IAKOV MOLAYEM

Dottore di ricerca

ciclo: XXXVI


supervisore: Prof. Roberto Gradini
relatore: Prof. Roberto Gradini

Titolo della tesi: Aromatase inhibitor consequences in breast cancer treatment: a “new” form of carpal tunnel syndrome?

Introduction: Female breast cancer was the leading cause of malignant tumor in 2020; about two-thirds of cases are hormone receptor positive: in these patients, aromatase inhibitors are a mainstay of treatment but associated musculoskeletal symptoms can negatively affect the compliance. Aromatase inhibitor induced carpal tunnel syndrome represents one of the main causes of aromatase inhibitor discontinuation, with non-compliance rate up to 67% and possible increase in cancer mortality. The aim of the study is to investigate estrogen receptor expression in its tissues, to better define etiopathogenesis and to derive preventive or therapeutic measures that can improve aromatase inhibitor patient compliance. Materials and methods: At the Jewish Hospital of Rome, between 2021 and 2023, we recruited 24 patients: 12 cases of aromatase inhibitor induced carpal tunnel syndrome (study group) and 12 of postmenopausal idiopathic carpal tunnel syndrome (control group). Each patient was evaluated with clinic visit, questionnaire, instrumental exams, serum hormone dosages and treated with open carpal tunnel release surgery, during which transverse carpal ligament and flexor tenosynovium samples were collected. Histological analysis was performed with particular attention to any pathological findings; for immunohistochemical experiments, sections were treated with anti-ERα and anti-ERβ antibodies. Results: Histological and immunohistochemical features in the study and control group are similar, demonstrating aromatase inhibitor induced carpal tunnel syndrome tissues as a target of direct estrogen action and correlating estrogen deprivation to disease etiogenesis. Surgery is effective in patient treatment. Conclusions: Aromatase inhibitor induced carpal tunnel syndrome is a disease form of new definition; it represents one of the main causes of aromatase inhibitor discontinuation, due to the negative impact on patient quality of life. Identification by clinicians of aromatase inhibitor use as a possible risk factor for carpal tunnel syndrome development is of essential importance: an early diagnosis and prompt management can improve patient compliance and, overall, breast cancer treatment results.

Produzione scientifica

11573/1692784 - 2023 - Benign and malignant tumors of the fingertip
Molayem, Iakov; Marcovici, Lucian Lior; Formica, Virginia; Pagnotta, Alessia - 02a Capitolo o Articolo
libro: An evidence-based approach to the fingertip diseases - (9789392819360)

11573/1692782 - 2023 - Microsurgery in hand non-union, bone necrosis, and bone loss of substance
Pagnotta, Alessia; Molayem, Iakov - 02a Capitolo o Articolo
libro: Reconstructive microsurgery of the hand - (978-88-3379-665-9)

11573/1692783 - 2023 - Microsurgery in wrist and hand non-union and bone necrosis
Pagnotta, Alessia; Molayem, Iakov; Tos, Pierluigi - 01a Articolo in rivista
rivista: MINERVA ORTHOPEDICS (Torino: Minerva medica) pp. 168-179 - issn: 2784-8469 - wos: WOS:001041764900002 (0) - scopus: 2-s2.0-85168327809 (1)

11573/1666420 - 2022 - 3D Carpal (Hand) Prosthesis
Pagnotta, Alessia; Molayem, Iakov - 02a Capitolo o Articolo
libro: 3D Printing in Bone Surgery - ()

11573/1666418 - 2022 - Extension Block Pinning Vs Single Kirshner Wiring To Treat Bony Mallet Finger. A Retrospective Study
Rocchi, Lorenzo; Fulchignoni, Camillo; De Vitis, Rocco; Molayem, Iakov; Caviglia, Daniele - 01a Articolo in rivista
rivista: ACTA BIOMEDICA (Fidenza, PR: Mattioli 1885) pp. - - issn: 2531-6745 - wos: (0) - scopus: 2-s2.0-85130442273 (0)

11573/1580664 - 2021 - A novel local adipofascial flap for the management of recalcitrant ulnar tunnel syndrome
Pagnotta, A.; Formica, V. M.; Marcovici, L. L.; Molayem, I.; Taglieri, E. - 01a Articolo in rivista
rivista: HAND SURGERY & REHABILITATION (Issy-les-Moulineaux : Elsevier Masson SAS) pp. 377-381 - issn: 2468-1229 - wos: WOS:000688563500003 (2) - scopus: 2-s2.0-85103972855 (3)

11573/1581429 - 2020 - Desmoplastic Fibroblastoma (Collagenous Fibroma): A Case Report.
Taccogna, Silvia; Ienzi, Sara; Molayem, Iakov; D’Angelo, Martina; Pagnotta, Alessia; Lippi, Basilio; Guarino, Margherita - 01a Articolo in rivista
rivista: ARCHIVES OF SURGERY AND SURGICAL EDUCATION (Herndon VA: Herald Scholarly Open Access, 2019-) pp. - - issn: 2689-3126 - wos: (0) - scopus: (0)

11573/1582854 - 2017 - Diagnostica per immagini nei pazienti affetti da morbo di Preiser
Lippi, Basilio; Guerrisi, Antonino; Del Monte, Stefano; Valentina Di Molfetta Giuseppe Gugliemo Aloise, Ippolita; Molayem, Iakov; Pagnotta, Alessia - 01a Articolo in rivista
rivista: IL GIORNALE ITALIANO DI RADIOLOGIA MEDICA () pp. - - issn: 2283-8376 - wos: (0) - scopus: (0)

11573/1581431 - 2017 - Osteochondral resurfacing in proximal row carpectomy.
Marcovici, Lucian Lior; Molayem, Iakov; Taglieri, Elena; Pagnotta, Alessia - 01a Articolo in rivista
rivista: RIVISTA DI CHIRURGIA DELLA MANO (Fidenza : Mattioli 1885, [2001]- .) pp. - - issn: 2384-8855 - wos: (0) - scopus: (0)

11573/1581422 - 2017 - The dorsoulnar artery perforator adipofascial flap in the treatment of distal radioulnar synostosis
Pagnotta, Alessia; Antonietti, Giorgio; Molayem, Iakov - 01i Case report
rivista: CASE REPORTS IN ORTHOPEDICS (Cairo: Hindawi Publishing Corporation) pp. 1-4 - issn: 2090-6749 - wos: (0) - scopus: (0)

11573/1581435 - 2016 - Ruolo della chirurgia plastica.
Pagnotta, Alessia; Taglieri, Elena; Molayem, Iakov; Marcovici, Lucian Lior - 02a Capitolo o Articolo
libro: Il trattamento del deficit osseo: metodi e procedure di ricostruzione. - (978-8893890021)

11573/1581418 - 2012 - Posterior interosseous artery distal radius graft for ulnar nonunion treatment
Pagnotta, A.; Taglieri, E.; Molayem, I.; Sadun, R. - 01a Articolo in rivista
rivista: JOURNAL OF HAND SURGERY (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 2605-2610 - issn: 0363-5023 - wos: WOS:000209089000029 (9) - scopus: 2-s2.0-84869414907 (10)

11573/1582856 - 2012 - Le lesioni osteocondrali della caviglia
Villani, C; Molayem, I; Marcovici, Ll; Persiani, P. - 02a Capitolo o Articolo
libro: Le patologie cartilaginee e legamentose della caviglia - ()

11573/1582881 - 2011 - Idrossiapatite: dall’adesione alla clinica [Hydroxyapatite: from adhesion to the clinics]
Villani, C.; Persiani, P.; Bove, M.; Molayem, I.; Marcovici, L. L. - 04c Atto di convegno in rivista
rivista: GIORNALE ITALIANO DI ORTOPEDIA E TRAUMATOLOGIA (Pisa : Pacini, 2000- Bologna : A. Gaggi, 1975-1999) pp. 109-112 - issn: 0390-0134 - wos: (0) - scopus: (0)
congresso: 96° congresso nazionale società italiana di ortopedia e traumatologia (Rimini)

11573/1582858 - 2011 - Complicanze nella chirurgia del piede neurologico dell’infanzia
Villani, C; Molayem, I; Marcovici, Ll; Martini, L. - 02a Capitolo o Articolo
libro: Complicanze nella chirurgia della caviglia e del piede - Prevenzione e trattamento - ()

11573/500969 - 2011 - Patologie neuromuscolari
Villani, Ciro; Persiani, Pietro; Molayem, I. - 02a Capitolo o Articolo
libro: ortopedia e traumatologia - ()

11573/1582860 - 2010 - La bella storia di Raffaele Paparella-Treccia
Romanini, L; Marcovici, Ll; Molayem, I. - 03a Saggio, Trattato Scientifico

11573/229050 - 2009 - Complications following correction of the planovalgus foot in cerebral palsy by arthroereisis
Molayem, Iakov; Persiani, Pietro; L. L., Marcovici; S., Rosi; Calistri, Alessandro; Villani, Ciro - 01a Articolo in rivista
rivista: ACTA ORTHOPAEDICA BELGICA (Association for the Society of Scientifique Medica Belgique:Weldadigheidsstraat 49, 3000 Leuven Belgium:011 32 16 232000, EMAIL: acta.cardiologica@chello.be, INTERNET: http://www.ulb.ac.be/medecine/loce/amb.htm, Fax: 011 32 16 231800) pp. 374-379 - issn: 0001-6462 - wos: WOS:000267608600014 (10) - scopus: 2-s2.0-68149156927 (14)

11573/229987 - 2008 - Hip subluxation and dislocation in cerebral palsy:outcome of bone surgery in 21 hips
Persiani, Pietro; Molayem, Iakov; Calistri, Alessandro; Rosi, S; Bove, M; Villani, Ciro - 01a Articolo in rivista
rivista: ACTA ORTHOPAEDICA BELGICA (Association for the Society of Scientifique Medica Belgique:Weldadigheidsstraat 49, 3000 Leuven Belgium:011 32 16 232000, EMAIL: acta.cardiologica@chello.be, INTERNET: http://www.ulb.ac.be/medecine/loce/amb.htm, Fax: 011 32 16 231800) pp. 609-614 - issn: 0001-6462 - wos: WOS:000260707000006 (2) - scopus: 2-s2.0-56249113351 (4)

11573/133014 - 2008 - Surgical treatment of congenital pseudarthrosis of the clavicle : A report on 17 cases
Persiani, Pietro; Molayem, Iakov; Villani, Ciro; C., Cadilhac; C., Glorion - 01a Articolo in rivista
rivista: ACTA ORTHOPAEDICA BELGICA (Association for the Society of Scientifique Medica Belgique:Weldadigheidsstraat 49, 3000 Leuven Belgium:011 32 16 232000, EMAIL: acta.cardiologica@chello.be, INTERNET: http://www.ulb.ac.be/medecine/loce/amb.htm, Fax: 011 32 16 231800) pp. 161-166 - issn: 0001-6462 - wos: WOS:000256232500002 (18) - scopus: 2-s2.0-43749120211 (27)

11573/1582879 - 2007 - Breve storia della fondazione della Clinica Ortopedica Universitaria e delle Scuole di Specializzazione della Scuola Romana della “Sapienza”
Romanini, Luigi; Molayem, Iakov - 02a Capitolo o Articolo
libro: Lavori scientifici di Medicina Fisica e Riabilitativa sperimentale - ()

11573/1582884 - 2007 - Osteogenesi imperfetta
Villani, Ciro; Persiani, Pietro; Bove, Marco; Martini, Lorena; Calistri, Alessandro; Rosi, Stefano; Molayem, Iakov; D'eufemia, Patrizia; Celli, Mauro; Zambrano, Anna - 03a Saggio, Trattato Scientifico

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma