Junichi SADOSHIMA | EXPERIMENTAL MEDICINE

AT1 receptor mutant lacking heterotrimeric G protein coupling activates the Src-Ras-ERK pathway without nuclear translocation of ERKs.

Seta K, Nanamori M, Modrall JG, Neubig RR, Sadoshima J. J Biol Chem. 2002 Mar 15;277(11):9268-77. doi: 10.1074/jbc.M109221200. Epub 2002 Jan 3. PMID: 11777928 Free article.

2

Novel AT(1) receptor-independent functions of losartan.

Sadoshima J. Circ Res. 2002 Apr 19;90(7):754-6. doi: 10.1161/01.res.0000016843.82450.8c. PMID: 11964366 Free article. No abstract available.

3

Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development.

Hardt SE, Sadoshima J. Circ Res. 2002 May 31;90(10):1055-63. doi: 10.1161/01.res.0000018952.70505.f1. PMID: 12039794 Free article. Review.

4

What is the unique function of SAPK3/p38gamma in cardiac myocytes?

Seta K, Sadoshima J. J Mol Cell Cardiol. 2002 Jun;34(6):597-600. doi: 10.1006/jmcc.2002.2000. PMID: 12054845 No abstract available.

5

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.

Sadoshima J, Montagne O, Wang Q, Yang G, Warden J, Liu J, Takagi G, Karoor V, Hong C, Johnson GL, Vatner DE, Vatner SF. J Clin Invest. 2002 Jul;110(2):271-9. doi: 10.1172/JCI14938. PMID: 12122119 Free PMC article.

6

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice.

Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J Jr. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12333-8. doi: 10.1073/pnas.172376399. PMID: 12237475 Free PMC article.

7

H11 kinase is a novel mediator of myocardial hypertrophy in vivo.

Depre C, Hase M, Gaussin V, Zajac A, Wang L, Hittinger L, Ghaleh B, Yu X, Kudej RK, Wagner T, Sadoshima J, Vatner SF. Circ Res. 2002 Nov 29;91(11):1007-14. doi: 10.1161/01.res.0000044380.54893.4b. PMID: 12456486 Free article.

8

Phosphorylation of tyrosine 319 of the angiotensin II type 1 receptor mediates angiotensin II-induced trans-activation of the epidermal growth factor receptor.

Seta K, Sadoshima J. J Biol Chem. 2003 Mar 14;278(11):9019-26. doi: 10.1074/jbc.M208017200. Epub 2003 Jan 9. PMID: 12522132 Free article.

9

Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus.

Morisco C, Sadoshima J, Trimarco B, Arora R, Vatner DE, Vatner SF. Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1043-7. doi: 10.1152/ajpheart.00990.2002. PMID: 12666659 Free article. Review. No abstract available.

10

Persistent stunning induces myocardial hibernation and protection: flow/function and metabolic mechanisms.

Kim SJ, Peppas A, Hong SK, Yang G, Huang Y, Diaz G, Sadoshima J, Vatner DE, Vatner SF. Circ Res. 2003 Jun 13;92(11):1233-9. doi: 10.1161/01.RES.0000076892.18394.B6. Epub 2003 May 15. PMID: 12750311 Free article.

11

Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.

Yamamoto S, Yang G, Zablocki D, Liu J, Hong C, Kim SJ, Soler S, Odashima M, Thaisz J, Yehia G, Molina CA, Yatani A, Vatner DE, Vatner SF, Sadoshima J. J Clin Invest. 2003 May;111(10):1463-74. doi: 10.1172/JCI17459. PMID: 12750396 Free PMC article.

12

Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to beta-adrenergic receptor stimulation.

Tomita H, Nazmy M, Kajimoto K, Yehia G, Molina CA, Sadoshima J. Circ Res. 2003 Jul 11;93(1):12-22. doi: 10.1161/01.RES.0000079794.57578.F1. Epub 2003 Jun 5. PMID: 12791704 Free article.

13

Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation.

Okumura S, Kawabe J, Yatani A, Takagi G, Lee MC, Hong C, Liu J, Takagi I, Sadoshima J, Vatner DE, Vatner SF, Ishikawa Y. Circ Res. 2003 Aug 22;93(4):364-71. doi: 10.1161/01.RES.0000086986.35568.63. Epub 2003 Jul 17. PMID: 12869393 Free article.

14

Disruption of type 5 adenylyl cyclase gene preserves cardiac function against pressure overload.

Okumura S, Takagi G, Kawabe J, Yang G, Lee MC, Hong C, Liu J, Vatner DE, Sadoshima J, Vatner SF, Ishikawa Y. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9986-90. doi: 10.1073/pnas.1733772100. Epub 2003 Aug 6. PMID: 12904575 Free PMC article.

15

Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.

Kim YK, Kim SJ, Yatani A, Huang Y, Castelli G, Vatner DE, Liu J, Zhang Q, Diaz G, Zieba R, Thaisz J, Drusco A, Croce C, Sadoshima J, Condorelli G, Vatner SF. J Biol Chem. 2003 Nov 28;278(48):47622-8. doi: 10.1074/jbc.M305909200. Epub 2003 Sep 16. PMID: 13129932 Free article.

16

Neurally-mediated increase in calcineurin activity regulates cardiac contractile function in absence of hypertrophy.

Li J, Yatani A, Kim SJ, Takagi G, Irie K, Zhang Q, Karoor V, Hong C, Yang G, Sadoshima J, Depre C, Vatner DE, West MJ, Vatner SF. Cardiovasc Res. 2003 Sep 1;59(3):649-57. doi: 10.1016/s0008-6363(03)00471-1. PMID: 14499866

17

Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy.

Yamamoto M, Yang G, Hong C, Liu J, Holle E, Yu X, Wagner T, Vatner SF, Sadoshima J. J Clin Invest. 2003 Nov;112(9):1395-406. doi: 10.1172/JCI17700. PMID: 14597765 Free PMC article.

18

Propranolol prevents enhanced stress signaling in Gs alpha cardiomyopathy: potential mechanism for beta-blockade in heart failure.

Karoor V, Vatner SF, Takagi G, Yang G, Thaisz J, Sadoshima J, Vatner DE. J Mol Cell Cardiol. 2004 Feb;36(2):305-12. doi: 10.1016/j.yjmcc.2003.11.006. PMID: 14871558

19

Phosphorylation of eukaryotic translation initiation factor 2Bepsilon by glycogen synthase kinase-3beta regulates beta-adrenergic cardiac myocyte hypertrophy.

Hardt SE, Tomita H, Katus HA, Sadoshima J. Circ Res. 2004 Apr 16;94(7):926-35. doi: 10.1161/01.RES.0000124977.59827.80. Epub 2004 Mar 4. PMID: 15001529 Free article.

20

Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells.

Kawabe J, Okumura S, Lee MC, Sadoshima J, Ishikawa Y. Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1845-52. doi: 10.1152/ajpheart.00593.2003. PMID: 15072971 Free article.

21

Rapid upregulation of CTGF in cardiac myocytes by hypertrophic stimuli: implication for cardiac fibrosis and hypertrophy.

Matsui Y, Sadoshima J. J Mol Cell Cardiol. 2004 Aug;37(2):477-81. doi: 10.1016/j.yjmcc.2004.05.012. PMID: 15276017 No abstract available.

22

Negative regulators of cardiac hypertrophy.

Hardt SE, Sadoshima J. Cardiovasc Res. 2004 Aug 15;63(3):500-9. doi: 10.1016/j.cardiores.2004.03.015. PMID: 15276475 Review.

23

Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.

Alcendor RR, Kirshenbaum LA, Imai S, Vatner SF, Sadoshima J. Circ Res. 2004 Nov 12;95(10):971-80. doi: 10.1161/01.RES.0000147557.75257.ff. Epub 2004 Oct 14. PMID: 15486319 Free article.

24

Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes.

Morisco C, Condorelli G, Trimarco V, Bellis A, Marrone C, Condorelli G, Sadoshima J, Trimarco B. Circ Res. 2005 Feb 4;96(2):180-8. doi: 10.1161/01.RES.0000152968.71868.c3. Epub 2004 Dec 9. PMID: 15591229 Free article.

25

H11 has dose-dependent and dual hypertrophic and proapoptotic functions in cardiac myocytes.

Hase M, Depre C, Vatner SF, Sadoshima J. Biochem J. 2005 Jun 1;388(Pt 2):475-83. doi: 10.1042/BJ20041314. PMID: 15656793 Free PMC article.

26

Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure.

Ding B, Abe JI, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C. Circulation. 2005 May 17;111(19):2469-2476. doi: 10.1161/01.CIR.0000165128.39715.87. Epub 2005 May 2. PMID: 15867171 Free PMC article.

27

Critical role of Mst1 in vascular remodeling after injury.

Ono H, Ichiki T, Ohtsubo H, Fukuyama K, Imayama I, Hashiguchi Y, Sadoshima J, Sunagawa K. Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1871-6. doi: 10.1161/01.ATV.0000174588.50971.1a. Epub 2005 Jun 16. PMID: 15961701

28

Preconditioning effects of PKCdelta.

Hirotani S, Sadoshima J. J Mol Cell Cardiol. 2005 Oct;39(4):719-21. doi: 10.1016/j.yjmcc.2005.07.001. PMID: 16099469 No abstract available.

29

Autophagy in chronically ischemic myocardium.

Yan L, Vatner DE, Kim SJ, Ge H, Masurekar M, Massover WH, Yang G, Matsui Y, Sadoshima J, Vatner SF. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13807-12. doi: 10.1073/pnas.0506843102. Epub 2005 Sep 20. PMID: 16174725 Free PMC article.

30

A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.

Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14771-6. doi: 10.1073/pnas.0506489102. Epub 2005 Sep 26. PMID: 16186489 Free PMC article.

31

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

Zhai P, Yamamoto M, Galeotti J, Liu J, Masurekar M, Thaisz J, Irie K, Holle E, Yu X, Kupershmidt S, Roden DM, Wagner T, Yatani A, Vatner DE, Vatner SF, Sadoshima J. J Clin Invest. 2005 Nov;115(11):3045-56. doi: 10.1172/JCI25330. PMID: 16276415 Free PMC article.

32

Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity.

Zebrowski DC, Alcendor RR, Kirshenbaum LA, Sadoshima J. J Mol Cell Cardiol. 2006 May;40(5):605-18. doi: 10.1016/j.yjmcc.2005.11.012. Epub 2006 Jan 19. PMID: 16427076

33

GDF15, a cardioprotective TGF-beta superfamily protein.

Ago T, Sadoshima J. Circ Res. 2006 Feb 17;98(3):294-7. doi: 10.1161/01.RES.0000207919.83894.9d. PMID: 16484622 Free article. No abstract available.

34

Overexpressed cardiac Gsalpha in rabbits.

Nishizawa T, Vatner SF, Hong C, Shen YT, Hardt SE, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE. J Mol Cell Cardiol. 2006 Jul;41(1):44-50. doi: 10.1016/j.yjmcc.2006.03.008. Epub 2006 May 5. PMID: 16678849

35

Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.

Chen IY, Lypowy J, Pain J, Sayed D, Grinberg S, Alcendor RR, Sadoshima J, Abdellatif M. J Biol Chem. 2006 Jul 14;281(28):19369-77. doi: 10.1074/jbc.M601443200. Epub 2006 May 10. PMID: 16687393 Free article.

36

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.

Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. J Biol Chem. 2006 Aug 4;281(31):21745-21754. doi: 10.1074/jbc.M602909200. Epub 2006 Jun 2. PMID: 16751189 Free article.

37

Autophagy: a novel protective mechanism in chronic ischemia.

Yan L, Sadoshima J, Vatner DE, Vatner SF. Cell Cycle. 2006 Jun;5(11):1175-7. doi: 10.4161/cc.5.11.2787. Epub 2006 Jun 1. PMID: 16760663 Review.

38

Global changes in gene expression during cardiac hypertrophy: a new direction of cardiac signaling research.

Usui S, Yeh I, Tian B, Sadoshima J. J Mol Cell Cardiol. 2006 Aug;41(2):219-22. doi: 10.1016/j.yjmcc.2006.05.006. Epub 2006 Jul 3. PMID: 16815433 No abstract available.

39

An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy.

Zhai P, Galeotti J, Liu J, Holle E, Yu X, Wagner T, Sadoshima J. Circ Res. 2006 Sep 1;99(5):528-36. doi: 10.1161/01.RES.0000240147.49390.61. Epub 2006 Aug 10. PMID: 16902180 Free article.

40

Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.

Liu J, Sadoshima J, Zhai P, Hong C, Yang G, Chen W, Yan L, Wang Y, Vatner SF, Vatner DE. J Mol Cell Cardiol. 2006 Oct;41(4):680-8. doi: 10.1016/j.yjmcc.2006.07.007. Epub 2006 Aug 22. PMID: 16928383

41

Redox regulation of growth and death in cardiac myocytes.

Sadoshima J. Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1621-4. doi: 10.1089/ars.2006.8.1621. PMID: 16987016 No abstract available.

42

Thioredoxin1 upregulates mitochondrial proteins related to oxidative phosphorylation and TCA cycle in the heart.

Ago T, Yeh I, Yamamoto M, Schinke-Braun M, Brown JA, Tian B, Sadoshima J. Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1635-50. doi: 10.1089/ars.2006.8.1635. PMID: 16987018

43

Thioredoxin and ventricular remodeling.

Ago T, Sadoshima J. J Mol Cell Cardiol. 2006 Nov;41(5):762-73. doi: 10.1016/j.yjmcc.2006.08.006. Epub 2006 Sep 26. PMID: 17007870 Free PMC article. Review.

44

Activation of the cardiac proteasome during pressure overload promotes ventricular hypertrophy.

Depre C, Wang Q, Yan L, Hedhli N, Peter P, Chen L, Hong C, Hittinger L, Ghaleh B, Sadoshima J, Vatner DE, Vatner SF, Madura K. Circulation. 2006 Oct 24;114(17):1821-8. doi: 10.1161/CIRCULATIONAHA.106.637827. Epub 2006 Oct 16. PMID: 17043166

45

Altered autonomic control in conscious transgenic rabbits with overexpressed cardiac Gsalpha.

Nishizawa T, Shen YT, Rossi F, Hong C, Robbins J, Ishikawa Y, Sadoshima J, Vatner DE, Vatner SF. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H971-5. doi: 10.1152/ajpheart.00791.2006. PMID: 17287453 Free article.

46

Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy.

Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, Asano T, Levine B, Sadoshima J. Circ Res. 2007 Mar 30;100(6):914-22. doi: 10.1161/01.RES.0000261924.76669.36. Epub 2007 Mar 1. PMID: 17332429 Free article.

47

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.

Odashima M, Usui S, Takagi H, Hong C, Liu J, Yokota M, Sadoshima J. Circ Res. 2007 May 11;100(9):1344-52. doi: 10.1161/01.RES.0000265846.23485.7a. Epub 2007 Mar 29. PMID: 17395874 Free article.

48

Thioredoxin1 as a negative regulator of cardiac hypertrophy.

Ago T, Sadoshima J. Antioxid Redox Signal. 2007 Jun;9(6):679-87. doi: 10.1089/ars.2007.1529. PMID: 17419666 Review.

49

Sirt1 regulates aging and resistance to oxidative stress in the heart.

Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J. Circ Res. 2007 May 25;100(10):1512-21. doi: 10.1161/01.RES.0000267723.65696.4a. Epub 2007 Apr 19. PMID: 17446436 Free article.

50

Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.

Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE. J Clin Invest. 2007 May;117(5):1335-43. doi: 10.1172/JCI29576. Epub 2007 Apr 19. PMID: 17446930 Free PMC article.

51

Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell.

Ohtsubo H, Ichiki T, Miyazaki R, Inanaga K, Imayama I, Hashiguchi Y, Sadoshima J, Sunagawa K. Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1549-55. doi: 10.1161/ATVBAHA.107.145011. Epub 2007 Apr 26. PMID: 17463330

52

AMPK mediates autophagy during myocardial ischemia in vivo.

Takagi H, Matsui Y, Hirotani S, Sakoda H, Asano T, Sadoshima J. Autophagy. 2007 Jul-Aug;3(4):405-7. doi: 10.4161/auto.4281. Epub 2007 Jul 13. PMID: 17471015

53

The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart.

Takagi H, Matsui Y, Sadoshima J. Antioxid Redox Signal. 2007 Sep;9(9):1373-81. doi: 10.1089/ars.2007.1689. PMID: 17627477 Review.

54

Type 5 adenylyl cyclase disruption increases longevity and protects against stress.

Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, Chen W, Hirotani S, Ishikawa Y, Sadoshima J, Vatner SF. Cell. 2007 Jul 27;130(2):247-58. doi: 10.1016/j.cell.2007.05.038. PMID: 17662940 Free article.

55

Insulin resistance affects the cytoprotective effect of insulin in cardiomyocytes through an impairment of MAPK phosphatase-1 expression.

Morisco C, Marrone C, Trimarco V, Crispo S, Monti MG, Sadoshima J, Trimarco B. Cardiovasc Res. 2007 Dec 1;76(3):453-64. doi: 10.1016/j.cardiores.2007.07.012. Epub 2007 Jul 25. PMID: 17698050

56

Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases.

Zhai P, Gao S, Holle E, Yu X, Yatani A, Wagner T, Sadoshima J. J Biol Chem. 2007 Nov 9;282(45):33181-91. doi: 10.1074/jbc.M705133200. Epub 2007 Sep 12. PMID: 17855351 Free article.

57

Inhibition of glycogen synthase kinase 3beta during heart failure is protective.

Hirotani S, Zhai P, Tomita H, Galeotti J, Marquez JP, Gao S, Hong C, Yatani A, Avila J, Sadoshima J. Circ Res. 2007 Nov 26;101(11):1164-74. doi: 10.1161/CIRCRESAHA.107.160614. Epub 2007 Sep 27. PMID: 17901358 Free article.

58

Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells.

Ohtsubo H, Ichiki T, Imayama I, Ono H, Fukuyama K, Hashiguchi Y, Sadoshima J, Sunagawa K. Biochem Biophys Res Commun. 2008 Mar 7;367(2):474-80. doi: 10.1016/j.bbrc.2007.12.173. Epub 2008 Jan 7. PMID: 18182160

59

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Ku… See abstract for full author list ➔ Autophagy. 2008 Feb;4(2):151-75. doi: 10.4161/auto.5338. Epub 2007 Nov 21. PMID: 18188003 Free PMC article. Review.

60

Endocytosis machinery is required for beta1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.

Morisco C, Marrone C, Galeotti J, Shao D, Vatner DE, Vatner SF, Sadoshima J. Cardiovasc Res. 2008 Apr 1;78(1):36-44. doi: 10.1093/cvr/cvn008. Epub 2008 Jan 14. PMID: 18194989 Free PMC article.

61

Sirt1 protects the heart from aging and stress.

Hsu CP, Odewale I, Alcendor RR, Sadoshima J. Biol Chem. 2008 Mar;389(3):221-31. doi: 10.1515/BC.2008.032. PMID: 18208353 Review.

62

Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion.

Matsui Y, Kyoi S, Takagi H, Hsu CP, Hariharan N, Ago T, Vatner SF, Sadoshima J. Autophagy. 2008 May;4(4):409-15. doi: 10.4161/auto.5638. Epub 2008 Jan 24. PMID: 18227645 Free PMC article. Review.

63

The role of autophagy during ischemia/reperfusion.

Sadoshima J. Autophagy. 2008 May;4(4):402-3. doi: 10.4161/auto.5924. Epub 2008 Mar 18. PMID: 18367869

64

SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells.

Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J, Sunagawa K. Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1263-9. doi: 10.1161/ATVBAHA.108.166991. Epub 2008 Apr 17. PMID: 18420994

65

A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.

Ago T, Liu T, Zhai P, Chen W, Li H, Molkentin JD, Vatner SF, Sadoshima J. Cell. 2008 Jun 13;133(6):978-93. doi: 10.1016/j.cell.2008.04.041. PMID: 18555775 Free article.

66

Quantitative analysis of redox-sensitive proteome with DIGE and ICAT.

Fu C, Hu J, Liu T, Ago T, Sadoshima J, Li H. J Proteome Res. 2008 Sep;7(9):3789-802. doi: 10.1021/pr800233r. Epub 2008 Aug 16. PMID: 18707151 Free PMC article.

67

Lats2 is a negative regulator of myocyte size in the heart.

Matsui Y, Nakano N, Shao D, Gao S, Luo W, Hong C, Zhai P, Holle E, Yu X, Yabuta N, Tao W, Wagner T, Nojima H, Sadoshima J. Circ Res. 2008 Nov 21;103(11):1309-18. doi: 10.1161/CIRCRESAHA.108.180042. Epub 2008 Oct 16. PMID: 18927464 Free PMC article.

68

Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning.

Shen YT, Depre C, Yan L, Park JY, Tian B, Jain K, Chen L, Zhang Y, Kudej RK, Zhao X, Sadoshima J, Vatner DE, Vatner SF. Circulation. 2008 Nov 4;118(19):1961-9. doi: 10.1161/CIRCULATIONAHA.108.788240. Epub 2008 Oct 20. PMID: 18936329 Free PMC article.

69

Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion.

Zhai P, Sadoshima J. Circ Res. 2008 Oct 24;103(9):910-3. doi: 10.1161/01.RES.0000338259.37472.b6. PMID: 18948628 Free PMC article. No abstract available.

70

Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.

Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S, Sadoshima J. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20900-5. doi: 10.1073/pnas.0808315106. Epub 2008 Dec 23. PMID: 19106302 Free PMC article.

71

Adenylyl cyclase type 5 disruption prolongs longevity and protects the heart against stress.

Vatner SF, Yan L, Ishikawa Y, Vatner DE, Sadoshima J. Circ J. 2009 Feb;73(2):195-200. doi: 10.1253/circj.cj-08-0957. Epub 2008 Dec 24. PMID: 19106458 Free article. Review.

72

Novel methods for measuring cardiac autophagy in vivo.

Perry CN, Kyoi S, Hariharan N, Takagi H, Sadoshima J, Gottlieb RA. Methods Enzymol. 2009;453:325-42. doi: 10.1016/S0076-6879(08)04016-0. PMID: 19216914 Free PMC article.

73

Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes.

Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, Vatner DE, Vatner SF, Abdellatif M. Circ Res. 2009 Apr 10;104(7):879-86. doi: 10.1161/CIRCRESAHA.108.193102. Epub 2009 Mar 5. PMID: 19265035 Free PMC article.

74

Autophagy in ischemic preconditioning and hibernating myocardium.

Yan L, Sadoshima J, Vatner DE, Vatner SF. Autophagy. 2009 Jul;5(5):709-12. doi: 10.4161/auto.5.5.8510. Epub 2009 Jul 23. PMID: 19398895

75

Elucidation of thioredoxin target protein networks in mouse.

Fu C, Wu C, Liu T, Ago T, Zhai P, Sadoshima J, Li H. Mol Cell Proteomics. 2009 Jul;8(7):1674-87. doi: 10.1074/mcp.M800580-MCP200. Epub 2009 May 4. PMID: 19416943 Free PMC article.

76

The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy.

Oka S, Ago T, Kitazono T, Zablocki D, Sadoshima J. J Mol Med (Berl). 2009 Aug;87(8):785-91. doi: 10.1007/s00109-009-0471-2. Epub 2009 May 8. PMID: 19424677 Review.

77

Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late ischemic preconditioning.

Bellis A, Castaldo D, Trimarco V, Monti MG, Chivasso P, Sadoshima J, Trimarco B, Morisco C. Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1207-12. doi: 10.1161/ATVBAHA.109.184135. Epub 2009 May 21. PMID: 19461052

78

Cytochrome c oxidase III as a mechanism for apoptosis in heart failure following myocardial infarction.

Wu C, Yan L, Depre C, Dhar SK, Shen YT, Sadoshima J, Vatner SF, Vatner DE. Am J Physiol Cell Physiol. 2009 Oct;297(4):C928-34. doi: 10.1152/ajpcell.00045.2009. Epub 2009 Jul 22. PMID: 19625613 Free PMC article.

79

Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.

Hsu CP, Oka S, Shao D, Hariharan N, Sadoshima J. Circ Res. 2009 Aug 28;105(5):481-91. doi: 10.1161/CIRCRESAHA.109.203703. Epub 2009 Aug 6. PMID: 19661458 Free PMC article.

80

Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.

Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, Cemerlang N, Sadoshima J, Shioi T, Izumo S, Lukoshkova EV, Dart AM, Jennings GL, McMullen JR. Am J Pathol. 2009 Sep;175(3):998-1009. doi: 10.2353/ajpath.2009.090126. Epub 2009 Aug 13. PMID: 19679877 Free PMC article.

81

Optimizing cell-based therapy for cardiac regeneration.

Del Re DP, Sadoshima J. Circulation. 2009 Sep 8;120(10):831-4. doi: 10.1161/CIRCULATIONAHA.109.887836. Epub 2009 Aug 24. PMID: 19704092 No abstract available.

82

Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload.

Gelpi RJ, Gao S, Zhai P, Yan L, Hong C, Danridge LM, Ge H, Maejima Y, Donato M, Yokota M, Molkentin JD, Vatner DE, Vatner SF, Sadoshima J. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1814-9. doi: 10.1152/ajpheart.00449.2009. Epub 2009 Aug 28. PMID: 19717730 Free PMC article.

83

Selective activation of the "b" splice variant of phospholipase Cbeta1 in chronically dilated human and mouse atria.

Woodcock EA, Grubb DR, Filtz TM, Marasco S, Luo J, McLeod-Dryden TJ, Kaye DM, Sadoshima J, Du XJ, Wong C, McMullen JR, Dart AM. J Mol Cell Cardiol. 2009 Nov;47(5):676-83. doi: 10.1016/j.yjmcc.2009.08.020. Epub 2009 Aug 31. PMID: 19729020

84

Adenylyl cyclase type 5 protein expression during cardiac development and stress.

Hu CL, Chandra R, Ge H, Pain J, Yan L, Babu G, Depre C, Iwatsubo K, Ishikawa Y, Sadoshima J, Vatner SF, Vatner DE. Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1776-82. doi: 10.1152/ajpheart.00050.2009. Epub 2009 Sep 4. PMID: 19734365 Free PMC article.

85

Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes.

Hsu CP, Hariharan N, Alcendor RR, Oka S, Sadoshima J. Autophagy. 2009 Nov;5(8):1229-31. doi: 10.4161/auto.5.8.10275. Epub 2009 Nov 8. PMID: 19855187

86

Distinct roles of glycogen synthase kinase (GSK)-3alpha and GSK-3beta in mediating cardiomyocyte differentiation in murine bone marrow-derived mesenchymal stem cells.

Cho J, Rameshwar P, Sadoshima J. J Biol Chem. 2009 Dec 25;284(52):36647-36658. doi: 10.1074/jbc.M109.019109. Epub 2009 Oct 26. PMID: 19858210 Free PMC article.

87

Bone marrow-derived cells contribute to fibrosis in the chronically failing heart.

Chu PY, Mariani J, Finch S, McMullen JR, Sadoshima J, Marshall T, Kaye DM. Am J Pathol. 2010 Apr;176(4):1735-42. doi: 10.2353/ajpath.2010.090574. Epub 2010 Feb 11. PMID: 20150435 Free PMC article.

88

Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.

Ago T, Kuroda J, Pain J, Fu C, Li H, Sadoshima J. Circ Res. 2010 Apr 16;106(7):1253-64. doi: 10.1161/CIRCRESAHA.109.213116. Epub 2010 Feb 25. PMID: 20185797 Free PMC article.

89

The one-two punch: knocking out angiotensin II in the heart.

Zablocki D, Sadoshima J. J Clin Invest. 2010 Apr;120(4):1028-31. doi: 10.1172/JCI42644. Epub 2010 Mar 24. PMID: 20335650 Free PMC article.

90

Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.

Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK. Sci Transl Med. 2010 Apr 7;2(26):26ra26. doi: 10.1126/scitranslmed.3000502. PMID: 20375365 Free PMC article.

91

New insights into the molecular phenotype of eccentric hypertrophy.

Sciarretta S, Sadoshima J. J Mol Cell Cardiol. 2010 Aug;49(2):153-6. doi: 10.1016/j.yjmcc.2010.03.018. Epub 2010 Apr 8. PMID: 20381498 Free PMC article. No abstract available.

92

NADPH oxidase and cardiac failure.

Kuroda J, Sadoshima J. J Cardiovasc Transl Res. 2010 Aug;3(4):314-20. doi: 10.1007/s12265-010-9184-8. Epub 2010 Mar 31. PMID: 20559780 Free PMC article. Review.

93

Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload.

Ago T, Yang Y, Zhai P, Sadoshima J. J Cardiovasc Transl Res. 2010 Aug;3(4):304-13. doi: 10.1007/s12265-010-9182-x. Epub 2010 May 1. PMID: 20559781 Free PMC article.

94

Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion.

Takagi H, Hsu CP, Kajimoto K, Shao D, Yang Y, Maejima Y, Zhai P, Yehia G, Yamada C, Zablocki D, Sadoshima J. Circ Res. 2010 Sep 3;107(5):642-9. doi: 10.1161/CIRCRESAHA.110.217554. Epub 2010 Jul 1. PMID: 20595653 Free PMC article.

95

Redox regulatory mechanism of transnitrosylation by thioredoxin.

Wu C, Liu T, Chen W, Oka S, Fu C, Jain MR, Parrott AM, Baykal AT, Sadoshima J, Li H. Mol Cell Proteomics. 2010 Oct;9(10):2262-75. doi: 10.1074/mcp.M110.000034. Epub 2010 Jul 21. PMID: 20660346 Free PMC article.

96

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.

Kuroda J, Ago T, Matsushima S, Zhai P, Schneider MD, Sadoshima J. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15565-70. doi: 10.1073/pnas.1002178107. Epub 2010 Aug 16. PMID: 20713697 Free PMC article.

97

Dietary restriction: standing up for sirtuins.

Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E. Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. doi: 10.1126/science.329.5995.1012. PMID: 20798296 Free PMC article. No abstract available.

98

Oxidative stress stimulates autophagic flux during ischemia/reperfusion.

Hariharan N, Zhai P, Sadoshima J. Antioxid Redox Signal. 2011 Jun;14(11):2179-90. doi: 10.1089/ars.2010.3488. Epub 2011 Jan 27. PMID: 20812860 Free PMC article.

99

Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice.

Del Re DP, Matsuda T, Zhai P, Gao S, Clark GJ, Van Der Weyden L, Sadoshima J. J Clin Invest. 2010 Oct;120(10):3555-67. doi: 10.1172/JCI43569. Epub 2010 Sep 20. PMID: 20890045 Free PMC article.

100

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes.

Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Circ Res. 2010 Dec 10;107(12):1470-82. doi: 10.1161/CIRCRESAHA.110.227371. Epub 2010 Oct 14. PMID: 20947830 Free PMC article.

101

Application of recombinant thioredoxin1 for treatment of heart disease.

Matsushima S, Zablocki D, Sadoshima J. J Mol Cell Cardiol. 2011 Oct;51(4):570-3. doi: 10.1016/j.yjmcc.2010.09.020. Epub 2010 Oct 16. PMID: 20955713 Free PMC article. Review.

102

Hypotonic swelling-induced activation of PKN1 mediates cell survival in cardiac myocytes.

Kajimoto K, Shao D, Takagi H, Maceri G, Zablocki D, Mukai H, Ono Y, Sadoshima J. Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H191-200. doi: 10.1152/ajpheart.00232.2010. Epub 2010 Oct 29. PMID: 21037231 Free PMC article.

103

Silent information regulator 1 protects the heart from ischemia/reperfusion.

Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, Shao D, Takagi H, Oka S, Sadoshima J. Circulation. 2010 Nov 23;122(21):2170-82. doi: 10.1161/CIRCULATIONAHA.110.958033. Epub 2010 Nov 8. PMID: 21060073 Free PMC article.

104

Injection of wild type embryonic stem cells into Mst1 transgenic blastocysts prevents adult-onset cardiomyopathy.

Zhao Q, Beck AJ, Vitale JM, Schneider JS, Chang C, Gao S, del Re D, Bhaumik M, Yehia G, Sadoshima J, Fraidenraich D. Stem Cell Rev Rep. 2011 Jun;7(2):326-30. doi: 10.1007/s12015-010-9206-6. PMID: 21086068 Free PMC article.

105

Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart?

Sciarretta S, Hariharan N, Monden Y, Zablocki D, Sadoshima J. Pediatr Cardiol. 2011 Mar;32(3):275-81. doi: 10.1007/s00246-010-9855-x. Epub 2010 Dec 19. PMID: 21170742 Free PMC article.

106

Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7.

Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J. Circ Res. 2011 Feb 4;108(3):305-13. doi: 10.1161/CIRCRESAHA.110.228437. Epub 2010 Dec 23. PMID: 21183740 Free PMC article.

107

Protection of the heart against ischemia/reperfusion by silent information regulator 1.

Yamamoto T, Sadoshima J. Trends Cardiovasc Med. 2011 Jan;21(1):27-32. doi: 10.1016/j.tcm.2012.01.005. PMID: 22498017 Free PMC article. Review.

108

The NADPH oxidase Nox4 and aging in the heart.

Ago T, Matsushima S, Kuroda J, Zablocki D, Kitazono T, Sadoshima J. Aging (Albany NY). 2010 Dec;2(12):1012-6. doi: 10.18632/aging.100261. PMID: 21212466 Free PMC article.

109

Regulation of myocardial growth and death by NADPH oxidase.

Maejima Y, Kuroda J, Matsushima S, Ago T, Sadoshima J. J Mol Cell Cardiol. 2011 Mar;50(3):408-16. doi: 10.1016/j.yjmcc.2010.12.018. Epub 2011 Jan 6. PMID: 21215757 Free PMC article. Review.

110

Myocardial injection with GSK-3β-overexpressing bone marrow-derived mesenchymal stem cells attenuates cardiac dysfunction after myocardial infarction.

Cho J, Zhai P, Maejima Y, Sadoshima J. Circ Res. 2011 Feb 18;108(4):478-89. doi: 10.1161/CIRCRESAHA.110.229658. Epub 2011 Jan 13. PMID: 21233455 Free PMC article.

111

Knocking out angiotensin II in the heart.

Zablocki D, Sadoshima J. Curr Hypertens Rep. 2011 Apr;13(2):129-35. doi: 10.1007/s11906-011-0180-4. PMID: 21234717 Free PMC article. Review.

112

Sirt3 targets mPTP and prevents aging in the heart.

Sadoshima J. Aging (Albany NY). 2011 Jan;3(1):12-3. doi: 10.18632/aging.100266. PMID: 21248376 Free PMC article. No abstract available.

113

Regulation of longevity by regulator of G-protein signaling protein, Loco.

Lin YR, Kim K, Yang Y, Ivessa A, Sadoshima J, Park Y. Aging Cell. 2011 Jun;10(3):438-47. doi: 10.1111/j.1474-9726.2011.00678.x. Epub 2011 Mar 22. PMID: 21255223 Free article.

114

Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies.

Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H. Antioxid Redox Signal. 2011 Nov 1;15(9):2565-604. doi: 10.1089/ars.2010.3831. Epub 2011 Jun 8. PMID: 21453190 Free PMC article. Review.

115

Is Raf1 a nexus for cardiac hypertrophic signaling in human disease?

Del Re DP, Sadoshima J. J Mol Cell Cardiol. 2011 Jul;51(1):1-3. doi: 10.1016/j.yjmcc.2011.04.004. Epub 2011 Apr 22. PMID: 21539844 No abstract available.

116

Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB.

Usui S, Maejima Y, Pain J, Hong C, Cho J, Park JY, Zablocki D, Tian B, Glass DJ, Sadoshima J. Circ Res. 2011 Jul 8;109(2):161-71. doi: 10.1161/CIRCRESAHA.110.238717. Epub 2011 May 26. PMID: 21617130 Free PMC article.

117

Pathophysiological roles of NADPH oxidase/nox family proteins in the vascular system. -Review and perspective-.

Ago T, Kuroda J, Kamouchi M, Sadoshima J, Kitazono T. Circ J. 2011;75(8):1791-800. doi: 10.1253/circj.cj-11-0388. Epub 2011 Jun 15. PMID: 21673456 Free article. Review.

118

Distinction of thioredoxin transnitrosylation and denitrosylation target proteins by the ICAT quantitative approach.

Wu C, Parrott AM, Liu T, Jain MR, Yang Y, Sadoshima J, Li H. J Proteomics. 2011 Oct 19;74(11):2498-509. doi: 10.1016/j.jprot.2011.06.001. Epub 2011 Jun 17. PMID: 21704743 Free PMC article.

119

Differential roles of GSK-3β during myocardial ischemia and ischemia/reperfusion.

Zhai P, Sciarretta S, Galeotti J, Volpe M, Sadoshima J. Circ Res. 2011 Aug 19;109(5):502-11. doi: 10.1161/CIRCRESAHA.111.249532. Epub 2011 Jul 7. PMID: 21737790 Free PMC article.

120

Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules.

Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B. PLoS One. 2011;6(7):e22391. doi: 10.1371/journal.pone.0022391. Epub 2011 Jul 22. PMID: 21799842 Free PMC article.

121

Redox modification of cell signaling in the cardiovascular system.

Shao D, Oka S, Brady CD, Haendeler J, Eaton P, Sadoshima J. J Mol Cell Cardiol. 2012 Mar;52(3):550-8. doi: 10.1016/j.yjmcc.2011.09.009. Epub 2011 Sep 17. PMID: 21945521 Free PMC article. Review.

122

PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway.

Oka S, Alcendor R, Zhai P, Park JY, Shao D, Cho J, Yamamoto T, Tian B, Sadoshima J. Cell Metab. 2011 Nov 2;14(5):598-611. doi: 10.1016/j.cmet.2011.10.001. PMID: 22055503 Free PMC article.

123

Meeting report for Basic Cardiovascular Sciences 2011 Scientific Sessions: from concept to clinic: leading cardiovascular translational science.

Sadoshima J, Hare JM. Circ Res. 2011 Nov 11;109(11):1204-5. doi: 10.1161/CIRCRESAHA.111.255257. PMID: 22076506 Free article. No abstract available.

124

Glycogen synthase kinase-3β controls autophagy during myocardial ischemia and reperfusion.

Zhai P, Sadoshima J. Autophagy. 2012 Jan;8(1):138-9. doi: 10.4161/auto.8.1.18314. Epub 2012 Jan 1. PMID: 22113201 Free PMC article.

125

The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling.

Messaoudi S, Zhang AD, Griol-Charhbili V, Escoubet B, Sadoshima J, Farman N, Jaisser F. PLoS One. 2012;7(1):e30156. doi: 10.1371/journal.pone.0030156. Epub 2012 Jan 23. PMID: 22291909 Free PMC article.

126

Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome.

Sciarretta S, Zhai P, Shao D, Maejima Y, Robbins J, Volpe M, Condorelli G, Sadoshima J. Circulation. 2012 Mar 6;125(9):1134-46. doi: 10.1161/CIRCULATIONAHA.111.078212. Epub 2012 Jan 31. PMID: 22294621 Free PMC article.

127

Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heart.

Oka S, Zhai P, Alcendor R, Park JY, Tian B, Sadoshima J. Cell Cycle. 2012 Mar 1;11(5):856-64. doi: 10.4161/cc.11.5.19210. Epub 2012 Mar 1. PMID: 22333581 Free PMC article.

128

Angiotensin II and oxidative stress in the failing heart.

Zablocki D, Sadoshima J. Antioxid Redox Signal. 2013 Oct 1;19(10):1095-109. doi: 10.1089/ars.2012.4588. Epub 2012 May 3. PMID: 22429089 Free PMC article.

129

Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1.

Del Re DP, Sadoshima J. Circ Res. 2012 Apr 27;110(9):1154-6. doi: 10.1161/CIRCRESAHA.112.269183. PMID: 22539751 Free PMC article. No abstract available.

130

Is reactivation of autophagy a possible therapeutic solution for obesity and metabolic syndrome?

Sciarretta S, Volpe M, Sadoshima J. Autophagy. 2012 Aug;8(8):1252-4. doi: 10.4161/auto.20670. Epub 2012 May 11. PMID: 22575843 Free PMC article.

131

RASSF1A Signaling in the Heart: Novel Functions beyond Tumor Suppression.

Del Re DP, Sadoshima J. Mol Biol Int. 2012;2012:154283. doi: 10.1155/2012/154283. Epub 2012 Apr 10. PMID: 22577551 Free PMC article.

132

Pharmacological modulation of autophagy during cardiac stress.

Sciarretta S, Zhai P, Volpe M, Sadoshima J. J Cardiovasc Pharmacol. 2012 Sep;60(3):235-41. doi: 10.1097/FJC.0b013e3182575f61. PMID: 22710813 Free PMC article. Review.

133

Interacting with thioredoxin-1--disease or no disease?

Zschauer TC, Matsushima S, Altschmied J, Shao D, Sadoshima J, Haendeler J. Antioxid Redox Signal. 2013 Mar 20;18(9):1053-62. doi: 10.1089/ars.2012.4822. Epub 2012 Sep 24. PMID: 22867430 Free PMC article. Review.

134

Overview of pyridine nucleotides review series.

Nakamura M, Bhatnagar A, Sadoshima J. Circ Res. 2012 Aug 17;111(5):604-10. doi: 10.1161/CIRCRESAHA.111.247924. PMID: 22904040 Free PMC article. Review.

135

Regulation of cell survival and death by pyridine nucleotides.

Oka S, Hsu CP, Sadoshima J. Circ Res. 2012 Aug 17;111(5):611-27. doi: 10.1161/CIRCRESAHA.111.247932. PMID: 22904041 Free PMC article. Review.

136

Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload.

Maejima Y, Galeotti J, Molkentin JD, Sadoshima J, Zhai P. Am J Physiol Heart Circ Physiol. 2012 Oct 15;303(8):H979-88. doi: 10.1152/ajpheart.00415.2012. Epub 2012 Aug 17. PMID: 22904158 Free PMC article.

137

Guidelines for the use and interpretation of assays for monitoring autophagy.

Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC Jr, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pier… See abstract for full author list ➔ Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496. PMID: 22966490 Free PMC article.

138

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.

Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y. PLoS One. 2012;7(12):e51621. doi: 10.1371/journal.pone.0051621. Epub 2012 Dec 7. PMID: 23236519 Free PMC article.

139

Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.

Matsushima S, Kuroda J, Ago T, Zhai P, Park JY, Xie LH, Tian B, Sadoshima J. Circ Res. 2013 Feb 15;112(4):651-63. doi: 10.1161/CIRCRESAHA.112.279760. Epub 2012 Dec 27. PMID: 23271793 Free PMC article.

140

Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury.

Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D, Sadoshima J. J Biol Chem. 2013 Feb 8;288(6):3977-88. doi: 10.1074/jbc.M112.436311. Epub 2012 Dec 30. PMID: 23275380 Free PMC article.

141

Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart.

Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, Maejima Y, Sadoshima J. PLoS One. 2013;8(1):e51632. doi: 10.1371/journal.pone.0051632. Epub 2013 Jan 7. PMID: 23308102 Free PMC article.

142

Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure.

Nicholson CK, Lambert JP, Molkentin JD, Sadoshima J, Calvert JW. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):744-51. doi: 10.1161/ATVBAHA.112.300484. Epub 2013 Jan 24. PMID: 23349187 Free PMC article.

143

Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1α and upregulation of peroxisome proliferator-activated receptor-α.

Matsushima S, Kuroda J, Ago T, Zhai P, Ikeda Y, Oka S, Fong GH, Tian R, Sadoshima J. Circ Res. 2013 Apr 12;112(8):1135-49. doi: 10.1161/CIRCRESAHA.111.300171. Epub 2013 Mar 8. PMID: 23476056 Free PMC article.

144

C2238 atrial natriuretic peptide molecular variant is associated with endothelial damage and dysfunction through natriuretic peptide receptor C signaling.

Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, Eberini I, Sadoshima J, Hobbs AJ, Volpe M, Rubattu S. Circ Res. 2013 May 10;112(10):1355-64. doi: 10.1161/CIRCRESAHA.113.301325. Epub 2013 Mar 25. PMID: 23529183 Free article.

145

Cardiovascular autophagy: concepts, controversies, and perspectives.

Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA. Autophagy. 2013 Oct;9(10):1455-66. doi: 10.4161/auto.25969. Epub 2013 Aug 14. PMID: 23959233 Review.

146

DYRK2 negatively regulates cardiomyocyte growth by mediating repressor function of GSK-3β on eIF2Bε.

Weiss CS, Ochs MM, Hagenmueller M, Streit MR, Malekar P, Riffel JH, Buss SJ, Weiss KH, Sadoshima J, Katus HA, Hardt SE. PLoS One. 2013 Sep 4;8(9):e70848. doi: 10.1371/journal.pone.0070848. eCollection 2013. PMID: 24023715 Free PMC article.

147

Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 pathway.

Sciarretta S, Zhai P, Shao D, Zablocki D, Nagarajan N, Terada LS, Volpe M, Sadoshima J. Circ Res. 2013 Nov 8;113(11):1253-64. doi: 10.1161/CIRCRESAHA.113.301787. Epub 2013 Sep 30. PMID: 24081881 Free PMC article.

148

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2.

Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, Sadoshima J. Nat Med. 2013 Nov;19(11):1478-88. doi: 10.1038/nm.3322. Epub 2013 Oct 20. PMID: 24141421 Free PMC article.

149

Enhanced autophagy ameliorates cardiac proteinopathy.

Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, Sadoshima J, Robbins J. J Clin Invest. 2013 Dec;123(12):5284-97. doi: 10.1172/JCI70877. Epub 2013 Nov 1. PMID: 24177425 Free PMC article.

150

Aggregate-prone R120GCRYAB triggers multifaceted modifications of the thioredoxin system.

Banerjee Mustafi S, Grose JH, Zhang H, Pratt GW, Sadoshima J, Christians ES, Benjamin IJ. Antioxid Redox Signal. 2014 Jun 20;20(18):2891-906. doi: 10.1089/ars.2013.5340. Epub 2014 Feb 4. PMID: 24180415 Free PMC article.

151

Solving the cardiac hypertrophy riddle: The angiotensin II-mechanical stress connection.

Zablocki D, Sadoshima J. Circ Res. 2013 Nov 8;113(11):1192-5. doi: 10.1161/CIRCRESAHA.113.302501. PMID: 24201113 Free article.

152

The importance of autophagy in cardioprotection.

Sciarretta S, Yee D, Shenoy V, Nagarajan N, Sadoshima J. High Blood Press Cardiovasc Prev. 2014 Mar;21(1):21-8. doi: 10.1007/s40292-013-0029-9. Epub 2013 Nov 14. PMID: 24235024 Review.

153

Elimination of NADPH oxidase activity promotes reductive stress and sensitizes the heart to ischemic injury.

Yu Q, Lee CF, Wang W, Karamanlidis G, Kuroda J, Matsushima S, Sadoshima J, Tian R. J Am Heart Assoc. 2014 Jan 27;3(1):e000555. doi: 10.1161/JAHA.113.000555. PMID: 24470522 Free PMC article.

154

Mammalian target of rapamycin signaling in cardiac physiology and disease.

Sciarretta S, Volpe M, Sadoshima J. Circ Res. 2014 Jan 31;114(3):549-64. doi: 10.1161/CIRCRESAHA.114.302022. PMID: 24481845 Free PMC article. Review.

155

NOX4 regulates autophagy during energy deprivation.

Sciarretta S, Volpe M, Sadoshima J. Autophagy. 2014 Apr;10(4):699-701. doi: 10.4161/auto.27955. Epub 2014 Jan 31. PMID: 24492492 Free PMC article.

156

A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation.

Shao D, Oka S, Liu T, Zhai P, Ago T, Sciarretta S, Li H, Sadoshima J. Cell Metab. 2014 Feb 4;19(2):232-45. doi: 10.1016/j.cmet.2013.12.013. PMID: 24506865 Free PMC article.

157

A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response.

Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D, Sadoshima J. Nat Commun. 2014;5:3315. doi: 10.1038/ncomms4315. PMID: 24525530 Free PMC article.

158

Muscle-specific RING finger 1 negatively regulates pathological cardiac hypertrophy through downregulation of calcineurin A.

Maejima Y, Usui S, Zhai P, Takamura M, Kaneko S, Zablocki D, Yokota M, Isobe M, Sadoshima J. Circ Heart Fail. 2014 May;7(3):479-90. doi: 10.1161/CIRCHEARTFAILURE.113.000713. Epub 2014 Feb 13. PMID: 24526353 Free PMC article.

159

Cardiac fibroblasts: the good, the bad, the ugly, the beautiful.

Sadoshima J, Weiss JN. J Mol Cell Cardiol. 2014 May;70:1. doi: 10.1016/j.yjmcc.2014.03.009. Epub 2014 Mar 17. PMID: 24650876 Free PMC article. No abstract available.

160

Elucidating ERK2 function in the heart.

Del Re DP, Sadoshima J. J Mol Cell Cardiol. 2014 Jul;72:336-8. doi: 10.1016/j.yjmcc.2014.04.009. Epub 2014 Apr 24. PMID: 24769140 No abstract available.

161

Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL.

Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP, Sadoshima J. Mol Cell. 2014 May 22;54(4):639-50. doi: 10.1016/j.molcel.2014.04.007. Epub 2014 May 8. PMID: 24813943 Free PMC article.

162

Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion.

Matsushima S, Tsutsui H, Sadoshima J. Trends Cardiovasc Med. 2014 Jul;24(5):202-5. doi: 10.1016/j.tcm.2014.03.003. Epub 2014 Apr 1. PMID: 24880746 Free PMC article. Review.

163

The role of SUMO-1 in cardiac oxidative stress and hypertrophy.

Lee A, Jeong D, Mitsuyama S, Oh JG, Liang L, Ikeda Y, Sadoshima J, Hajjar RJ, Kho C. Antioxid Redox Signal. 2014 Nov 10;21(14):1986-2001. doi: 10.1089/ars.2014.5983. Epub 2014 Aug 4. PMID: 24893265 Free PMC article.

164

Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion.

Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, Sadoshima J. PLoS One. 2014 Jun 6;9(6):e98972. doi: 10.1371/journal.pone.0098972. eCollection 2014. PMID: 24905194 Free PMC article.

165

Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation.

Hasumi Y, Baba M, Hasumi H, Huang Y, Lang M, Reindorf R, Oh HB, Sciarretta S, Nagashima K, Haines DC, Schneider MD, Adelstein RS, Schmidt LS, Sadoshima J, Marston Linehan W. Hum Mol Genet. 2014 Nov 1;23(21):5706-19. doi: 10.1093/hmg/ddu286. Epub 2014 Jun 6. PMID: 24908670 Free PMC article.

166

Rag GTPases are cardioprotective by regulating lysosomal function.

Kim YC, Park HW, Sciarretta S, Mo JS, Jewell JL, Russell RC, Wu X, Sadoshima J, Guan KL. Nat Commun. 2014 Jul 1;5:4241. doi: 10.1038/ncomms5241. PMID: 24980141 Free PMC article.

167

The Hippo signal transduction network in skeletal and cardiac muscle.

Wackerhage H, Del Re DP, Judson RN, Sudol M, Sadoshima J. Sci Signal. 2014 Aug 5;7(337):re4. doi: 10.1126/scisignal.2005096. PMID: 25097035 Review.

168

New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart.

Ikeda Y, Sciarretta S, Nagarajan N, Rubattu S, Volpe M, Frati G, Sadoshima J. Oxid Med Cell Longev. 2014;2014:210934. doi: 10.1155/2014/210934. Epub 2014 Jul 15. PMID: 25132912 Free PMC article. Review.

169

Identification of novel nuclear targets of human thioredoxin 1.

Wu C, Jain MR, Li Q, Oka S, Li W, Kong AN, Nagarajan N, Sadoshima J, Simmons WJ, Li H. Mol Cell Proteomics. 2014 Dec;13(12):3507-18. doi: 10.1074/mcp.M114.040931. Epub 2014 Sep 17. PMID: 25231459 Free PMC article.

170

SUMOylation: a novel protein quality control modifier in the heart.

Maejima Y, Sadoshima J. Circ Res. 2014 Sep 26;115(8):686-9. doi: 10.1161/CIRCRESAHA.114.304989. PMID: 25258400 Free PMC article. No abstract available.

171

The function of nicotinamide phosphoribosyltransferase in the heart.

Hsu CP, Yamamoto T, Oka S, Sadoshima J. DNA Repair (Amst). 2014 Nov;23:64-8. doi: 10.1016/j.dnarep.2014.08.005. Epub 2014 Sep 29. PMID: 25277684 Free PMC article. Review.

172

Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system.

Ikeda Y, Shirakabe A, Brady C, Zablocki D, Ohishi M, Sadoshima J. J Mol Cell Cardiol. 2015 Jan;78:116-22. doi: 10.1016/j.yjmcc.2014.09.019. Epub 2014 Oct 7. PMID: 25305175 Free PMC article. Review.

173

Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines.

Chen L, Xiao J, Kuroda J, Ago T, Sadoshima J, Cohen RA, Tong X. Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2489-99. doi: 10.1016/j.bbadis.2014.10.007. PMID: 25315297 Free article.

174

Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress.

Ikeda Y, Shirakabe A, Maejima Y, Zhai P, Sciarretta S, Toli J, Nomura M, Mihara K, Egashira K, Ohishi M, Abdellatif M, Sadoshima J. Circ Res. 2015 Jan 16;116(2):264-78. doi: 10.1161/CIRCRESAHA.116.303356. Epub 2014 Oct 20. PMID: 25332205 Free article.

175

Recent progress in research on molecular mechanisms of autophagy in the heart.

Maejima Y, Chen Y, Isobe M, Gustafsson ÅB, Kitsis RN, Sadoshima J. Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H259-68. doi: 10.1152/ajpheart.00711.2014. Epub 2014 Nov 14. PMID: 25398984 Free PMC article. Review.

176

Mending a broken heart: the role of mitophagy in cardioprotection.

Moyzis AG, Sadoshima J, Gustafsson ÅB. Am J Physiol Heart Circ Physiol. 2015 Feb 1;308(3):H183-92. doi: 10.1152/ajpheart.00708.2014. Epub 2014 Nov 26. PMID: 25437922 Free PMC article. Review.

177

Heart over mind: metabolic control of white adipose tissue and liver.

Nakamura M, Sadoshima J. EMBO Mol Med. 2014 Dec;6(12):1521-4. doi: 10.15252/emmm.201404749. PMID: 25471454 Free PMC article.

178

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.

Sapra G, Tham YK, Cemerlang N, Matsumoto A, Kiriazis H, Bernardo BC, Henstridge DC, Ooi JY, Pretorius L, Boey EJ, Lim L, Sadoshima J, Meikle PJ, Mellet NA, Woodcock EA, Marasco S, Ueyama T, Du XJ, Febbraio MA, McMullen JR. Nat Commun. 2014 Dec 9;5:5705. doi: 10.1038/ncomms6705. PMID: 25489988 Free article.

179

Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes.

Sciarretta S, Yee D, Ammann P, Nagarajan N, Volpe M, Frati G, Sadoshima J. Clin Sci (Lond). 2015 Apr;128(7):387-403. doi: 10.1042/CS20140336. PMID: 25515000

180

mTORC2 regulates cardiac response to stress by inhibiting MST1.

Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe M, Frati G, Li H, Sadoshima J. Cell Rep. 2015 Apr 7;11(1):125-36. doi: 10.1016/j.celrep.2015.03.010. Epub 2015 Apr 2. PMID: 25843706 Free PMC article.

181

Molecular mechanisms of mitochondrial autophagy/mitophagy in the heart.

Saito T, Sadoshima J. Circ Res. 2015 Apr 10;116(8):1477-90. doi: 10.1161/CIRCRESAHA.116.303790. PMID: 25858070 Free PMC article. Review.

182

Inside-Out Signaling: Moving the AT1 Receptor in to Get the Message Out.

Zablocki D, Sadoshima J. Circulation. 2015 Jun 16;131(24):2097-100. doi: 10.1161/CIRCULATIONAHA.115.016978. Epub 2015 May 20. PMID: 25995314 Free PMC article. No abstract available.

183

From Contractile Enhancement to Pathological Hypertrophy: Angiotensin II-Induced Nox2-Mediated Reactive Oxygen Species.

Ago T, Sadoshima J. J Am Coll Cardiol. 2015 Jul 21;66(3):273-277. doi: 10.1016/j.jacc.2015.05.058. PMID: 26184621 Free article. No abstract available.

184

The role of sirtuins in cardiac disease.

Matsushima S, Sadoshima J. Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1375-89. doi: 10.1152/ajpheart.00053.2015. Epub 2015 Jul 31. PMID: 26232232 Free PMC article. Review.

185

An Ideal PPAR Response Element Bound to and Activated by PPARα.

Tzeng J, Byun J, Park JY, Yamamoto T, Schesing K, Tian B, Sadoshima J, Oka S. PLoS One. 2015 Aug 4;10(8):e0134996. doi: 10.1371/journal.pone.0134996. eCollection 2015. PMID: 26241474 Free PMC article.

186

miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival.

Yang Y, Del Re DP, Nakano N, Sciarretta S, Zhai P, Park J, Sayed D, Shirakabe A, Matsushima S, Park Y, Tian B, Abdellatif M, Sadoshima J. Circ Res. 2015 Oct 23;117(10):891-904. doi: 10.1161/CIRCRESAHA.115.306624. Epub 2015 Sep 2. PMID: 26333362 Free PMC article.

187

Master redox regulator Trx1 upregulates SMYD1 & modulates lysine methylation.

Liu T, Wu C, Jain MR, Nagarajan N, Yan L, Dai H, Cui C, Baykal A, Pan S, Ago T, Sadoshima J, Li H. Biochim Biophys Acta. 2015 Dec;1854(12):1816-1822. doi: 10.1016/j.bbapap.2015.09.006. Epub 2015 Sep 26. PMID: 26410624 Free PMC article.

188

Peroxisome Proliferator Activated Receptor-α Association With Silent Information Regulator 1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart.

Oka S, Zhai P, Yamamoto T, Ikeda Y, Byun J, Hsu CP, Sadoshima J. Circ Heart Fail. 2015 Nov;8(6):1123-32. doi: 10.1161/CIRCHEARTFAILURE.115.002216. Epub 2015 Oct 6. PMID: 26443578 Free PMC article.

189

Pivotal role of miR-448 in the development of ROS-induced cardiomyopathy.

Kyrychenko S, Kyrychenko V, Badr MA, Ikeda Y, Sadoshima J, Shirokova N. Cardiovasc Res. 2015 Dec 1;108(3):324-34. doi: 10.1093/cvr/cvv238. Epub 2015 Oct 26. PMID: 26503985 Free PMC article.

190

Boosting autophagy in the diabetic heart: a translational perspective.

Sciarretta S, Boppana VS, Umapathi M, Frati G, Sadoshima J. Cardiovasc Diagn Ther. 2015 Oct;5(5):394-402. doi: 10.3978/j.issn.2223-3652.2015.07.02. PMID: 26543826 Free PMC article.

191

Regulation of autophagy by Beclin 1 in the heart.

Maejima Y, Isobe M, Sadoshima J. J Mol Cell Cardiol. 2016 Jun;95:19-25. doi: 10.1016/j.yjmcc.2015.10.032. Epub 2015 Nov 9. PMID: 26546165 Free PMC article. Review.

192

Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia.

Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J, Cohen RA. J Mol Cell Cardiol. 2015 Dec;89(Pt B):185-94. doi: 10.1016/j.yjmcc.2015.11.013. Epub 2015 Nov 12. PMID: 26582463

193

Detrimental role of pericyte Nox4 in the acute phase of brain ischemia.

Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K, Kitazono T. J Cereb Blood Flow Metab. 2016 Jun;36(6):1143-54. doi: 10.1177/0271678X15606456. Epub 2015 Oct 13. PMID: 26661159 Free PMC article.

194

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, … See abstract for full author list ➔ Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. PMID: 26799652 Free PMC article. No abstract available.

195

Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase.

Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. J Mol Cell Cardiol. 2016 Mar;92:30-40. doi: 10.1016/j.yjmcc.2016.01.020. Epub 2016 Jan 23. PMID: 26812119 Free PMC article.

196

Evaluating mitochondrial autophagy in the mouse heart.

Shirakabe A, Fritzky L, Saito T, Zhai P, Miyamoto S, Gustafsson ÅB, Kitsis RN, Sadoshima J. J Mol Cell Cardiol. 2016 Mar;92:134-9. doi: 10.1016/j.yjmcc.2016.02.007. Epub 2016 Feb 9. PMID: 26868976

197

Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure.

Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. Circulation. 2016 Mar 29;133(13):1249-63. doi: 10.1161/CIRCULATIONAHA.115.020502. Epub 2016 Feb 25. PMID: 26915633 Free PMC article.

198

Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1.

D Annunzio V, Perez V, Mazo T, Muñoz MC, Dominici FP, Carreras MC, Poderoso JJ, Sadoshima J, Gelpi RJ. Oncotarget. 2016 Mar 15;7(11):11889-98. doi: 10.18632/oncotarget.7726. PMID: 26933812 Free PMC article.

199

Poldip2 negatively regulates matrix synthesis at focal adhesions.

Matsushima S, Zablocki D, Tsutsui H, Sadoshima J. J Mol Cell Cardiol. 2016 May;94:10-12. doi: 10.1016/j.yjmcc.2016.03.001. Epub 2016 Mar 3. PMID: 26947023 No abstract available.

200

Thioredoxin-1 Attenuates Ventricular and Mitochondrial Postischemic Dysfunction in the Stunned Myocardium of Transgenic Mice.

Perez V, D'Annunzio V, Valdez LB, Zaobornyj T, Bombicino S, Mazo T, Carbajosa NL, Gironacci MM, Boveris A, Sadoshima J, Gelpi RJ. Antioxid Redox Signal. 2016 Jul 10;25(2):78-88. doi: 10.1089/ars.2015.6459. Epub 2016 May 6. PMID: 27000416

Mitochondrial autophagy in cardiomyopathy.

Tong M, Sadoshima J. Curr Opin Genet Dev. 2016 Jun;38:8-15. doi: 10.1016/j.gde.2016.02.006. Epub 2016 Mar 19. PMID: 27003723 Free PMC article. Review.

202

Aging and Autophagy in the Heart.

Shirakabe A, Ikeda Y, Sciarretta S, Zablocki DK, Sadoshima J. Circ Res. 2016 May 13;118(10):1563-76. doi: 10.1161/CIRCRESAHA.116.307474. PMID: 27174950 Free PMC article. Review.

203

Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.

Nakamura M, Zhai P, Del Re DP, Maejima Y, Sadoshima J. JCI Insight. 2016 Apr 21;1(5):e86217. doi: 10.1172/jci.insight.86217. PMID: 27218122 Free PMC article.

204

Sex differences in response to miRNA-34a therapy in mouse models of cardiac disease: identification of sex-, disease- and treatment-regulated miRNAs.

Bernardo BC, Ooi JY, Matsumoto A, Tham YK, Singla S, Kiriazis H, Patterson NL, Sadoshima J, Obad S, Lin RC, McMullen JR. J Physiol. 2016 Oct 15;594(20):5959-5974. doi: 10.1113/JP272512. Epub 2016 Jul 20. PMID: 27270487 Free PMC article.

205

Regulation of Myocardial Cell Growth and Death by the Hippo Pathway.

Ikeda S, Sadoshima J. Circ J. 2016 Jun 24;80(7):1511-9. doi: 10.1253/circj.CJ-16-0476. Epub 2016 Jun 10. PMID: 27302848 Free article. Review.

206

NF2 Activates Hippo Signaling and Promotes Ischemia/Reperfusion Injury in the Heart.

Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park J, Hsu CP, Tian B, Pan D, Sadoshima J, Del Re DP. Circ Res. 2016 Aug 19;119(5):596-606. doi: 10.1161/CIRCRESAHA.116.308586. Epub 2016 Jul 11. PMID: 27402866 Free PMC article.

207

Nanoparticle-Mediated Delivery of Mitochondrial Division Inhibitor 1 to the Myocardium Protects the Heart From Ischemia-Reperfusion Injury Through Inhibition of Mitochondria Outer Membrane Permeabilization: A New Therapeutic Modality for Acute Myocardial Infarction.

Ishikita A, Matoba T, Ikeda G, Koga J, Mao Y, Nakano K, Takeuchi O, Sadoshima J, Egashira K. J Am Heart Assoc. 2016 Jul 22;5(7):e003872. doi: 10.1161/JAHA.116.003872. PMID: 27451459 Free PMC article.

208

Response by Shirakabe et al to Letter Regarding Article, "Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure".

Shirakabe A, Zhai P, Ikeda Y, Saito T, Maejima Y, Hsu CP, Nomura M, Egashira K, Levine B, Sadoshima J. Circulation. 2016 Aug 9;134(6):e75-6. doi: 10.1161/CIRCULATIONAHA.116.023667. PMID: 27502914 Free PMC article. No abstract available.

209

Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.

Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu CP, Li H, Tsutsui H, Sadoshima J. J Clin Invest. 2016 Sep 1;126(9):3403-16. doi: 10.1172/JCI85624. Epub 2016 Aug 15. PMID: 27525436 Free PMC article.

210

Does Autophagy Mediate Cardiac Myocyte Death During Stress?

Nah J, Fernández ÁF, Kitsis RN, Levine B, Sadoshima J. Circ Res. 2016 Sep 30;119(8):893-5. doi: 10.1161/CIRCRESAHA.116.309765. PMID: 27688304 Free PMC article. Review.

211

Cardioprotection and lifespan extension by the natural polyamine spermidine.

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Nat Med. 2016 Dec;22(12):1428-1438. doi: 10.1038/nm.4222. Epub 2016 Nov 14. PMID: 27841876 Free PMC article.

212

Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model.

Hsu YJ, Hsu SC, Hsu CP, Chen YH, Chang YL, Sadoshima J, Huang SM, Tsai CS, Lin CY. Int J Cardiol. 2017 Feb 1;228:543-552. doi: 10.1016/j.ijcard.2016.11.247. Epub 2016 Nov 14. PMID: 27875732

213

Modulation of signaling mechanisms in the heart by thioredoxin 1.

Nagarajan N, Oka S, Sadoshima J. Free Radic Biol Med. 2017 Aug;109:125-131. doi: 10.1016/j.freeradbiomed.2016.12.020. Epub 2016 Dec 16. PMID: 27993729 Free PMC article. Review.

214

Dietary spermidine for lowering high blood pressure.

Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, Stekovic S, Schipke J, Magnes C, Schmidt A, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Carmona-Gutierrez D, Pietrocola F, Pieber TR, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Autophagy. 2017 Apr 3;13(4):767-769. doi: 10.1080/15548627.2017.1280225. Epub 2017 Jan 24. PMID: 28118075 Free PMC article.

215

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.

Hammerling BC, Najor RH, Cortez MQ, Shires SE, Leon LJ, Gonzalez ER, Boassa D, Phan S, Thor A, Jimenez RE, Li H, Kitsis RN, Dorn GW II, Sadoshima J, Ellisman MH, Gustafsson ÅB. Nat Commun. 2017 Jan 30;8:14050. doi: 10.1038/ncomms14050. PMID: 28134239 Free PMC article.

216

Unexpected Functional Consequences of the Loss of the Autophagy-Related Conjugation System.

Saito T, Sadoshima J. Circ Res. 2017 Feb 17;120(4):610-612. doi: 10.1161/CIRCRESAHA.117.310450. PMID: 28209790 Free PMC article. Review.

217

Rac1 Pharmacological Inhibition Rescues Human Endothelial Dysfunction.

Carrizzo A, Vecchione C, Damato A, di Nonno F, Ambrosio M, Pompeo F, Cappello E, Capocci L, Peruzzi M, Valenti V, Biondi-Zoccai G, Marullo AG, Palmerio S, Carnevale R, Spinelli CC, Puca AA, Rubattu S, Volpe M, Sadoshima J, Frati G, Sciarretta S. J Am Heart Assoc. 2017 Feb 28;6(3):e004746. doi: 10.1161/JAHA.116.004746. PMID: 28246076 Free PMC article.

218

How to be young at heart? miR-22 as a potential therapeutic target to boost autophagy and protect the old myocardium.

Sciarretta S, De Falco E, Frati G, Sadoshima J. Ann Transl Med. 2017 Feb;5(3):52. doi: 10.21037/atm.2017.01.52. PMID: 28251131 Free PMC article. No abstract available.

219

A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy.

Byun S, Kim YC, Zhang Y, Kong B, Guo G, Sadoshima J, Ma J, Kemper B, Kemper JK. EMBO J. 2017 Jun 14;36(12):1755-1769. doi: 10.15252/embj.201695500. Epub 2017 Apr 26. PMID: 28446510 Free PMC article.

220

Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.

Kang H, Oka S, Lee DY, Park J, Aponte AM, Jung YS, Bitterman J, Zhai P, He Y, Kooshapur H, Ghirlando R, Tjandra N, Lee SB, Kim MK, Sadoshima J, Chung JH. Nat Commun. 2017 May 15;8:15560. doi: 10.1038/ncomms15560. PMID: 28504272 Free PMC article.

221

Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H221-H223. doi: 10.1152/ajpheart.00329.2017. Epub 2017 Jun 16. PMID: 28626081 Free article. No abstract available.

222

Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigenetics.

Warren JS, Oka SI, Zablocki D, Sadoshima J. Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H584-H596. doi: 10.1152/ajpheart.00103.2017. Epub 2017 Jun 23. PMID: 28646024 Free PMC article. Review.

223

Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1.

Huang C, Alapa M, Shu P, Nagarajan N, Wu C, Sadoshima J, Kholodovych V, Li H, Beuve A. J Biol Chem. 2017 Sep 1;292(35):14362-14370. doi: 10.1074/jbc.M117.787390. Epub 2017 Jun 28. PMID: 28659344 Free PMC article.

224

BAG3 plays a central role in proteostasis in the heart.

Mizushima W, Sadoshima J. J Clin Invest. 2017 Aug 1;127(8):2900-2903. doi: 10.1172/JCI95839. Epub 2017 Jul 24. PMID: 28737514 Free PMC article.

225

What Should We Learn From the Recent Decline of Basic Cardiovascular Science in Japan?

Sadoshima J, Tomoike H. Circ Res. 2017 Aug 4;121(4):314-316. doi: 10.1161/CIRCRESAHA.117.311411. PMID: 28775005 Free PMC article. No abstract available.

226

Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury.

Cao Y, Bojjireddy N, Kim M, Li T, Zhai P, Nagarajan N, Sadoshima J, Palmiter RD, Tian R. Circ Res. 2017 Oct 27;121(10):1182-1191. doi: 10.1161/CIRCRESAHA.117.311159. Epub 2017 Aug 23. PMID: 28835357 Free PMC article.

227

Mitophagy as a Protective Mechanism against Myocardial Stress.

Nah J, Miyamoto S, Sadoshima J. Compr Physiol. 2017 Sep 12;7(4):1407-1424. doi: 10.1002/cphy.c170005. PMID: 28915329 Review.

228

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes.

Oka SI, Hirata T, Suzuki W, Naito D, Chen Y, Chin A, Yaginuma H, Saito T, Nagarajan N, Zhai P, Bhat S, Schesing K, Shao D, Hirabayashi Y, Yodoi J, Sciarretta S, Sadoshima J. J Biol Chem. 2017 Nov 17;292(46):18988-19000. doi: 10.1074/jbc.M117.807735. Epub 2017 Sep 22. PMID: 28939765 Free PMC article.

229

The Role of Autophagy in the Heart.

Sciarretta S, Maejima Y, Zablocki D, Sadoshima J. Annu Rev Physiol. 2018 Feb 10;80:1-26. doi: 10.1146/annurev-physiol-021317-121427. Epub 2017 Oct 25. PMID: 29068766 Review.

230

Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School.

Sadoshima J. Circ Res. 2017 Oct 27;121(10):1127-1129. doi: 10.1161/CIRCRESAHA.117.311373. PMID: 29074531 Free PMC article. No abstract available.

231

HAX-1 regulates SERCA2a oxidation and degradation.

Bidwell PA, Liu GS, Nagarajan N, Lam CK, Haghighi K, Gardner G, Cai WF, Zhao W, Mugge L, Vafiadaki E, Sanoudou D, Rubinstein J, Lebeche D, Hajjar R, Sadoshima J, Kranias EG. J Mol Cell Cardiol. 2018 Jan;114:220-233. doi: 10.1016/j.yjmcc.2017.11.014. Epub 2017 Nov 21. PMID: 29169992 Free PMC article.

232

Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies.

Tham YK, Huynh K, Mellett NA, Henstridge DC, Kiriazis H, Ooi JYY, Matsumoto A, Patterson NL, Sadoshima J, Meikle PJ, McMullen JR. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Mar;1863(3):219-234. doi: 10.1016/j.bbalip.2017.12.003. Epub 2017 Dec 6. PMID: 29217479

233

New Insights Into the Role of mTOR Signaling in the Cardiovascular System.

Sciarretta S, Forte M, Frati G, Sadoshima J. Circ Res. 2018 Feb 2;122(3):489-505. doi: 10.1161/CIRCRESAHA.117.311147. PMID: 29420210 Free PMC article. Review.

234

Aspirin Recapitulates Features of Caloric Restriction.

Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Mariño G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, Kroemer G. Cell Rep. 2018 Feb 27;22(9):2395-2407. doi: 10.1016/j.celrep.2018.02.024. PMID: 29490275 Free PMC article.

235

Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids.

Sauvat A, Chen G, Müller K, Tong M, Aprahamian F, Durand S, Cerrato G, Bezu L, Leduc M, Franz J, Rockenfeller P, Sadoshima J, Madeo F, Kepp O, Kroemer G. EBioMedicine. 2018 Apr;30:261-272. doi: 10.1016/j.ebiom.2018.03.028. Epub 2018 Mar 27. PMID: 29606629 Free PMC article.

236

Mechanisms of physiological and pathological cardiac hypertrophy.

Nakamura M, Sadoshima J. Nat Rev Cardiol. 2018 Jul;15(7):387-407. doi: 10.1038/s41569-018-0007-y. PMID: 29674714 Review.

237

Trehalose-Induced Activation of Autophagy Improves Cardiac Remodeling After Myocardial Infarction.

Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Schirone L, Forte M, Rubattu S, Shirakabe A, Boppana VS, Volpe M, Frati G, Zhai P, Sadoshima J. J Am Coll Cardiol. 2018 May 8;71(18):1999-2010. doi: 10.1016/j.jacc.2018.02.066. PMID: 29724354 Free PMC article.

238

Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure.

Nguyen MN, Su Y, Vizi D, Fang L, Ellims AH, Zhao WB, Kiriazis H, Gao XM, Sadoshima J, Taylor AJ, McMullen JR, Dart AM, Kaye DM, Du XJ. Sci Rep. 2018 May 29;8(1):8213. doi: 10.1038/s41598-018-26115-y. PMID: 29844319 Free PMC article.

239

Leducq Network: Modulating Autophagy to Treat Cardiovascular Disease.

Madrigal-Matute J, Scorrano L, Sadoshima J. Circ Res. 2018 Jul 20;123(3):323-325. doi: 10.1161/CIRCRESAHA.118.313091. PMID: 30026377 Free PMC article. No abstract available.

240

Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling.

Nguyen MN, Ziemann M, Kiriazis H, Su Y, Thomas Z, Lu Q, Donner DG, Zhao WB, Rafehi H, Sadoshima J, McMullen JR, El-Osta A, Du XJ. Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H45-H60. doi: 10.1152/ajpheart.00609.2018. Epub 2018 Nov 2. PMID: 30387702 Free article.

241

Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction.

Usui S, Chikata A, Takatori O, Takashima SI, Inoue O, Kato T, Murai H, Furusho H, Nomura A, Zablocki D, Kaneko S, Sadoshima J, Takamura M. J Mol Cell Cardiol. 2019 Jan;126:1-12. doi: 10.1016/j.yjmcc.2018.11.002. Epub 2018 Nov 6. PMID: 30408466

242

An alternative mitophagy pathway mediated by Rab9 protects the heart against ischemia.

Saito T, Nah J, Oka SI, Mukai R, Monden Y, Maejima Y, Ikeda Y, Sciarretta S, Liu T, Li H, Baljinnyam E, Fraidenraich D, Fritzky L, Zhai P, Ichinose S, Isobe M, Hsu CP, Kundu M, Sadoshima J. J Clin Invest. 2019 Feb 1;129(2):802-819. doi: 10.1172/JCI122035. Epub 2019 Jan 22. PMID: 30511961 Free PMC article.

243

Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload.

Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Circ Res. 2019 Jan 18;124(2):292-305. doi: 10.1161/CIRCRESAHA.118.314048. PMID: 30582455 Free PMC article.

244

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo.

Venkatesh S, Li M, Saito T, Tong M, Rashed E, Mareedu S, Zhai P, Bárcena C, López-Otín C, Yehia G, Sadoshima J, Suzuki CK. J Mol Cell Cardiol. 2019 Mar;128:38-50. doi: 10.1016/j.yjmcc.2018.12.017. Epub 2019 Jan 6. PMID: 30625302

245

Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload.

Byun J, Del Re DP, Zhai P, Ikeda S, Shirakabe A, Mizushima W, Miyamoto S, Brown JH, Sadoshima J. J Biol Chem. 2019 Mar 8;294(10):3603-3617. doi: 10.1074/jbc.RA118.006123. Epub 2019 Jan 11. PMID: 30635403 Free PMC article.

246

Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy.

Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. Cell Metab. 2019 May 7;29(5):1119-1134.e12. doi: 10.1016/j.cmet.2019.01.005. Epub 2019 Feb 7. PMID: 30745182 Free PMC article.

247

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration.

Abdullah CS, Alam S, Aishwarya R, Miriyala S, Bhuiyan MAN, Panchatcharam M, Pattillo CB, Orr AW, Sadoshima J, Hill JA, Bhuiyan MS. Sci Rep. 2019 Feb 14;9(1):2002. doi: 10.1038/s41598-018-37862-3. PMID: 30765730 Free PMC article.

248

Intermittent Fasting Reverses an Advanced Form of Cardiomyopathy.

Mukai R, Zablocki D, Sadoshima J. J Am Heart Assoc. 2019 Feb 19;8(4):e011863. doi: 10.1161/JAHA.118.011863. PMID: 30773085 Free PMC article.

249

The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species.

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F. Nat Commun. 2019 Feb 19;10(1):651. doi: 10.1038/s41467-019-08555-w. PMID: 30783116 Free PMC article.

250

Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy.

Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Circ Res. 2019 Apr 26;124(9):1360-1371. doi: 10.1161/CIRCRESAHA.118.314607. PMID: 30786833 Free PMC article.

251

Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca²⁺-ATPase in Heart Failure.

Gorski PA, Jang SP, Jeong D, Lee A, Lee P, Oh JG, Chepurko V, Yang DK, Kwak TH, Eom SH, Park ZY, Yoo YJ, Kim DH, Kook H, Sunagawa Y, Morimoto T, Hasegawa K, Sadoshima J, Vangheluwe P, Hajjar RJ, Park WJ, Kho C. Circ Res. 2019 Apr 26;124(9):e63-e80. doi: 10.1161/CIRCRESAHA.118.313865. PMID: 30786847 Free PMC article.

252

Recruitment of RNA Polymerase II to Metabolic Gene Promoters Is Inhibited in the Failing Heart Possibly Through PGC-1α (Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α) Dysregulation.

Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI. Circ Heart Fail. 2019 Mar;12(3):e005529. doi: 10.1161/CIRCHEARTFAILURE.118.005529. PMID: 30798619 Free PMC article.

253

Cardiomyopathy in obesity, insulin resistance and diabetes.

Nakamura M, Sadoshima J. J Physiol. 2020 Jul;598(14):2977-2993. doi: 10.1113/JP276747. Epub 2019 Apr 3. PMID: 30869158 Free article. Review.

254

Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway.

Zhao WB, Lu Q, Nguyen MN, Su Y, Ziemann M, Wang LN, Kiriazis H, Puthalakath H, Sadoshima J, Hu HY, Du XJ. Br J Pharmacol. 2019 Jul;176(14):2465-2481. doi: 10.1111/bph.14674. Epub 2019 May 30. PMID: 30932177 Free PMC article.

255

Ketone body can be a fuel substrate for failing heart.

Nakamura M, Sadoshima J. Cardiovasc Res. 2019 Sep 1;115(11):1567-1569. doi: 10.1093/cvr/cvz104. PMID: 30989167 Free PMC article. No abstract available.

256

Scientists on the Spot: Autophagy and heart disease.

Voigt N, Sadoshima J. Cardiovasc Res. 2019 Aug 1;115(10):e91-e92. doi: 10.1093/cvr/cvz124. PMID: 31263872 Free PMC article. No abstract available.

257

The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused murine myocardium.

Francisco J, Byun J, Zhang Y, Kalloo OB, Mizushima W, Oka S, Zhai P, Sadoshima J, Del Re DP. J Biol Chem. 2019 Aug 30;294(35):13131-13144. doi: 10.1074/jbc.RA119.008970. Epub 2019 Jul 16. PMID: 31311858 Free PMC article.

258

Translationally controlled tumor protein (TCTP) plays a pivotal role in cardiomyocyte survival through a Bnip3-dependent mechanism.

Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Shigeta M, Kiyonari H, Umemura M, Yokoyama U, Sadoshima J, Ishikawa Y. Cell Death Dis. 2019 Jul 18;10(8):549. doi: 10.1038/s41419-019-1787-7. PMID: 31320615 Free PMC article.

259

Both gain and loss of Nampt function promote pressure overload-induced heart failure.

Byun J, Oka SI, Imai N, Huang CY, Ralda G, Zhai P, Ikeda Y, Ikeda S, Sadoshima J. Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H711-H725. doi: 10.1152/ajpheart.00222.2019. Epub 2019 Jul 26. PMID: 31347918 Free PMC article.

260

Dual peroxisome-proliferator-activated-receptor-α/γ activation inhibits SIRT1-PGC1α axis and causes cardiac dysfunction.

Kalliora C, Kyriazis ID, Oka SI, Lieu MJ, Yue Y, Area-Gomez E, Pol CJ, Tian Y, Mizushima W, Chin A, Scerbo D, Schulze PC, Civelek M, Sadoshima J, Madesh M, Goldberg IJ, Drosatos K. JCI Insight. 2019 Aug 8;5(17):e129556. doi: 10.1172/jci.insight.129556. PMID: 31393858 Free PMC article.

261

YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells.

Kashihara T, Zablocki D, Sadoshima J. Biotarget. 2019 Aug;3:14. doi: 10.21037/biotarget.2019.08.01. Epub 2019 Aug 23. PMID: 31511850 Free PMC article. No abstract available.

262

Thioredoxin-1 maintains mitochondrial function via mechanistic target of rapamycin signalling in the heart.

Oka SI, Chin A, Park JY, Ikeda S, Mizushima W, Ralda G, Zhai P, Tong M, Byun J, Tang F, Einaga Y, Huang CY, Kashihara T, Zhao M, Nah J, Tian B, Hirabayashi Y, Yodoi J, Sadoshima J. Cardiovasc Res. 2020 Aug 1;116(10):1742-1755. doi: 10.1093/cvr/cvz251. PMID: 31584633 Free PMC article.

263

3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB.

Chen G, Xie W, Nah J, Sauvat A, Liu P, Pietrocola F, Sica V, Carmona-Gutierrez D, Zimmermann A, Pendl T, Tadic J, Bergmann M, Hofer SJ, Domuz L, Lachkar S, Markaki M, Tavernarakis N, Sadoshima J, Madeo F, Kepp O, Kroemer G. EMBO Mol Med. 2019 Nov 7;11(11):e10469. doi: 10.15252/emmm.201910469. Epub 2019 Oct 14. PMID: 31609086 Free PMC article.

264

Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart.

Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H, Sadoshima J. JACC Basic Transl Sci. 2019 Sep 23;4(5):611-622. doi: 10.1016/j.jacbts.2019.05.006. eCollection 2019 Sep. PMID: 31768477 Free PMC article.

265

Nuclear miR-320 Controls Lipotoxicity.

Tong M, Sadoshima J. Circ Res. 2019 Dec 6;125(12):1121-1123. doi: 10.1161/CIRCRESAHA.119.316199. Epub 2019 Dec 5. PMID: 31804912 Free PMC article. No abstract available.

266

Role of YAP/TAZ in Energy Metabolism in the Heart.

Kashihara T, Sadoshima J. J Cardiovasc Pharmacol. 2019 Dec;74(6):483-490. doi: 10.1097/FJC.0000000000000736. PMID: 31815864 Free PMC article. Review.

267

Interaction between the autophagy protein Beclin 1 and Na+,K+-ATPase during starvation, exercise, and ischemia.

Fernández ÁF, Liu Y, Ginet V, Shi M, Nah J, Zou Z, Zhou A, Posner BA, Xiao G, Tanguy M, Paradis V, Sadoshima J, Rautou PE, Puyal J, Hu MC, Levine B. JCI Insight. 2020 Jan 16;5(1):e133282. doi: 10.1172/jci.insight.133282. PMID: 31941841 Free PMC article.

268

The role of Drp1 in mitophagy and cell death in the heart.

Tong M, Zablocki D, Sadoshima J. J Mol Cell Cardiol. 2020 May;142:138-145. doi: 10.1016/j.yjmcc.2020.04.015. Epub 2020 Apr 14. PMID: 32302592 Free PMC article. Review.

269

Autocrine Bradykinin Release Promotes Ischemic Preconditioning-Induced Cytoprotection in Bovine Aortic Endothelial Cells.

Bellis A, Sorriento D, Fiordelisi A, Izzo R, Sadoshima J, Mauro C, Cerasuolo F, Mancusi C, Barbato E, Pilato E, Trimarco B, Morisco C. Int J Mol Sci. 2020 Apr 23;21(8):2965. doi: 10.3390/ijms21082965. PMID: 32340102 Free PMC article.

270

Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury.

Nah J, Zhai P, Huang CY, Fernández ÁF, Mareedu S, Levine B, Sadoshima J. J Clin Invest. 2020 Jun 1;130(6):2978-2991. doi: 10.1172/JCI132366. PMID: 32364533 Free PMC article.

271

SIRT1-NOX4 signaling axis regulates cancer cachexia.

Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. J Exp Med. 2020 Jul 6;217(7):e20190745. doi: 10.1084/jem.20190745. PMID: 32441762 Free PMC article.

272

Perm1 regulates cardiac energetics as a downstream target of the histone methyltransferase Smyd1.

Oka SI, Sabry AD, Horiuchi AK, Cawley KM, O'Very SA, Zaitsev MA, Shankar TS, Byun J, Mukai R, Xu X, Torres NS, Kumar A, Yazawa M, Ling J, Taleb I, Saijoh Y, Drakos SG, Sadoshima J, Warren JS. PLoS One. 2020 Jun 23;15(6):e0234913. doi: 10.1371/journal.pone.0234913. eCollection 2020. PMID: 32574189 Free PMC article.

273

Autosis: A New Target to Prevent Cell Death.

Nah J, Zablocki D, Sadoshima J. JACC Basic Transl Sci. 2020 Aug 24;5(8):857-869. doi: 10.1016/j.jacbts.2020.04.014. eCollection 2020 Aug. PMID: 32875173 Free PMC article. Review.

274

Editorial commentary: How to implement research studies on extracellular vesicle administration in myocardial infarction.

Sciarretta S, Schirone L, Sadoshima J. Trends Cardiovasc Med. 2021 Oct;31(7):416-418. doi: 10.1016/j.tcm.2020.09.003. Epub 2020 Sep 22. PMID: 32976978 No abstract available.

275

Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure.

Nakamura M, Odanovic N, Nakada Y, Dohi S, Zhai P, Ivessa A, Yang Z, Abdellatif M, Sadoshima J. Cardiovasc Res. 2021 Sep 28;117(11):2365-2376. doi: 10.1093/cvr/cvaa298. PMID: 33070172 Free PMC article.

276

Caloric restriction mimetics for the treatment of cardiovascular diseases.

Sciarretta S, Forte M, Castoldi F, Frati G, Versaci F, Sadoshima J, Kroemer G, Maiuri MC. Cardiovasc Res. 2021 May 25;117(6):1434-1449. doi: 10.1093/cvr/cvaa297. PMID: 33098415 Review.

277

Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells.

Venkatesh S, Baljinnyam E, Tong M, Kashihara T, Yan L, Liu T, Li H, Xie LH, Nakamura M, Oka SI, Suzuki CK, Fraidenraich D, Sadoshima J. Am J Physiol Regul Integr Comp Physiol. 2021 Apr 1;320(4):R547-R562. doi: 10.1152/ajpregu.00207.2020. Epub 2020 Oct 28. PMID: 33112656 Free PMC article.

278

Sleep deficiency and mortality: is the solution in the gut?

Nakada Y, Sadoshima J. Cardiovasc Res. 2021 Jan 21;117(2):e26-e28. doi: 10.1093/cvr/cvaa309. PMID: 33179722 Free PMC article. No abstract available.

279

Molecular mechanisms and clinical implications of multiple forms of mitophagy in the heart.

Saito T, Hamano K, Sadoshima J. Cardiovasc Res. 2021 Dec 17;117(14):2730-2741. doi: 10.1093/cvr/cvaa340. PMID: 33331644 Free PMC article. Review.

280

YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.

Ikeda S, Nah J, Shirakabe A, Zhai P, Oka SI, Sciarretta S, Guan KL, Shimokawa H, Sadoshima J. J Clin Invest. 2021 Mar 1;131(5):e143173. doi: 10.1172/JCI143173. PMID: 33373332 Free PMC article.

281

The complex network of mTOR signalling in the heart.

Sciarretta S, Forte M, Frati G, Sadoshima J. Cardiovasc Res. 2022 Jan 29;118(2):424-439. doi: 10.1093/cvr/cvab033. PMID: 33512477 Free PMC article. Review.

282

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy.

Kyriazis ID, Hoffman M, Gaignebet L, Lucchese AM, Markopoulou E, Palioura D, Wang C, Bannister TD, Christofidou-Solomidou M, Oka SI, Sadoshima J, Koch WJ, Goldberg IJ, Yang VW, Bialkowska AB, Kararigas G, Drosatos K. Circ Res. 2021 Feb 5;128(3):335-357. doi: 10.1161/CIRCRESAHA.120.316738. Epub 2020 Dec 2. PMID: 33539225 Free PMC article.

283

Editorial: Mitochondrial Dysfunction and Cardiovascular Diseases.

Sadoshima J, Kitsis RN, Sciarretta S. Front Cardiovasc Med. 2021 Jan 22;8:645986. doi: 10.3389/fcvm.2021.645986. eCollection 2021. PMID: 33585590 Free PMC article. No abstract available.

284

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹.

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. PMID: 33634751 Free PMC article.

285

Estrogen Plays a Crucial Role in Rab9-Dependent Mitochondrial Autophagy, Delaying Arterial Senescence.

Sasaki Y, Ikeda Y, Uchikado Y, Akasaki Y, Sadoshima J, Ohishi M. J Am Heart Assoc. 2021 Apr 6;10(7):e019310. doi: 10.1161/JAHA.120.019310. Epub 2021 Mar 15. PMID: 33719502 Free PMC article.

286

NOX4 Mediates Pseudomonas aeruginosa-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium.

Fu P, Ramchandran R, Sudhadevi T, Kumar PPK, Krishnan Y, Liu Y, Zhao Y, Parinandi NL, Harijith A, Sadoshima J, Natarajan V. Antioxidants (Basel). 2021 Mar 17;10(3):477. doi: 10.3390/antiox10030477. PMID: 33802941 Free PMC article.

287

The roles of the inhibitory autophagy regulator Rubicon in the heart: A new therapeutic target to prevent cardiac cell death.

Nah J, Zablocki D, Sadoshima J. Exp Mol Med. 2021 Apr;53(4):528-536. doi: 10.1038/s12276-021-00600-3. Epub 2021 Apr 14. PMID: 33854187 Free PMC article. Review.

288

Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy.

Oka SI, Byun J, Huang CY, Imai N, Ralda G, Zhai P, Xu X, Kashyap S, Warren JS, Alan Maschek J, Tippetts TS, Tong M, Venkatesh S, Ikeda Y, Mizushima W, Kashihara T, Sadoshima J. Circ Res. 2021 Jun 25;129(1):114-130. doi: 10.1161/CIRCRESAHA.120.317943. Epub 2021 Apr 30. PMID: 33928788 Free PMC article.

289

A Novel Inducer of Autophagy in the Heart.

Mukai R, Sadoshima J. JACC Basic Transl Sci. 2021 Apr 27;6(4):381-383. doi: 10.1016/j.jacbts.2021.02.007. eCollection 2021 Apr. PMID: 33999043 Free PMC article.

290

Editors' Preamble to The Journal of Cardiovascular Aging.

Marian AJ, Asatryan B, Bolli R, Cheedipudi SM, Dhalla NS, Finkel T, Frangogiannis NG, Gurha P, Belmonte JCI, Hare JM, Hong K, Kirshenbaum LA, Lee RT, Leesar MA, Libby P, Madonna R, Nagueh SF, Roberts R, Rosenzweig A, Rouhi L, Sadoshima J, Sussman MA, Taffet GE, Tanaka H, Torella D, Wang Y, Wang DW. J Cardiovasc Aging. 2021;1:1. doi: 10.20517/jca.2021.01. Epub 2021 Apr 27. PMID: 34327514 Free PMC article. No abstract available.

291

β-Hydroxybutyrate, a Ketone Body, Potentiates the Antioxidant Defense via Thioredoxin 1 Upregulation in Cardiomyocytes.

Oka SI, Tang F, Chin A, Ralda G, Xu X, Hu C, Yang Z, Abdellatif M, Sadoshima J. Antioxidants (Basel). 2021 Jul 20;10(7):1153. doi: 10.3390/antiox10071153. PMID: 34356388 Free PMC article.

292

NAD⁺ Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy.

Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H, Lee CF. Circ Heart Fail. 2021 Aug;14(8):e008170. doi: 10.1161/CIRCHEARTFAILURE.120.008170. Epub 2021 Aug 10. PMID: 34374300 Free PMC article.

293

Autophagy in major human diseases.

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MI, Cuervo AM, Deretic V, Dikic I, Elazar Z, Eskelinen EL, Fimia GM, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, Lopez-Otin C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon HU, Simon AK, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F. EMBO J. 2021 Oct 1;40(19):e108863. doi: 10.15252/embj.2021108863. Epub 2021 Aug 30. PMID: 34459017 Free PMC article. Review.

294

Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice.

Wu W, Ziemann M, Huynh K, She G, Pang ZD, Zhang Y, Duong T, Kiriazis H, Pu TT, Bai RY, Li JJ, Zhang Y, Chen MX, Sadoshima J, Deng XL, Meikle PJ, Du XJ. Theranostics. 2021 Aug 21;11(18):8993-9008. doi: 10.7150/thno.62302. eCollection 2021. PMID: 34522223 Free PMC article.

295

YAP Promotes Infarct Resolution by Stimulating Intercellular Signaling.

Sadoshima J. Circ Res. 2021 Oct;129(8):798-800. doi: 10.1161/CIRCRESAHA.121.319981. Epub 2021 Sep 30. PMID: 34591659 Free PMC article. No abstract available.

296

Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy.

Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Circ Res. 2021 Dec 3;129(12):1105-1121. doi: 10.1161/CIRCRESAHA.121.319377. Epub 2021 Nov 2. PMID: 34724805 Free article.

297

Ser9 phosphorylation of GSK-3β promotes aging in the heart through suppression of autophagy.

Chen Y, Maejima Y, Shirakabe A, Yamamoto T, Ikeda Y, Sadoshima J, Zhai P. J Cardiovasc Aging. 2021;1:9. doi: 10.20517/jca.2021.13. Epub 2021 Aug 23. PMID: 34778891 Free PMC article.

298

Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload.

Shao D, Zhai P, Hu C, Mukai R, Sciarretta S, Del Re D, Sadoshima J. Sci Rep. 2021 Dec 6;11(1):23469. doi: 10.1038/s41598-021-02846-3. PMID: 34873220 Free PMC article.

299

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance.

Xirouchaki CE, Jia Y, McGrath MJ, Greatorex S, Tran M, Merry TL, Hong D, Eramo MJ, Broome SC, Woodhead JST, D'souza RF, Gallagher J, Salimova E, Huang C, Schittenhelm RB, Sadoshima J, Watt MJ, Mitchell CA, Tiganis T. Sci Adv. 2021 Dec 17;7(51):eabl4988. doi: 10.1126/sciadv.abl4988. Epub 2021 Dec 15. PMID: 34910515 Free PMC article.

300

The role of autophagy in death of cardiomyocytes.

Ikeda S, Zablocki D, Sadoshima J. J Mol Cell Cardiol. 2022 Apr;165:1-8. doi: 10.1016/j.yjmcc.2021.12.006. Epub 2021 Dec 14. PMID: 34919896 Free PMC article. Review.

301

Sadoshima J. Cardiovasc Res. 2022 Feb 21;118(3):662-663. doi: 10.1093/cvr/cvab376. PMID: 34984443 No abstract available.

302

Ulk1-dependent alternative mitophagy plays a protective role during pressure overload in the heart.

Nah J, Shirakabe A, Mukai R, Zhai P, Sung EA, Ivessa A, Mizushima W, Nakada Y, Saito T, Hu C, Jung YK, Sadoshima J. Cardiovasc Res. 2022 Sep 20;118(12):2638-2651. doi: 10.1093/cvr/cvac003. PMID: 35018428 Free PMC article.

303

Alternative mitophagy is a major form of mitophagy in the chronically stressed heart.

Sadoshima J. Autophagy. 2022 Sep;18(9):2252-2253. doi: 10.1080/15548627.2022.2025573. Epub 2022 Jan 13. PMID: 35025704 Free PMC article.

304

Tfeb-Mediated Transcriptional Regulation of Autophagy Induces Autosis during Ischemia/Reperfusion in the Heart.

Nah J, Sung EA, Zhai P, Zablocki D, Sadoshima J. Cells. 2022 Jan 13;11(2):258. doi: 10.3390/cells11020258. PMID: 35053374 Free PMC article.

305

Boosting circadian autophagy by means of intermittent time-restricted feeding: a novel anti-ageing strategy?

Sciarretta S, Forte M, Sadoshima J. J Cardiovasc Aging. 2022;2:5. doi: 10.20517/jca.2021.33. Epub 2022 Jan 1. PMID: 35083475 Free PMC article. No abstract available.

306

YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload.

Kashihara T, Mukai R, Oka SI, Zhai P, Nakada Y, Yang Z, Mizushima W, Nakahara T, Warren JS, Abdellatif M, Sadoshima J. J Clin Invest. 2022 Mar 15;132(6):e150595. doi: 10.1172/JCI150595. PMID: 35133975 Free PMC article.

307

The role of the Hippo pathway in autophagy in the heart.

Maejima Y, Zablocki D, Nah J, Sadoshima J. Cardiovasc Res. 2023 Jan 18;118(17):3320-3330. doi: 10.1093/cvr/cvac014. PMID: 35150237 Free PMC article. Review.

308

Primary Cilia and Their Role in Acquired Heart Disease.

Hale ZE, Sadoshima J. Cells. 2022 Mar 11;11(6):960. doi: 10.3390/cells11060960. PMID: 35326411 Free PMC article. Review.

309

TRAF2 Mediates Physiological Mitophagy.

Sadoshima J. JACC Basic Transl Sci. 2022 Mar 28;7(3):244-246. doi: 10.1016/j.jacbts.2021.11.012. eCollection 2022 Mar. PMID: 35411322 Free PMC article.

310

New intranasal and injectable gene therapy for healthy life extension.

Jaijyan DK, Selariu A, Cruz-Cosme R, Tong M, Yang S, Stefa A, Kekich D, Sadoshima J, Herbig U, Tang Q, Church G, Parrish EL, Zhu H. Proc Natl Acad Sci U S A. 2022 May 17;119(20):e2121499119. doi: 10.1073/pnas.2121499119. Epub 2022 May 10. Retraction in: Proc Natl Acad Sci U S A. 2025 Aug 19;122(33):e2519570122. doi: 10.1073/pnas.2519570122. PMID: 35537048 Free PMC article.

311

Yin and Yang of NADPH Oxidases in Myocardial Ischemia-Reperfusion.

Matsushima S, Sadoshima J. Antioxidants (Basel). 2022 May 27;11(6):1069. doi: 10.3390/antiox11061069. PMID: 35739967 Free PMC article. Review.

312

Fasting confers stress resistance to skeletal muscle stem cells through non-metabolic actions of β-hydroxybutyrate: implications in cardioprotection and aging.

Sadoshima J. J Cardiovasc Aging. 2022 Jul;2(3):34. doi: 10.20517/jca.2022.24. Epub 2022 Jul 4. PMID: 35891705 Free PMC article.

313

PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARα and PGC-1α.

Huang CY, Oka SI, Xu X, Chen CF, Tung CY, Chang YY, Mourad Y, Vehra O, Ivessa A, Yehia G, Romanienko P, Hsu CP, Sadoshima J. Sci Rep. 2022 Aug 26;12(1):14576. doi: 10.1038/s41598-022-18885-3. PMID: 36028747 Free PMC article.

314

The role of autophagic cell death in cardiac disease.

Nah J, Zablocki D, Sadoshima J. J Mol Cell Cardiol. 2022 Dec;173:16-24. doi: 10.1016/j.yjmcc.2022.08.362. Epub 2022 Sep 6. PMID: 36084743 Review.

315

ACBP/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis.

Motiño O, Lambertucci F, Anagnostopoulos G, Li S, Nah J, Castoldi F, Senovilla L, Montégut L, Chen H, Durand S, Bourgin M, Aprahamian F, Nirmalathasan N, Alvarez-Valadez K, Sauvat A, Carbonnier V, Djavaheri-Mergny M, Pietrocola F, Sadoshima J, Maiuri MC, Martins I, Kroemer G. Proc Natl Acad Sci U S A. 2022 Oct 11;119(41):e2207344119. doi: 10.1073/pnas.2207344119. Epub 2022 Oct 3. PMID: 36191214 Free PMC article.

316

Editorial commentary: Targeting CLOCK: BMAL1 for treatment of ischemia/reperfusion injury.

Sadoshima J. Trends Cardiovasc Med. 2024 Jan;34(1):8-9. doi: 10.1016/j.tcm.2022.10.004. Epub 2022 Oct 25. PMID: 36306993 No abstract available.

317

Mitochondrial Quality Control Mechanisms during Diabetic Cardiomyopathy.

Ketenci M, Zablocki D, Sadoshima J. JMA J. 2022 Oct 17;5(4):407-415. doi: 10.31662/jmaj.2022-0155. Epub 2022 Sep 30. PMID: 36407069 Free PMC article. Review.

318

Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia.

Nagarajan N, Oka SI, Nah J, Wu C, Zhai P, Mukai R, Xu X, Kashyap S, Huang CY, Sung EA, Mizushima W, Titus AS, Takayama K, Mourad Y, Francisco J, Liu T, Chen T, Li H, Sadoshima J. J Clin Invest. 2023 Feb 1;133(3):e162326. doi: 10.1172/JCI162326. PMID: 36480290 Free PMC article.

319

Molecular properties and regulation of NAD⁺ kinase (NADK).

Oka SI, Titus AS, Zablocki D, Sadoshima J. Redox Biol. 2023 Feb;59:102561. doi: 10.1016/j.redox.2022.102561. Epub 2022 Dec 5. PMID: 36512915 Free PMC article. Review.

320

Where is the field of autophagy research heading?

Abeliovich H, Debnath J, Ding WX, Jackson WT, Kim DH, Klionsky DJ, Ktistakis N, Margeta M, Münz C, Petersen M, Sadoshima J, Vergne I. Autophagy. 2023 Apr;19(4):1049-1054. doi: 10.1080/15548627.2023.2166301. Epub 2023 Jan 23. PMID: 36628432 Free PMC article.

321

Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction.

She G, Du JC, Wu W, Pu TT, Zhang Y, Bai RY, Zhang Y, Pang ZD, Wang HF, Ren YJ, Sadoshima J, Deng XL, Du XJ. Theranostics. 2023 Jan 1;13(2):560-577. doi: 10.7150/thno.79227. eCollection 2023. PMID: 36632235 Free PMC article.

322

Caveolin-3 Nitration Drives Insulin Resistance in Prediabetic Hearts.

Sadoshima J. Circulation. 2023 Apr 11;147(15):1180-1182. doi: 10.1161/CIRCULATIONAHA.123.064250. Epub 2023 Apr 10. PMID: 37036910 Free PMC article. No abstract available.

323

Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy.

Tong M, Mukai R, Mareedu S, Zhai P, Oka SI, Huang CY, Hsu CP, Yousufzai FAK, Fritzky L, Mizushima W, Babu GJ, Sadoshima J. Circ Res. 2023 Jun 23;133(1):6-21. doi: 10.1161/CIRCRESAHA.123.322512. Epub 2023 May 26. PMID: 37232152 Free PMC article.

324

Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress.

Francisco J, Guan J, Zhang Y, Nakada Y, Mareedu S, Sung EA, Hu CM, Oka S, Zhai P, Sadoshima J, Del Re DP. J Mol Cell Cardiol. 2023 Aug;181:1-14. doi: 10.1016/j.yjmcc.2023.05.004. Epub 2023 May 24. PMID: 37235928 Free PMC article.

325

MST1 mediates doxorubicin-induced cardiomyopathy by SIRT3 downregulation.

Schirone L, Vecchio D, Valenti V, Forte M, Relucenti M, Angelini A, Zaglia T, Schiavon S, D'Ambrosio L, Sarto G, Stanzione R, Mangione E, Miglietta S, Di Bona A, Fedrigo M, Ghigo A, Versaci F, Petrozza V, Marchitti S, Rubattu S, Volpe M, Sadoshima J, Frati L, Frati G, Sciarretta S. Cell Mol Life Sci. 2023 Aug 11;80(9):245. doi: 10.1007/s00018-023-04877-7. PMID: 37566283 Free PMC article.

326

Muscle-restricted Nox4 knockout partially corrects muscle contractility following spinal cord injury in mice.

Toro CA, De Gasperi R, Aslan A, Johnson N, Siddiq MM, Chow C, Zhao W, Harlow L, Graham Z, Liu XH, Sadoshima J, Iyengar R, Cardozo CP. bioRxiv [Preprint]. 2023 Aug 4:2023.08.04.551985. doi: 10.1101/2023.08.04.551985. Update in: Neurotrauma Rep. 2024 Apr 01;5(1):304-316. doi: 10.1089/neur.2023.0089. PMID: 37577656 Free PMC article. Preprint.

327

Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice.

Nakamura M, Keller MA, Fefelova N, Zhai P, Liu T, Tian Y, Ikeda S, Del Re DP, Li H, Xie LH, Sadoshima J. Nat Commun. 2023 Sep 19;14(1):5805. doi: 10.1038/s41467-023-41595-x. PMID: 37726310 Free PMC article.

328

Ketone Bodies Preserve Mitochondria Through Epigenetics.

Mukai R, Sadoshima J. JACC Basic Transl Sci. 2023 Sep 25;8(9):1138-1140. doi: 10.1016/j.jacbts.2023.05.013. eCollection 2023 Sep. PMID: 37791309 Free PMC article.

329

Mitophagy for cardioprotection.

Titus AS, Sung EA, Zablocki D, Sadoshima J. Basic Res Cardiol. 2023 Oct 5;118(1):42. doi: 10.1007/s00395-023-01009-x. PMID: 37798455 Free PMC article. Review.

330

Infiltrating macrophages amplify doxorubicin-induced cardiac damage: role of catecholamines.

Gambardella J, Santulli G, Fiordelisi A, Cerasuolo FA, Wang X, Prevete N, Sommella E, Avvisato R, Buonaiuto A, Altobelli GG, Rinaldi L, Chiuso F, Feliciello A, Dal Piaz F, Campiglia P, Ciccarelli M, Morisco C, Sadoshima J, Iaccarino G, Sorriento D. Cell Mol Life Sci. 2023 Oct 11;80(11):323. doi: 10.1007/s00018-023-04922-5. PMID: 37819449 Free PMC article.

331

Cardiomyocyte NOX4 regulates resident macrophage-mediated inflammation and diastolic dysfunction in stress cardiomyopathy.

Vendrov AE, Xiao H, Lozhkin A, Hayami T, Hu G, Brody MJ, Sadoshima J, Zhang YY, Runge MS, Madamanchi NR. Redox Biol. 2023 Nov;67:102937. doi: 10.1016/j.redox.2023.102937. Epub 2023 Oct 19. PMID: 37871532 Free PMC article.

332

Metabolic control of mitophagy.

Zimmermann A, Madeo F, Diwan A, Sadoshima J, Sedej S, Kroemer G, Abdellatif M. Eur J Clin Invest. 2024 Apr;54(4):e14138. doi: 10.1111/eci.14138. Epub 2023 Dec 1. PMID: 38041247 Review.

333

Mitochondria- and NOX4-dependent antioxidant defense mitigates progression to nonalcoholic steatohepatitis in obesity.

Greatorex S, Kaur S, Xirouchaki CE, Goh PK, Wiede F, Genders AJ, Tran M, Jia Y, Raajendiran A, Brown WA, McLean CA, Sadoshima J, Watt MJ, Tiganis T. J Clin Invest. 2023 Dec 7;134(3):e162533. doi: 10.1172/JCI162533. PMID: 38060313 Free PMC article.

334

Regulation of myocardial glucose metabolism by YAP/TAZ signaling.

Kashihara T, Sadoshima J. J Cardiol. 2024 May;83(5):323-329. doi: 10.1016/j.jjcc.2024.01.002. Epub 2024 Jan 23. PMID: 38266816 Free article. Review.

335

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.

Chen X, Tsvetkov AS, Shen HM, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon HU, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein DC, Chi JT, Zhang DD, Li C, Toyokuni S, Liu J, Roh JL, Dai E, Juhasz G, Liu W, Zhang J, Yang M, Liu J, Zhu LQ, Zou W, Piacentini M, Ding WX, Yue Z, Xie Y, Petersen M, Gewirtz DA, Mandell MA, Chu CT, Sinha D, Eftekharpour E, Zhivotovsky B, Besteiro S, Gabrilovich DI, Kim DH, Kagan VE, Bayir H, Chen GC, Ayton S, Lünemann JD, Komatsu M, Krautwald S, Loos B, Baehrecke EH, Wang J, Lane JD, Sadoshima J, Yang WS, Gao M, Münz C, Thumm M, Kampmann M, Yu D, Lipinski MM, Jones JW, Jiang X, Zeh HJ, Kang R, Klionsky DJ, Kroemer G, Tang D. Autophagy. 2024 Jun;20(6):1213-1246. doi: 10.1080/15548627.2024.2319901. Epub 2024 Mar 24. PMID: 38442890 Free PMC article. Review.

336

Muscle-Restricted Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 Knockout Partially Corrects Muscle Contractility After Spinal Cord Injury in Mice.

Toro CA, De Gasperi R, Aslan A, Johnson N, Siddiq MM, Chow C, Zhao W, Harlow L, Graham Z, Liu XH, Sadoshima J, Iyengar R, Cardozo CP. Neurotrauma Rep. 2024 Apr 1;5(1):304-316. doi: 10.1089/neur.2023.0089. eCollection 2024. PMID: 41178910 Free PMC article.

337

Improved mitochondrial function in the hearts of sarcolipin-deficient dystrophin and utrophin double-knockout mice.

Mareedu S, Fefelova N, Galindo CL, Prakash G, Mukai R, Sadoshima J, Xie LH, Babu GJ. JCI Insight. 2024 Apr 2;9(9):e170185. doi: 10.1172/jci.insight.170185. PMID: 38564291 Free PMC article.

338

Decoding the Impact of the Hippo Pathway on Different Cell Types in Heart Failure.

Hu C, Francisco J, Del Re DP, Sadoshima J. Circ J. 2024 Dec 25;89(1):6-15. doi: 10.1253/circj.CJ-24-0171. Epub 2024 Apr 19. PMID: 38644191 Free article. Review.

339

Suppression of autophagy induces senescence in the heart.

Zhai P, Sung EA, Shiheido-Watanabe Y, Takayama K, Tian Y, Sadoshima J. bioRxiv [Preprint]. 2024 May 30:2024.05.26.595978. doi: 10.1101/2024.05.26.595978. Update in: J Mol Cell Cardiol. 2024 Oct;195:83-96. doi: 10.1016/j.yjmcc.2024.08.001. PMID: 38854107 Free PMC article. Preprint.

340

Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation.

Chen YC, Wijekoon S, Matsumoto A, Luo J, Kiriazis H, Masterman E, Yildiz G, Cross J, Parslow AC, Chooi R, Sadoshima J, Greening DW, Weeks KL, McMullen JR. Clin Sci (Lond). 2024 Aug 7;138(15):941-962. doi: 10.1042/CS20240178. PMID: 39018488 Free PMC article.

341

Mst1-mediated phosphorylation of FoxO1 and C/EBP-β stimulates cell-protective mechanisms in cardiomyocytes.

Maejima Y, Nah J, Aryan Z, Zhai P, Sung EA, Liu T, Takayama K, Moghadami S, Sasano T, Li H, Sadoshima J. Nat Commun. 2024 Jul 25;15(1):6279. doi: 10.1038/s41467-024-50393-y. PMID: 39060225 Free PMC article.

342

Suppression of autophagy induces senescence in the heart.

Zhai P, Sung EA, Shiheido-Watanabe Y, Takayama K, Tian Y, Sadoshima J. J Mol Cell Cardiol. 2024 Oct;195:83-96. doi: 10.1016/j.yjmcc.2024.08.001. Epub 2024 Aug 6. PMID: 39117176 Free article.

343

Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart.

Zhai P, Sadoshima J. J Cardiovasc Aging. 2024 Apr;4(2):18. doi: 10.20517/jca.2024.06. Epub 2024 May 30. PMID: 39119147 Free PMC article.

344

Nobiletin, a polymethoxylated flavonoid, regulates cell survival via the nuclear receptor RORα in cardiomyocytes.

Shiheido-Watanabe Y, Sadoshima J. J Cardiovasc Aging. 2024 Jan;4(1):6. doi: 10.20517/jca.2023.46. Epub 2023 Dec 31. PMID: 39119356 Free PMC article. No abstract available.

345

A transcriptional regulatory mechanism of genes in the tricarboxylic acid cycle in the heart.

Veera S, Tang F, Mourad Y, Kim S, Liu T, Li H, Wang Y, Warren JS, Park J, Van C, Sadoshima J, Oka SI. J Biol Chem. 2024 Sep;300(9):107677. doi: 10.1016/j.jbc.2024.107677. Epub 2024 Aug 14. PMID: 39151728 Free PMC article.

346

An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy.

Belkin TG, Masterman EI, Yildiz GS, Kiriazis H, Mellett NA, Cross J, Grigolon K, Dogra A, Donner D, Chooi R, Liang A, Kompa AR, Sadoshima J, Edgley AJ, Greening DW, Meikle PJ, Tham YK, McMullen JR. J Mol Cell Cardiol Plus. 2024 Dec 4;11:100273. doi: 10.1016/j.jmccpl.2024.100273. eCollection 2025 Mar. PMID: 39802264 Free PMC article.

347

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction.

Abdellatif M, Vasques-Nóvoa F, Trummer-Herbst V, Durand S, Koser F, Islam M, Nah J, Sung EA, Feng R, Aprahamian F, Prokesch A, Zardoya-Laguardia P, Sadoshima J, Diwan A, Linke WA, Ferreira JP, Kroemer G, Sedej S. Eur Heart J. 2025 May 14;46(19):1863-1866. doi: 10.1093/eurheartj/ehaf062. PMID: 39995248 Free PMC article. No abstract available.

348

Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1.

She G, Hai XX, Jia LY, Zhang YJ, Ren YJ, Pang ZD, Wu LH, Han MZ, Zhang Y, Li JJ, Bai RY, Lai BC, Yang YY, Sadoshima J, Du XJ, Deng XL, Zhang Y. Redox Biol. 2025 May;82:103597. doi: 10.1016/j.redox.2025.103597. Epub 2025 Mar 14. PMID: 40107016 Free PMC article.

349

On the utility of immobilized phenylarsine oxide in the study of redox sensitive cardiac proteins.

Francois AA, Yin X, Oka S, Sadoshima J, Mayr M, Eaton P. Sci Rep. 2025 May 3;15(1):15554. doi: 10.1038/s41598-025-00665-4. PMID: 40319072 Free PMC article.

350

NAD⁺ repletion restores cardioprotective autophagy and mitophagy in obesity-associated heart failure by suppressing excessive trophic signaling.

Abdellatif M, Vasques-Nóvoa F, Ferreira JP, Sadoshima J, Diwan A, Linke WA, Kroemer G, Sedej S. Autophagy. 2025 Oct;21(10):2296-2298. doi: 10.1080/15548627.2025.2522127. Epub 2025 Jul 4. PMID: 40556426

351

S913 phosphorylation of Ulk1 protects the heart from aging through inhibition of cardiac senescence.

Zhai P, Sung EA, Takayama K, Ikeda S, Matsushita M, Nakada Y, Tian Y, Sadoshima J. Cardiovasc Res. 2025 Aug 28;121(10):1609-1622. doi: 10.1093/cvr/cvaf129. PMID: 40726430

352

Potential Molecular Mechanism of FNDC4 Protection Against Aging in the Heart.

Matsushita M, Sadoshima J. JACC Basic Transl Sci. 2025 Jul;10(7):101304. doi: 10.1016/j.jacbts.2025.04.018. PMID: 40738520 Free PMC article.

353

Fabry disease cardiomyopathy: A state-of-the-art review.

Pande S, Varzideh F, Gambardella J, Jankauskas SS, Cerasuolo FA, Spinelli L, Kansakar U, De Luca A, Kurland IJ, Sidoli S, Iaccarino G, Sadoshima J, Santulli G. Prog Cardiovasc Dis. 2025 Sep-Oct;92:43-65. doi: 10.1016/j.pcad.2025.08.003. Epub 2025 Aug 19. PMID: 40840785 Free PMC article.

354

Prognostic impact of excessive mitochondrial fission in patients with heart failure and evaluation of mitochondrial dynamics-related miRNAs in heart failure.

Shirakabe A, Ikeda Y, Uchikado Y, Matsushita M, Sawatani T, Shigihara S, Tani K, Morooka M, Takahashi M, Kobayashi N, Ohishi M, Sadoshima J, Asai K. Hypertens Res. 2025 Nov;48(11):2950-2960. doi: 10.1038/s41440-025-02338-1. Epub 2025 Sep 3. PMID: 40903535

355

p22^phox prevents the oxidation of SERCA2a and stabilizes it in the heart.

Nakada Y, Titus AS, Mizushima W, Yang Y, Zhai P, Tian Y, Oka S, Kashihara T, Fefelova N, Pamarthi SH, Liu T, Li H, Xie LH, Takayama K, Ikeda S, Matsushita M, Huang CY, Hsu CP, Onoue K, Saito Y, Sadoshima J. Nat Cardiovasc Res. 2025 Sep;4(9):1187-1205. doi: 10.1038/s44161-025-00699-x. Epub 2025 Sep 3. PMID: 40903547 Free PMC article.

356

Clinical significance of mitochondrial dynamics-related miRNAs in the superacute phase of acute heart failure in patients presenting to the emergency department.

Shirakabe A, Ikeda Y, Uchikado Y, Okazaki H, Matsushita M, Sawatani T, Shigihara S, Tani K, Morooka M, Kobayashi N, Ohishi M, Sadoshima J, Asai K. Int J Cardiol. 2026 Feb 1;444:133967. doi: 10.1016/j.ijcard.2025.133967. Epub 2025 Oct 15. PMID: 41106436

357

Recent progress regarding the role of autophagy in cardiac disease.

Maejima Y, Titus AS, Zablocki D, Sadoshima J. Cardiovasc Res. 2025 Dec 9;121(15):2299-2317. doi: 10.1093/cvr/cvaf203. PMID: 41144634 Review.

358

Role of Vascular Niche in Cardiac Aging.

Ikeda S, Sung EA, Sadoshima J. Circ Res. 2025 Nov 7;137(11):1368-1370. doi: 10.1161/CIRCRESAHA.125.327363. Epub 2025 Nov 6. PMID: 41196955 Free article. No abstract available.

359

Prognostic impact of mitochondrial dynamics-related miRNA levels during the treatment of acute heart failure in the hospital.

Shirakabe A, Ikeda Y, Uchikado Y, Okazaki H, Matsushita M, Sawatani T, Shigihara S, Tani K, Morooka M, Takahashi M, Kobayashi N, Ohishi M, Sadoshima J, Asai K. Sci Rep. 2025 Nov 14;15(1):39938. doi: 10.1038/s41598-025-23792-4. PMID: 41238728 Free PMC article.

360

Cardiomyocyte-specific deficiency of C/EBPβ aggravates pressure overload-induced heart failure.

Nah J, Sung EA, Zhai P, Maejima Y, Hu C, Ramos-Zepeda J, Ikeda S, Mizushima W, Sadoshima J. Cardiovasc Res. 2026 Mar 26;122(4):527-538. doi: 10.1093/cvr/cvag029. PMID: 41618689

361

PPARα-NF-κB heterodimer mediates obesity-induced diastolic dysfunction through autocrine production of IL-6.

Oka SI, Sung EA, Zhai P, Schesing KB, Bhat S, Chin A, Park J, Chung YJ, Shirakabe A, Yamamoto T, Ikeda Y, Mizushima W, Ikeda S, Tong M, Byun J, Nakamura M, Kim SI, Francisco J, Del Re DP, Sadoshima J. J Clin Invest. 2026 Feb 12;136(7):e196238. doi: 10.1172/JCI196238. eCollection 2026 Apr 1. PMID: 41678287 Free PMC article.

362

Targeting immunometabolism for the treatment of diabetic cardiomyopathy.

Takada T, Francisco J, Sciarretta S, Sadoshima J. Nat Cardiovasc Res. 2026 Feb;5(2):91-93. doi: 10.1038/s44161-025-00771-6. PMID: 41731059 No abstract available.