LUCA D'ONOFRIO

Dottore di ricerca

ciclo: XXXV


supervisore: Prof.ssa Raffaella Buzzetti
relatore: Prof.ssa Raffaella Buzzetti

Titolo della tesi: COVID-19 AND DIABETES: EFFECTS OF A DANGEROUS RELATIONSHIP, FROM CLINICAL MANIFESTATION TO VACCINE EFFICACY

Rationale: At the end of 2019, SARS-CoV-2 was the cause of a pandemic disease named Covid-19, that deeply affect society worldwide. Diabetes mellitus has been described as one of the most important chronic conditions worsening the Covid-19 prognosis, which is worrisome considering that diabetes affects about half a billion people. For this reason, the aim of this project was to assess the relationship between diabetes mellitus and Covid-19 focusing on hospitalization, the impact of lockdown and vaccination. Methods: Four studies have been conducted. All of them with the common aim of elucidating the relationship between diabetes and Covid-19: 1) In the CoViDiab I study, a multicentre study, () we evaluate the risk profile of subjects with type 2 diabetes mellitus (T2D) hospitalized for Covid-19 comparing them with subjects with T2D without signs or symptoms of SARS-CoV-2 infection; 2) in the CoViDiab II, a multicentre retrospective study, we collected and compared data from patients hospitalized for Covid-19 with and without diabetes; 3) in the Glycalock study a retrospective multicentre study (), we compared the differences in glycaemic controls (in terms of HbA1c) in subjects with T2D exposed to lockdown with matched controls with T2D who attended the study centres 1 year before, with a stable glycaemic control; 4) Finally, in CoVaDiab I study, in a prospective monocentric study (), we evaluated efficacy of vaccination with mRNA vaccine towards SARS-CoV-2, in terms of antibody (Ab) response, in people with and without diabetes and we further assessed the short term effects of vaccination on glucose control in subjects with autoimmune diabetes (AD). Results: In CoViDiab study I, a case-control study, performed in subjects with T2D hospitalized for Covid-19 (n=79) compared to subjects with T2D but without Covid-19 (n=158), matched for age and gender, a higher prevalence of chronic obstructive pulmonary disease (COPD) (OR 3.72, 95%CI: 1.42–9.72, p = 0.007) and of chronic kidney disease were found (CKD) (OR 3.08, 95%CI: 1.18–8.06, p=0.022) but no difference in previous cardiovascular disease history. In the CoViDiab study II, 354 patients were enrolled (subjects with diabetes: n=81), and the risk of the primary composite outcome (any of mechanical ventilation, admission to an intensive care unit or death) was higher in subjects with diabetes (Adjusted Odds Ratio (adjOR) 2.04, 95%CI 1.12–3.73, p=0.020) compared to subjects without diabetes. In the Glycalock study, no difference in delta HbA1c was found between the lockdown and control groups (lockdown group −0.1% [−0.5%−0.3%] vs. control group −0.1% [−0.4% −0.2%]; p=0.482). In the lockdown group, subjects with worse psychological well-being, as evaluated by tertiles of the Psychological General Well-Being Index (PGWBS), showed a worsening of HbA1c (p=0.041 for the trend among PGWBS tertiles) and BMI (p=0.022). In the CoVaDiab study I, subjects with diabetes (n=128) showed decreased levels of Ab after one month of vaccination compared to controls (N=202) (1217[747-1887] BAU/mL Vs 1477[942-2556] BAU/mL, p=0.002), even after correction for age and gender (p=0.002). No difference was found between subjects with type 1 DM (T1D) and T2D. After six months, Ab levels significantly decreased in people with and without diabetes, with no differences between groups. Finally, in subjects with AD no significant differences were observed in glucose control, expressed as time in range evaluated by continuous glucose monitoring comparing the 3 days after the SARS-CoV-2 vaccine with the 14 days preceding the vaccine was observed. Conclusion: CKD and COPD and worse metabolic control were risk factors for hospitalization in subjects with diabetes and SARS-CoV-2 infection. Moreover, subjects with diabetes showed a worse prognosis during Covid-19. Subjects with diabetes, regardless of the type of diabetes and glycaemic control, showed an impaired response to vaccination, even if the vaccine was safe in terms of the effect on glucose control in the following days after the vaccination. Finally, subjects with poor psychological well-being may experience a worsening glycaemic control in distressing conditions, such as lockdown, highlighting the relevance of management of people with DM during these difficult times. Nevertheless, patients with good glycaemic control could cope well during distressing conditions, such as lockdown, pointing out the relevance of self-management of disease.

Produzione scientifica

11573/1700859 - 2024 - Characterizing the Sardinia candidate site for the Einstein Telescope
Naticchioni, Luca; Allocca, Annalisa; Boschi, Valerio; Cadeddu, Matteo; Cadoni, Mariano; Calloni, Enrico; Cardello, Giovanni Luca; Cardini, Alessandro; Carpinelli, Massimo; Cittadino, Daniele; Contu, Andrea; D'ambrosio, Michele; D'onofrio, Luca; D'urso, Domenico; Davari, Nazanin; De Rosa, Rosario; Di Fiore, Luciano; Di Giovanni, Matteo; Dordei, Francesca; Fiori, Irene; Giunchi, Carlo; Harms, Jan; Koley, Soumen; Longo, Vittorio; Mangano, Valentina; Marsella, Maria; Migoni, Carlo; Molinari, Irene; Olivieri, Marco; Paoletti, Federico; Puppo, Paola; Rapagnani, Piero; Razzano, Massimiliano; Ricci, Fulvio; Rozza, Davide; Saccorotti, Gilberto; Schillaci, Gaetano; Sipala, Valeria; Tringali, Maria Concetta; Trozzo, Lucia; Tuveri, Matteo - 04c Atto di convegno in rivista
rivista: POS PROCEEDINGS OF SCIENCE (Trieste : Scuola Internazionale Superiore di Studi Avanzati) pp. - - issn: 1824-8039 - wos: (0) - scopus: (0)
congresso: TAUP2023: XVIII International Conference on Topics in Astroparticle and Underground Physics (Wien)

11573/1691316 - 2023 - Lack of Association between Serum Chitotriosidase Activity and Arterial Stiffness in Type 2 Diabetes without Cardiovascular Complications
D’Onofrio, Luca; Amendolara, Rocco; Mignogna, Carmen; Leto, Gaetano; Tartaglione, Lida; Mazzaferro, Sandro; Maddaloni, Ernesto; Buzzetti, Raffaella - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-9 - issn: 1422-0067 - wos: WOS:001103257400001 (0) - scopus: 2-s2.0-85176462993 (0)

11573/1663163 - 2023 - Reduced early response to SARS-CoV2 vaccination in people with type 1 and type 2 diabetes, a six months follow-up study. The CoVaDiab study I
D'onofrio, Luca; Fogolari, Marta; Amendolara, Rocco; Siena, Antonio; De Fata, Riccardo; Davini, Flavio; Coraggio, Lucia; Mignogna, Carmen; Moretti, Chiara; Maddaloni, Ernesto; Angeletti, Silvia; Buzzetti, Raffaella - 01a Articolo in rivista
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (Chichester UK: John Wiley & Sons, ©2000-) pp. 1-7 - issn: 1520-7560 - wos: WOS:000904036300001 (3) - scopus: 2-s2.0-85145309567 (4)

11573/1677514 - 2023 - Impact of baseline kidney function on the effects of sodium-glucose co-transporter-2 inhibitors on kidney and heart failure outcomes: A systematic review and meta-analysis of randomized controlled trials
Maddaloni, Ernesto; Cavallari, Ilaria; La Porta, Ylenia; Appetecchia, Alessandro; D'onofrio, Luca; Grigioni, Francesco; Buzzetti, Raffaella; Holman, Rury R - 01a Articolo in rivista
rivista: DIABETES, OBESITY AND METABOLISM (Oxford, U.K. : Blackwell Science) pp. 1341-1350 - issn: 1463-1326 - wos: WOS:000936632000001 (6) - scopus: 2-s2.0-85148304739 (7)

11573/1675564 - 2023 - Association of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease and retinopathy in type 2 diabetes
Maddaloni, Ernesto; Coraggio, Lucia; Amendolara, Rocco; Baroni, Marco G; Cavallo, Maria G; Copetti, Massimiliano; Cossu, Efisio; D'angelo, Paola; D'onofrio, Luca; Cosmo, Salvatore De; Leonetti, Frida; Morano, Susanna; Morviducci, Lelio; Napoli, Nicola; Prudente, Sabrina; Pugliese, Giuseppe; Park, Kyoungmin; Holman, Rury R; Trischitta, Vincenzo; Buzzetti, Raffaella - 01a Articolo in rivista
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 1-9 - issn: 1520-7552 - wos: WOS:000956423900001 (3) - scopus: 2-s2.0-85151070822 (3)

11573/1630528 - 2022 - Development of a clinical risk score to predict death in patients with COVID-19
Alhamar, G.; Maddaloni, E.; Al Shukry, A.; Al-Sabah, S.; Al-Haddad, M.; Al-Youha, S.; Jamal, M.; Almazeedi, S.; Al-Shammari, A. A.; Abu-Farha, M.; Abubaker, J.; Alattar, A. T.; Alozairi, E.; Alessandri, F.; D'onofrio, L.; Leto, G.; Mastroianni, C. M.; Mignogna, C.; Pascarella, G.; Pugliese, F.; Ali, H.; Al Mulla, F.; Buzzetti, R.; Pozzilli, P. - 01g Articolo di rassegna (Review)
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 1-8 - issn: 1520-7552 - wos: WOS:000771768500001 (9) - scopus: 2-s2.0-85126831193 (7)

11573/1643701 - 2022 - Corneal confocal microscopy identifies small nerve fibre damage in patients with hypertriglyceridemia
D'onofrio, L.; Ferdousi, M.; Kalteniece, A.; Iqbal, Z.; Petropoulos, I. N.; Ponirakis, G.; Buzzetti, R.; Malik, R. A.; Soran, H. - 01a Articolo in rivista
rivista: JOURNAL OF CLINICAL LIPIDOLOGY (New York, NY : Elsevier, c2007-) pp. 1-9 - issn: 1933-2874 - wos: WOS:000878622100014 (5) - scopus: 2-s2.0-85130311157 (5)

11573/1639821 - 2022 - Diastolic Pressure And Acr Are Modifiable Risk Factors Of Arterial Stiffness In T2DM Without Cardiovascular Disease
Leto, Gateano; Tartaglione, Lida; Rotondi, Silverio; Pasquali, Marzia; Maddaloni, Ernesto; Mignogna, Carmen; D'onofrio, Luca; Zampetti, Simona; Carlone, Angela; Muci, Maria Luisa; Mastroluca, Daniela; Fassino, Valeria; Buzzetti, Raffaella; Mazzaferro, Sandro - 01a Articolo in rivista
rivista: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (-Springfield, Ill. : Charles C. Thomas -Philadelphia : J.B. Lippincott Co. -Baltimore, Md. : Issued for the Endocrine Society by the Williams & Wilkins Co. -Bethesda, MD : Endocrine Society -Chevy Chase, MD : Endocrine Society) pp. 1-9 - issn: 0021-972X - wos: WOS:000805246100001 (1) - scopus: 2-s2.0-85136910043 (1)

11573/1633232 - 2022 - Third dose of COVID-19 vaccine in diabetes. Relevance of good metabolic control to improve its efficacy
Pieralice, Silvia; D'onofrio, Luca; Pozzilli, Paolo; Buzzetti, Raffaella - 01b Commento, Erratum, Replica e simili
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 1-3 - issn: 1520-7552 - wos: WOS:000789584200001 (4) - scopus: 2-s2.0-85129015173 (5)

11573/1660193 - 2022 - The sodium–glucose co-transporter-2 (SGLT2) inhibitors reduce platelet activation and thrombus formation by lowering NOX2-related oxidative stress: a pilot study
Pignatelli, Pasquale; Baratta, Francesco; Buzzetti, Raffaella; D’Amico, Alessandra; Castellani, Valentina; Bartimoccia, Simona; Siena, Antonio; D'onofrio, Luca; Maddaloni, Ernesto; Pingitore, Annachiara; Alfonso Chiariello, Giovanni; Santilli, Francesca; Pastori, Daniele; Cocomello, Nicholas; Violi, Francesco; Del Ben, Maria; Cammisotto, Vittoria; Carnevale, Roberto - 01a Articolo in rivista
rivista: ANTIOXIDANTS (Basel: MDPI) pp. 1-12 - issn: 2076-3921 - wos: WOS:000872054400001 (7) - scopus: 2-s2.0-85140490548 (10)

11573/1663160 - 2022 - Immunoreactivities Against Different Tyrosine-Phosphatase 2 (IA-2)(256-760) Protein Domains Characterize Distinct Phenotypes in Subjects With LADA
Tiberti, C.; D'onofrio, L.; Panimolle, F.; Zampetti, S.; Maddaloni, E.; Buzzetti, R. - 01a Articolo in rivista
rivista: FRONTIERS IN ENDOCRINOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. 921886- - issn: 1664-2392 - wos: WOS:000890903700001 (2) - scopus: 2-s2.0-85134028216 (3)

11573/1573592 - 2021 - Short-term safety profile of Sars-Cov2 vaccination on glucose control. Continuous glucose monitoring data in people with autoimmune diabetes
D'onofrio, L.; Coraggio, L.; Zurru, A.; Carlone, A.; Mignogna, C.; Moretti, C.; Maddaloni, E.; Buzzetti, R. - 01a Articolo in rivista
rivista: DIABETES RESEARCH AND CLINICAL PRACTICE (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 1-3 - issn: 0168-8227 - wos: WOS:000696929400020 (14) - scopus: 2-s2.0-85113812509 (13)

11573/1548713 - 2021 - Small nerve fiber damage and Langerhans cells in type 1 and type 2 diabetes and LADA measured by corneal confocal microscopy
D'onofrio, L.; Kalteniece, A.; Ferdousi, M.; Azmi, S.; Petropoulos, I. N.; Ponirakis, G.; Alam, U.; Asghar, O.; Marshall, A.; Boulton, A. J. M.; Efron, N.; Buzzetti, R.; Soran, H.; Malik, R. A. - 01a Articolo in rivista
rivista: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (St. Louis, MO. : C.V. Mosby Co.; c1977-) pp. - - issn: 1552-5783 - wos: WOS:000685196300024 (17) - scopus: 2-s2.0-85105307713 (19)

11573/1521661 - 2021 - Decrease of coronary heart disease risk with GLP1-receptor agonists or SGLT2 inhibitors therapy in patients with type 2 diabetes in primary cardiovascular prevention: a 24 months follow-up study
D'onofrio, L.; Mignogna, C.; Carlone, A.; Bellizzi, E.; Di Guida, M.; Moretti, C.; Zampetti, S.; Leto, G.; Maddaloni, E.; Buzzetti, R. - 01a Articolo in rivista
rivista: DIABETES RESEARCH AND CLINICAL PRACTICE (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. - - issn: 0168-8227 - wos: WOS:000636363400024 (1) - scopus: 2-s2.0-85100382123 (9)

11573/1548715 - 2021 - Effects of the COVID-19 lockdown on glycaemic control in subjects with type 2 diabetes: the glycalock study
D'onofrio, L.; Pieralice, S.; Maddaloni, E.; Mignogna, C.; Sterpetti, S.; Coraggio, L.; Luordi, C.; Guarisco, G.; Leto, G.; Leonetti, F.; Manfrini, S.; Buzzetti, R. - 01a Articolo in rivista
rivista: DIABETES, OBESITY AND METABOLISM (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. - - issn: 1462-8902 - wos: WOS:000637082900001 (41) - scopus: 2-s2.0-85103542538 (45)

11573/1580406 - 2021 - Corneal keratocyte density and corneal nerves are reduced in patients with severe obesity and improve after bariatric surgery
Iqbal, Zohaib; Kalteniece, Alise; Ferdousi, Maryam; Adam, Safwaan; D'onofrio, Luca; Ho, Jan H; Rao, Anoop Prasanna; Dhage, Shaishav; Azmi, Shazli; Liu, Yifen; Donn, Rachelle; Malik, Rayaz A; Soran, Handrean - 01a Articolo in rivista
rivista: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (St. Louis, MO. : C.V. Mosby Co.; c1977-) pp. 20- - issn: 1552-5783 - wos: WOS:000610085900013 (13) - scopus: 2-s2.0-85100324862 (15)

11573/1573616 - 2021 - Impact of cardiovascular disease on clinical outcomes in hospitalized patients with Covid-19. a systematic review and meta-analysis
Maddaloni, E.; D'onofrio, L.; Siena, A.; Luordi, C.; Mignogna, C.; Amendolara, R.; Cavallari, I.; Grigioni, F.; Buzzetti, R. - 01g Articolo di rassegna (Review)
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia Roma : CEPI) pp. 1-11 - issn: 1828-0447 - wos: WOS:000673721700001 (6) - scopus: 2-s2.0-85110813556 (6)

11573/1521681 - 2021 - Risk of cardiac autonomic neuropathy in latent autoimmune diabetes in adults is similar to type 1 diabetes and lower compared to type 2 diabetes. A cross-sectional study
Maddaloni, E.; Moretti, C.; Del Toro, R.; Sterpetti, S.; Ievolella, M. V.; Arnesano, G.; Strollo, R.; Briganti, S. I.; D'onofrio, L.; Pozzilli, P.; Buzzetti, R. - 01a Articolo in rivista
rivista: DIABETIC MEDICINE (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. 1-9 - issn: 0742-3071 - wos: WOS:000591502100001 (7) - scopus: 2-s2.0-85096645909 (7)

11573/1612629 - 2021 - Investigational therapies targeting CD3 for prevention and treatment of type 1 diabetes
Mignogna, C.; Maddaloni, E.; D'onofrio, L.; Buzzetti, R. - 01g Articolo di rassegna (Review)
rivista: EXPERT OPINION ON INVESTIGATIONAL DRUGS (-London United Kingdom:Informa Healthcare -London, United Kingdom: Ashley Publications Limited) pp. 1209-1219 - issn: 1354-3784 - wos: WOS:000740923900001 (13) - scopus: 2-s2.0-85122723230 (14)

11573/1579994 - 2021 - Spinal Inhibitory Dysfunction in Patients With Painful or Painless Diabetic Neuropathy
Worthington, A.; Kalteniece, A.; Ferdousi, M.; D'onofrio, L.; Dhage, S.; Azmi, S.; Adamson, C.; Hamdy, S.; Malik, R. A.; Calcutt, N. A.; Marshall, A. G. - 01a Articolo in rivista
rivista: DIABETES CARE ([Alexandria, VA, etc.] : American Diabetes Association) pp. 1835-1841 - issn: 1935-5548 - wos: WOS:000687944700020 (9) - scopus: 2-s2.0-85111156593 (9)

11573/1579997 - 2021 - Optimal utility of h-reflex rdd as a biomarker of spinal disinhibition in painful and painless diabetic neuropathy
Worthington, A.; Kalteniece, A.; Ferdousi, M.; D'onofrio, L.; Dhage, S.; Azmi, S.; Adamson, C.; Hamdy, S.; Malik, R. A.; Calcutt, N. A.; Marshall, A. G. - 01a Articolo in rivista
rivista: DIAGNOSTICS (Basel: MDPI) pp. 1-12 - issn: 2075-4418 - wos: WOS:000677339600001 (5) - scopus: 2-s2.0-85111146533 (5)

11573/1663298 - 2020 - Diabetes, diabetic medications, and risk of fracture
D'onofrio, Luca; Palermo, Andrea; Napoli, Nicola. - 02a Capitolo o Articolo
libro: Marcus and Feldman’s Osteoporosis - (9780128130735; 9780128130742)

11573/1580412 - 2020 - Corneal confocal microscopy compared with quantitative sensory testing and nerve conduction for diagnosing and stratifying the severity of diabetic peripheral neuropathy
Ferdousi, M.; Kalteniece, A.; Azmi, S.; Petropoulos, I. N.; Worthington, A.; D'onofrio, L.; Dhage, S.; Ponirakis, G.; Alam, U.; Marshall, A.; Faber, C. G.; Lauria, G.; Soran, H.; Malik, R. A. - 01a Articolo in rivista
rivista: BMJ OPEN DIABETES RESEARCH AND CARE (London : BMJ Publishing Group Ltd) pp. - - issn: 2052-4897 - wos: WOS:000601148400001 (14) - scopus: 2-s2.0-85098116578 (16)

11573/1467150 - 2020 - Clinical features of patients with type 2 diabetes with and without Covid-19: a case control study (CoViDiab I)
Maddaloni, E.; D'onofrio, L.; Alessandri, F.; Mignogna, C.; Leto, G.; Coraggio, L.; Sterpetti, S.; Pascarella, G.; Mezzaroma, I.; Lichtner, M.; Pozzilli, P.; Agro, F. E.; Rocco, M.; Pugliese, F.; Mastroianni, C. M.; Buzzetti, R. - 01a Articolo in rivista
rivista: DIABETES RESEARCH AND CLINICAL PRACTICE (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. - - issn: 0168-8227 - wos: WOS:000598123600028 (21) - scopus: 2-s2.0-85092410856 (28)

11573/1502585 - 2020 - Cardiometabolic multimorbidity is associated with a worse Covid-19 prognosis than individual cardiometabolic risk factors. A multicentre retrospective study (CoViDiab II)
Maddaloni, E.; D'onofrio, L.; Alessandri, F.; Mignogna, C.; Leto, G.; Pascarella, G.; Mezzaroma, I.; Lichtner, M.; Pozzilli, P.; Agro, F. E.; Rocco, M.; Pugliese, F.; Lenzi, A.; Holman, R. R.; Mastroianni, C. M.; Buzzetti, R.; Ajassa, C.; Alban, R.; Alessi, F.; Aronica, R.; Belvisi, V.; Candy, M.; Caputi, A.; Carrara, A.; Casali, E.; Cavallari, E. N.; Ceccarelli, G.; Celani, L.; Ciardi, M. R.; Coraggio, L.; Curtolo, A.; D'agostino, C.; D'ettorre, G.; De Giorgi, F.; De Girolamo, G.; Filippi, V.; Gnessi, L.; Luordi, C.; Moretti, C.; Recchia, G.; Ridolfi, M.; Romani, F. E.; Russo, G.; Ruberto, F.; Savelloni, G.; Siccardi, G.; Siena, A.; Sterpetti, S.; Valeri, S.; Vera, M.; Volpicelli, L.; Watanabe, M.; Aiuti, M.; Campagna, G.; Del Borgo, C.; Fondaco, L.; Kertusha, B.; Leonetti, F.; Marocco, R.; Masala, R.; Zuccala, P.; Nonnis, G.; Rigoli, A.; Strumia, A.; Alampi, D. - 01a Articolo in rivista
rivista: CARDIOVASCULAR DIABETOLOGY (London: BioMed Central.) pp. 1-11 - issn: 1475-2840 - wos: WOS:000576891000003 (77) - scopus: 2-s2.0-85092454453 (80)

11573/1444504 - 2020 - Clinical, Biochemical, and Radiological Profile of Normocalcemic Primary Hyperparathyroidism
Palermo, A.; Naciu, A. M.; Tabacco, G.; Falcone, S.; Santonati, A.; Maggi, D.; D'onofrio, L.; Briganti, S. I.; Castellitto, D.; Casini, A.; Pedone, C.; Lelli, D.; Fabbri, A.; Bilezikian, J. P.; Napoli, N.; Pozzilli, P.; Manfrini, S.; Cesareo, R. - 01a Articolo in rivista
rivista: THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (Baltimore, MD : Endocrine Society) pp. e2609-e2616 - issn: 1945-7197 - wos: WOS:000565922200031 (21) - scopus: 2-s2.0-85084137441 (21)

11573/1347607 - 2019 - Chitotriosidase Activity Is Inversely Associated with Diastolic Blood Pressure and HbA1c but Not with Arterial Stiffness in Patients with Type 2 Diabetes without Complications
D'onofrio, Luca; Luordi, Cecilia; Mignogna, Carmen; Carlone, Angela; Moretti, Chiara; Tartaglione, Lida; Maddaloni, Ernesto; Leto, Gaetano; Mazzaferro, Sandro; Buzzetti, Raffaella - 04d Abstract in atti di convegno
congresso: 79th Scientific Sessions | American Diabetes Association (San Francisco, California.)
libro: Diabetes - ()

11573/1324544 - 2019 - Osteocalcin and sclerostin. Background characters or main actors in cardiovascular disease?
D'onofrio, Luca; Maddaloni, Ernesto; Buzzetti, Raffaella - 01b Commento, Erratum, Replica e simili
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 1-3 - issn: 1520-7552 - wos: WOS:000492775200001 (13) - scopus: 2-s2.0-85074557895 (13)

11573/1206405 - 2019 - Sclerostin is expressed in the atherosclerotic plaques of patients who undergoing carotid endarterectomy
Leto, Gaetano; D'onofrio, Luca; Lucantoni, Federica; Zampetti, Simona; Campagna, Giuseppe; Foffi, Chiara; Moretti, Chiara; Carlone, Angela; Palermo, Andrea; Leopizzi, Martina; Porta, Natale; Massucci, Marco; Lenzi, Andrea; Bertoletti, Giovanni Battista; Rocca, Carlo Della; Buzzetti, Raffaella - 01a Articolo in rivista
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 1-7 - issn: 1520-7552 - wos: WOS:000454798100018 (25) - scopus: 2-s2.0-85054318508 (24)

11573/1303942 - 2019 - Wrist circumference is a biomarker of adipose tissue dysfunction and cardiovascular risk in children with obesity
Luordi, C; Maddaloni, E; Bizzarri, C; Pedicelli, S; Zampetti, S; D'onofrio, L; Moretti, C; Cappa, M; Buzzetti, R - 01a Articolo in rivista
rivista: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (Sprimger Milano: Kurtis) pp. - - issn: 1720-8386 - wos: WOS:000512013400011 (13) - scopus: 2-s2.0-85069644625 (15)

11573/1663161 - 2019 - Alpha-Tocopherol and contrast-induced nephropathy: a meta-analysis of randomized controlled trials
Monami, Matteo; Cignarelli, Angelo; Pinto, Sara; D'onofrio, Luca; Milluzzo, Agostino; Miccoli, Roberto; Penno, Giuseppe; Mannucci, Edoardo (Young Academy Group) - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH (Huber & Lang:Laenggass Strasse 76, CH 3000 Bern 9 Switzerland:011 41 31 3004646, EMAIL: contactbern@huberlang.com, INTERNET: http://www.huberlang.com, Fax: 011 41 31 3004656) pp. 188-196 - issn: 0300-9831 - wos: WOS:000614114700022 (6) - scopus: 2-s2.0-85089195866 (5)

11573/1550029 - 2019 - EVALUATION OF ARTERIAL STIFFNESS IN A COHORT OF TYPE 2 DIABETES PATIENTS
Tartaglione, Lida; Rotondi, S; Gaetano, Leto2; Marzia, Pasquali1; D'onofrio, Luca; Daniela, Mastroluca1; Maria Luisa Muci1, ; Buzzetti, Raffaella; Sandro, Mazzaferro - 01h Abstract in rivista
rivista: NEPHROLOGY DIALYSIS TRANSPLANTATION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. - - issn: 0931-0509 - wos: WOS:000495412900575 (0) - scopus: (0)

11573/1203353 - 2018 - Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes
Bertoccini, Laura; Bailetti, Diego; Summer Study In Diabetes Group (Summer, ; Alessi, Elena; Bagella, Francesco Maria; Barchetta, Ilaria; Capoccia, Danila; Silvia, Carletti; Coccia, Federica; Conti, Francesco; D'onofrio, Luca; Filardi, Tiziana; Giulia, Leanza; Gianluca, Margiotta; Incani, Michela; Moretti, Chiara; Pezzilli, Serena; Pibiri, Carlotta; Pamela, Piscitelli; Maria Giovanna Scarale, ; Sentinelli, Federica; Tavaglione, Federica; Buzzetti, Raffaella; Cavallo, Maria Gisella; Copetti, Massimiliano; Cossu, Efisio; D'angelo, Paola; De Cosmo, Salvatore; Di Mauro, Lazzaro; Leonetti, Frida; Morano, Susanna; Morviducci, Lelio; Napoli, Nicola; Prudente, Sabrina; Pugliese, Giuseppe; Trischitta, Vincenzo; Baroni Marco, Giorgio. - 01a Articolo in rivista
rivista: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 34911-34918 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85063158482 (5)

11573/1181344 - 2018 - Espressione di sclerostina nelle placche aterosclerotiche di pazienti sottoposti a tea carotidea
D'onofrio, L; Leto, G; Lucantoni, F; Campagna, G; Foffi, C; Moretti, C; Carlone, A; Mignogna, Carmen; Luordi, C; Palermo, A; Massucci, M; Della Rocca, C; Bertoletti, G; Buzzetti, R - 04d Abstract in atti di convegno
congresso: 27° Congresso Nazionale Società Italiana Diabetologia (Rimini; Italy)
libro: Il Diabete Online - ()

11573/1184860 - 2018 - Livelli aumentati di sclerostina in corso di diabete mellito tipo 2 e complicanze macrovascolari
D'onofrio, L; Lucantoni, F; Strollo, R; Leto, G; Campagna, G; Foffi, C; Moretti, C; Carlone, A; Mignogna, C; Luordi, C; Zampetti, S; Palermo, A; Lenzi, A; Napoli, N; Buzzetti, R - 04d Abstract in atti di convegno
congresso: 27° Congresso Nazionale Società Italiana Diabetologia (Rimini, Italy)
libro: Il Diabete Online - ()

11573/1086113 - 2018 - Serum sclerostin and bone turnover in latent autoimmune diabetes in adults
Napoli, Nicola; Strollo, Rocky; Defeudis, Giuseppe; Leto, Gaetano; Moretti, Chiara; Zampetti, Simona; D'onofrio, Luca; Campagna, Giuseppe; Palermo, Andrea; Greto, Valentina; Manfrini, Silvia; Hawa, Mohammed I; Leslie, R David; Pozzilli, Paolo; Buzzetti, Raffaella - 01a Articolo in rivista
rivista: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (-Springfield, Ill. : Charles C. Thomas -Philadelphia : J.B. Lippincott Co. -Baltimore, Md. : Issued for the Endocrine Society by the Williams & Wilkins Co. -Bethesda, MD : Endocrine Society -Chevy Chase, MD : Endocrine Society) pp. 1921-1928 - issn: 0021-972X - wos: WOS:000432309500020 (28) - scopus: 2-s2.0-85047219809 (32)

11573/1550017 - 2018 - EVALUATION OF VASCULAR DAMAGE BY CARDIO-ANKLE VASCULAR INDEX (CAVI) IN TYPE 2 DIABETES PATIENTS
Tartaglione, Lida; Leto, Gaetano; Marzia, Pasquali; Rotondi, Silverio; Carlone, Angela; D'onofrio, Luca; Muci, Maria Luisa; Mastroluca, Daniela; Buzzetti, Raffaella; Mazzaferro, Sandro - 01h Abstract in rivista
rivista: NEPHROLOGY DIALYSIS TRANSPLANTATION (Oxford University Press:Journals Department, Great Clarendon Street, Oxford OX2 6DP United Kingdom:011 44 1865 556767, EMAIL: jnlorders@oup.co.uk, INTERNET: http://www.oup.co.uk, Fax: 011 44 1865 267485) pp. - - issn: 0931-0509 - wos: WOS:000433059801558 (0) - scopus: (0)

11573/1111925 - 2018 - Relation Between Wrist Circumference and Left Ventricular Structure in Overweight Children
Zampetti, Simona; Campagna, Giuseppe; Leto, Gaetano; Lucantoni, Federica; D'onofrio, Luca; Marandola, Lidia; Moretti, Chiara; Chiesa, Claudio; Pacifico, Lucia; Buzzetti, Raffaella - 01a Articolo in rivista
rivista: THE AMERICAN JOURNAL OF CARDIOLOGY (NY : Elsevier Science Incorporated / NY; EXCERPTA MEDICA INC) pp. 1624-1628 - issn: 0002-9149 - wos: WOS:000436383200027 (8) - scopus: 2-s2.0-85045124113 (9)

11573/1111928 - 2018 - Wrist circumference is associated with increased systolic blood pressure in children with overweight/obesity
Zampetti, Simona; Campagna, Giuseppe; Lucantoni, Federica; Marandola, Lidia; D'onofrio, Luca; Chiesa, Claudio; Pacifico, Lucia; Vania, Andrea; Buzzetti, Raffaella; Leto, Gaetano - 01a Articolo in rivista
rivista: HYPERTENSION RESEARCH () pp. 193-197 - issn: 0916-9636 - wos: WOS:000426685300006 (12) - scopus: 2-s2.0-85040702573 (12)

11573/972317 - 2017 - Pathophysiology of Bone Fragility in Patients with Diabetes
Palermo, Andrea; D'onofrio, Luca; Buzzetti, Raffaella; Manfrini, Silvia; Napoli, Nicola - 01a Articolo in rivista
rivista: CALCIFIED TISSUE INTERNATIONAL (New York : Springer.) pp. 122-132 - issn: 0171-967X - wos: WOS:000394373400003 (56) - scopus: 2-s2.0-85011838420 (70)

11573/972274 - 2017 - Vitamin K and osteoporosis: Myth or reality?
Palermo, Andrea; Tuccinardi, Dario; D'onofrio, Luca; Watanabe, Mikiko; Maggi, Daria; Maurizi, Anna Rita; Greto, Valentina; Buzzetti, Raffaella; Napoli, Nicola; Pozzilli, Paolo; Manfrini, Silvia - 01g Articolo di rassegna (Review)
rivista: METABOLISM, CLINICAL AND EXPERIMENTAL (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 57-71 - issn: 0026-0495 - wos: WOS:000400037600007 (84) - scopus: 2-s2.0-85013765648 (91)

11573/872519 - 2016 - Frailty and geography: Should these two factors be added to the ABCDE contemporary guide to diabetes therapy?
Maddaloni, Ernesto; D'onofrio, Luca; Pozzilli, Paolo - 01b Commento, Erratum, Replica e simili
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 169-175 - issn: 1520-7552 - wos: WOS:000370716800004 (16) - scopus: 2-s2.0-84958175376 (16)

11573/872536 - 2016 - Serum chitotriosidase in postmenopausal women with severe osteoporosis
Musumeci, M.; Palermo, A; D'onofrio, Luca; Vadalà, G.; Greto, V.; Di Stasio, E.; Maddaloni, E.; Di Rosa, Manuela; Tibullo, D.; Silvia, A.; Napoli, N.; Denaro, V.; Manfrini, S. - 01a Articolo in rivista
rivista: OSTEOPOROSIS INTERNATIONAL (Springer-Verlag London Limited:Sweetapple House, Catteshall Road, Godalming Surrey GU7 3DJ United Kingdom:011 44 1483 418822, EMAIL: postmaster@svl.co.uk, Fax: 011 44 1483 415151) pp. 711-716 - issn: 0937-941X - wos: WOS:000370046200030 (4) - scopus: 2-s2.0-84957429732 (3)

11573/1680200 - 2016 - Serum chitotriosidase in postmenopausal women with severe osteoporosis
Musumeci, M; Palermo, A; D'onofrio, L; Vadalà, G; Greto, V; Di Stasio, E; Maddaloni, E; Di Rosa, M; Tibullo, D; Angeletti, S; Napoli, N; Denaro, V; Manfrini, S - 01a Articolo in rivista
rivista: OSTEOPOROSIS INTERNATIONAL (Springer-Verlag London Limited:Sweetapple House, Catteshall Road, Godalming Surrey GU7 3DJ United Kingdom:011 44 1483 418822, EMAIL: postmaster@svl.co.uk, Fax: 011 44 1483 415151) pp. 711-716 - issn: 0937-941X - wos: WOS:000370046200030 (5) - scopus: 2-s2.0-84957429732 (4)

11573/927624 - 2016 - BMI and BMD: The potential interplay between obesity and bone fragility
Palermo, Andrea; Tuccinardi, Dario; Defeudis, Giuseppe; Watanabe, Mikiko; D'onofrio, Luca; Lauria, Angelo Pantano; Napoli, Nicola; Pozzilli, Paolo; Manfrini, Silvia - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (Basel: MDPI 2003-) pp. 544- - issn: 1660-4601 - wos: WOS:000378860100023 (99) - scopus: 2-s2.0-84971520508 (106)

11573/872766 - 2015 - Effectiveness and safety of calcium and vitamin D treatment for postmenopausal osteoporosis
Cesareo, Roberto; Iozzino, Mario; D'onofrio, Luca; Terrinoni, I; Maddaloni, E; Casini, A; Campagna, G; Santonati, A; Palermo, A. - 01a Articolo in rivista
rivista: MINERVA ENDOCRINOLOGICA (Torino: Minerva Medica) pp. 231-237 - issn: 0391-1977 - wos: WOS:000363831600008 (24) - scopus: 2-s2.0-85018193559 (26)

11573/872538 - 2015 - Oral anti-diabetic drugs and fracture risk, cut to the bone: safe or dangerous? A narrative review
Palermo, A; D'onofrio, Luca; Eastell, R.; Schwartz, A. V.; Pozzilli, Paolo; Napoli, N. - 01g Articolo di rassegna (Review)
rivista: OSTEOPOROSIS INTERNATIONAL (Springer-Verlag London Limited:Sweetapple House, Catteshall Road, Godalming Surrey GU7 3DJ United Kingdom:011 44 1483 418822, EMAIL: postmaster@svl.co.uk, Fax: 011 44 1483 415151) pp. 2073-2089 - issn: 0937-941X - wos: WOS:000358040800004 (69) - scopus: 2-s2.0-84938980132 (87)

11573/853495 - 2015 - Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity
Palermo, Andrea; Strollo, Rocky; Maddaloni, Ernesto; Tuccinardi, Dario; D'onofrio, Luca; Briganti, Silvia Irina; Defeudis, Giuseppe; De Pascalis, Mariangela; Lazzaro, Maria Concetta; Colleluori, Georgia; Manfrini, Silvia; Pozzilli, Paolo; Napoli, Nicola - 01a Articolo in rivista
rivista: CLINICAL ENDOCRINOLOGY (MALDEN, USA, MA: WILEY-BLACKWELL United Kingdom: Blackwell Science Limited) pp. 615-619 - issn: 0300-0664 - wos: WOS:000350982900023 (87) - scopus: 2-s2.0-84924117090 (94)

11573/872773 - 2014 - Osteocalcin levels are inversely associated with Hba1c and BMI in adult subjects with long-standing type 1 diabetes
Maddaloni, Ernesto; D'onofrio, Luca; Lauria, Angelo; Maurizi, Anna Rita; Strollo, Rocky; Palermo, Andrea; Napoli, Nicola; Angeletti, Silvia; Pozzilli, Paolo; Manfrini, Silvia - 01a Articolo in rivista
rivista: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (Springer Milano: Editrice Kurtis Srl) pp. 661-666 - issn: 0391-4097 - wos: WOS:000338541200009 (46) - scopus: 2-s2.0-84903738765 (50)

11573/872770 - 2014 - Severe hypophosphatemic osteomalacia secondary to fanconi syndrome due to adefovir: A case report
Palermo, Andrea; Strollo, Rocky; Papalia, Rocco; D'onofrio, Luca; Maddaloni, Ernesto; Briganti, Silvia Irina; Napoli, Nicola; Vespasiani, Umberto; Costantino, Sebastiano; Pozzilli, Paolo; Denaro, Vincenzo; Manfrini, Silvia; Maddaloni, Ernesto - 01a Articolo in rivista
rivista: ENDOCRINE PRACTICE (Jacksonville, Fla. : The College and the Association,) pp. e246-e249 - issn: 1530-891X - wos: WOS:000350030800004 (2) - scopus: 2-s2.0-84919976763 (2)

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