Laura Gigante

PhD Graduate

PhD program:: XXXV

supervisor: Prof. Antonio Pizzuti

Thesis title: Chromosomal, obstetrical, and neonatal outcomes after the transfer of mosaic embryos analyzed by high resolution Next Generation Sequencing

Objective: Expand the information about clinical outcome in pregnancies obtained after the transfer of mosaic embryos. Provide further insight in the management of prenatal diagnosis in pregnancies after PGT-A result of mosaicism. Setting: Multi-center study Patient(s): A total of 11.222 euploid blastocysts and 1808 mosaic blastocysts used in clinical transfers in patients undergoing fertility treatment. Main Outcome Measure(s): Implantation (gestational sac), ongoing pregnancy, birth, spontaneous abortion, length of gestation, and weight at birth. Result(s): The euploid group had significantly more favorable rates of implantation and ongoing pregnancy/birth (OP/B-R) compared with the combined mosaic group or the mosaic group affecting only whole chromosomes (implantation: 58,8% vs. 47,7% vs 42,0%; OP/B-R: 52,3% vs 37,9% vs 31,7%), as well as higher risk of Miscarriage ( 9,0% vs 19,7% vs 23,4%). Whole chromosome mosaic embryos with low level (<50%) mosaicism had significantly more favorable outcomes than the high level (>50%) group (implantation: 43,6% vs. 26,4%; OP/B: 34,2% vs. 13,6%). Mosaic type (nature of the aneuploidy implicated in mosaicism) affected outcomes, with a significant correlation between number of affected chromosomes and unfavorable outcomes. Length of gestation and weight at birth were evaluated in case-matched subset of pregnancies resulting in non-significant difference in pregnancies obtained after transfer of mosaic and euploid embryos (length of gestation: 266 d vs 268: weight at birth: 3119 g vs 3189 g). Results of prenatal investigation were collected for a total of 249 pregnancies with a total 364 test results including NIPT, CVS, and Amniocentesis. Test results were normal in 95.2% of pregnancies. The remaining 4.8% had abnormal prenatal test, with 2 (0,8%) confirming persistence of mosaicism detected with PGT-A at the blastocyst stage. Conclusion(s): this study confirmed that percentage and type of mosaicism influence implantation rate, ongoing pregnancy/birth rate and miscarriage rate, and demonstrated that mosaicism ad blastocyst stage, independently of type and percentage, does not influence birth weight and length of gestation. Evaluation of prenatal testing confirmed the importance of prenatal diagnosis after transfer of mosaic embryos.

Research products

11573/1697503 - 2023 - Non-ceruloplasmin copper identifies a subtype of Alzheimer's disease (CuAD): characterization of the cognitive profile and case of a CuAD patient carrying an RGS7 stop-loss variant

Squitti, Rosanna; Catalli, Claudio; Gigante, Laura; Marianetti, Massimo; Rosari, Mattia; Mariani, Stefania; Bucossi, Serena; Mastromoro, Gioia; Ventriglia, Mariacarla; Simonelli, Ilaria; Tondolo, Vincenzo; Singh, Parminder; Kumar, Ashok; Pal, Amit; Rongioletti, Mauro - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. 1-18 - issn: 1422-0067 - wos: WOS:000970114300001 (9) - scopus: 2-s2.0-85152353965 (10)

11573/1616023 - 2021 - Seroprevalence of anti-SARS-CoV-2 IgG antibodies in children with household exposure to adults with COVID-19: Preliminary findings

Buonsenso, D.; Valentini, P.; De Rose, C.; Pata, D.; Sinatti, D.; Speziale, D.; Ricci, R.; Carfi, A.; Landi, F.; Ferrari, V.; De Maio, F.; Palucci, I.; Sanguinetti, M.; Sali, M.; Landi, F.; Gremese, E.; Bernabei, R.; Fantoni, M.; Gasbarrini, A.; Settanni, C. R.; Benvenuto, F.; Bramato, G.; Carfi, A.; Ciciarello, F.; Lo Monaco, M. R.; Martone, A. M.; Marzetti, E.; Napolitano, C.; Pagano, F.; Rocchi, S.; Rota, E.; Salerno, A.; Tosato, M.; Tritto, M.; Calvani, R.; Catalano, L.; Picca, A.; Savera, G.; Cauda, R.; Tamburrini, E.; Borghetti, A.; Di Gianbenedetto, S.; Murri, R.; Cingolani, A.; Ventura, G.; Taddei, E.; Moschese, D.; Ciccullo, A.; Stella, L.; Addolorato, G.; Franceschi, F.; Mingrone, G.; Zocco, M. A.; Cattani, P.; Marchetti, S.; Posteraro, B.; Sali, M.; Bizzarro, A.; Lauria, A.; Rizzo, S.; Savastano, M. C.; Gambini, G.; Cozzupoli, G. M.; Culiersi, C.; Passali, G. C.; Paludetti, G.; Galli, J.; Crudo, F.; Di Cintio, G.; Longobardi, Y.; Tricarico, L.; Santantonio, M.; Buonsenso, D.; Valentini, P.; Pata, D.; Sinatti, D.; De Rose, C.; Richeldi, L.; Lombardi, F.; Calabrese, A.; Sani, G.; Janiri, D.; Giuseppin, G.; Molinaro, M.; Modica, M.; Natale, L.; Larici, A. R.; Marano, R.; Paglionico, A.; Petricca, L.; Gigante, L.; Natalello, G.; Fedele, A. L.; Lizzio, M. M.; Tolusso, B.; Alivernini, S.; Santoliquido, A.; Santoro, L.; Nesci, A.; Popolla, V. - 01a Articolo in rivista

11573/1616070 - 2021 - Residual respiratory impairment after COVID-19 pneumonia

Lombardi, F.; Calabrese, A.; Iovene, B.; Pierandrei, C.; Lerede, M.; Varone, F.; Richeldi, L.; Sgalla, G.; Landi, F.; Gremese, E.; Bernabei, R.; Fantoni, M.; Gasbarrini, A.; Romano Settanni, C.; Benvenuto, F.; Bramato, G.; Carfi, A.; Ciciarello, F.; Rita Lo Monaco, M.; Maria Martone, A.; Marzetti, E.; Napolitano, C.; Pagano, F.; Rocchi, S.; Rota, E.; Salerno, A.; Tosato, M.; Tritto, M.; Calvani, R.; Catalano, L.; Picca, A.; Savera, G.; Tamburrini, E.; Borghetti, A.; Di Gianbenedetto, S.; Murri, R.; Cingolani, A.; Ventura, G.; Taddei, E.; Moschese, D.; Ciccullo, A.; Stella, L.; Addolorato, G.; Franceschi, F.; Mingrone, G.; Assunta Zocco, M.; Sanguinetti, M.; Cattani, P.; Marchetti, S.; Bizzarro, A.; Lauria, A.; Rizzo, S.; Cristina Savastano, M.; Gambini, G.; Grazia Cozzupoli, M.; Culiersi, C.; Cesare Passali, G.; Paludetti, G.; Galli, J.; Crudo, F.; Di Cintio, G.; Longobardi, Y.; Tricarico, L.; Santantonio, M.; Buonsenso, D.; Valentini, P.; Pata, D.; Sinatti, D.; De Rose, C.; Calabrese, A.; Sani, G.; Janiri, D.; Giuseppin, G.; Molinaro, M.; Modica, M.; Natale, L.; Rita Larici, A.; Marano, R.; Paglionico, A.; Petricca, L.; Gigante, L.; Natalello, G.; Laur, A. Fedele A.; Maria Lizzio, M.; Santoliquido, A.; Santoro, L.; Nesci, A.; Popolla, V. - 01a Articolo in rivista

paper: BMC PULMONARY MEDICINE (London: BioMed Central.) pp. - - issn: 1471-2466 - wos: WOS:000675458100003 (8) - scopus: 2-s2.0-85111897510 (12)

11573/1669246 - 2021 - Incidental SOS1 variant identified by non-invasive prenatal screening. Prenatal diagnosis and family clinical reassessment

Mastromoro, Gioia; Guadagnolo, Daniele; Marchionni, Enrica; Di Palma, Francesca; Gigante, Laura; Versacci, Paolo; Ventriglia, Flavia; Baldi, Marina; Pizzuti, Antonio - 01a Articolo in rivista

paper: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114 Precedente: Excerpta Medica,Shannon.) pp. 518-520 - issn: 0301-2115 - wos: WOS:000604431000086 (1) - scopus: 2-s2.0-85097446682 (1)

11573/1615991 - 2021 - Retinal capillary involvement in early post-COVID-19 patients: a healthy controlled study

Savastano, M. C.; Gambini, G.; Cozzupoli, G. M.; Crincoli, E.; Savastano, A.; De Vico, U.; Culiersi, C.; Falsini, B.; Martelli, F.; Minnella, A. M.; Landi, F.; Pagano, F. C.; Rizzo, S.; Santoliquido, A.; Santoro, L.; Nesci, A.; Popolla, V.; Settanni, C. R.; Benvenuto, F.; Bramato, G.; Carfi, A.; Ciciarello, F.; Lo Monaco, M. R.; Martone, A. M.; Marzetti, E.; Rocchi, S.; Rota, E.; Salerno, A.; Tritto, M.; Calvani, R.; Picca, A.; Catalano, L.; Savera, G.; Fantoni, M.; Tamburrini, E.; Borghetti, A.; Di Gianbenedetto, S.; Addolorato, G.; Franceschi, F.; Mingrone, G.; Stella, L.; Sanguinetti, M.; Cattani, P.; Marchetti, S.; Bizzarro, A.; Lauria, A.; Passali, G. C.; Paludetti, G.; Galli, J.; Crudo, F.; Di Cintio, G.; Longobardi, Y.; Tricarico, L.; Santantonio, M.; Buonsenso, D.; Valentini, P.; Pata, D.; Sinatti, D.; De Rose, C.; Richeldi, L.; Lombardi, F.; Calabrese, A.; Sani, G.; Janiri, D.; Giuseppin, G.; Molinaro, M.; Modica, M.; Natale, L.; Larici, A. R.; Marano, R.; Paglionico, A.; Petricca, L.; Gigante, L.; Natalello, G. - 01a Articolo in rivista

paper: GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229) pp. 2157-2165 - issn: 0721-832X - wos: WOS:000613886600001 (19) - scopus: 2-s2.0-85102679201 (18)

11573/1616000 - 2020 - Post-COVID-19 global health strategies: the need for an interdisciplinary approach

Landi, F.; Gremese, E.; Bernabei, R.; Fantoni, M.; Gasbarrini, A.; Settanni, C. R.; Benvenuto, F.; Bramato, G.; Carfi, A.; Ciciarello, F.; Lomonaco, M. R.; Martone, A. M.; Marzetti, E.; Napolitano, C.; Pagano, F.; Rocchi, S.; Rota, E.; Salerno, A.; Tosato, M.; Tritto, M.; Calvani, R.; Catalano, L.; Picca, A.; Savera, G.; Tamburrini, E.; Borghetti, A.; Di Gianbenedetto, S.; Murri, R.; Cingolani, A.; Ventura, G.; Taddei, E.; Moschese, D.; Ciccullo, A.; Stella, L.; Addolorato, G.; Franceschi, F.; Mingrone, G.; Zocco, M. A.; Sanguinetti, M.; Cattani, P.; Marchetti, S.; Bizzarro, A.; Lauria, A.; Rizzo, S.; Savastano, M. C.; Gambini, G.; Cozzupoli, G. M.; Culiersi, C.; Passali, G. C.; Paludetti, G.; Galli, J.; Crudo, F.; Di Cintio, G.; Longobardi, Y.; Tricarico, L.; Santantonio, M.; Buonsenso, D.; Valentini, P.; Pata, D.; Sinatti, D.; De Rose, C.; Richeldi, L.; Lombardi, F.; Calabrese, A.; Sani, G.; Janiri, D.; Giuseppin, G.; Molinaro, M.; Modica, M.; Natale, L.; Larici, A. R.; Marano, R.; Paglionico, A.; Petricca, L.; Gigante, L.; Natalello, G.; Fedele, A. L.; Lizzio, M. M.; Santoliquido, A.; Santoro, L.; Nesci, A.; Popolla, V. - 01a Articolo in rivista

paper: AGING CLINICAL AND EXPERIMENTAL RESEARCH (Springer Nature Milano: Editrice Kurtis) pp. 1613-1620 - issn: 1594-0667 - wos: WOS:000539914700002 (87) - scopus: 2-s2.0-85086401140 (89)

11573/124132 - 2010 - Role of NT in the detection of high risk pregnancy for congenital heart disease: a 2 year experience of a Prenatal Diagnosis Centre.

Giancotti, Antonella; Bisogni, Francescantonio; Muto, Brunella; Gigante, Laura; Spagnuolo, Antonella; Pasquali, Gaia; D'ambrosio, Valentina; De Gado, Fabrizio; Benedetti Panici, Pierluigi - 04c Atto di convegno in rivista

paper: THE JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (London: Informa UK Limited trading as Taylor & Francis Group London: Taylor & Francis, 2002- United Kingdom: Parthenon Publishing) pp. 434-435 - issn: 1476-7058 - wos: (0) - scopus: (0)

11573/124130 - 2010 - Decrease of fetal weight in the third trimester in pregnant patient affected by Systematic Lupus Erythematosus.

Giancotti, Antonella; Spagnuolo, Antonella; D'ambrosio, Valentina; Pasquali, Gaia; Muto, Brunella; Gigante, Laura; De Gado, Fabrizio; Benedetti Panici, Pierluigi - 04c Atto di convegno in rivista

11573/124131 - 2010 - Management and outcome of pregnancies with Congenital Heart Disease: experience of a single centre of Prenatal Diagnosis.

Giancotti, Antonella; Spagnuolo, Antonella; Muto, Brunella; Bisogni, Francescantonio; Gigante, Laura; Pasquali, Gaia; D'ambrosio, Valentina; De Gado, Fabrizio - 04c Atto di convegno in rivista