alessandro; Pesce, Marcella; Lu, Jie; Esposito, Giovanni; Sanseverino, Walter; Corpetti, Chiara; Basili Franzin, Silvia; Seguella, Luisa; Palenca, Irene; Rurgo, Sara; Domenica, Fatima; De Palma, Elisa; Zilli, Aurora; Esposito, Giuseppe - 01a Articolo in rivista
paper: BIOMOLECULES (Basel: MDPI) pp. - - issn: 2218-273X - wos: WOS:000954229800001 (5) - scopus: 2-s2.0-85151110597 (6)

11573/1683624 - 2023 - Mini-review: Interaction between intestinal microbes and enteric glia in health and disease
Seguella, Luisa; Palenca, Irene; Basili Franzin, Silvia; Zilli, Aurora; Esposito, Giuseppe - 01g Articolo di rassegna (Review)
paper: NEUROSCIENCE LETTERS (Limerick Ireland: Elsevier Science Ireland Limited) pp. - - issn: 0304-3940 - wos: WOS:000984005600001 (7) - scopus: 2-s2.0-85152137816 (8)

11573/1696092 - 2023 - Miconazole-like scaffold is a promising lead for Naegleria fowleri-specific CYP51 inhibitors
Sharma, Vandna; Madia, Valentina Noemi; Tudino, Valeria; V Nguyen, Jennifer; Debnath, Anjan; Messore, Antonella; Ialongo, Davide; Patacchini, Elisa; Palenca, Irene; Basili Franzin, Silvia; Seguella, Luisa; Esposito, Giuseppe; Petrucci, Rita; Di Matteo, Paola; Bortolami, Martina; Saccoliti, Francesco; Di Santo, Roberto; Scipione, Luigi; Costi, Roberta; M Podust, Larissa - 01a Articolo in rivista
paper: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 17059-17073 - issn: 0022-2623 - wos: WOS:001134079100001 (2) - scopus: 2-s2.0-85180091142 (2)

11573/1691502 - 2023 - PHARMACOGNOSY, PHYTOTHERAPY AND ENTERIC SYSTEM PHARMACOLOGY: INNOVATIVE APPROACHES FOR GREEN PHARMACOLOGICAL STRATEGIES
Vitalone, Annabella; Di Sotto, Antonella; Di Giacomo, Silvia; Gullì, Marco; Percaccio, Ester; Seguella, Luisa; Corpetti, Chiara; Del Re, Alessandro; Palenca, Irene; Basili Franzin, Silvia; Esposito, Giuseppe - 04f Poster
conference: La Facoltà di Farmacia e Medicina presenta le attività di ricerca scientifica dei Dipartimenti di afferenza (Roma)
book: La Facoltà di Farmacia e Medicina presenta le attività di ricerca scientifica dei Dipartimenti di afferenza - ()

11573/1637865 - 2022 - LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction
Ahmadzai, Mohammad M.; Mcclain, Jonathon L.; Dharshika, Christine; Seguella, Luisa; Giancola, Fiorella; De Giorgio, Roberto; Gulbransen, Brian D. - 01a Articolo in rivista
paper: THE JOURNAL OF CLINICAL INVESTIGATION (American Society for Clinical Investigation:PO Box 7226:Ann Arbor, MI 48107:(734)222-6050, EMAIL: rhickman@the-jci.org, INTERNET: http://www.jci.org, Fax: (734)222-6058) pp. - - issn: 0021-9738 - wos: WOS:000759463100006 (13) - scopus: 2-s2.0-85124609147 (13)

11573/1629080 - 2022 - Nutraceuticals and diet supplements in Crohn’s Disease. A general overview of the most promising approaches in the clinic
De Conno, Barbara; Pesce, Marcella; Chiurazzi, Martina; Andreozzi, Marta; Rurgo, Sara; Corpetti, Chiara; Seguella, Luisa; Del Re, Alessandro; Palenca, Irene; Esposito, Giuseppe; Giovanni Sarnelli, And - 01g Articolo di rassegna (Review)
paper: FOODS (Basel: MDPI) pp. 1-18 - issn: 2304-8158 - wos: WOS:000781548000001 (7) - scopus: 2-s2.0-85128696792 (8)

11573/1637859 - 2022 - Oral Adelmidrol Administration Up-Regulates Palmitoylethanolamide Production in Mice Colon and Duodenum through a PPAR-γ Independent Action
Del Re, Alessandro; Palenca, Irene; Seguella, Luisa; Pesce, Marcella; Corpetti, Chiara; Steardo, Luca; Rurgo, Sara; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: METABOLITES (Basel : MDPI) pp. - - issn: 2218-1989 - wos: WOS:000803226800001 (5) - scopus: 2-s2.0-85130866662 (4)

11573/1652976 - 2022 - N-Palmitoyl-D-Glucosamine Inhibits TLR-4/NLRP3 and Improves DNBS-Induced Colon Inflammation through a PPAR-α-Dependent Mechanism
Palenca, Irene; Seguella, Luisa; Del Re, Alessandro; Basili Franzin, Silvia; Corpetti, Chiara; Pesce, Marcella; Rurgo, Sara; Steardo, Luca; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: BIOMOLECULES (Basel: MDPI) pp. - - issn: 2218-273X - wos: WOS:000846201600001 (11) - scopus: 2-s2.0-85137125391 (11)

11573/1637861 - 2022 - Next-Generation Probiotics for Inflammatory Bowel Disease
Pesce, Marcella; Seguella, Luisa; Del Re, Alessandro; Lu, Jie; Palenca, Irene; Corpetti, Chiara; Rurgo, Sara; Sanseverino, Walter; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000803187100001 (13) - scopus: 2-s2.0-85129900111 (16)

11573/1650662 - 2022 - Sleeve Gastrectomy-Induced Body Mass Index Reduction Increases the Intensity of Taste Perception’s and Reduces Bitter-Induced Pleasantness in Severe Obesity
Rurgo, Sara; Cantone, Elena; Pesce, Marcella; Efficie, Eleonora; Musella, Mario; Polese, Barbara; De Conno, Barbara; Pagliaro, Marta; Seguella, Luisa; Guida, Bruna; Esposito, Giuseppe; Sarnelli, Giovanni - 01a Articolo in rivista
paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. - - issn: 2077-0383 - wos: WOS:000831978800001 (3) - scopus: 2-s2.0-85133730110 (4)

11573/1661236 - 2022 - Functional Intraregional and Interregional Heterogeneity between Myenteric Glial Cells of the Colon and Duodenum in Mice
Seguella, Luisa; Mcclain, Jonathon L; Esposito, Giuseppe; Gulbransen, Brian D - 01a Articolo in rivista
paper: THE JOURNAL OF NEUROSCIENCE (Washington, D.C. : Society for Neuroscience, c1981-) pp. 8694-8708 - issn: 1529-2401 - wos: WOS:000903701700010 (11) - scopus: 2-s2.0-85142012176 (12)

11573/1580250 - 2021 - Circuit-specific enteric glia regulate intestinal motor neurocircuits
Ahmadzai, M. M.; Seguella, L.; Gulbransen, B. D. - 01a Articolo in rivista
paper: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (National Academy of Sciences:2101 Constitution Avenue Northwest:Washington, DC 20418:(877)314-2253, (615)377-3322, EMAIL: subspnas@nas.edu, INTERNET: http://www.pnas.org, Fax: (615)377-0525) pp. 1-12 - issn: 0027-8424 - wos: WOS:000710707500019 (28) - scopus: 2-s2.0-85116327775 (26)

11573/1580164 - 2021 - Cannabidiol inhibits SARS-Cov-2 spike (S) protein-induced cytotoxicity and inflammation through a PPARγ-dependent TLR4/NLRP3/Caspase-1 signaling suppression in Caco-2 cell line
Corpetti, Chiara; Del Re, Alessandro; Seguella, Luisa; Palenca, Irene; Rurgo, Sara; De Conno, Barbara; Pesce, Marcella; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: PHYTOTHERAPY RESEARCH (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 1-11 - issn: 0951-418X - wos: WOS:000706541700001 (38) - scopus: 2-s2.0-85116901609 (43)

11573/1566802 - 2021 - Ultramicronized palmitoylethanolamide inhibits NLRP3 inflammasome expression and pro-inflammatory response activated by SARS-CoV-2 spike protein in cultured murine alveolar macrophages
Del Re, Alessandro; Corpetti, Chiara; Pesce, Marcella; Seguella, Luisa; Steardo, Luca; Palenca, Irene; Rurgo, Sara; De Conno, Barbara; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: METABOLITES (Basel : MDPI) pp. 1-13 - issn: 2218-1989 - wos: WOS:000701736000001 (19) - scopus: 2-s2.0-85114748844 (21)

11573/1545987 - 2021 - A palmitoylethanolamide producing lactobacillus paracasei improves clostridium difficile toxin a-induced colitis
Esposito, Giuseppe; Corpetti, Chiara; Pesce3, Marcella; Seguella, Luisa; Annunziata, Giuseppe; Del Re, Alessandro; Vincenzi, Martina; Lattanzi, Roberta; Lu, Jie; Sanseverino, Walter; Sarnelli, Giovanni - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. 1-13 - issn: 1663-9812 - wos: WOS:000648986000001 (5) - scopus: 2-s2.0-85105612462 (6)

11573/1518802 - 2021 - Engineered Lactobacillus paracasei Producing Palmitoylethanolamide (PEA) Prevents Colitis in Mice
Esposito, Giuseppe; Pesce, Marcella; Seguella, Luisa; Lu, Jie; Corpetti, Chiara; Del Re, Alessandro; Domenica Elisa De Palma, Fatima; Esposito, Giovanni; Sanseverino, Walter; Sarnelli, Giovanni - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000645704200001 (16) - scopus: 2-s2.0-85102431059 (17)

11573/1586257 - 2021 - Role of Enteric Glia as Bridging Element between Gut Inflammation and Visceral Pain Consolidation during Acute Colitis in Rats
Lucarini, Elena; Seguella, Luisa; Vincenzi, Martina; Parisio, Carmen; Micheli, Laura; Toti, Alessandra; Corpetti, Chiara; Del Re, Alessandro; Squillace, Silvia; Maftei, Daniela; Lattanzi, Roberta; Ghelardini, Carla; Di Cesare Mannelli, Lorenzo; Esposito, Giuseppe - 01a Articolo in rivista
paper: BIOMEDICINES (Basel: MDPI) pp. 1-15 - issn: 2227-9059 - wos: WOS:000726682500001 (13) - scopus: 2-s2.0-85119678308 (16)

11573/1438201 - 2021 - Lathyrus sativus diamine oxidase reduces clostridium difficile toxin a-induced toxicity in caco-2 cells by rescuing rhoa-gtpase and inhibiting pp38-mapKknf-κb/hif-1α activation
Pietrangeli, Paola; Corpetti, Chiara; Seguella, Luisa; Del Re, Alessandro; Pesce, Marcella; Vincenzi, Martina; Lori, Chiara; Annunziata, Giuseppe; A Mateescu, Mircea; Sarnelli, Giovanni; Esposito, Giuseppe; Marcocci, Lucia - 01a Articolo in rivista
paper: PHYTOTHERAPY RESEARCH (New York : J. Wiley) pp. 415-423 - issn: 1099-1573 - wos: WOS:000567717700001 (3) - scopus: 2-s2.0-85090792133 (5)

11573/1462600 - 2021 - Impaired duodenal palmitoylethanolamide release underlies acid-induced mast cell activation in functional dyspepsia
Sarnelli, Giovanni; Pesce, Marcella; Seguella, Luisa; Lu, Jie; Efficie, Eleonora; Tack, Jan; Domenica Elisa De Palma, Fatima; D'alessandro, Alessandra; Esposito, Giuseppe - 01a Articolo in rivista
paper: CMGH (New York : Elsevier) pp. 841-855 - issn: 2352-345X - wos: WOS:000621254400012 (12) - scopus: 2-s2.0-85100169505 (13)

11573/1561613 - 2021 - Enteric glial biology, intercellular signaling, and roles in gastrointestinal disease
Seguella, Luisa; D Gulbransen, Brian - 01g Articolo di rassegna (Review)
paper: NATURE REVIEWS. GASTROENTEROLOGY & HEPATOLOGY (London : Nature Publishing Group, 2009-) pp. - - issn: 1759-5045 - wos: WOS:000629854800001 (131) - scopus: 2-s2.0-85102991345 (144)

11573/1548098 - 2021 - High-fat diet impairs duodenal barrier function and elicits glia-dependent changes along the gut-brain axis that are required for anxiogenic and depressive-like behaviors
Seguella, Luisa; Pesce, Mirella; Capuano, Riccardo; Casano, Fabrizio; Pesce, Marcella; Corpetti, Chiara; Vincenzi, Martina; Maftei, Daniela; Lattanzi, Roberta; Del Re, Alessandro; Sarnelli, Giovanni; Gulbransen, Brian D.; Esposito, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF NEUROINFLAMMATION (London : BioMed Central.) pp. 1-17 - issn: 1742-2094 - wos: WOS:000656975100001 (24) - scopus: 2-s2.0-85105796293 (30)

11573/1408445 - 2020 - The potential of cannabidiol in the COVID-19 pandemic.
Esposito, Giuseppe; Pesce, Marcella; Seguella, Luisa; Sanseverino, Walter; Lu, Jie; Corpetti, Chiara; Sarnelli, Giovanni - 01f Lettera, Nota
paper: BRITISH JOURNAL OF PHARMACOLOGY (Basingstoke: Nature Publishing Group London: Macmillan, 1968-) pp. - - issn: 0007-1188 - wos: WOS:000548683700001 (79) - scopus: 2-s2.0-85088127133 (87)

11573/1466526 - 2020 - Phytotherapics in COVID19: why palmitoylethanolamide?
Pesce, M.; Seguella, L.; Cassarano, S.; Aurino, L.; Sanseverino, W.; Lu, J.; Corpetti, C.; Del Re, A.; Vincenzi, M.; Sarnelli, G.; Esposito, G. - 01g Articolo di rassegna (Review)
paper: PHYTOTHERAPY RESEARCH (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. - - issn: 0951-418X - wos: WOS:000596645100001 (13) - scopus: 2-s2.0-85097307819 (14)

11573/1408443 - 2020 - Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion?
Pesce, Marcella; Esposito, Giuseppe; Seguella, Luisa; Sanseverino, Walter; Lu, Jie; Sarnelli, Giovanni - 01f Lettera, Nota
paper: BRAIN BEHAVIOR AND IMMUNITY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. - - issn: 0889-1591 - wos: WOS:000542965400027 (62) - scopus: 2-s2.0-85084041334 (64)

11573/1406348 - 2020 - Pentamidine niosomes thwart S100B effects in human colon carcinoma biopsies favouring wtp53 rescue
Seguella, L.; Rinaldi, F.; Marianecci, C.; Capuano, R.; Pesce, M.; Annunziata, G.; Casano, F.; Bassotti, G.; Sidoni, A.; Milone, M.; Aprea, G.; De Palma, G. D.; Carafa, M.; Pesce, M.; Esposito, G.; Sarnelli, G. - 01a Articolo in rivista
paper: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (Bucharest : Foundation for Cellular and Molecular Medicine.) pp. 3053-3063 - issn: 1582-1838 - wos: WOS:000511027100001 (24) - scopus: 2-s2.0-85078959170 (28)

11573/1277015 - 2019 - Lathyrus sativus diamine oxidase counteracts histamine-induced cell proliferation, migration and pro-angiogenic mediators release in human colon adenocarcinoma cell line caco-2
Pietrangeli, P; Seguella, L; Annunziata, Giulia; Casano, Fabrizio; Capuano, R; Pesce, M; De Conno, B; Gigli, S; Sarnelli, G; Pesce, M; Mateescu, Ma; Esposito, G; Marcocci, L. - 01a Articolo in rivista
paper: PHYTOTHERAPY RESEARCH (New York : J. Wiley) pp. 1-10 - issn: 1099-1573 - wos: WOS:000477912800012 (7) - scopus: 2-s2.0-85066492584 (8)

11573/1206595 - 2019 - inPentasomes: an innovative nose-to-brain pentamidine delivery blunts MPTP parkinsonism in mice
Rinaldi, Federica; 1, ; Seguella, Luisa; 1, ; Gigli, Stefano; 1, ; Hanieh, Patrizia Nadia; Del Favero, Elena; Cantù, Laura; Pesce, Marcella; Sarnelli, Giovanni; Marianecci, Carlotta; ⁎, ; Esposito, Giuseppe; 2, ; Carafa, Maria. - 01a Articolo in rivista
paper: JOURNAL OF CONTROLLED RELEASE (Controlled Release Society:13355 Tenth Avenue, Suite 108:Minneapolis, MN 55441:(763)512-0909, EMAIL: registration@ardel.com) pp. 17-26 - issn: 0168-3659 - wos: WOS:000455852000002 (42) - scopus: 2-s2.0-85058041288 (44)

11573/1408449 - 2019 - HIV-1 Tat-induced diarrhea drives a glial inflammatory reaction to the central nervous system associated with a significant cognitive decline.
Seguella, L.; Pesce, M.; Capuano1, R.; Sarnelli, G.; Pesce, M.; Esposito, G. - 04f Poster
conference: 39th National Conference of Italian Pharmacology Society (SIF), Florence, November 20th-23th 2019, Italy. (Florence)
book: 39th National Conference of Italian Pharmacology Society (SIF), Florence, November 20th-23th 2019, Italy. - ()

11573/1408450 - 2019 - Regional heterogeneity of cholecystokinin sensing by enteric glia.
Seguella, L; Esposito, G; Gulbransen, Bd - 04f Poster
conference: XIV European Meeting on Glial cells in Health and Disease, Porto, July 10-13 2019, Portugal. (Porto, Portugal)
book: XIV European Meeting on Glial cells in Health and Disease, Porto, July 10-13 2019, Portugal. - ()

11573/1415146 - 2019 - S100B protein stimulates proliferation and angiogenic mediators release through RAGE/pAkt/mTOR pathway in human colon adenocarcinoma Caco-2 Cells
Seguella, Luisa; Capuano, Riccardo; Pesce, Mirella; Annunziata, Giuseppe; Pesce, Marcella; De Conno, Barbara; Sarnelli, Giovanni; Aurino, Laura; Esposito, Giuseppe - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000477041100127 (26) - scopus: 2-s2.0-85068668474 (27)

11573/1283114 - 2019 - Play in advance against neurodegeneration: exploring enteric glial cells in gut-brain axis during neurodegenerative diseases
Seguella, Luisa; Capuano, Riccardo; Sarnelli, Giovanni; Esposito, Giuseppe - 01g Articolo di rassegna (Review)
paper: EXPERT REVIEW OF CLINICAL PHARMACOLOGY (--London, United Kingdom: Expert Reviews Ltd -London : Future Drugs, 2008-) pp. 555-564 - issn: 1751-2433 - wos: WOS:000469126400008 (21) - scopus: 2-s2.0-85066413881 (22)

11573/1408440 - 2019 - Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson's disease
Seguella, Luisa; Sarnelli, Giovanni; Esposito, Giuseppe - 01g Articolo di rassegna (Review)
paper: NEURAL REGENERATION RESEARCH (Shenyang : Publishing House of Neural Regeneration Research.) pp. - - issn: 1673-5374 - wos: WOS:000508008900015 (22) - scopus: 2-s2.0-85076891053 (22)

11573/1012435 - 2018 - Endocannabinoid-related compounds in gastrointestinal diseases
Marcella, Pesce; Alessandra, D'alessandro; Osvaldo, Borrelli; Gigli, Stefano; Seguella, Luisa; Rosario, Cuomo; Esposito, Giuseppe; Giovanni, Sarnelli - 01a Articolo in rivista
paper: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (Bucharest : University Press "Carol Davila" Bucharest: Foundation for Cellular and Molecular Medicine, 2000-) pp. 706-715 - issn: 1582-4934 - wos: WOS:000423361500002 (30) - scopus: 2-s2.0-85030635147 (37)

11573/1088896 - 2018 - HIV-1 Tat-induced diarrhea is improved by the PPAR alpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia
Sarnelli, Giovanni; Seguella, Luisa; Pesce, Marcella; Lu, Jie; Gigli, Stefano; Bruzzese, Eugenia; Lattanzi, Roberta; D'alessandro, Alessandra; Cuomo, Rosario; Steardo, Luca; Esposito, Giuseppe - 01a Articolo in rivista
paper: JOURNAL OF NEUROINFLAMMATION (London : BioMed Central.) pp. - - issn: 1742-2094 - wos: WOS:000428572300001 (20) - scopus: 2-s2.0-85044357425 (21)

11573/1005534 - 2017 - HIV-1 Tat-induced diarrhea evokes an enteric glia-dependent neuroinflammatory response in the central nervous system
Esposito, Giuseppe; Capoccia, Elena; Gigli, Stefano; Pesce, Marcella; Bruzzese, Eugenia; D'alessandro, Alessandra; Cirillo, Carla; Di Cerbo, Alessandro; Cuomo, Rosario; Seguella, Luisa; Steardo, Luca; Sarnelli, Giovanni - 01a Articolo in rivista
paper: SCIENTIFIC REPORTS (London: Springer Nature London: Nature Publishing Group) pp. - - issn: 2045-2322 - wos: WOS:000407400100022 (27) - scopus: 2-s2.0-85030717878 (54)

11573/1088917 - 2017 - Cannabidiol restores intestinal barrier dysfunction and inhibits the apoptotic process induced by Clostridium difficile toxin A in Caco-2 cells
Gigli, Stefano; Seguella, Luisa; Pesce, Marcella; Bruzzese, Eugenia; D’Alessandro, Alessandra; Cuomo, Rosario; Steardo, Luca; Sarnelli, Giovanni; Esposito, Giuseppe - 01a Articolo in rivista
paper: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (Usa: SAGE Publications) pp. 1108-1115 - issn: 2050-6406 - wos: WOS:000416825100006 (29) - scopus: 2-s2.0-85037033439 (33)

11573/870601 - 2016 - Rifaximin, a non-absorbable antibiotic, inhibits the release of pro-angiogenic mediators in colon cancer cells through a pregnane X receptor-dependent pathway
Esposito, Giuseppe; Gigli, Stefano; Seguella, Luisa; Nobile, Nicola; D'alessandro, Alessandra; Pesce, Marcella; Capoccia, Elena; Steardo, Luca; Cirillo, Carla; Cuomo, Rosario; Sarnelli, Giovanni - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF ONCOLOGY (National Hellenic Research Foundation:48 Vas Constatinou Avenue, Athens 11635 Greece:011 30 1 7241505, Fax: 011 30 1 7241505Editore attuale:PROFESSOR D A SPANDIDOS, 1, S MERKOURI ST, EDITORIAL OFFICE,, ATHENS, GREECE, 116 35. Editore precedente:Editorial Academy of the International Journal of Oncology.) pp. 639-645 - issn: 1019-6439 - wos: WOS:000378263600021 (19) - scopus: 2-s2.0-84978436694 (19)

11573/870432 - 2016 - Rifaximin improves clostridium difficile toxin A-induced toxicity in caco-2 cells by the PXR-dependent TLR4/MyD88/NF-κB pathway
Esposito, Giuseppe; Nobile, Nicola; Gigli, Stefano; Seguella, Luisa; Pesce, Marcella; D'alessandro, Alessandra; Bruzzese, Eugenia; Capoccia, Elena; Steardo, Luca; Cuomo, Rosario; Sarnelli, Giovanni - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000375406900003 (31) - scopus: 2-s2.0-84974533500 (41)

11573/870611 - 2016 - Palmitoylethanolamide modulates inflammation-associated vascular endothelial growth factor (VEGF) signaling via the Akt/mTOR pathway in a selective peroxisome proliferator-activated receptor alpha (PPAR-α)-dependent manner.
Sarnelli, Giovanni; D'alessandro, Alessandra; Iuvone, Teresa; Capoccia, Elena; Gigli, Stefano; Pesce, Marcella; Seguella, Luisa; Nobile, Nicola; Aprea, Giovanni; Maione, Francesco; De Palma Giovanni, Domenico; Cuomo, Rosario; Steardo, Luca; Esposito, Giuseppe - 01a Articolo in rivista
paper: PLOS ONE (San Francisco, CA : Public Library of Science) pp. - - issn: 1932-6203 - wos: WOS:000376880700050 (39) - scopus: 2-s2.0-84973866694 (42)

11573/867800 - 2016 - Palmitoylethanolamide Exerts Antiproliferative Effect and Downregulates VEGF Signaling in Caco-2 Human Colon Carcinoma Cell Line Through a Selective PPAR-α-Dependent Inhibition of Akt/mTOR Pathway
Sarnelli, Giovanni; Gigli, Stefano; Capoccia, Elena; Iuvone, Teresa; Cirillo, Carla; Seguella, Luisa; Nobile, Nicola; D'alessandro, Alessandra; Pesce, Marcella; Steardo, Luca; Cuomo, Rosario; Esposito, Giuseppe - 01a Articolo in rivista
paper: PHYTOTHERAPY RESEARCH (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 963-970 - issn: 0951-418X - wos: WOS:000377261100010 (25) - scopus: 2-s2.0-84959477206 (26)

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