LETIZIA CIAFARDINI

PhD Student

PhD program:: XL
email: letizia.ciafardini@uniroma1.it
building: Dipartimento di Scienze Biochimiche A. Rossi Fanelli (edificio CU027)
room: 301

supervisor: Fabio Di Domenico
advisor: Fabio Di Domenico

Research: Alteration of protein homeostasis promotes neurodegeneration in Alzheimer-like dementias.

EDUCATION & TRAINING: • (2014-2019) Scientific High School Diploma at Liceo Scientifico Statale Plinio Seniore in Rome. • (2019-2022) Bachelor's Degree in Biological Sciences at La Sapienza University of Rome; Thesis title: Cellular senescence: telomere shortening and migratory properties of CD8+ T lymphocytes in patients with Ankylosing Spondylitis. • (2022-2024) Master's Degree in Biochemistry at Sapienza University of Rome; Thesis title: Aberrant proteostasis promotes neurodegeneration in Down syndrome under metabolic alterations: understanding molecular mechanisms and potential therapeutic approaches. • (November 2024 - ongoing) PhD in Biochemistry at the Department of Biochemical Sciences Alessandro Rossi Fanelli (CU027) Sapienza University of Rome.

Research products

11573/1759965 - 2026 - Systemic administration of the OGT inhibitor OSMI-1 normalizes hippocampal O-GlcNAcylation and improves recognition memory, redox balance, and brain mitochondrial homeostasis in a Rett syndrome mouse model

Sette, Chiara; Urbinati, Chiara; Lanzillotta, Chiara; Prestia, Francesca; Ciafardini, Letizia; Cosentino, Livia; Pietraforte, Donatella; Quattrini, Maria Cristina; Perluigi, Marzia; Di Domenico, Fabio; De Filippis, Bianca - 01a Articolo in rivista

paper: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-17 - issn: 0891-5849 - wos: WOS:001655538400001 (0) - scopus: (0)