Phd in LIFE SCIENCE

email: lucia.nencioni@uniroma1.it
phone: 0649914608
building: CU015
room: P2 74

CV Nencioni Lucia

ACADEMIC TITLES
21/12/2023 - to date Full Professor of Microbiology (SSD MED 07), Sapienza University of Rome
2015 - 20/12/2023 Associate Professor of Microbiology (SSD MED 07), Sapienza University of Rome
2006 - 2015 Assistant Professor of Microbiology (SSD MED 07), Sapienza University of Rome
2003 - 2006 Contract Researcher, Sapienza University of Rome
2002 - 2003 Contract Researcher, University of Rome Tor Vergata
2002 PhD in Neuroscience, University of Rome Tor Vergata
1993 Degree in Biological Sciences, University of Florence

PROFESSIONAL EXPERIENCE
2017 Visiting Professor at Department of Biology, Queens College City University of New York, NY, USA.
1997 Fellowship in the project “Study of signal transduction of nerve growth factor in memory B lymphocytes. CNR, Institute of Experimental Medicine, Rome
1995 - 1996 Fellowship in the project “Purification of an autocrine growth factor in myeloma cells”, Department of Clinical Physiopathology, University of Florence
1993 - 1995 Post lauream stage in the project “Study of modulation of macrophage colony stimulating factor receptor after cytokine treatment”, Institute of General Pathology, University of Florence

MAIN RESEARCH AIMS
- Study of the molecular mechanisms involved in regulation of viral replication and host cell response (death/survival; inflammatory and immune response);
- Study of relationship between intra/extracellular redox state and viral infection and evaluation of antiviral effect of compounds with antioxidant activity in vitro and in vivo models.
- Study of new antiviral strategies aimed at inhibiting host cell functions, rather than viral structure, that are essential for replication of different viruses. Identification and characterization of new synthesized or natural antiviral compounds.
- Evaluation of antiviral activity of new synthesized or natural molecules in vitro and in vivo models.
- Study of cooperation between different pathogens (bacteria and viruses) in the pathogenesis of acute and chronic diseases.

MAIN AWARDED RESEARCH GRANTS
- RiPREI 2022 (Istituto Superiore di Sanità) (2 years), project title “Gaining insight into COVID-19 neuropathogenesis: a closer look to SARS-CoV-2 infection and driven neuroinflammation in the neuron/microglia axis”, Principal Investigator (PI)
- PRIN 2022 PNRR (MUR) (2 years), project title “Dual acting rEdox- modulating thiol molecules targeting Viral rEplication and infLammatory respOnse in resPiratory virus infections (DEVELOP)”. Coordinator of the project.
- PRIN 2022 (MUR) (2 years), project title “Dissecting the host cellular response to develop novel host-targeted approaches against RNA viruses”, PI
- PNRR Investimento 1.3 Partenariati estesi PE13 Malattie infettive 2022 (MUR) (3 years), project title “One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases” INFACT, 3 anni. Responsabile di Unità di Ricerca (massa critica Spoke 1).
- Fondazione Cenci Bolognetti - Istituto Pasteur 2019 (2 years), project title “Role of Glucose-6-phosphate dehydrogenase (G6PD) in regulating influenza virus replication and host response to infection”, PI
- PRIN 2017 (MUR) (3 years), project title “ORIGINALE CHEMIAE in Antiviral Strategy - Origin and Modernization of Multi-Component Chemistry as a Source of Innovative Broad Spectrum Antiviral Strategy, PI Research Unit Sapienza
- Ateneo 2021 (Sapienza University of Rome) (3 years), project title “Redox-modulating compounds in the treatment of influenza virus and coronavirus infections”, PI
- Ateneo 2020 (Sapienza University of Rome) (3 years), project title “The role of redox state in modulating ACE2 expression: a cell targeting based-approach for the treatment of SARS-CoV2 pathogenesis and inflammation”, PI
- ISS-USA 2012 (Istituto Superiore di Sanità) (1 year), project title “Discovery of influenza A virus non-structural protein 1 (NS1) inhibitors”, PI
- PRIN 2010-2011 (MUR) (3 years), project title “Tecnologie OMICS e Systems Biology per la definizione di nuove strategie finalizzate al controllo delle infezioni virali”, PI Research Unit Sapienza

Main publications (2015-2024)
1. De Angelis M., Anichini G., Palamara A.T., Nencioni L.*, Gori Savellini G.*. Dysregulation of intracellular redox homeostasis by SARS-CoV-2 ORF6 protein. Virology J 2023: 20, 239. doi.org/10.1186/s12985-023-02208-7
2. Marsili G., Acchioni C., Remoli A.L., Amatore D., De Angelis M., Orsatti R., Acchioni M., Astolfi A., Iraci N., Puzelli S., Facchini M., Perrotti E., Cecchetti V., Sabatini S., Superti F., Agamennone M., Barreca M.L., Hiscott J., Nencioni L., Sgarbanti M. Identification of anti-influenza A compounds inhibiting the NS-1 viral protein using a type I IFN-driven screening strategy. Int J Mol Sci 2023: 24, 10495. doi.org/10.3390/ijms241310495
3. Sorrentino L., Toscanelli W., Fracella M., De Angelis M., Frasca F., Scagnolari C., Petrarca L., Nenna R., Midulla F., Palamara A.T., Nencioni L.*, Pierangeli A.*. NRF2 antioxidant response and Interferon-stimulated genes are differentially expressed in respiratory syncytial virus and rhinovirus infected hospitalized children. Pathogens 2023: 12, 577. doi.org/10.3390/pathogens12040577
4. Fraternale A., De Angelis M., De Santis R., Amatore D., Masini S., Monittola F., Menotta M., Biancucci F., Bartoccini F., Retini M., Fiori V., Fioravanti R., Magurano F., Chiarantini L., Lista R.F., Piersanti G., Palamara A.T., Nencioni L., Magnani M., Crinelli R. Targeting SARS-CoV-2 by synthetic dual-acting thiol compounds that inhibit Spike/ACE2 interaction and viral protein production. FASEB J 2023: 37, e22741 doi.org/10.1096/fj.202201157RR
5. Checconi P., Coni C., Limongi D., Baldelli S., Ciccarone F., De Angelis M., Mengozzi M., Ghezzi P., Ciriolo M.R., Nencioni L.*, Palamara A.T.*. Influenza virus replication is affected by glutaredoxin1-mediated protein deglutathionylation. FASEB J 2023: 37, e22729 doi.org/10.1096/fj.202201239RR
6. Bizzarri B.*, Fanelli A., Ciprini S., Giorgi A., De Angelis M., Fioravanti R., Nencioni L.*, Saladino R. Multicomponent synthesis of diaminopurine and guanine PNA’s analogues active against influenza A virus from prebiotic compounds ACS Omega 2022: 7(49), 45253-45264. doi: 10.1021/acsomega.2c05754
7. De Angelis M., De Filippis B., Balaha M., Giampietro L., Miteva M.T., De Chiara G., Palamara A.T., Nencioni L.*, Mollica A.*. Nitrostilbenes: Synthesis and Biological Evaluation as Potential Anti-Influenza Virus Agents. Pharmaceuticals 2022: 15, 1061. doi.org/10.3390/ph15091061
8. Marcocci M.E., Jackowska B.G., Prezioso C., Protto V., De Angelis M., Di Leva F.S., Casciaro B., Carotenuto A., Mangoni M.L., Palamara A.T., Pietropaolo V., De Chiara G., Nencioni L. The Inhibition of DNA Viruses by the Amphibian Antimicrobial Peptide Temporin G: A Virological Study Addressing HSV-1 and JCPyV. IJMS 2022: 23, 7194. https://doi.org/10.3390/ijms23137194
9. Madia V.N., Toscanelli W., De Vita D., De Angelis M., Messore A., Ialongo D., Garzoli S., Scipione L., Tudino V., D’Auria F.D., Di Santo R., Stringaro A.R., Colone M., Marchetti M., Superti F., Nencioni L.*, Costi R.* Ultrastructural Damages to H1N1 Influenza Virus Caused by Vapor Essential Oils. Molecules 2022: 27, 3718. doi.org/10.3390/molecules27123718
10. De Angelis M., Amatore D., Checconi P., Zevini A., Fraternale A., Magnani M., Hiscott J., De Chiara G., Palamara A.T., Nencioni L. Influenza virus down-modulates G6PD expression and activity to induce oxidative stress and promote its replication. Frontiers Cell Infect Microbiol. 2022: 11, Article 804976. doi: 10.3389/fcimb.2021.804976
11. De Angelis M., Della-Morte D., Buttinelli G., Di Martino A., Pacifici F., Checconi P., Ambrosio L., Stefanelli P., Palamara A.T., Garaci E., Ricordi C., Nencioni L. Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection in vitro. Biomedicines 2021: 9, 1721. doi.org/10.3390/biomedicines9111721
12. De Santis R., Luca V., Näslund J., Ehmann R.K., De Angelis M., Lundmark E., Nencioni L., Faggioni G., Fillo S., Amatore D., Regalbuto E., Molinari F., Petralito G., Wölfel R., Stefanelli P., Rezza G., Palamara A.T., Antwerpen M., Forsman M., Lista F. Rapid inactivation of SARS-CoV-2 with LED irradiation of visible spectrum wavelengths. J Photochem Photob 2021: 8, 100082, 10.1016/j.jpap.2021.100082
13. Fiorentino F., De Angelis M., Menna M., Rovere A., Caccuri A.M., D’Acunzo F., Palamara A.T., Nencioni L.*, Rotili D.*, Mai A. Anti-influenza A virus activity and structure-activity relationship of a series of nitrobenzoxadiazole derivatives. J Enz Inhib Med Chem 2021: 36(1), 2128-2138, doi.org/10.1080/14756366.2021.1982932
14. Bizzarri B.M.*, Fanelli A., Botta L., De Angelis M., Palamara A.T., Nencioni L.*, Saladino R. Aminomalononitrile inspired prebiotic chemistry as a novel multicomponent tool for the synthesis of imidazole and purine derivatives with anti-influenza A virus activity. RSC Advances 2021: 11, 30020, 10.1039/d1ra05240c
15. Vicenti I., Martina M.G., Boccuto A., De Angelis M., Giavarini G., Dragoni F., Marchi S., Trombetta C.M., Crespan E., Maga G., Eydoux C., Decroly E., Montomoli E., Nencioni L., Zazzi M., Radi M. System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2. EJMCH 2021: 224, 113683 https://doi.org/10.1016/j.ejmech.2021.113683
16. Fraternale A., Zara C., De Angelis M., Nencioni L., Palamara A.T., Retini M., Di Mambro T., Magnani M., Crinelli R. Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection. IJMS 2021, 22(7), 3603. https://doi.org/10.3390/ijms22073603
17. Madia V.N., De Angelis M., De Vita D., Messore A., De Leo A., Ialongo D., Tudino V., Saccoliti F., De Chiara G., Garzoli S., Scipione L., Palamara A.T., Di Santo R., Nencioni L.*, Costi R.* Investigation of Commiphora myrrha (T. Nees) Engl oil and its main components for antiviral activity. Pharmaceuticals 2021, 14(3), 243 doi.org/10.3390/ph14030243
18. Zippilli C., Botta L., Bizzarri B.M., Nencioni L.* De Angelis M., Protto V., Giorgi G., Baratto M.C., Pogni R., Saladino R.* Laccase-catalyzed 1,4-dioxane-mediated synthesis of belladine N-oxides with anti-influenza A virus activity. IJMS 2021: 22(3), 1337 doi.org/10.3390/ijms22031337
19. De Angelis M., Casciaro B., Genovese A., Brancaccio D., Marcocci M.E., Novellino E., Carotenuto A., Palamara A.T., Mangoni M.L., Nencioni L. Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: insights into biological activity and mechanism of action. FASEB J 2021: 35 (2), e21358; doi.org/10.1096/fj.202001885RR
20. Checconi Paola, De Angelis Marta, Marcocci Maria Elena, Fraternale Alessandra, Magnani Mauro, Palamara A.T., Nencioni L. Redox-modulating agents in the treatment of viral infections. IJMS 2020: 21, 4084, doi:10.3390/ijms21114084
21. Bizzarri B.M.*, Fanelli A., Piccinino D., De Angelis M., Dolfa C., Palamara A.T., Nencioni L.*, Zippilli C., Crucianelli M., Saladino R. Synthesis of Stilbene and Chalcone Inhibitors of Influenza A Virus by SBA-15 Supported Hoveyda-Grubbs Metathesis. Catalysts 2019: 9, 983. doi:10.3390/catal9120983
22. Checconi P., Limongi D., Baldelli S., Ciriolo M.R., Nencioni L.*, Palamara A.T.* Role of Glutathionylation in Infection and Inflammation. Nutrients 2019: 11, 1952. doi:10.3390/nu11081952
23. Amatore D., Celestino I., Brundu S., Galluzzi L., Coluccio P., Checconi P., Magnani M., Palamara A.T., Fraternale A., Nencioni L. Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus FASEB Bioadv 2019: 1, 296-305. doi: 10.1096/fba.2018-00066.
24. Anticoli S., Amatore D., Matarrese P., Palamara A.T., Nencioni L.*, Ruggieri A.* Counteraction of HCV-induced oxidative stress concurs to establish chronic infection in liver cell cultures. Oxidat Med Cell Long 2019: 2019, ID 6452390.
25. Di Sotto A., Di Giacomo S., Amatore D., Locatelli M., Vitalone A., Toniolo C., Rotino G.L., Lo Scalzo R., Palamara A.T., Marcocci M.E., Nencioni L. A Polyphenol Rich Extract from Solanum melongena L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex Virus Type 1 Activity in vitro. Molecules 2018: 23 (8), E2066.
26. Celestino I., Checconi P., Amatore D., De Angelis M., Coluccio P., Dattilo R., Alunni Fegatelli D., Clemente A.M., Matarrese P., Torcia M.G., Mancinelli R., Mammola C.L., Garaci E., Vestri A.R., Malorni W., Palamara A.T., Nencioni L. Differential redox state contributes to sex disparities in the response to influenza virus infection in male and female mice. Frontiers Immunol. 2018: 9, 1747.
27. Di Sotto A., Checconi P., Celestino I., Locatelli M., Carissimi S., De Angelis M., Rossi V., Limongi D., Toniolo C., Martinoli L., Di Giacomo S., Palamara A.T., Nencioni L. Antiviral and antioxidant activity of a hydroalcoholic extract from Humulus lupulus L. Oxidat Med Cell Long 2018: 2018, ID 5919237.
28. Marcocci M. E., Amatore D., Villa S., Casciaro B., Aimola P., Franci G., Grieco P., Galdiero M., Palamara A.T., Mangoni M.L., Nencioni L. The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection. Antimicrob Agents Chemother 2018: 62 (5): e02367-17.
29. Aleandri M., Conte M.P., Simonetti G., Panella S., Celestino I., Checconi P., Marazzato M., Longhi C., Nicoletti M., Garaci E., Barnich N., Palamara A.T., Schippa S., Nencioni L. Influenza A virus infection of intestinal epithelial cells promotes the adhesiveness of Escherichia coli strains isolated from Crohn’s disease patients. PLoS One 2015: 10(2), e0117005.
30. Amatore D., Sgarbanti R., Aquilano K., Baldelli S., Limongi D., Civitelli L., Nencioni L., Garaci E., Ciriolo M.R., Palamara A.T. Influenza virus replication in lung epithelial cells depends on redox-sensitive pathways activated by NOX4-derived ROS. Cell Microbiol 2015: 17(1), 131-145.