JESSICA SEBASTIANI

PhD Student

PhD program:: XXXVI
email: jessica.sebastiani@uniroma1.it
phone: +39 0649913404
building: CU020
room: Lab. 5A

supervisor: Prof Giuseppe La Regina

• Working experience -11 / 2020- IN PROGRESS. PhD in Molecular design and characterization for the promotion of health and well-being from drug to food. -06 / 2019– 06/2020. Experimental Degree Thesis in Pharmaceutical Chemistry: design, synthesis and purification of compounds with anticancer activity - Sapienza University of Rome, Department of Pharmaceutical Chemistry and Technology). -10/2018 - 03/2019. Trainee Pharmacist - Sangiorgi Pharmacy, Via Civita Castellana, 11/13, Corchiano, 01030 • Education and training -11/2020. Qualified as a Pharmacist - Sapienza University of Rome. -21/10/2020. Pharmaceutical Chemistry and Technology degree - Sapienza University of Rome (110 cum laude). - 07/2014. Scientific high school diploma, Scientific High School "Fabio Besta" - Orte. • Scientific Publications 1. Puxeddu, M .; Shen, H .; Bai, R .; Coluccia, A .; Bufano, M .; Nalli, M .; Sebastiani, J. et al. Discovery of Pyrrole Derivatives for the Treatment of Glioblastoma and Chronic Myeloid Leukemia. Eur. J. Med. Chem. 2021, 113532. 2. Puxeddu, M., La Regina, G .; Sebastiani, J .; Nalli, M .; Silvestri, R. Discovery of a novel class of norovirus inhibitors with high barrier of resistance. Pharmaceuticals. 2021, 14 (10), 1006.

Research products

11573/1684557 - 2023 - Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent (01a Articolo in rivista)
Marianna NALLI, LAURA DI MAGNO, XINWEI LIU, MICHELE D'AMBROSIO, MICHELA PUXEDDU, ANASTASIA PARISI, JESSICA SEBASTIANI, ANDREA SORATO, Antonio COLUCCIA, SILVIA RIPA, FIORELLA DI PASTENA, DAVIDE CAPELLI, ROBERTA MONTANARI, DOMIZIANA MASCI, CHIARA NARO, Viviana ORLANDO, SARA D'ANGELO, Stefano BIAGIONI, ARIANNA PASTORE, Gianluca CANETTIERI, Romano SILVESTRI, GIUSEPPE LA REGINA
11573/1669754 - 2023 - RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo (01a Articolo in rivista)
JESSICA SEBASTIANI, MICHELA PUXEDDU, Marianna NALLI, LUDOVICA ALTIERI, FLAVIA SPRIANO, Cinzia FIONDA, DOMIZIANA MASCI, Federico Bertoni, Romano SILVESTRI, GIUSEPPE LA REGINA
11573/1604507 - 2021 - Discovery of a novel class of norovirus inhibitors with high barrier of resistance (01a Articolo in rivista)
MICHELA PUXEDDU, GIUSEPPE LA REGINA, JESSICA SEBASTIANI, Marianna NALLI, Romano SILVESTRI
11573/1554523 - 2021 - Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia (01a Articolo in rivista)
MICHELA PUXEDDU, Antonio COLUCCIA, MARIANNA BUFANO, Marianna NALLI, JESSICA SEBASTIANI, Viviana ORLANDO, Stefano BIAGIONI, Romano SILVESTRI, GIUSEPPE LA REGINA