JULIAN TOSO

PhD Student

PhD program:: XL
email: julian.toso@uniroma1.it
building: Dept. Biochemical Sciences "A. Rossi Fanelli"
room: 217

supervisor: Stefano Gianni

Research: Kinetic characterization of protein-protein interactions in WW adaptor domains of MAGI1 protein

Name: Julian Toso
Email: julian.toso@uniroma1.it

Education:

January 2024: M.Sc. in Biochemistry at Sapienza University of Rome, Rome, Italy, final grade of 110/110 cum laude. Title of dissertation: "Investigating the structural and functional connections between the evolutionarily conserved baseplate and an atypical membrane complex from a B. fragilis type III T6SS", supervisors: Dr. Eric Durand, Prof. Giorgio Giardina

October 2021: B.S. in Biological Sciences at Roma Tre University, Rome, Italy, final grade of 110/110 cum laude. Title of dissertation: "New evidence on the mechanism of action of colistin and its clinical implications", supervisor: Prof. Francesco Imperi

Previous work experience and fellowships:

April 2024 - October 2024: Research fellow at Sapienza University of Rome, Department of Biochemical Sciences “A. Rossi Fanelli”. Tutor: Prof. Stefano Gianni

January 2024 - March 2024: Research scholarship from Istituto Pasteur Italia Fondazione Cenci Bolognetti,
conducted at Sapienza University of Rome, Department of Biochemical Sciences “A. Rossi Fanelli”. Tutor: Dr. Angelo Toto

Publications:

Pennacchietti, V.; di Matteo, S.; Pagano, L.; Toplek., FB.; Stegani, B.; Toto, A.; Toso, J.; Puglisi, E.; Capelli, R.; Di Felice, M.; Malagrinò, F.; Camilloni, C.; Gianni, S. A PDZ tandem repeat folds and unfolds via different pathways. Protein Sci. 2024, Dec, 33, 12. https://doi.org/10.1002/pro.5203

Pagano, L.; Pennacchietti, V.; Malagrinò, F.; Di Felice, M.; Toso, J.; Puglisi, E.; Gianni, S.; Toto, A. Folding and Binding Kinetics of the Tandem of SH2 Domains from SHP2. Int. J. Mol. Sci. 2024, 25, 6566. https://doi.org/10.3390/ijms25126566

Language skills:

Italian: Mother tongue
English: C2
French: A2

Research products

11573/1739861 - 2025 - Allosteric modulation of Grb2 drives ligand-dependent signal responses

Di Felice, Mariana; Rolfi, Lucrezia Romana; Toso, Julian; Pennacchietti, Valeria; Ventura, Eduarda S.; Toto, Angelo; Tramutola, Antonella; Gianni, Stefano - 01a Articolo in rivista

paper: BIOLOGY DIRECT (London: BioMed Central) pp. - - issn: 1745-6150 - wos: (0) - scopus: 2-s2.0-105005785642 (0)

11573/1738574 - 2025 - A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the MATH domain of SPOP

Pagano, Livia; Diop, Awa; Pennacchietti, Valeria; Di Felice, Mariana; Ventura, Eduarda S.; Toso, Julian; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

paper: PROTEIN SCIENCE (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. - - issn: 0961-8368 - wos: (0) - scopus: (0)

11573/1738206 - 2025 - Unveiling an unexpected redox regulation of the folding, function and inhibition in the phosphotyrosine binding domain of FRS2

Pennacchietti, Valeria; Pagano, Livia; Di Felice, Mariana; Toso, Julian; Bufano, Marianna; Coluccia, Antonio; Silvestri, Romano; Capelli, Riccardo; Camilloni, Carlo; Malagrinò, Francesca; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (-Attuale :ELSEVIER SCIENCE BV, PO BOX 211, AMSTERDAM, NETHERLANDS, 1000 AE -Butterworth Heinemann Publishers:Linacre House Jordan Hill, Oxford OX2 8DP United Kingdom:011 44 1865 314569, EMAIL: bhmarketing@repp.co.uk, INTERNET: http://www.laxtonsprices.co.uk, Fax: 011 44 1865 314569) pp. - - issn: 0141-8130 - wos: WOS:001469698000001 (0) - scopus: 2-s2.0-105002147407 (0)

11573/1738207 - 2025 - Topological determinants in protein folding dynamics: a comparative analysis of metamorphic proteins

Toso, Julian; Pennacchietti, Valeria; Di Felice, Mariana; Ventura, Eduarda S.; Toto, Angelo; Gianni, Stefano - 01a Articolo in rivista

paper: BIOLOGY DIRECT (London: BioMed Central) pp. - - issn: 1745-6150 - wos: WOS:001459118300001 (0) - scopus: 2-s2.0-105002780010 (0)

11573/1711822 - 2024 - Folding and binding kinetics of the tandem of SH2 domains from SHP2

Pagano, Livia; Pennacchietti, Valeria; Malagrinò, Francesca; Di Felice, Mariana; Toso, Julian; Puglisi, Elena; Gianni, Stefano; Toto, Angelo - 01a Articolo in rivista

paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:001255961100001 (0) - scopus: 2-s2.0-85197293747 (0)

11573/1726961 - 2024 - A PDZ tandem repeat folds and unfolds via different pathways

Pennacchietti, Valeria; Di Matteo, Sara; Pagano, Livia; Toplek, Fran Bačić; Stegani, Bruno; Toto, Angelo; Toso, Julian; Puglisi, Elena; Capelli, Riccardo; Di Felice, Mariana; Malagrinò, Francesca; Camilloni, Carlo; Gianni, Stefano - 01a Articolo in rivista