LAURA LIBONATI

Dottoressa di ricerca

ciclo: XXXVI


supervisore: prof Inghilleri

Titolo della tesi: UNVEILING ALS PHENOTYPIC CHARACTERISTICS: TOWARDS A NOVEL MODEL FOR UTILIZING SYNTHETIC PLACEBO POPULATIONS IN RANDOMIZED CLINICAL TRIALS

BACKGROUND We have investigated the idea of creating a population of virtual patients to serve as a comparison group in clinical trials. To do this effectively, it is essential to develop a realistic model that captures the key characteristics of patients with ALS. Recent advancements in genetics technology have allowed to analyze specific gene mutations. Additionally, certain environmental factors, such soccer, have been implicated as potential risk factors for ALS. Understanding and accurately modelling these characteristics would allow for more accurate trial design, and potentially reduce the need for a placebo arm. METHODS - Use of synthetic placebo populations in ALS randomized clinical trials Sample subsets were extracted from the MND register using an evolutionary algorithm to match baseline variables with a target trials group, with additional adjustments to mimic real recruitment practices. A survival prediction model was used to estimate survival for the target population. The survival of the synthetic placebo population was compared to that of real trial placebo arms using Kaplan-Meier analysis and log-rank tests. Two target populations were studied: participants enrolled in the LiCALS trial and individuals included in the PRO-ACT clinical trials database. -Analysis of genetic characteristics A total of 194 patients were enrolled. All exons of the SOD1 gene were sequenced. Hexanucleotide intronic repeat expansions (G4C2) in the C9orf72 gene were tested. Whole Exome NGS sequencing was performed. An in silico multigene panel targeted for neuromuscular diseases, and other diseases was used to filter the mutations found after WES sequencing. Nonparametric tests, Kaplan-Meier survival curves and log-rank tests were employed to evaluate differences between groups. - Prevalence of ALS cases among soccer players All professional soccer players practicing in the period 1946-2015 were identified. ALS cases diagnosed among football players during the specified period were considered to calculate disease incidence. The expected incidence rate was calculated as the number of ALS cases per 100,000 person-years expected in the cohort. The standardized incidence ratio (SIR) was then calculated as the ratio between observed and expected cases. RESULTS - Use of synthetic placebo populations in ALS randomized clinical trials The synthetic placebo groups generated from the MND register closely matched the target trials outcomes. The ENCALS model produced synthetic placebo groups that differed significantly from real placebo groups. However, when participants were censored at 6-month intervals, the ENCALS synthetic group closely matched the target group between 24 and 48 months, indicating a potential timeframe for utilizing this method. - Analysis of genetic characteristics Clinically significant pathogenetic variants were detected in 14.43% of cases. The highest prevalence of pathogenetic variants was observed in fALS patients, but a substantial proportion of sALS patients also displayed at least one mutation, either pathogenetic or of uncertain significance (VUS). The most observed pathogenetic mutation was the expansion of the C9orf72 gene, which was associated with a shorter survival. SOD1 mutations were found in 1.6% of fALS and 2.5% of sALS patients. - Prevalence of ALS cases among soccer players A total of 14 cases of ALS were identified. A significant decrease in the risk of ALS diagnosis was observed, with an SIR of 0.407 (95% CI 0.163-0.838). Individuals who initiated their careers prior to 1950 exhibited a higher reduction in risk. The period between 1990 and 2015 showed the highest increase in risk. The risk reduction did not reach statistical significance within the different age groups considered. Former soccer players experienced the onset of the disease approximately 10.8 years earlier than expected. DISCUSSION - Use of synthetic placebo populations in ALS randomized clinical trials It is possible to use filters and an evolutionary algorithm to match the demographics of people in a dataset collected at a population level to people in the placebo arm of a trial. Using a prognostic model to predict survival generates comparable estimates to people in the active arm of trials. The implementation of a prognostic model for survival prediction yields comparable results to individuals in the active arm of trials. Notably, both the register-based approach and the ENCALS prognostic model have successfully generated synthetic placebo groups that closely resemble those observed in historical trials - Analysis of genetic characteristics The study reveals a significant number of ALS patients carrying pathogenic mutations. The expansion of the C9orf72 gene is the most common, affecting familial and sporadic cases. SOD1 mutations are detected at an unexpectedly higher rate, even in patients without a sALS, underscoring the crucial role of genetic testing in treatment decisions and potential participation in clinical trials. We also investigated mutations in other genes, shedding light on their potential involvement in ALS. These findings underscore the complexity of interpreting variants of uncertain significance (VUS) and their ethical implications in patient communication and genetic counseling for patients' relatives. - Prevalence of ALS cases among soccer players The observed pattern, indicating a lower risk for players who began their careers before 1950 and a slightly higher risk for those who started between 1990 and 2015, may be influenced by certain biases. As the intensity and demands of the sport have evolved over time, it is possible that these changes have had an impact on the health outcomes of players. The former soccer players were diagnosed with ALS at an earlier stage compared to the general population. This finding suggests that the combination of high-intensity exercise and the overall strain on the body may potentially accelerate the onset of ALS in individuals who are predisposed to the disease. CONCLUSION The study demonstrated the potential of using ALS as a model disease to address challenges in clinical trials. We have shown that two different strategies can be used to create synthetic placebo populations: matching people from population registers and predicting non-treatment survival of people enrolled in trials. However, these results need to be replicated with new trial data It is of utmost importance to underscore the diverse genetic foundation of ALS and advocate for the integration of comprehensive genetic testing into diagnostic protocols. The presence of VUS serves as a reminder of the multifaceted nature of ALS genetics, thereby prompting further exploration into the intricate interactions among genetic variations, environmental factors, and the development of the disease. The discovery that soccer players have a lower risk of developing ALS in comparison to the general population highlights the significance of acknowledging the limitations inherent in these findings during interpretation. To obtain a more precise representation of ALS incidence among soccer players, it is crucial to involve validated medical records and consider the data's origin in subsequent investigations.

Produzione scientifica

11573/1708847 - 2024 - Emotion recognition in amyotrophic lateral sclerosis in a dynamic environment
Ceccanti, Marco; Libonati, Laura; Moret, Federica; D’Andrea, Edoardo; Gori, Maria Cristina; Bersani, Francesco Saverio; Inghilleri, Maurizio; Cambieri, Chiara - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0022-510X - wos: (0) - scopus: 2-s2.0-85190533280 (0)

11573/1705210 - 2024 - Chronic inflammatory demyelinating polyneuropathy and HEV antibody status: A case-control study from Lazio, Italy
Moret, Federica; Spada, Enea; Ceccanti, Marco; Libonati, Laura; D’Andrea, Edoardo; Villano, Umbertina; Madonna, Elisabetta; Chionne, Paola; Carocci, Alberto; Pisani, Giulio; Fionda, Laura; Antonini, Giovanni; Petrucci, Antonio; Bruni, Roberto; Rita Ciccaglione, Anna; Taliani, Gloria; Rivano Capparuccia, Marco; Nobile-Orazio, Eduardo; Inghilleri, Maurizio; Cambieri, Chiara - 01a Articolo in rivista
rivista: JOURNAL OF THE NEUROLOGICAL SCIENCES (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0022-510X - wos: (0) - scopus: 2-s2.0-85188011351 (0)

11573/1705621 - 2024 - MiR206 and 423‑3p Are Differently Modulated in Fast and Slow‑Progressing Amyotrophic Lateral Sclerosis Patients
Musaro', Antonio; Dobrowolny, Gabriella; Cambieri, Chiara; Libonati, Laura; Moret, Federica; Casola, Irene; Laurenzi, Gaia; Garibaldi, Matteo; Inghilleri, Maurizio; Ceccanti, Marco - 01a Articolo in rivista
rivista: NEUROMOLECULAR MEDICINE (New York : Springer US Totowa N.J. : Humana Press, 2002-) pp. - - issn: 1559-1174 - wos: WOS:001183970300001 (0) - scopus: 2-s2.0-85187938749 (0)

11573/1684498 - 2023 - Does Patisiran Reduce Ocular Transthyretin Synthesis? A Pilot Study of Two Cases
Cambieri, Chiara; Marenco, Marco; Colasanti, Tania; Mancone, Carmine; Corsi, Alessandro; Riminucci, Mara; Libonati, Laura; Moret, Federica; Chimenti, Cristina; Lambiase, Alessandro; Conti, Fabrizio; Garibaldi, Matteo; Inghilleri, Maurizio; Ceccanti, Marco - 01i Case report
rivista: CURRENT NEUROPHARMACOLOGY (Hilversum: Bentham Science Publishers) pp. - - issn: 1570-159X - wos: WOS:001087552300011 (1) - scopus: 2-s2.0-85169539357 (2)

11573/1684833 - 2023 - Withdrawal of mechanical ventilation in amyotrophic lateral sclerosis patients: a multicenter Italian survey
Cristina, Moglia; Francesca, Palumbo; Simone, Veronese; Angelocola, Stefania; Barone, Paolo; Bartolomei, Ilaria; Bersano, Enrica; Bombaci, Alessandro; Borghero, Giuseppe; Cabras, Sara; Cambieri, Chiara; Canali, Elena; Canosa, Antonio; Capasso, Margherita; Caponnetto, Claudia; Cardinali, Patrizio; Casmiro, Mario; Ceccanti, Marco; Chiò, Adriano; Consonni, Monica; Dalla Bella, Eleonora; De Marchi, Fabiola; De Mattei, Filippo; D'errico, Eustachio; Di Pede, Francesca; Diamanti, Luca; Dubbioso, Raffaele; Filippi, Massimo; Filosto, Massimiliano; Fini, Nicola; Gianferrari, Giulia; Grassano, Maurizio; Inghilleri, Maurizio; La Bella, Vincenzo; Lauria Pinter, Giuseppe; Libonati, Laura; Logullo, Francesco; Mandrioli, Jessica; Manera, Umberto; Martinelli, Ilaria; Martusciello, Gioacchino; Matà, Sabrina; Matteoni, Enrico; Mazzini, Letizia; Medici, Doriana; Miniello, Stefania; Moret, Federica; Nozzoli, Cecilia; Piccirillo, Giovanni; Pilurzi, Giovanna; Riva, Nilo; Romito, Silvia; Russo, Massimo; Salvi, Fabrizio; Sette, Elisabetta; Silani, Vincenzo; Laura Simone, Isabella; Simonini, Cecilia; Spataro, Rossella; Squintani, Giovanna; Stano, Salvatore; Tanel, Raffaella; Tedeschi, Gioacchino; Ticozzi, Nicola; Toriello, Antonella; Tremolizzo, Lucio; Trojsi, Francesca; Vacchiano, Veria; Vasta, Rosario; Volanti, Paolo; Zinno, Lucia; Zucchi, Elisabetta; Andrea, Calvo - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:001023981000001 (1) - scopus: 2-s2.0-85164102654 (0)

11573/1697035 - 2023 - Genetics screening in an Italian cohort of patients with Amyotrophic Lateral Sclerosis: the importance of early testing and its implication
Libonati, Laura; Cambieri, Chiara; Colavito, Davide; Moret, Federica; D’Andrea, Edoardo; Del Giudice, Elda; Leon, Alberta; Inghilleri, Maurizio; Ceccanti, Marco - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg: Springer Verlag Heidelberg: Steinkopff) pp. - - issn: 1432-1459 - wos: WOS:001130355600001 (0) - scopus: 2-s2.0-85180186858 (0)

11573/1684481 - 2023 - Retrospective observational study on the use of acetyl-L-carnitine in ALS
Sassi, Serena; Bianchi, Elisa; Diamanti, Luca; Tornabene, Danilo; Sette, Elisabetta; Medici, Doriana; Matà, Sabrina; Leccese, Deborah; Sperti, Martina; Martinelli, Ilaria; Ghezzi, Andrea; Mandrioli, Jessica; Iuzzolino, Valentina Virginia; Dubbioso, Raffaele; Trojsi, Francesca; Passaniti, Carla; D'alvano, Giulia; Filosto, Massimiliano; Padovani, Alessandro; Mazzini, Letizia; De Marchi, Fabiola; Zinno, Lucia; Nuredini, Andi; Bongioanni, Paolo; Dolciotti, Cristina; Canali, Elena; Toschi, Giulia; Petrucci, Antonio; Perna, Alessia; Riso, Vittorio; Inghilleri, Maurizio; Libonati, Laura; Cambieri, Chiara; Pupillo, Elisabetta - 01a Articolo in rivista
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. - - issn: 0340-5354 - wos: WOS:001018011800001 (3) - scopus: 2-s2.0-85163315568 (2)

11573/1655523 - 2022 - Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial
Beghi, Ettore; Pupillo, Elisabetta; Bianchi, Elisa; Bonetto, Valentina; Luotti, Silvia; Pasetto, Laura; Bendotti, Caterina; Tortarolo, Massimo; Sironi, Francesca; Camporeale, Laura; Sherman, Alexander V; Paganoni, Sabrina; Scognamiglio, Ada; De Marchi, Fabiola; Bongioanni, Paolo; Del Carratore, Renata; Caponnetto, Claudia; Diamanti, Luca; Martinelli, Daniele; Calvo, Andrea; Filosto, Massimiliano; Padovani, Alessandro; Piccinelli, Stefano Cotti; Ricci, Claudia; Dalla Giacoma, Stefania; De Angelis, Nicoletta; Inghilleri, Maurizio; Spataro, Rossella; La Bella, Vincenzo; Logroscino, Giancarlo; Lunetta, Christian; Tarlarini, Claudia; Mandrioli, Jessica; Martinelli, Ilaria; Simonini, Cecilia; Zucchi, Elisabetta; Monsurrò, Maria Rosaria; Ricciardi, Dario; Trojsi, Francesca; Riva, Nilo; Filippi, Massimo; Simone, Isabella Laura; Sorarù, Gianni; Spera, Cristina; Florio, Lucia; Messina, Sonia; Russo, Massimo; Siciliano, Gabriele; Conte, Amelia; Saddi, Maria Valeria; Carboni, Nicola; Letizia, Mazzini; Rn S60-Als Study Group (Gabriele Enia, ; Zucchella, Andrea; Pinzani, Lorenzo; Lorena De Giorgi, ; Nicoletti, Celeste; Semprucci, Elisa; Emilio Davide Arippol, ; Giussani, Giorgia; Graziani, Monica; Ferrari, Cinzia; Cantello, Roberto; Bersano, Enrica; Dolciotti, Cristina; Silvia Maria Masciandaro, ; Ilaria Da Prato, ; Cabona, Corrado; Meo, Giuseppe; Ceroni, Mauro; Beatrice Dal Fabbro, ; Chiò, Adriano; Moglia, Cristina; Manera, Umberto; Fuda, Giuseppe; Casale, Federico; Giovanni De Marco, ; Salamone, Paolina; Giannini, Fabio; Bocci, Silvia; Ceccanti, Marco; Cambieri, Chiara; Libonati, Laura; Moret, Federica; Frasca, Vittorio; Coletti, Tiziana; Tortelli, Rosanna; Capozzo, Rosa; Gerardi, Francesca; Sansone, Valeria; Fini, Nicola; Gianferrari, Giulia; Gessani, Annalisa; Falzone, Yuri; Schito, Paride; Pozzi, Laura; Domi, Teuta; D'errico, Eustachio; Morea, Antonella; Milella, Gianmarco; Gizzi, Matteo; Paci, Francesca; Ferracchiato, Simonetta; Zarrelli, Michele; Desina, Nino; Govoni, Alessandra; Schirinzi, Erika; Simoncini, Costanza; Sabatelli, Mario; Bernardo, Daniela; Bisogni, Giulia; Piras, Giovanna; Monne, Maria; Manca), Elisabetta - 01l Trial clinico
rivista: EUROPEAN JOURNAL OF NEUROLOGY (Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. - - issn: 1351-5101 - wos: WOS:000864742100001 (8) - scopus: 2-s2.0-85139406869 (10)

11573/1652602 - 2022 - The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis
Cambieri, Chiara; Libonati, Laura; Moret, Federica; Tartaglia, Giorgio; Garibaldi, Matteo; Chimenti, Cristina; Inghilleri, Maurizio; Ceccanti, Marco - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. 2073- - issn: 2227-9059 - wos: WOS:000858528700001 (2) - scopus: 2-s2.0-85138648980 (2)

11573/1649904 - 2022 - Effects of Skin Stimulation on Sensory-Motor Networks Excitability: Possible Implications for Physical Training in Amyotrophic Lateral Sclerosis
Ceccanti, Marco; Cambieri, Chiara; Libonati, Laura; Tartaglia, Giorgio; Moret, Federica; Garibaldi, Matteo; Inghilleri, Maurizio - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROLOGY (Lausanne: Frontiers Research Foundation, 2010-) pp. 868792- - issn: 1664-2295 - wos: WOS:001027331800001 (0) - scopus: 2-s2.0-85131858505 (0)

11573/1652690 - 2022 - Effects of 3,4-diaminopyridine on myasthenia gravis: Preliminary results of an open-label study
Ceccanti, Marco; Libonati, Laura; Ruffolo, Gabriele; Cifelli, Pierangelo; Moret, Federica; Frasca, Vittorio; Palma, Eleonora; Inghilleri, Maurizio; Cambieri, Chiara - 01a Articolo in rivista
rivista: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000848348100001 (2) - scopus: 2-s2.0-85137984729 (2)

11573/1639962 - 2022 - Classical and Unexpected Effects of Ultra-Micronized {PEA} in Neuromuscular Function
Cifelli, Pierangelo; Ruffolo, Gabriele; Ceccanti, Marco; Cambieri, Chiara; Libonati, Laura; Palma, Eleonora; Inghilleri, Maurizio - 01g Articolo di rassegna (Review)
rivista: BIOMOLECULES (Basel: MDPI) pp. 758- - issn: 2218-273X - wos: WOS:000818317500001 (0) - scopus: 2-s2.0-85130994832 (1)

11573/1655525 - 2022 - Validation of the DYALS (dysphagia in amyotrophic lateral sclerosis) questionnaire for the evaluation of dysphagia in ALS patients
Diamanti, Luca; Borrelli, Paola; Dubbioso, Raffaele; Capasso, Margherita; Morelli, Claudia; Lunetta, Christian; Petrucci, Antonio; Mora, Gabriele; Volanti, Paolo; Inghilleri, Maurizio; Tremolizzo, Lucio; Mandrioli, Jessica; Mazzini, Letizia; Vedovello, Marcella; Siciliano, Gabriele; Filosto, Massimiliano; Matà, Sabrina; Montomoli, Cristina; Dyals Study Group (Giuliana Capece, ; Andrea, Ghezzi; Giuseppe, Fiamingo; Francesco Pio Ausiello, ; Laura, Ferri; Alberto, Doretti; Eleonora, Colombo; Gianluca, Demirtzidis; Vittorio, Riso; Federica, Bianchi; Micol, Castellari; Francesca, Madonia; Ceccanti, Marco; Cambieri, Chiara; Libonati, Laura; Fanella, Gaia; Carlo, Ferrarese; Annalisa, Gessani; Carla, Budriesi; Fabiola De Marchi, ; Francesca, Bianchi; Cecilia, Carlesi) - 01a Articolo in rivista
rivista: NEUROLOGICAL SCIENCES (Springer-Verlag Italia Srl:via Decembrio 28, 20137 Milan Italy:011 39 2 5425971, EMAIL: riccardi@springer.it, Fax: 011 39 2 55193360) pp. 3195-3200 - issn: 1590-3478 - wos: WOS:000724632100001 (2) - scopus: 2-s2.0-85128610795 (3)

11573/1606399 - 2022 - A novel homozygous mutation in TBK1 gene causing ALS-FTD
Libonati, L.; Ceccanti, M.; Cambieri, C.; Colavito, D.; Moret, F.; Fiorini, I.; Inghilleri, M. - 01f Lettera, Nota
rivista: NEUROLOGICAL SCIENCES (-Springer-Verlag Italia -Masson SPA:via Flli Bressan 2, I 20126 Milan Italy:011 39 02 27074286, EMAIL: aboonamenti@masson.it, INTERNET: http://www.masson.it, Fax: 011 39 02 27074210) pp. - - issn: 1590-1874 - wos: WOS:000742331200003 (3) - scopus: 2-s2.0-85123066608 (2)

11573/1477877 - 2021 - A case of acute motor and sensory axonal neuropathy mimicking brain death
Libonati, Laura; Fiorini, Ilenia; Cambieri, Chiara; Ceccanti, Marco; Inghilleri, Maurizio - 01i Case report
rivista: NEUROLOGICAL SCIENCES (Springer-Verlag Italia Srl:via Decembrio 28, 20137 Milan Italy:011 39 2 5425971, EMAIL: riccardi@springer.it, Fax: 011 39 2 55193360) pp. - - issn: 1590-3478 - wos: WOS:000608654000005 (2) - scopus: 2-s2.0-85100024428 (1)

11573/1582785 - 2021 - PREVALENCE OF AMYOTROPHIC LATERAL SCLEROSIS IN LATIUM REGION (ITALY)
Puopolo, Maria; Bacigalupo, Ilaria; Piscopo, Paola; Lacorte, Eleonora; Di Pucchio, Alessandra; Santarelli, Marialaura; Inghilleri, Maurizio; Petrucci, Antonio; Sabatelli, Mario; Libonati, Laura; Ceccanti, Marco; Vanacore, Nicola - 01a Articolo in rivista
rivista: BRAIN AND BEHAVIOR (Wiley Online Library) pp. 1-7 - issn: 2162-3279 - wos: WOS:000712751200001 (2) - scopus: 2-s2.0-85122772068 (2)

11573/1392645 - 2020 - Creatine kinase and progression rate in amyotrophic lateral sclerosis
Ceccanti, Marco; Pozzilli, Valeria; Cambieri, Chiara; Libonati, Laura; Onesti, Emanuela; Frasca, Vittorio; Fiorini, Ilenia; Petrucci, Antonio; Garibaldi, Matteo; Palma, Eleonora; Bendotti, Caterina; Fabbrizio, Paola; Chiara Trolese, Maria; Nardo, Giovanni; Inghilleri, Maurizio - 01a Articolo in rivista
rivista: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. 1-12 - issn: 2073-4409 - wos: WOS:000539340200108 (17) - scopus: 2-s2.0-85084596042 (18)

11573/1268228 - 2019 - HETERONYMOUS H REFLEX IN TEMPORAL MUSCLE AS SIGN OF HYPEREXCITABILITY IN ALS PATIENTS
Libonati, Laura; Francesco Barone, Tommaso; Ceccanti, Marco; Cambieri, Chiara; Tartaglia, Giorgio; Onesti, Emanuela; Petrucci, Antonio; Frasca, Vittorio; Inghilleri, Maurizio - 01a Articolo in rivista
rivista: CLINICAL NEUROPHYSIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 1455-1459 - issn: 1388-2457 - wos: WOS:000473588400036 (6) - scopus: 2-s2.0-85066324507 (6)

11573/1227689 - 2019 - Short-Term Ultramicronized Palmitoylethanolamide Therapy in Patients with Myasthenia Gravis: a Pilot Study to Possible Future Implications of Treatment.
Onesti, E; Frasca, V; Ceccanti, M; Tartaglia, G; Gori, Mc; Cambieri, C; Libonati, L; Palma, E; Inghilleri, M. - 01a Articolo in rivista
rivista: CNS & NEUROLOGICAL DISORDERS. DRUG TARGETS (Sharjah : Bentham Science Publishers) pp. 232-238 - issn: 1871-5273 - wos: WOS:000466102200006 (9) - scopus: 2-s2.0-85065569554 (10)

11573/1327965 - 2019 - A case of motor neuron involvement in Gaucher disease
Pozzilli, V; Giona, F; Ceccanti, M; Cambieri, C; Frasca, V; Onesti, E; Libonati, L; Di Bari, S; Fiorini, I; Cardarelli, L; Santopietro, M; Inghilleri, M - 01i Case report
rivista: MOLECULAR GENETICS AND METABOLISM REPORTS (Amsterdam : Elsevier) pp. - - issn: 2214-4269 - wos: WOS:000500718300045 (3) - scopus: 2-s2.0-85074647770 (3)

11573/1172572 - 2018 - Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome/interstitial cystitis
Cervigni, M; Onesti, E; Ceccanti, M; Gori, Mc; Tartaglia, G; Campagna, G; Panico, G; Vacca, L; Cambieri, C; Libonati, Laura; Inghilleri, M - 01a Articolo in rivista
rivista: NEUROUROLOGY AND URODYNAMICS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1-10 - issn: 0733-2467 - wos: WOS:000448184900046 (31) - scopus: 2-s2.0-85047667552 (37)

11573/1118004 - 2018 - Chronic inflammatory demyelinating polyneuropathy: evaluation of the vestibular system with cervical and ocular vestibular evoked myogenic potentials
Magliulo, Giuseppe; Iannella, Giannicola; Libonati, Laura; Onesti, Emanuela; Angeletti, Diletta; Pace, Annalisa; Gulotta, Giampiero; Inghilleri, Maurizio - 01a Articolo in rivista
rivista: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (Berlin; Heidelberg: Springer) pp. 1507-1512 - issn: 0937-4477 - wos: WOS:000432207000017 (5) - scopus: 2-s2.0-85045903651 (7)

11573/889938 - 2017 - Vitamina D in Amyotorphic Lateral Sclerosis
Libonati, Laura; Onesti, Emanuela; Gori, Maria Cristina; Ceccanti, Marco; Cambieri, Chiara; Fabbri, A; Frasca, Vittorio; Inghilleri, Maurizio - 01a Articolo in rivista
rivista: FUNCTIONAL NEUROLOGY (CIC Edizioni Internazionali:Corso Trieste N 42, I 00198 Rome Italy:011 39 06 8412673, EMAIL: abbonamenti@gruppocic.it, INTERNET: http://www.gruppocic.it, Fax: 011 39 06 8412688) pp. 35-40 - issn: 0393-5264 - wos: WOS:000397573300006 (20) - scopus: 2-s2.0-85017246840 (22)

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