LUCIA GIULIANO

Dottoressa di ricerca

ciclo: XXXIV

supervisore: Luigi Faillace
relatore: Palumbo Luigi
co-supervisore: Andrea Mostacci

Titolo della tesi: Electron Linacs for Flash Radiotherapy

Radiation Therapy (RT) is nowadays the most common methodology to treat cancer cells. The goal of the treatment is to destroy the tumor and to minimize the damage of the healthy tissues as well as any side effect. The Flash radiotherapy has been shown a reduction in normal tissue toxicity but the same efficiency of the conventional treatment to inhibit tumor growth. This innovative technique delivers very high dose rates (> 60 Gy/s), several orders of magnitude greater than in conventional radiotherapy, in very short time of irradiation (< 200 ms). The protective role of Flash therapy in normal tissues, called FLASH effect, has been demonstrated from several study but the underlying biological mechanisms remain to be fully elucidated. For this purpose, we have developed a dedicated S-band (2.998 GHz) linear accelerator for FLASH radiotherapy, that is optimized for a nominal energy of 7 MeV and a pulsed electron beam current of > 100 mA, currently installed at Curie Institute in Orsay (France). In order to have a very compact machine a new C-band (5.712 GHz) linear accelerator was developed with nominal energy of 12 MeV and pulsed electron beam current of 50 mA. Here, we will discuss the genesis of the Flash methodology, we will summarize the current evidence of the FLASH effect and its implementation based on electron linear accelerators. We will show the RF and beam dynamics design of the S-band and C-band linacs as well as the commissioning and power RF tests. Finally, challenges associated with clinical translation of FLASH-RT and its future prospects are discussed.

Produzione scientifica

11573/1704992 - 2024 - Advanced studies for the dynamics of high brightness electron beams with the code MILES

Bosco, F.; Behtouei, M.; Camacho, O.; Carillo, M.; Chiadroni, E.; Faillace, L.; Ficcadenti, L.; Francescone, D.; Giannessi, L.; Giribono, A.; Giuliano, L.; Nguyen, F.; Palumbo, L.; Rosenzweig, J.; Silvi, G. J.; Spataro, B.; Vaccarezza, C.; Migliorati, M. - 01a Articolo in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. 1-8 - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85184147510 (0)

11573/1706356 - 2024 - Beam dynamics optimization for high gradient beam driven plasma wakefield acceleration at SPARC-LAB

Carillo, M.; Alesini, D.; Anania, M. P.; Behtouei, M.; Bellaveglia, M.; Biagioni, A.; Chiadroni, E.; Cianchi, A.; Costa, G.; Crincoli, L.; Dotto, A. D.; Giorno, M. D.; Pirro, G. D.; Faillace, L.; Francescone, D.; Galletti, M.; Giannessi, L.; Giribono, A.; Giuliano, L.; Iovine, P.; Mostacci, A.; Petrillo, V.; Pompili, R.; Parise, G.; Romeo, S.; Rossi, A. R.; Silvi, G. J.; Shpakov, V.; Vaccarezza, C.; Villa, F.; Ferrario, M. - 04c Atto di convegno in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. 1-8 - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85184151381 (0)

congresso: 14th International Particle Accelerator Conference, IPAC 2023 (Venice Convention Centre, ita)

11573/1704991 - 2024 - Space Charge Forces analytical model for emittance compensation

Carillo, M.; Bosco, F.; Chiadroni, E.; Faillace, L.; Giuliano, L.; Mostacci, A.; Migliorati, M.; Spataro, B.; Rosenzweig, J.; Palumbo, L. - 01a Articolo in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. - - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85184152366 (0)

11573/1707554 - 2024 - On the betatron radiation in cylindrically symmetric plasma-ion channels

Francescone, D.; Bosco, F.; Carillo, M.; Chiadroni, E.; Curcio, A.; Cianchi, A.; Ferrario, M.; Galletti, M.; Giuliano, L.; Migliorati, M.; Mostacci, A.; Palumbo, L.; Rossi, A. R.; Shpakov, V.; Silvi, G. J. - 04c Atto di convegno in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. 2170-2173 - issn: 1742-6588 - wos: (0) - scopus: (0)

congresso: 14th International Particle Accelerator Conference, IPAC 2023 (Venice Convention Centre, ita) (Venezia)

11573/1704990 - 2024 - Design and test of C-band Linac prototypes for electron FLASH radiotherapy

Giuliano, L.; Bosco, F.; Carillo, M.; Ficcadenti, L.; Magi, M.; Mostacci, A.; Palumbo, L.; Migliorati, M.; Faillace, L.; Alesini, D.; Gallo, A.; Iovine, P.; Spataro, B.; Felici, G.; Di Francesco, M. - 01a Articolo in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. 1-9 - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85184152952 (0)

11573/1695865 - 2023 - Fast models for the evaluation of self-induced field effects in linear accelerators

Bosco, F.; Camacho, O.; Carillo, M.; Chiadroni, E.; Faillace, L.; Fukasawa, A.; Giribono, A.; Giuliano, L.; Majernik, N.; Mostacci, A.; Palumbo, L.; Rosenzweig, J. B.; Spataro, B.; Vaccarezza, C.; Migliorati, M. - 01a Articolo in rivista

rivista: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH. SECTION A, ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0168-9002 - wos: WOS:001073965600001 (1) - scopus: 2-s2.0-85170405580 (2)

11573/1667462 - 2023 - Modeling and mitigation of long-range wakefields for advanced linear colliders

Bosco, F; Camacho, O; Carillo, M; Chiadroni, E; Faillace, L; Fukasawa, A; Giribono, A; Giuliano, L; Majernik, N; Mostacci, A; Palumbo, L; Rosenzweig, J; Spataro, B; Vaccarezza, C; Migliorati, M - 01a Articolo in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. 012059- - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85147194969 (0)

11573/1683786 - 2023 - RF design and measurements of a C-Band prototype structure for an Ultra-High Dose-Rate medical linac

Giuliano, L.; Bosco, F.; Carillo, M.; Felici, G.; Ficcadenti, L.; Mostacci, A.; Migliorati, M.; Palumbo, L.; Spataro, B.; Faillace, L. - 01a Articolo in rivista

rivista: INSTRUMENTS (Basel : MDPI AG, 2016-) pp. - - issn: 2410-390X - wos: (0) - scopus: 2-s2.0-85150974133 (2)

11573/1667482 - 2023 - Proposal of a VHEE Linac for FLASH radiotherapy

Giuliano, L; Bosco, F; Carillo, M; Arcangelis, D De; Ficcadenti, L; Francescone, D; Gregorio, A De; Franciosini, G; Migliorati, M; Mostacci, A; Palumbo, L; Patera, V; Sarti, A; Alesini, D; Behtouei, M; Faillace, L; Gallo, A; Spataro, B; Vannozzi, A; Cirrone, P; Cuttone, G; Torrisi, G; Bisogni, M G; Pensavalle, J H; Martino, F Di; Favaudon, V; Heinrich, S; Patriarca, A - 04c Atto di convegno in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. 012087- - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85147192466 (2)

congresso: IPAC International Particle Accelerator Conference (Bangkok Thailand)

11573/1664350 - 2023 - Characterization of ultra-high-dose rate electron beams with electron flash linac

Giuliano, Lucia; Franciosini, Gaia; Palumbo, Luigi; Aggar, Lilia; Dutreix, Marie; Faillace, Luigi; Favaudon, Louis Vincent Philippe; Felici, Giuseppe; Galante, Federica; Mostacci, Andrea; Migliorati, Mauro; Pacitti, Matteo; Patriarca, Annalisa; Heinrich, Sophie - 01a Articolo in rivista

rivista: APPLIED SCIENCES (Basel: MDPI AG, 2011-) pp. 631- - issn: 2076-3417 - wos: WOS:000911157700001 (5) - scopus: 2-s2.0-85145742754 (9)

11573/1707592 - 2023 - SAFEST. A compact C-band linear accelerator for VHEE-FLASH radiotherapy

Palumbo, L.; Sarti, A.; Mostacci, A.; De Gregorio, A.; De Arcangelis, D.; Francescone, D.; Chiadroni, E.; Franciosini, G.; Ficcadenti, L.; Magi, M.; Carillo, M.; Patera, V.; Gallo, A.; Vannozzi, A.; Spataro, B.; Alesini, D.; Cardelli, F.; Romano, F.; Cuttone, G.; Mauro, G.; Franzini, G.; Milluzzo, G.; Cirrone, G.; Torrisi, G.; Piersanti, L.; Giuliano, L.; Faillace, L.; Di Raddo, R.; Bosco, F.; Di Martino, F.; Bisogni, M.; Silvi, G.; Migliorati, M.; Sorbello, G. - 04c Atto di convegno in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. 5079-5082 - issn: 1742-6588 - wos: (0) - scopus: (0)

congresso: 14th International Particle Accelerator Conference, IPAC 2023 (Venice Convention Centre, ita) (Venezia)

11573/1667461 - 2022 - Space charge analysis for low energy photoinjector

Carillo, Martina; Behtouei, Mostafa; Bosco, Fabio; Camacho, Obed; Chiadroni, Enrica; Faillace, Luigi; Ficcadenti, Luca; Fukasawa, Atsushi; Giuliano, Lucia; Migliorati, Mauro; Mostacci, Andrea; Palumbo, Luigi; Rosenzweig, James Benjamin; Spataro, Bruno - 04c Atto di convegno in rivista

rivista: JOURNAL OF PHYSICS. CONFERENCE SERIES (Bristol : Institute of Physics Publishing) pp. - - issn: 1742-6588 - wos: (0) - scopus: 2-s2.0-85147192463 (1)

congresso: International Particle Accelerator Conference 2022 (Bangkok, Thailand)

11573/1655735 - 2022 - High field hybrid photoinjector electron source for advanced light source applications

Faillace, L.; Agustsson, R.; Behtouei, M.; Bosco, F.; Bruhwiler, D.; Camacho, O.; Carillo, M.; Fukasawa, A.; Gadjev, I.; Giribono, A.; Giuliano, L.; Kutsaev, S.; Majernik, N.; Migliorati, M.; Mostacci, A.; Murokh, A.; Palumbo, L.; Spataro, B.; Tantawi, S.; Vaccarezza, C.; Williams, O.; Rosenzweig, J. B. - 01a Articolo in rivista

rivista: PHYSICAL REVIEW. ACCELERATORS AND BEAMS (College Park, MD : American Physical Society, [2016]-) pp. - - issn: 2469-9888 - wos: WOS:000809862700002 (8) - scopus: 2-s2.0-85132326055 (11)

11573/1663477 - 2022 - Perspectives in linear accelerator for FLASH VHEE: study of a compact C-band system

Faillace, L.; Alesini, D.; Bisogni, G.; Bosco, F.; Carillo, M.; Cirrone, P.; Cuttone, G.; De Arcangelis, D.; De Gregorio, A.; Di Martino, F.; Favaudon, V.; Ficcadenti, L.; Francescone, D.; Franciosini, G.; Gallo, A.; Heinrich, S.; Migliorati, M.; Mostacci, A.; Palumbo, L.; Patera, V.; Patriarca, A.; Pensavalle, J.; Perondi, F.; Remetti, R.; Sarti, A.; Spataro, B.; Torrisi, G.; Vannozzi, A.; Giuliano, L. - 01a Articolo in rivista

rivista: PHYSICA MEDICA (UK: Elsevier Pisa: Istituti Editoriali e Poligrafici Internazionali. Pisa Italy: Giardini Editori Stampatori) pp. 149-159 - issn: 1120-1797 - wos: WOS:000892262400004 (5) - scopus: 2-s2.0-85143055739 (6)

11573/1667464 - 2022 - Start-to-end beam-dynamics simulations of a compact C-band electron beam source for high spectral brilliance applications

Faillace, Luigi; Agustsson, Ronald; Behtouei, Mostafa; Bosco, Fabio; Bruhwiler, David; Camacho, Obed; Carillo, Martina; Fukasawa, Atsushi; Gadjev, Ivan; Giribono, Anna; Giuliano, Lucia; Kutsaev, Sergey; Majernik, Nathan; Migliorati, Mauro; Mostacci, Andrea; Murokh, Alex; Palumbo, Luigi; Rosenzweig, James Benjamin; Spataro, Bruno; Tantawi, Sami; Vaccarezza, Cristina; Williams, Oliver - 04b Atto di convegno in volume

congresso: International Particle Accelerator Conference 2022 (Bangkok, Thailand)

libro: Start-to-End Beam-Dynamics Simulations of a Compact C-Band Electron Beam Source for High Spectral Brilliance Applications - ()

11573/1620021 - 2022 - Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry

Marinelli, M.; Felici, G.; Galante, F.; Gasparini, A.; Giuliano, L.; Heinrich, S.; Pacitti, M.; Prestopino, G.; Vanreusel, V.; Verellen, D.; Verona, C.; Verona Rinati, G. - 01a Articolo in rivista

rivista: MEDICAL PHYSICS (Hoboken NJ: John Wiley & Sons New York: Published for the American Association of Physicists in Medicine by the American Institute of Physics) pp. 1902-1910-1910 - issn: 0094-2405 - wos: WOS:000748697400001 (21) - scopus: 2-s2.0-85123924779 (29)

11573/1571263 - 2021 - Modeling Short Range Wakefield Effects in a High Gradient Linac

Bosco, Fabio; Behtouei, Mostafa; Carillo, Martina; Faillace, Luigi; Giribono, Anna; Giuliano, Lucia; Migliorati, Mauro; Mostacci, Andrea; Palumbo, Luigi; Rosenzweig, James; Spataro, Bruno; Vaccarezza, Cristina - 04b Atto di convegno in volume

congresso: 12th International Particle Accelerator Conference (Campinas, SP, Brazil)

libro: JACoW Publishing - (978-3-95450-214-1)

11573/1571265 - 2021 - Three-Dimensional Space Charge Oscillations in a Hybrid Photoinjector

Carillo, Martina; Behtouei, Mostafa; Bosco, Fabio; Faillace, Luigi; Ficcadenti, Luca; Giribono, Anna; Giuliano, Lucia; Migliorati, Mauro; Mostacci, Andrea; Palumbo, Luigi; Rosenzweig, James; Spataro, Bruno; Vaccarezza, Cristina - 04b Atto di convegno in volume

congresso: 12th Int. Particle Acc. Conf IPAC2021 (Campinas, SP, Brazil)

libro: JACoW Publishing - ()

11573/1541706 - 2021 - Corrigendum: FLASH Radiotherapy With Electrons: Issues Related to the Production, Monitoring, and Dosimetric Characterization of the Beam

Di Martino, F.; Barca, P.; Barone, S.; Bortoli, E.; Borgheresi, R.; De Stefano, S.; Di Francesco, M.; Faillace, L.; Giuliano, L.; Grasso, L.; Linsalata, S.; Marfisi, D.; Migliorati, M.; Pacitti, M.; Palumbo, L.; Felici, G. - 01b Commento, Erratum, Replica e simili

rivista: FRONTIERS IN PHYSICS (Lausanne : Frontiers Editorial Office, 2013-) pp. - - issn: 2296-424X - wos: WOS:000617639500001 (1) - scopus: 2-s2.0-85100966586 (430)

11573/1548061 - 2021 - Compact S-band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy

Faillace, L.; Barone, S.; Battistoni, G.; Di Francesco, M.; Felici, G.; Ficcadenti, L.; Franciosini, G.; Galante, F.; Giuliano, L.; Grasso, L.; Mostacci, A.; Muraro, S.; Pacitti, M.; Palumbo, L.; Patera, V.; Migliorati, M. - 01a Articolo in rivista

rivista: PHYSICAL REVIEW. ACCELERATORS AND BEAMS (College Park, MD : American Physical Society, [2016]-) pp. - - issn: 2469-9888 - wos: WOS:000656234600001 (12) - scopus: 2-s2.0-85107143461 (16)

11573/1571284 - 2021 - Beam Dynamics for a High Field C-Band Hybrid Photoinjector

Faillace, Luigi; Agustsson, Ronald; Behtouei, Mostafa; Bosco, Fabio; Carillo, Martina; Fukasawa, Atsushi; Gadjev, Ivan; Giribono, Anna; Giuliano, Lucia; Kutsaev, Sergey; Majernik, Nathan; Migliorati, Mauro; Mostacci, Andrea; Murokh, Alex; Palumbo, Luigi; Rosenzweig, James Benjamin; Spataro, Bruno; Tantawi, Sami; Vaccarezza, Cristina; Williams, Oliver - 04b Atto di convegno in volume

congresso: 12th Int. Particle Acc. Conf. IPAC2021 (Campinas, SP, Brazil)

libro: JACoW Publishing - ()

11573/1571261 - 2021 - Preliminary Studies of a Compact VHEE Linear Accelerator System for FLASH Radiotherapy

Giuliano, Lucia; Alesini, David; Behtouei, Mostafa; Bosco, Fabio; Carillo, Martina; Cuttone, Giacomo; De Arcangelis, Daniele; Faillace, Luigi; Favaudon, Vincent; Ficcadenti, Luca; Heinrich, Sophie; Migliorati, Mauro; Mostacci, Andrea; Palumbo, Luigi; Patriarca, Annalisa; Spataro, Bruno; Torrisi, Giuseppe - 04b Atto di convegno in volume

congresso: 12th Int. Particle Acc. Conf. IPAC2021 (Campinas, SP, Brazil)

libro: JACoW Publishing - (978-3-95450-214-1)

11573/1486155 - 2020 - FLASH radiotherapy with electrons: issues related to the production, monitoring, and dosimetric characterization of the beam

Di Martino, Fabio; Barca, Patrizio; Barone, Salvatore; Bortoli, Eleonora; Borgheresi, Rita; De Stefano, Silvia; Di Francesco, Massimo; Faillace, Luigi; Giuliano, Lucia; Grasso, Luigi; Linsalata, Stefania; Marfisi, Daniela; Migliorati, Mauro; Pacitti, Matteo; Palumbo, Luigi; Felici, Giuseppe - 01a Articolo in rivista

rivista: FRONTIERS IN PHYSICS (Lausanne : Frontiers Editorial Office, 2013-) pp. - - issn: 2296-424X - wos: WOS:000589346900001 (36) - scopus: 2-s2.0-85091483126 (40)

11573/1542381 - 2020 - Flash therapy: An innovation in radiation therapy

Giuliano, L - 01a Articolo in rivista

rivista: IL NUOVO CIMENTO C (Bologna: Società italiana di fisica) pp. - - issn: 2037-4909 - wos: WOS:000582928200020 (0) - scopus: 2-s2.0-85105948381 (0)

11573/1264111 - 2018 - Use of a CMOS image sensor for beta-emitting radionuclide measurements

Solestizi, L. Alunni; Biasini, M.; Bocci, V.; Campeggi, C.; Capotosti, A.; Collamati, F.; Faccini, R.; Fresch, P.; Giuliano, L.; Kanxheri, K.; Terracciano, C. Mancini; Mantini, S.; Marafini, M.; Meddi, F.; Morganti, S.; Mirabelli, Riccardo; Camillocci, E. Solfaroli; Traini, G.; Servoli, L. - 01a Articolo in rivista

rivista: JOURNAL OF INSTRUMENTATION (Bristol : IOP Publishing Ltd, 2006-) pp. - - issn: 1748-0221 - wos: WOS:000437207400003 (2) - scopus: 2-s2.0-85051456922 (8)