COSENTINO LIVIA

PhD Graduate

PhD program:: XXXIII



Thesis title: The role of the methyl-CpG binding protein 2 (MECP2) in shaping vulnerability for psychopathology

Exposure to trauma is a common experience worldwide, which may lead to multiple adverse consequences for physical and mental health, and is compulsory for the diagnosis of post-traumatic stress disorder (PTSD), a chronic mental disorder characterized by symptoms of persistent anxiety and hypervigilance. Considering the key role played by susceptibility in determining the outcome of traumatic experiences, and the well-documented contribution of epigenetic mechanisms in the establishment of interindividual differences in PTSD risk and resilience, this dissertation aimed at translationally addressing the potential contribution of the X-linked epigenetic regulator methyl-CpG binding protein 2 (MECP2) in shaping vulnerability to develop stress and trauma-related disorders. With this goal, taking advantage of a transgenic mouse line, we evaluated whether disruptions in MeCP2 functionality may predispose to the onset of PTSD-like symptomatology in the aftermath of a traumatic event. Male mice constitutively expressing a hypofunctional form of MeCP2 protein and exposed to unescapable footshocks displayed exaggerated fear and increased avoidance of trauma cues, overgeneralization of fear responses and altered circadian rhythms, mimicking the psychopathological symptoms experienced by patients. Also, traumatized mutants displayed peripheral alterations in gene expression mirroring patterns already evidenced in people suffering from PTSD. Interestingly, although mutant females displayed similar disruptions in fear memory compared to males, sex-dependent alterations in stress responsivity were evidenced among mutants, with females releasing lower and males higher levels of glucocorticoids compared to sex-matched wild type (wt) controls. At the brain level, a region- and sex- specific pattern of stress-related alterations in gene expression was found. We also aimed at confirming that reduced MECP2 functionality was associated with increased stress vulnerability in human cohorts. This issue was addressed in two different studies. The first including healthy participants, explored the link between blood MECP2 expression and childhood adversities, and addressed its effect on symptoms of depression and anxiety, which could confer vulnerability to stress-related disorders. The second study focused on the evaluation of blood MECP2 levels in PTSD patients and healthy traumatized and non-traumatized controls, with or without stress during childhood, and their correlation with the severity of PTSD symptomatology. In the first study we found that decreased MECP2 expression was indirectly associated with increased depressed mood and trait anxiety in healthy participants, a correlation mediated by childhood stress and moderated by gender. In line with this, in the second study we observed that childhood stress mediated the association between decreased MECP2 expression and increased PTSD symptom severity in traumatized participants, especially among women, further corroborating a role for MECP2 downregulation in promoting trauma vulnerability. Interestingly, men traumatized at adulthood overexpressed MECP2, independently from the severity of childhood stress. Overall, the present work presents strong evidence for the role of decreased MECP2 functionality in boosting susceptibility to develop PTSD in the aftermath of traumatic experiences, opening to the possibility that MECP2-related epigenetic pathways might be involved in the etiology of the disorder. Importantly, gender emerges as an important modulator of the association between MECP2 and PTSD susceptibility.

Research products

11573/1657453 - 2022 - Serotonin receptor 7 stimulation rescues fear generalization in a male mouse model of post-traumatic stress disorder
Di Crescenzo, L.; Cosentino, L.; Urbinati, C.; Lacivita, E.; Leopoldo, M.; De Filippis, B. - 04c Atto di convegno in rivista
paper: NEUROSCIENCE APPLIED (Amsterdam: Elsevier B.V) pp. 100043- - issn: 2772-4085 - wos: (0) - scopus: (0)
conference: Workshop for Early Career Scientists in Europe organized by European College of Neuropsychopharmacology (ECNP), (Nice (FR))

11573/1672906 - 2022 - Pharmacological stimulation of the serotonin receptor 7 rescues fear generalization in a PTSD mouse model carrying a truncated form of MeCP2.
Di Crescenzo, L.; Cosentino, L.; Urbinati, C.; Lacivita, E.; Leopoldo, M.; De Filippis, B. - 04d Abstract in atti di convegno
conference: Federation of European Neuroscience Societies (FENS) 2022 (Paris (FR))
book: Abstractbook - ()

11573/1657450 - 2022 - Treatment with FRAX486 rescues neurobehavioral and metabolic alterations in a female mouse model of CDKL5 deficiency disorder
Fuchs, Claudia; Cosentino, Livia; Urbinati, Chiara; Talamo, Maria Cristina; Medici, Giorgio; Quattrini, Maria Cristina; Mottolese, Nicola; Pietraforte, Donatella; Fuso, Andrea; Ciani, Elisabetta; De Filippis, Bianca - 01a Articolo in rivista
paper: CNS NEUROSCIENCE & THERAPEUTICS (Oxford : Blackwell, 2008-) pp. 1718-1732 - issn: 1755-5930 - wos: WOS:000836897900001 (2) - scopus: 2-s2.0-85135447896 (2)

11573/1672908 - 2022 - Treatment with the CB1R antagonist rimonabant rescues brain mitochondrial dysfunction via inhibition of intra-mitochondrial protein kinase A signalling in a mouse model of Rett syndrome
Urbinati, C.; Cosentino, L.; Valenti, D.; De Rasmo, D.; Signorile, A.; Pellas, M.; Vacca, R. A.; De Filippis, B. - 04d Abstract in atti di convegno
conference: Federation of European Neuroscience Societies (FENS) 2022 (Paris (FR))
book: Abstractbook - ()

11573/1539694 - 2021 - Methyl-CpG binding protein 2 dysfunction provides stress vulnerability with sex- and zygosity-dependent outcomes
Cosentino, L.; Bellia, F.; Pavoncello, N.; Vigli, D.; D'addario, C.; De Filippis, B. - 01a Articolo in rivista
paper: EUROPEAN JOURNAL OF NEUROSCIENCE (Blackwell Science Limited:PO Box 88, Oxford OX2 0NE United Kingdom:011 44 1865 776868, 011 44 1865 206038, EMAIL: journals.cs@blacksci.co.uk, INTERNET: http://www.blackwell-science.com, Fax: 011 44 1865 721205) pp. - - issn: 0953-816X - wos: WOS:000633536100001 (6) - scopus: 2-s2.0-85103160583 (5)

11573/1657452 - 2021 - Pharmacological stimulation of the serotonin receptor 7 rescues PTSD-like behavioural alterations in male mice carrying a truncated form of mecp2.
Di Crescenzo, Livia; Cosentino, Livia; Urbinati, Chiara; Lacivita, Enza; Leopoldo, Marco; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 49th Meeting of European Brain and Behaviour Society (EBBS) (Lausanne (CH))
book: EBBS Abstractbook - ()

11573/1539692 - 2021 - Stimulation of the serotonin receptor 7 restores brain histone H3 acetylation and MeCP2 corepressor protein levels in a female mouse model of Rett syndrome
Napoletani, G.; Vigli, D.; Cosentino, L.; Grieco, M.; Talamo, M. C.; Lacivita, E.; Leopoldo, M.; Laviola, G.; Fuso, A.; D'erme, M.; De Filippis, B. - 01a Articolo in rivista
paper: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (American Association of Neuropathologists:University of Iowa, College of Medicine, Division of Neuropathology, Rm. 148A-ML:Iowa City, IA 52242:(319)335-8273, Fax: (319)335-6510) pp. 265-273 - issn: 0022-3069 - wos: WOS:000637311200007 (1) - scopus: 2-s2.0-85102222596 (2)

11573/1519774 - 2021 - P.219 The antidiabetic drug metformin improves cognitive flexibility deficits in a female mouse model of Rett syndrome
Urbinati, C.; Cosentino, L.; Evoli, M.; De Filippis, B. - 01h Abstract in rivista
paper: EUROPEAN NEUROPSYCHOPHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. S28-S29 - issn: 0924-977X - wos: WOS:000624608100039 (0) - scopus: (0)

11573/1605799 - 2021 - Treatment with the bacterial toxin CNF1 selectively rescues cognitive and brain mitochondrial deficits in a female mouse model of Rett syndrome carrying a MeCP2-null mutation
Urbinati, C.; Cosentino, L.; Germinario, E. A. P.; Valenti, D.; Vigli, D.; Ricceri, L.; Laviola, G.; Fiorentini, C.; Vacca, R. A.; Fabbri, A.; De Filippis, B. - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000671220100001 (5) - scopus: 2-s2.0-85108295315 (6)

11573/1605803 - 2021 - Long-term treatment with the antidiabetic drug metformin ameliorates cognitive flexibility deficits in a female mouse model of Rett syndrome.
Urbinati, Chiara; Cosentino, Livia; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 49th Meeting of European Brain and Behaviour Society (EBBS) (Lausanne, Switzerland)
book: Abstractbook - ()

11573/1605805 - 2021 - The first-line antidiabetic drug Metformin improves the impaired cognitive flexibility in a female mouse model of Rett syndrome.
Urbinati, Chiara; Cosentino, Livia; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 19th SINS National Congress (Virtual)
book: Abstractbook - ()

11573/1488991 - 2021 - Chronic treatment with cannabidiolic acid (CBDA) reduces thermal pain sensitivity in male mice and rescues the hyperalgesia in a mouse model of rett syndrome
Vigli, D.; Cosentino, L.; Pellas, M.; De Filippis, B. - 01a Articolo in rivista
paper: NEUROSCIENCE (Oxford: Elsevier Ltd. Oxford; New York: Pergamon Press) pp. 113-123 - issn: 0306-4522 - wos: WOS:000607499400009 (13) - scopus: 2-s2.0-85094147923 (16)

11573/1489007 - 2020 - P.861Gender-specific involvement of Methyl-CpG binding protein 2 in vulnerability to stress: evidence from a healthy cohort
Cosentino, L.; Zidda, F.; Witt, S.; De Filippis, B.; Flor, H. - 01h Abstract in rivista
paper: EUROPEAN NEUROPSYCHOPHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. S477-S478 - issn: 0924-977X - wos: WOS:000593520800606 (0) - scopus: (0)

11573/1487099 - 2020 - MECP2: a sex dependent actor in stress regulation of memory
Cosentino, Livia; Bellia, Fabio; Pavoncello, Nicole; Urbinati, Chiara; D'addario, Claudio; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: Neuroscience PhD Meeting 2020, SINS (Naples, Italy)
book: PhD national meeting, SINS - ()

11573/1406172 - 2020 - LP-211 persistently rescues neurobehavioral and physiological impairments via epigenetic modulation of brain histone acetylation in a mouse model of Rett syndrome
Cosentino, Livia; Napoletani, Giorgia; Vigli, Daniele; Grieco, Maddalena; Cristina Talamo, Maria; Lacivita, Enza; Leopoldo, Marcello; Laviola, Giovanni; Fuso, Andrea; D'erme, Maria; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: FENS 2020 virtual forum (virtual)
book: FENS 2020 virtual forum - ()

11573/1406176 - 2020 - Fight, flight or freeze? MECP2 involvement in choosing the strategy to cope with stress
Cosentino, Livia; Zidda, Francesca; Witt, Stephanie; Di Crescenzo, Livia; Flor, Herta; De Filippis, Bianca. - 04d Abstract in atti di convegno
conference: 27th International "Stress and Behavior" Neuroscience and Biopsychiatry Conference (Saint Petersburg)
book: 27th International "Stress and Behavior" Neuroscience and Biopsychiatry Conference - ()

11573/1406167 - 2020 - Inhibition of p21-activated kinase rescues disrupted phenotype in a mouse model of CDKL5 deficiency disorder
Cristina Talamo, Maria; Pellas, Mattia; Urbinati, Chiara; Cosentino, Livia; De Filippis, Bianca - 04c Atto di convegno in rivista
paper: EUROPEAN NEUROPSYCHOPHARMACOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0924-977X - wos: WOS:000509788000060 (0) - scopus: (0)
conference: ECNP workshop for early career scientists in Europe (Nice, France)

11573/1406171 - 2020 - Potential therapeutic value of the anti-diabetic drug metformin in a mouse model of Rett syndrome: a preclinical study
Urbinati, Chiara; Zuliani, Ilaria; Valenti, Daniela; Cristina Quattrini, Maria; Cosentino, Livia; Medici, Vanessa; Pietraforte, Donatella; Di Domenico, Fabio; Perluigi, Marzia; Anna Vacca, Rosa; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: FENS 2020 virtual forum (virtual)
book: FENS 2020 virtual forum - ()

11573/1406139 - 2020 - The anti-diabetic drug metformin rescues aberrant mitochondrial activity and restrains oxidative stress in a female mouse model of rett syndrome
Zuliani, Ilaria; Urbinati, Chiara; Valenti, Daniela; Cristina Quattrini, Maria; Medici, Vanessa; Cosentino, Livia; Pietraforte, Donatella; Di Domenico, Fabio; Perluigi, Marzia; Anna Vacca, Rosa; De Filippis, Bianca - 01a Articolo in rivista
paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. - - issn: 2077-0383 - wos: WOS:000549226700001 (16) - scopus: 2-s2.0-85102223213 (16)

11573/1227100 - 2019 - Trauma-exposed methyl-CpG binding protein 2 mutant mice: a new animal model for post-traumatic stress disorder
Cosentino, L.; Vigli, D.; Medici, V.; Flor, H.; Lucarelli, M.; Fuso, A.; De Filippis, B. - 04d Abstract in atti di convegno
conference: ECNP workshop for early career scientists (Nice, France)
book: ECNP workshop for early career scientists - ()

11573/1286407 - 2019 - Methyl-CpG binding protein 2 (MeCP2) dysfunction provides vulnerability to traumatic events in male mice
Cosentino, L.; Vigli, D.; Medici, V.; Flor, H.; Lucarelli, M.; Fuso, A.; De Filippis, B. - 04d Abstract in atti di convegno
conference: 48th Meeting of the European Brain and Behaviour Society (Prague, Czech Republic)
book: 48th Meeting of the European Brain and Behaviour Society - ()

11573/1286409 - 2019 - MeCP2 aberrant functionality interacts with sex in shaping stress effects on cognitive functions
Cosentino, L.; Vigli, D.; Pellas, M.; De Filippis, B. - 04d Abstract in atti di convegno
conference: 48th Meeting of the European Brain and Behaviour Society (Prague, Czech Republic)
book: 48th Meeting of the European Brain and Behaviour Society - ()

11573/1286384 - 2019 - Rett syndrome before regression: a time window of overlooked opportunities for diagnosis and intervention
Cosentino, L; Vigli, D; Franchi, F; Laviola, G; De Filippis, B. - 01g Articolo di rassegna (Review)
paper: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0149-7634 - wos: WOS:000501388000012 (24) - scopus: 2-s2.0-85071337131 (27)

11573/1286396 - 2019 - Stress affects cognitive functions through an interplay between MeCP2 and sex
Cosentino, L; Vigli, D; Talamo, Mc; De Filippis, B - 04d Abstract in atti di convegno
conference: INTERNATIONAL SCHOOL OF ETHOLOGY “Danilo Mainardi” 45th Course on: “Sex Differences, Dimorphisms, Divergences: Impact on Brain and Behavior in Health and Disease” (Erice, Italy)
book: INTERNATIONAL SCHOOL OF ETHOLOGY “Danilo Mainardi” 45th Course on: “Sex Differences, Dimorphisms, Divergences: Impact on Brain and Behavior in Health and Disease” - ()

11573/1227101 - 2019 - Alterations in Methyl-CpG binding protein 2 functionality provide vulnerability to traumatic events
Cosentino, Livia; Flor, Herta; Lucarelli, Marco; Fuso, Andrea; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: PhD national meeting, SINS (Naples, Italy)
book: PhD national meeting, SINS - ()

11573/1282147 - 2019 - Methyl-CpG binding protein 2 functional alterations provide vulnerability to develop behavioral and molecular features of post-traumatic stress disorder in male mice
Cosentino, Livia; Vigli, Daniele; Medici, Vanessa; Flor, Herta; Lucarelli, Marco; Fuso, Andrea; De Filippis, Bianca - 01a Articolo in rivista
paper: NEUROPHARMACOLOGY (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 107664- - issn: 0028-3908 - wos: WOS:000497252100020 (12) - scopus: 2-s2.0-85074278534 (8)

11573/1348637 - 2019 - Male mice carrying dysfunctional methyl-CpG binding protein 2 are vulnerable to traumas
Cosentino, Livia; Vigli, Daniele; Medici, Vanessa; Flor, Herta; Lucarelli, Marco; Fuso, Andrea; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 6th European Conference on Behaviour and Cognition, (Padova)
book: 6th European Conference on Behaviour and Cognition - ()

11573/1348645 - 2019 - Pharmacological inhibition of p21-Activated Kinase rescues the behavioral phenotype in a female mouse model of CDKL5 Deficiency Disorder
Cristina Talamo, Maria; Pellas, Mattia; Urbinati, Chiara; Cosentino, Livia; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 6th European Conference on Behaviour and Cognition, (Padova)
book: 6th European Conference on Behaviour and Cognition - ()

11573/1348652 - 2019 - Systemic treatment with Rimonabant, a CB1 receptor antagonist, improves behavioural alterations in a mouse model of Rett syndrome
Pellas, Mattia; Cristina Talamo, Maria; Cosentino, Livia; Vigli, Daniele; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 6th European Conference on Behaviour and Cognition, (Padova)
book: 6th European Conference on Behaviour and Cognition - ()

11573/1286403 - 2019 - Group I p21-activated kinases as innovative therapeutic targets for CDKL5 Deficiency Disorder.
Talamo, M. C.; Fuchs, C.; Pellas, M.; Quattrini, M. C.; Medici, G.; Cosentino, L.; Pietraforte, D.; Ciani, E.; De Filippis, B. - 04d Abstract in atti di convegno
conference: 18th National Congress of the Italian Society of Neuroscience (Perugia, Italy)
book: 18th National Congress of the Italian Society of Neuroscience - ()

11573/1286405 - 2019 - Pharmacological inhibition of p21-Activated Kinase rescues the behavioural phenotype in a female mouse model of CDKL5 Deficiency Disorder
Talamo, M. C.; Pellas, M.; Urbinati, C.; Cosentino, L.; De Filippis, B - 04d Abstract in atti di convegno
conference: 48th Meeting of the European Brain and Behaviour Society (Prague, Czech Republic)
book: 48th Meeting of the European Brain and Behaviour Society - ()

11573/1348640 - 2019 - Metformin treatment rescues aberrant mitochondrial activity and oxidative stress status in the brain of female mouse model of Rett syndrome
Urbinati, Chiara; Zuliani, Ilaria; Valenti, Daniela; Medici, Vanessa; Cosentino, Livia; Vigli, Daniele; Di Domenico, Fabio; Perluigi, Marzia; Anna Vacca, Rosa; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 6th European Conference on Behaviour and Cognition, (Padova)
book: 6th European Conference on Behaviour and Cognition - ()

11573/1286404 - 2019 - Pharmacological stimulation of the serotonin receptor 7 substantially rescues behavioral, physiological and brain molecular alterations in a female mouse model of Rett syndrome
Vigli, D.; Napoletani, G.; Cosentino, L.; Grieco, M.; Talamo, M. C.; Lacivita, E.; Leopoldo, M.; Laviola, G.; Fuso, A.; D’Erme, M.; De Filippis, B. - 04d Abstract in atti di convegno
conference: 18th National Congress of the Italian Society of Neuroscience (Perugia, Italy)
book: 18th National Congress of the Italian Society of Neuroscience - ()

11573/1174112 - 2019 - Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 deficiency disorder
Vigli, Daniele; Rusconi, L.; Valenti, D.; La, Montanara; Cosentino, Livia; Lacivita, E.; Leopoldo, M.; Amendola, E.; Gross, C.; Landsberger, N.; Laviola, G.; Kilstrup-Nielsen, C.; Vacca, R. A.; De Filippis, B. - 01a Articolo in rivista
paper: NEUROPHARMACOLOGY (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0028-3908 - wos: WOS:000454374900011 (23) - scopus: 2-s2.0-85055965128 (24)

11573/1227091 - 2018 - MECP2 mutant mice: a new animal model for susceptibility to traumatic events
Cosentino, L.; Vigli, D.; De Filippis, B. - 04d Abstract in atti di convegno
conference: 11th FENS Forum of Neuroscience (Berlin)
book: 11th FENS Forum of Neuroscience - ()

11573/1227092 - 2018 - MECP2 mutant mice: a new animal model for susceptibility to traumatic events
Cosentino, L.; Vigli, D.; De Filippis, B. - 04d Abstract in atti di convegno
conference: EBPS workshop “Computational Approaches on Animal and Human Behavior” (Cambridge, United Kingdom)
book: EBPS workshop “Computational Approaches on Animal and Human Behavior” - ()

11573/1227090 - 2018 - Pharmacological stimulation of the central serotonin receptor 7 rescues prepulse inhibition deficit and brain mitochondrial dysfunction in a mouse model of CDKL5 disorder
De Filippis, B.; Vigli, D.; Rusconi, L.; Valenti, D.; La Montanara, P.; Cosentino, L.; Lacivita, E.; Leopoldo, M.; Amendola, E.; Gross, C.; Landsberger, N.; Laviola, G.; Kilstrup-Nielsen, C.; Vacca, R. A. - 04d Abstract in atti di convegno
conference: 11th FENS Forum of Neuroscience (Berlin)
book: 11th FENS Forum of Neuroscience - ()

11573/1227096 - 2018 - Pharmacological stimulation of 5-HT7 receptor rescues Sensory-motor gating and emotional memory-associative learning function in MeCP2-308 female mice.
Vigli, D.; Cosentino, L.; Lacivita, E.; Leopoldo, M.; Laviola, G.; De Filippis, B. - 04d Abstract in atti di convegno
conference: Rett syndrome research, towards the future (Rome, Italy)
book: Rett syndrome research, towards the future - ()

11573/1227089 - 2018 - Behavioural alterations and brain atrophy are rescued by chronic treatment with the phytocannabinoid, Cannabidivarin (CBDV), in a mouse model of Rett syndrome
Vigli, D.; Cosentino, L.; Raggi, C.; Laviola, G.; Woolley-Roberts, M.; De Filippis, B. - 04d Abstract in atti di convegno
conference: 11th FENS Forum of Neuroscience (Berlin)
book: 11th FENS Forum of Neuroscience - ()

11573/1174107 - 2018 - Chronic treatment with the phytocannabinoid cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of rett syndrome
Vigli, D.; Cosentino, L.; Raggi, C.; Laviola, G.; Woolley-Roberts, M.; De, Filippis - 01a Articolo in rivista
paper: NEUROPHARMACOLOGY (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 121-129 - issn: 0028-3908 - wos: WOS:000445717100011 (46) - scopus: 2-s2.0-85053105087 (46)

11573/1227097 - 2018 - The phytocannabinoid cannabidivarin (CBDV) rescues behavioural alterations and brainatrophy in Mecp2-308 hemizygous male mice
Vigli, D; Cosentino, L; Raggi, C; Laviola, G; Woolley-Roberts, M; De Filippis, B. - 04d Abstract in atti di convegno
conference: Rett syndrome research, towards the future (Rome, Italy)
book: Rett syndrome research, towards the future - ()

11573/1227093 - 2018 - Prepulse inhibition defects and brain mitochondrial dysfunctions are rescued by selective stimulation of serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder.
Vigli, D; Rusconi, L; Valenti, D; Cosentino, L; Lacivita, E; Leopoldo, M; Amendola, E; Gross, C; Landsberger, N; Laviola, G; Kilstrup, C; De Filippis, B. - 04d Abstract in atti di convegno
conference: “Rett syndrome research, towards the future (Rome, Italy)
book: Rett syndrome research, towards the future - ()

11573/1227074 - 2017 - Characterization of the estrous cycle in female mice modelling Rett syndrome
Cosentino, Livia; Vigli, Daniele; Laviola, Giovanni; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 9th international meeting “Steroids and nervous system" (Turin, Italy)
book: 9th international meeting “Steroids and nervous system" - ()

11573/1227082 - 2017 - Stimulation of the brain serotonin receptor 7 rescues sensory motor gating impairments, emotional memory deficits and brain mithocondrial dysfunction in a mouse model of Rett Syndrome
Vigli, Daniele; Valenti, Daniela; Cosentino, Livia; Lacivita, Enza; Leopoldo, Marcello; Laviola, Giovanni; Anna Vacca, Rosa; De Filippis, Bianca - 04d Abstract in atti di convegno
conference: 47th EBBS Meeting (Bilbao)
book: 47th EBBS Meeting - ()

11573/1179718 - 2016 - Genes and sex hormones interaction in neurodevelopmental disorders
Romano, Emilia; Cosentino, Livia; Laviola, Giovanni; De Filippis, Bianca - 01g Articolo di rassegna (Review)
paper: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 9-24 - issn: 0149-7634 - wos: WOS:000380627700003 (27) - scopus: 2-s2.0-84961815202 (31)

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