LAURA DI MUZIO

PhD Graduate

PhD program:: XXXIII

Thesis title: SYNTHESIS AND DRUG DELIVERY APPLICATIONS OF NATURAL AND SEMI-SYNTHETIC BIOPOLYMERS

Over the last years, the use of biopolymers has gained an increasingly important role in everyday life because of their specific properties, which make them suitable for a wide range of applications. Particularly, there is a growing interest toward the use of biopolymers for applications in the field of tissue engineering and drug delivery. Based on the above, this research work has been based on the investigation and application of natural and semi-synthetic biopolymers and it has been organised into two sections. The first part will focus on the development of drug delivery systems (DDS) based on polysaccharides. In particular, gellan gum-based oral thin films and polymeric beads and dextran-based cryogel will be developed and evaluated as controlled drug delivery systems. The second section will focus on fine optimization and characterization of chondroitin and gelatin methacrylate derivatives as promising materials for tissue engineering and drug delivery applications.

Research products

11573/1711321 - 2024 - Gellan gum-based nanocomposites films containing bio-reduced silver nanoparticles. Synthesis, characterisation and antifungal activity

Di Muzio, Laura; Cairone, Francesco; Cesa, Stefania; Sergi, Claudia; Tirillò, Jacopo; Angiolella, Letizia; Giammarino, Andrea; Giusiano, Gustavo; Petralito, Stefania; Casadei, Maria Antonietta; Paolicelli, Patrizia - 01a Articolo in rivista

paper: CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS (Oxford: Elsevier Ltd.) pp. 1-12 - issn: 2666-8939 - wos: WOS:001219358000001 (1) - scopus: 2-s2.0-85188752793 (1)

11573/1725654 - 2024 - Experimental and modelling study of controlled release from dextran-based cryogels

Lauriola, Carolina; Di Muzio, Laura; Paolicelli, Patrizia; Casadei, Maria Antonietta; Sergi, Claudia; Tirillò, Jacopo; Carriero, Vito Cosimo; Adrover, Alessandra - 01a Articolo in rivista

paper: PHARMACEUTICS (Basel: MDPI, 2009-) pp. 1-16 - issn: 1999-4923 - wos: WOS:001342616700001 (0) - scopus: 2-s2.0-85207678460 (0)

11573/1698140 - 2023 - Cryogel Scaffolds for Tissue-Engineering: Advances and Challenges for Effective Bone and Cartilage Regeneration

Carriero, Vito Cosimo; Di Muzio, Laura; Petralito, Stefania; Casadei, Maria Antonietta; Paolicelli, Patrizia - 01a Articolo in rivista

paper: GELS (Basel : MDPI) pp. - - issn: 2310-2861 - wos: WOS:001130565400001 (4) - scopus: 2-s2.0-85180470306 (8)

11573/1682960 - 2023 - Gelatin-based spongy and compressive resistant cryogels with shape recovery ability as ideal scaffolds to support cell adhesion for tissue regeneration

Di Muzio, L.; Sergi, C.; Carriero, V. C.; Tirillo, J.; Adrover, A.; Messina, E.; Gaetani, R.; Petralito, S.; Casadei, M. A.; Paolicelli, P. - 01a Articolo in rivista

paper: REACTIVE & FUNCTIONAL POLYMERS (Amsterdam Netherlands: Elsevier BV) pp. 105607- - issn: 1381-5148 - wos: WOS:001006120700001 (10) - scopus: 2-s2.0-85159758432 (11)

11573/1619657 - 2022 - Valorization of Kiwi Peels. Fractionation, bioactives analyses and hypotheses on complete peels recycle

Cairone, F.; Garzoli, S.; Menghini, L.; Simonetti, G.; Casadei, M. A.; Di Muzio, L.; Cesa, S. - 01a Articolo in rivista

paper: FOODS (Basel: MDPI) pp. 1-15 - issn: 2304-8158 - wos: WOS:000806522200002 (7) - scopus: 2-s2.0-85124965365 (11)

11573/1672517 - 2022 - Insights into the reaction of chondroitin sulfate with glycidyl methacrylate: 1D and 2D NMR investigation

Di Muzio, Laura; Paolicelli, Patrizia; Trilli, Jordan; Petralito, Stefania; Carriero, Vito Cosimo; Brandelli, Chiara; Spano, Mattia; Sobolev, Anatoly Petrovich; Mannina, Luisa; Casadei, Maria Antonietta - 01a Articolo in rivista

paper: CARBOHYDRATE POLYMERS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-10 - issn: 0144-8617 - wos: WOS:000843529700001 (4) - scopus: 2-s2.0-85135413725 (4)

11573/1645551 - 2022 - Solvent casting and UV photocuring for easy and safe fabrication of nanocomposite film dressings

Di Muzio, Laura; Simonetti, Prisca; Carriero, Vito Cosimo; Brandelli, Chiara; Trilli, Jordan; Sergi, Claudia; Tirillo', Jacopo; Cairone, Francesco; Cesa, Stefania; Radocchia, Giulia; Schippa, Serena; Petralito, Stefania; Paolicelli, Patrizia; Casadei, Maria Antonietta - 01a Articolo in rivista

paper: MOLECULES (Basel: MDPI Berlin: Springer, 1996-) pp. - - issn: 1420-3049 - wos: WOS:000795264200001 (1) - scopus: 2-s2.0-85130058937 (1)

11573/1649187 - 2021 - Injectable and in situ gelling dextran derivatives containing hydrolyzable groups for the delivery of large molecules

Di Muzio, L.; Paolicelli, P.; Brandelli, C.; Cesa, S.; Trilli, J.; Petralito, S.; Casadei, M. A. - 01a Articolo in rivista

paper: GELS (Basel : MDPI) pp. - - issn: 2310-2861 - wos: WOS:000737541800001 (2) - scopus: 2-s2.0-85116278981 (2)

11573/1557499 - 2021 - A convenient strategy to synthesize highly tunable gelatin methacryloyl with very low gelation temperature

Di Muzio, Laura; Cienzo, Federica; Paolicelli, Patrizia; Petralito, Stefania; Garzoli, Stefania; Brandelli, Chiara; Trilli, Jordan; Antonietta Casadei, Maria - 01a Articolo in rivista

paper: EUROPEAN POLYMER JOURNAL (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. - - issn: 0014-3057 - wos: WOS:000661756200011 (15) - scopus: 2-s2.0-85108701240 (15)

11573/1557507 - 2021 - Dextran-polyethylene glycol cryogels as spongy scaffolds for drug delivery

Pacelli, S.; Di Muzio, L.; Paolicelli, P.; Fortunati, V.; Petralito, S.; Trilli, J.; Casadei, M. A. - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (-Attuale :ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE -Butterworth Heinemann Publishers:Linacre House Jordan Hill, Oxford OX2 8DP United Kingdom:011 44 1865 314569, EMAIL: bhmarketing@repp.co.uk, INTERNET: http://www.laxtonsprices.co.uk, Fax: 011 44 1865 314569) pp. 1292-1300 - issn: 0141-8130 - wos: WOS:000603588400122 (39) - scopus: 2-s2.0-85096087552 (47)

11573/1435467 - 2020 - Enhanced loading efficiency and mucoadhesion properties of gellan gum thin films by complexation with Hydroxypropyl-β-Cyclodextrin

Adrover, Alessandra; Di Muzio, Laura; Trilli, Jordan; Brandelli, Chiara; Paolicelli, Patrizia; Petralito, Stefania; Casadei, Maria Antonietta - 01a Articolo in rivista

paper: PHARMACEUTICS (Basel: MDPI, 2009-) pp. - - issn: 1999-4923 - wos: WOS:000586091500001 (9) - scopus: 2-s2.0-85092330414 (13)

11573/1422694 - 2020 - Non thermal electromagnetic fields to trigger on -demand drug release from high-Tm magnetoliposomes

Petralito, Stefania; Paolicelli, Patrizia; Casadei, Maria Antonietta; Trilli, Jordan; Di Muzio, Laura; Liberti And Francesca Apollonio, Micaela - 04d Abstract in atti di convegno

conference: 21st international conference and exibition on pharmaceutics & Novel drug delivery system (Roma)

book: Pharmaceutical Biotechnology: Current Research - ()

11573/1406379 - 2020 - Gelation of the internal core of liposomes as a strategy for stabilization and modified drug delivery II. Theoretical analysis and modelling of in-vitro release experiments

Petralito, Stefania; Paolicelli, Patrizia; Nardoni, Martina; Tedesco, Andrea; Trilli, Jordan; Di Muzio, Laura; Cesa, Stefania; Antonietta Casadei, Maria; Adrover, Alessandra - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF PHARMACEUTICS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0378-5173 - wos: WOS:000549823500009 (2) - scopus: 2-s2.0-85085880021 (4)

11573/1406367 - 2020 - Gelation of the internal core of liposomes as a strategy for stabilization and modified drug delivery I. Physico-chemistry study

Petralito, Stefania; Paolicelli, Patrizia; Nardoni, Martina; Trilli, Jordan; Di Muzio, Laura; Cesa, Stefania; Relucenti, Michela; Matassa, Roberto; Vitalone, Annabella; Adrover, Alessandra; Antonietta Casadei, Maria - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF PHARMACEUTICS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-10 - issn: 0378-5173 - wos: WOS:000547812700010 (12) - scopus: 2-s2.0-85085882697 (11)

11573/1410280 - 2019 - Freeze-dried nanocomposite gel beads for oral drug delivery. In vitro simulation of gastro-intestinal drug release

Adrover, Alessandra; Di Muzio, Laura; Trilli, Jordan; Petralito, Stefania; Paolicelli, Patrizia; Casadei, Maria Antonietta - 04b Atto di convegno in volume

conference: 7th European drying conference Politecnico di Torino (Torino; Italy)

book: Proceedings of Eurodrying 2019 - ()

11573/1261401 - 2019 - Gellan gum/laponite beads for the modified release of drugs: experimental and modeling study of gastrointestinal release

Adrover, Alessandra; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura; Trilli, Jordan; Cesa, Stefania; Tho, Ingunn; Casadei, Maria Antonietta - 01a Articolo in rivista

paper: PHARMACEUTICS (Basel: MDPI, 2009-) pp. - - issn: 1999-4923 - wos: WOS:000467301400042 (27) - scopus: 2-s2.0-85067824171 (37)

11573/1195238 - 2018 - Experimental and modeling study of drug release from HPMC-based erodible oral thin films

Adrover, Alessandra; Varani, Gabriele; Paolicelli, Patrizia; Petralito, Stefania; Di Muzio, Laura; Casadei, Maria Antonietta; Tho, Ingunn - 01a Articolo in rivista

paper: PHARMACEUTICS (Basel: MDPI, 2009-) pp. - - issn: 1999-4923 - wos: WOS:000455853800060 (24) - scopus: 2-s2.0-85057084106 (28)

11573/1113149 - 2018 - Design of a tunable nanocomposite double network hydrogel based on gellan gum for drug delivery applications

Pacelli, Settimio; Paolicelli, Patrizia; Avitabile, Michele; Varani, Gabriele; Di Muzio, Laura; Cesa, Stefania; Tirillò, Jacopo; Bartuli, Cecilia; Nardoni, Martina; Petralito, Stefania; Adrover, Alessandra; Casadei, Maria Antonietta - 01a Articolo in rivista

paper: EUROPEAN POLYMER JOURNAL (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 184-193 - issn: 0014-3057 - wos: WOS:000436886800023 (41) - scopus: 2-s2.0-85048732229 (54)

11573/1113197 - 2018 - Effect of glycerol on the physical and mechanical properties of thin gellan gum films for oral drug delivery

Paolicelli, Patrizia; Petralito, Stefania; Varani, Gabriele; Nardoni, Martina; Pacelli, Settimio; Di Muzio, Laura; Tirillò, Jacopo; Bartuli, Cecilia; Cesa, Stefania; Casadei, Maria Antonietta; Adrover, Alessandra - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF PHARMACEUTICS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 226-234 - issn: 0378-5173 - wos: WOS:000439096500021 (49) - scopus: 2-s2.0-85048471811 (57)