Phd in LIFE SCIENCE

email: lucia.nencioni@uniroma1.it
phone: 0649914608
building: CU015
room: P2 74

CV Nencioni Lucia

ACADEMIC TITLES
2018 National Scientific Qualification for the role of Full Professor in Microbiology (SSD MED 07)
2015 - to date Associate Professor of Microbiology (SSD MED 07), Sapienza University of Rome
2006 - 2015 Assistant Professor of Microbiology (SSD MED 07), Sapienza University of Rome
2003 - 2006 Contract Researcher, Sapienza University of Rome
2002 - 2003 Contract Researcher, University of Rome Tor Vergata
2002 PhD in Neuroscience, University of Rome Tor Vergata
1993 Degree in Biological Sciences, University of Florence

PROFESSIONAL EXPERIENCE
2017 Visiting Professor at Department of Biology, Queens College City University of New York, NY, USA.
1997 Fellowship in the project “Study of signal transduction of nerve growth factor in memory B lymphocytes. CNR, Institute of Experimental Medicine, Rome
1995 - 1996 Fellowship in the project “Purification of an autocrine growth factor in myeloma cells”, Department of Clinical Physiopathology, University of Florence
1993 - 1995 Post lauream stage in the project “Study of modulation of macrophage colony stimulating factor receptor after cytokine treatment”, Institute of General Pathology, University of Florence

MAIN RESEARCH AIMS
- Study of the molecular mechanisms involved in regulation of viral replication and host cell response (death/survival; inflammatory and immune response);
- Study of relationship between intra/extracellular redox state and viral infection and evaluation of antiviral effect of compounds with antioxidant activity in vitro and in vivo models.
- Study of new antiviral strategies aimed at inhibiting host cell functions, rather than viral structure, that are essential for replication of different viruses. Identification and characterization of new synthesized or natural antiviral compounds.
- Evaluation of antiviral activity of new synthesized or natural molecules in vitro and in vivo models.
- Study of cooperation between different pathogens (bacteria and viruses) in the pathogenesis of acute and chronic diseases.

AWARDED RESEARCH GRANTS
- Fondazione Cenci Bolognetti - Istituto Pasteur 2019 (2 years), project title “Role of Glucose-6-phosphate dehydrogenase (G6PD) in regulating influenza virus replication and host response to infection”, Principal Investigator (PI)
- PRIN 2017 (MIUR) (3 years), project title “ORIGINALE CHEMIAE in Antiviral Strategy - Origin and Modernization of Multi-Component Chemistry as a Source of Innovative Broad Spectrum Antiviral Strategy, PI Research Unit Sapienza
- Ateneo 2021 (Sapienza University of Rome) (3 years), project title “Redox-modulating compounds in the treatment of influenza virus and coronavirus infections”. PI
- Ateneo 2020 (Sapienza University of Rome) (3 years), project title “The role of redox state in modulating ACE2 expression: a cell targeting based-approach for the treatment of SARS-CoV2 pathogenesis and inflammation”. PI
- Ateneo 2019 (Sapienza University of Rome) (3 years), project title “Amphibian skin-derived peptides as novel tools against drug-resistant respiratory microbial and viral strains in elderly and cystic fibrosis patients”, PI
- Ateneo 2018 (Sapienza University of Rome) (3 years), project title “Hop and echinacea extracts as antiviral agents to support and prevent influenza virus infection”, PI
- Ateneo 2017 (Sapienza University of Rome) (3 years), project title “Antiviral activity of frog-skin antimicrobial peptides on DNA and RNA enveloped viruses”, PI
- Ateneo 2015 (Sapienza University of Rome) (3 years), project title “Evaluation of antiviral activity of frog-skin antimicrobial peptides and derivatives”, PI
- ISS-USA 2012 (Istituto Superiore di Sanità) (1 year), project title “Discovery of influenza A virus non-structural protein 1 (NS1) inhibitors”, PI
- PRIN 2010-2011 (MIUR) (3 years), project title “Tecnologie OMICS e Systems Biology per la definizione di nuove strategie finalizzate al controllo delle infezioni virali”, PI Research Unit Sapienza

Main publications (2013-2022)
1. De Angelis M., Amatore D., Checconi P., Zevini A., Fraternale A., Magnani M., Hiscott J., De Chiara G., Palamara A.T., Nencioni L. Influenza virus down-modulates G6PD expression and activity to induce oxidative stress and promote its replication. Frontiers Cell Infect Microbiol. 2022: 11, Article 804976. doi: 10.3389/fcimb.2021.804976
2. De Angelis M., Della-Morte D., Buttinelli G., Di Martino A., Pacifici F., Checconi P., Ambrosio L., Stefanelli P., Palamara A.T., Garaci E., Ricordi C., Nencioni L. Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARSCoV-2 Infection in vitro. Biomedicines 2021: 9, 1721. doi.org/10.3390/biomedicines9111721
3. De Santis R., Luca V., Näslund J., Ehmann R.K., De Angelis M., Lundmark E., Nencioni L., Faggioni G., Fillo S., Amatore D., Regalbuto E., Molinari F., Petralito G., Wölfel R., Stefanelli P., Rezza G., Palamara A.T., Antwerpen M., Forsman M., Lista F. Rapid inactivation of SARS-CoV-2 with LED irradiation of visible spectrum wavelengths. J Photochem Photob 2021: 8, 100082, 10.1016/j.jpap.2021.100082
4. Fiorentino F., De Angelis M., Menna M., Rovere A., Caccuri A.M., D’Acunzo F., Palamara A.T., Nencioni L.*, Rotili D.*, Mai A. Anti-influenza A virus activity and structure-activity relationship of a series of nitrobenzoxadiazole derivatives. J Enz Inhib Med Chem 2021: 36(1), 2128-2138, doi.org/10.1080/14756366.2021.1982932 (*corresponding authors)
5. Bizzarri B.M.*, Fanelli A., Botta L., De Angelis M., Palamara A.T., Nencioni L.*, Saladino R. Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity. RSC Advances 2021: 11, 30020, 10.1039/d1ra05240c (*corresponding authors)
6. Vicenti I., Martina M.G., Boccuto A., De Angelis M., Giavarini G., Dragoni F., Marchi S., Trombetta C.M., Crespan E., Maga G., Eydoux C., Decroly E., Montomoli E., Nencioni L., Zazzi M., Radi M. System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2. EJMCH 2021: 224, 113683 https://doi.org/10.1016/j.ejmech.2021.113683
7. Fraternale A., Zara C., De Angelis M., Nencioni L., Palamara A.T.,
Retini M., Di Mambro T., Magnani M., Crinelli R. Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection. IJMS 2021, 22(7), 3603. ht tps://doi.org/10.3390/ijms22073603
8. Madia V.N., De Angelis M., De Vita D., Messore A., De Leo A., Ialongo D., Tudino V., Saccoliti F., De Chiara G., Garzoli S., Scipione L., Palamara A.T., Di Santo R., Nencioni L.*, Costi R.* Investigation of Commiphora myrrha (T. Nees) Engl oil and its main components for antiviral activity. Pharmaceuticals 2021, 14(3), 243 doi.org/10.3390/ph14030243 (*co-authors)
9. Zippilli C., Botta L., Bizzarri B.M., Nencioni L.* De Angelis M., Protto V., Giorgi G., Baratto M.C., Pogni R., Saladino R.* Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine N-oxides with anti-influenza A virus activity. IJMS 2021: 22(3), 1337 doi.org/10.3390/ijms22031337 (*corresponding authors)
10. De Angelis M., Casciaro B., Genovese A., Brancaccio D., Marcocci M.E., Novellino E., Carotenuto A., Palamara A.T., Mangoni M.L., Nencioni L. Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: insights into biological activity and mechanism of action. FASEB J 2021: 35 (2), e21358; doi.org/10.1096/fj.202001885RR
11. Checconi Paola, De Angelis Marta, Marcocci Maria Elena, Fraternale Alessandra, Magnani Mauro, Palamara A.T., Nencioni L. Redox-modulating agents in the treatment of viral infections. IJMS 2020: 21, 4084, doi:10.3390/ijms21114084
12. Bizzarri B.M.*, Fanelli A., Piccinino D., De Angelis M., Dolfa C., Palamara A.T., Nencioni L.*, Zippilli C., Crucianelli M., Saladino R. Synthesis of Stilbene and Chalcone Inhibitors of Influenza A Virus by SBA-15 Supported Hoveyda-Grubbs Metathesis. Catalysts 2019: 9, 983. doi:10.3390/catal9120983 (*corresponding authors).
13. Checconi P., Limongi D., Baldelli S., Ciriolo M.R., Nencioni L.*, Palamara A.T.* Role of Glutathionylation in Infection and Inflammation. Nutrients 2019: 11, 1952. doi:10.3390/nu11081952 (*co-authors).
14. Amatore D., Celestino I., Brundu S., Galluzzi L., Coluccio P., Checconi P., Magnani M., Palamara A.T., Fraternale A., Nencioni L. Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus FASEB Bioadv 2019: 1, 296-305. doi: 10.1096/fba.2018-00066.
15. Anticoli S., Amatore D., Matarrese P., Palamara A.T., Nencioni L.*, Ruggieri A.* Counteraction of HCV-induced oxidative stress concurs to establish chronic infection in liver cell cultures. Oxidat Med Cell Long 2019: 2019, ID 6452390. (*co-authors).
16. Di Sotto A., Di Giacomo S., Amatore D., Locatelli M., Vitalone A., Toniolo C., Rotino G.L., Lo Scalzo R., Palamara A.T., Marcocci M.E., Nencioni L. A Polyphenol Rich Extract from Solanum melongena L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex Virus Type 1 Activity in vitro. Molecules 2018: 23 (8), E2066.
17. Celestino I., Checconi P., Amatore D., De Angelis M., Coluccio P., Dattilo R., Alunni Fegatelli D., Clemente A.M., Matarrese P., Torcia M.G., Mancinelli R., Mammola C.L., Garaci E., Vestri A.R., Malorni W., Palamara A.T., Nencioni L. Differential redox state contributes to sex disparities in the response to influenza virus infection in male and female mice. Frontiers Immunol. 2018: 9, 1747.
18. Di Sotto A., Checconi P., Celestino I., Locatelli M., Carissimi S., De Angelis M., Rossi V., Limongi D., Toniolo C., Martinoli L., Di Giacomo S., Palamara A.T., Nencioni L. Antiviral and antioxidant activity of a hydroalcoholic extract from Humulus lupulus L. Oxidat Med Cell Long 2018: 2018, ID 5919237.
19. Marcocci M. E., Amatore D., Villa S., Casciaro B., Aimola P., Franci G., Grieco P., Galdiero M., Palamara A.T., Mangoni M.L., Nencioni L. The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection. Antimicrob Agents Chemother 2018: 62 (5): e02367-17.
20. Bizzarri BM., Botta L., Capecchi E., Celestino I., Checconi P., Palamara AT., Nencioni L.*, Saladino R.*. Regioselective IBX mediated synthesis of coumarin derivatives with antioxidant and anti-influenza activities. J Natural products 2017: 80(12), 3247-3254. doi: 10.1021/acs.jnatprod.7b00665 (*corresponding and co-authors).
21. Aleandri M., Conte M.P., Simonetti G., Panella S., Celestino I., Checconi P., Marazzato M., Longhi C., Nicoletti M., Garaci E., Barnich N., Palamara A.T., Schippa S., Nencioni L. Influenza A virus infection of intestinal epithelial cells promotes the adhesiveness of Escherichia coli strains isolated from Crohn’s disease patients. PLoS One 2015: 10(2), e0117005.
22. Amatore D., Sgarbanti R., Aquilano K., Baldelli S., Limongi D., Civitelli L., Nencioni L., Garaci E., Ciriolo M.R., Palamara A.T. Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS. Cell Microbiol 2015: 17(1), 131-145.
23. Sgarbanti R., Amatore D., Celestino I., Marcocci M.E., Fraternale A., Ciriolo M.R., Magnani M., Saladino R., Garaci E., Palamara A.T., Nencioni L. Intracellular redox state as target for anti-influenza therapy: are antioxidants always effective? Curr Top Med Chem 2014: 14 (22), 2529-2541.
24. Checconi P., Sgarbanti R., Celestino I., Limongi D., Amatore D., Iuvara A., Alimonti A., Garaci E., Palamara A. T., Nencioni L. The environmental pollutant Cadmium promotes influenza virus replication in MDCK cells by altering their redox state. Int J Mol Sci 2013: 14, 4148-4162.