LORENZO IANNASCOLI

Dottore di ricerca

ciclo: XXXIV


Titolo della tesi: ALCOR: Astrobiology Lab-on-Chip for Cubesat On Board Research

This work presents three years of research activities aimed at designing and developing innovative devices meant to assess the space environment effects on model biological systems. In this framework, Lab-on-Chip (\glspl{LOC}) technologies have been thoroughly investigated as they meet the requirements of spacecraft applications, by minimizing resource consumption (power, volume, and mass), demonstrating high application flexibility, and operating in a gravity-independent fashion. An on-chip microincubator consisting of a fully integrated microsystem has been engineered. It enables real-time monitoring of microbial cultures activity, employing a combination of different thin-- and thick--film fabrication technologies jointly used to achieve a compact, automated and low-power device. Acquired techniques and know-how have been further employed to develop microfluidic systems for in-vitro growth of plant--bacteria and RNA virus amplification and sensing. Research effort was lastly devoted to implementing \gls{LOC} technologies aboard nanosatellite platforms, taking into account all the components required for their operation. The case study of Astrobio CubeSat (ABCS) is reported. Several novel solutions, ranging from optimized experimental protocol to peculiar system-level arrangements, have been implemented to meet the requirements arising from the challenging mission scenario. Some of them represent a breakthrough compared to the state–of–the–art and available products on the market. This research has been carried out with a multidisciplinary approach, involving microelectronics, microfluidics, mechanics, chemistry and biology. Microfabrication technologies, CAD modelling and FEM analysis were deeply investigated and extensively practised to manufacture prototypes of the proposed devices as well as to verify and validate design choices. Experimental tests and proofs of concept were carried out to assess performances and to confirm their novelty and originality.

Produzione scientifica

11573/1669513 - 2023 - AstroBio-CubeSat: A lab-in-space for chemiluminescence-based astrobiology experiments
Calabria, D.; Trozzi, I.; Lazzarini, E.; Pace, A.; Zangheri, M.; Iannascoli, L.; Maipan Davis, N.; Gosikere Matadha, S. S.; Baratto De Albuquerque, T.; Pirrotta, S.; Del Bianco, M.; Impresario, G.; Popova, L.; Lovecchio, N.; De Cesare, G.; Caputo, D.; Brucato, J.; Nascetti, A.; Guardigli, M.; Mirasoli, M. - 01a Articolo in rivista
rivista: BIOSENSORS & BIOELECTRONICS (Barking: Elsevier Science Publishers) pp. 1-10 - issn: 0956-5663 - wos: WOS:000929351800001 (5) - scopus: 2-s2.0-85147451355 (9)

11573/1673256 - 2023 - 3D-Printed Face Mask with Integrated Sensors as Protective and Monitoring Tool
Casalinuovo, Silvia; Buzzin, Alessio; Mastrandrea, Antonio; Mazzetta, Ivan; Barbirotta, Marcello; Iannascoli, Lorenzo; Nascetti, Augusto; De Cesare, Giampiero; Puglisi, Donatella; Caputo, Domenico - 04b Atto di convegno in volume
congresso: XXI Conferenza Nazionale Sensori e Microsistemi (AISEM 2022) (Roma)
libro: Sensors and Microsystems Proceedings of AISEM 2022 - (978-3-031-25705-6; 978-3-031-25706-3)

11573/1681915 - 2023 - Characterization of temperature distribution in microfluidic chip for DNA amplification
Lovecchio, N.; Costantini, F.; Orsatti, M.; Iannascoli, L.; Nascetti, A.; De Cesare, G.; Caputo, D. - 04b Atto di convegno in volume
congresso: 21st National Conference on Sensors and Microsystems, AISEM 2022 (Rome; Italy)
libro: Sensors and microsystems proceedings of AISEM 2022 - (978-3-031-25705-6; 978-3-031-25706-3)

11573/1690104 - 2023 - In-orbit Characterization of a Lab- on-Chip Payload with Integrated Thin-Film Photosensors for Chemiluminescent Immunoassays aboard the AstroBio CubeSat Mission
Nascetti, A; Carletta, S; Schirone, L; Caputo, D; Lovecchio, N; De Cesare, G; Davis, Nm; De Albuquerque, Tb; Granello, P; Iannascoli, L; Sansolini, S; Mirasoli, M; Impresario, G; Meneghin, A; Brucato, Jr - 04b Atto di convegno in volume
congresso: 9th IEEE International Workshop on Advances in Sensors and Interfaces, IWASI 2023 (Monopoli)
libro: Proceedings of the 9th IEEE International Workshop on Advances in Sensors and Interfaces, IWASI 2023 - (979-8-3503-3694-8)

11573/1690107 - 2023 - On the Electrical Power System of the ASTROBIO CubeSat
Schirone, Luigi; Granello, Pierpaolo; Carletta, Stefano; Maipan Davis, Nithin; Iannascoli, Lorenzo; Paris, Claudio; Nascetti, Augusto; Greco, Erminio; Campesato, Roberta - 04b Atto di convegno in volume
congresso: 13th European Space Power Conference – ESPC 2023 (Elche, Spain)
libro: Proceedings of the 13th European Space Power Conference – ESPC 2023 - ()

11573/1692940 - 2023 - In-flight validation of End-Of-Life optimized Triple Junction solar cells onboard ASTROBIO cubesat
Schirone, Luigi; Granello, Pierpaolo; Ferrara, Matteo; Avoli, Matteo; Imperatori, Davide; Maipan Davis, Nithin; Iannascoli, Lorenzo; Nascetti, Augusto; Carletta, Stefano; Paris, Claudio; Greco, Erminio; Campesato, Roberta - 04b Atto di convegno in volume
congresso: 50tn IEEE Photovoltaic Specialists Conference (San Juan, Puertorico, USA)
libro: Proceedings of the 50th IEEE Photovoltaic Specialists Conference - ()

11573/1668019 - 2022 - Characterization and Testing of the Passive Magnetic Attitude Control System for the 3U AstroBio CubeSat
Carletta, S.; Nascetti, A.; Gosikere Matadha, S. S.; Iannascoli, L.; Baratto De Albuquerque, T.; Maipan Davis, N.; Schirone, L.; Impresario, G.; Pirrotta, S.; Brucato, J. R. - 01a Articolo in rivista
rivista: AEROSPACE (Basel : MDPI) pp. 1-16 - issn: 2226-4310 - wos: WOS:000895803700001 (1) - scopus: 2-s2.0-85145738650 (3)

11573/1583871 - 2021 - Implementation and testing of a passive magnetic attitude control system for the 3U AstroBio CubeSat orbiting in the Van Alllen belt
Carletta, Stefano; Gosikere Matadha, Sagar Sarvad; Ramesh, Sai Vishal; Iannascoli, Lorenzo; Paglialunga, Daniele; Nascetti, Augusto; Schirone, Luigi - 04b Atto di convegno in volume
congresso: 72nd International Astronautical Congress (Dubai, UAE)
libro: Proceedings of the 72nd International Astronautical Congress - ()

11573/1604702 - 2021 - Split aptamers immobilized on polymer brushes integrated in a lab-on-chip system based on an array of amorphous silicon photosensors. A novel sensor assay
Nandimandalam, M.; Costantini, F.; Lovecchio, N.; Iannascoli, L.; Nascetti, A.; De Cesare, G.; Caputo, D.; Manetti, C. - 01a Articolo in rivista
rivista: MATERIALS (Basel: Molecular Diversity Preservation International-MDPI) pp. 1-11 - issn: 1996-1944 - wos: WOS:000735025500001 (3) - scopus: 2-s2.0-85119988058 (4)

11573/1473212 - 2020 - RNA/DNA amplification methods for the detection of bacteria and virus through an optoelectronic lab-on-chip
Costantini, F.; Lovecchio, N.; Iannascoli, L.; Scala, V.; Faggioli, F.; Pucci, N.; Loreti, S.; Decesare, G.; Nascetti, A.; Caputo, D. - 04b Atto di convegno in volume
congresso: 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 (Virtual, Online)
libro: MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences - ()

11573/1411997 - 2020 - Micro-incubator based on lab-on-glass technology for nanosatellite missions
Iannascoli, L.; Costantini, F.; Lovecchio, N.; Buzzin, A.; Caputo, D.; De Cesare, G.; Nascetti, A. - 04b Atto di convegno in volume
congresso: 20th AISEM National conference on sensors and microsystems, 2019 (Naples; Italy)
libro: Sensors and Microsystems. Proceedings of the 20th AISEM 2019 National Conference - (978-3-030-37557-7)

11573/1574059 - 2020 - Astrobio cubesat: Enabling technologies for astrobiology research in space
Iannascoli, Lorenzo; Nascetti, Augusto; Carletta, Stefano; Schirone, Luigi; Meneghin, Andrea; Robert Brucato, John; Paglialunga, Daniele; Poggiali, Giovanni; Pirrotta, Simone; Impresario, Gabriele; Sabatini, Alessia; Pacelli, Claudia - 04b Atto di convegno in volume
congresso: 71st International Astronautical Congress, IAC 2020 (Virtual Event)
libro: Proceedings of the 71st International Astronautical Congress - ()

11573/1570742 - 2020 - Astrobio cubesat: A nanosatellite for astrobiology experiments in space
Meneghin, A.; Brucato, J. R.; Paglialunga, D.; Nascetti, A.; Fiacco, G.; Pirrotta, S.; Odogoudra, N.; Carletta, S.; Schirone, L.; Granello, P.; Ferrara, M.; Teofilatto, P.; Massaioli, S.; Paris, C.; Parisse, M.; Iannascoli, L.; Caputo, D.; De Cesare, G.; Mirasoli, M.; Zangheri, M.; Anfossi, L.; Popova, L. - 04b Atto di convegno in volume
congresso: 5th IAA conference on University Satellite Missions and Cubesat Workshop, 2020 (Rome; Italy)
libro: Advances in the Astronautical Sciences - ()

11573/1318613 - 2019 - Integrated 3D microfluidic device for impedance spectroscopy in lab-on-chip systems
Buzzin, A.; Iannascoli, L.; Muzi, M.; Veroli, A.; Caputo, D.; De Cesare, G.; Maiolo, L.; Maita, F.; Ricci, G. - 04b Atto di convegno in volume
congresso: 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019 (Otranto (LE) - Italy)
libro: Proceedings - 2019 8th International Workshop on Advances in Sensors and Interfaces, IWASI 2019 - (978-1-7281-0557-4)

11573/1301877 - 2019 - Lab-on-chip for integrated cell culture monitoring
Buzzin, A.; Muzi, M.; Veroli, A.; Iannascoli, L.; Frezza, F.; Nascetti, A.; De Cesare, G.; Caputo, D.; Maiolo, L.; Maita, F.; Ricci, G. - 04b Atto di convegno in volume
congresso: AISEM 2019 (Napoli)
libro: Proc. AISEM 2019 - ()

11573/1473191 - 2019 - Flexible microfluidic networks enabling rapid prototyping of novel surface chemistries in lab-on-chip
Costantini, F.; Iannascoli, L.; Lovecchio, N.; Mirasoli, M.; De Cesare, G.; Caputo, D.; Nascetti, A. - 04b Atto di convegno in volume
congresso: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (Basel, Switzerland)
libro: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - (978-173341900-0)

11573/1366810 - 2019 - On-chip cell-culture support and monitoring device with integrated thin-film sensors and actuators
Iannascoli, L.; Nascetti, A.; Buzzin, A.; Costantini, F.; Lovecchio, N.; Caputo, D.; De Cesare, G. - 04b Atto di convegno in volume
congresso: 70th International Astronautical Congress, IAC 2019 (Waschington, D.C. –USA)
libro: Proceedings of the International Astronautical Congress, IAC - ()

11573/1366815 - 2019 - PLEIADES: A highly integrated lab-on-chip system for the detection of life markers in extraterrestrial environments
Nascetti, A.; Mirasoli, M.; Costantini, F.; Iannascoli, L.; Zangheri, M.; Paglialunga, D.; Roda, A.; Pirrotta, S.; De Cesare, G.; Caputo, D. - 04b Atto di convegno in volume
congresso: 70th International Astronautical Congress, IAC 2019 (Waschington, D.C. –USA)
libro: Proceedings of the International Astronautical Congress, IAC - ()

11573/1174783 - 2019 - Integrated chemiluminescence-based lab-on-chip for detection of life markers in extraterrestrial environments
Nascetti, A.; Mirasoli, M.; Marchegiani, E.; Zangheri, M.; Costantini, F.; Porchetta, A.; Iannascoli, L.; Lovecchio, N.; Caputo, D.; De Cesare, G.; Pirrotta, S.; Roda, A. - 01a Articolo in rivista
rivista: BIOSENSORS & BIOELECTRONICS (Barking: Elsevier Science Publishers) pp. 195-203 - issn: 0956-5663 - wos: WOS:000450376600024 (27) - scopus: 2-s2.0-85052848427 (30)

11573/1131644 - 2018 - On-chip micro-incubator with integrated sensors and actuators
Iannascoli, Lorenzo; Nardecchia, Marco; Costantini, Francesca; Pirrotta, Simone; Lovecchio, Nicola; Caputo, Domenico; De Cesare, Giampiero; Nascetti, Augusto - 04b Atto di convegno in volume
congresso: 4th IAA Conference on University Satellite Missions and CubeSat Workshop, 2017 (Rome, Italy)
libro: Advances in the Astronautical Sciences - (9780877036470)

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