Phd in MOLECULAR DESIGN AND CHARACTERIZATION FOR THE
PROMOTION OF HEALTH AND WELL-BEING: FROM DRUG TO FOOD

email: giancarlo.fabrizi@uniroma1.it
phone: +39 06 49693317
building: CU032
room: 6 - Piano III

Born in Roma, Giancarlo Fabrizi began his university training at the University of Roma where he obtained a Laurea summa cum laude in Pharmaceutical Chemistry in 1987 under the supervision of Prof. Cacchi. After doing his national service (1988-1989), from 1990 to 1994 he was researcher at the University of L’Aquila and, from 1994 to 2001, at the University “La Sapienza”, Rome. At the University “La Sapienza” he became Associate Professor of Organic Chemistry in 2001 and, subsequently (2011), full Professor of Organic Chemistry.
Dr. Fabrizi made a contribution in the field of organometallic chemistry, particularly in the utilization of palladium catalysis in organic synthesis, developing new and selective synthetic procedures directed towards the functionalization or preparation of complex molecules, with particular emphasis on the chemistry of molecules of biological interest.
His scientific contributions have involved the introduction of organotriflates in the Heck reaction and other palladium-catalyzed reactions such as carbonylation, reduction, Heck-Sonogashira-Cassar coupling of terminal alkynes; the development of oxy- and aminopalladation/reductive elimination protocols for the construction of functionalized heterocycles; pioneering work on the capture of carbopalladation adducts with nucleophiles which led to the development of hydroarylation and hydrovinylation reactions of alkenes and alkynes, including domino hydroarylation(hydrovinylation)/cyclization processes particularly suited for the synthesis of heterocycles; the development of various domino coupling/cyclization and vinylic substitution/cyclization procedures for the synthesis of heterocycles.
The development of environmentally friendly processes is also one of his main current scientific interests and some of his recent studies investigated the utilization of unusual media, such as supercritical carbon dioxide and ionic liquids, in palladium-catalyzed reactions. Recently, the utilization of nanoparticles based catalysts (palladium, gold) has been also proposed in conjunction with bioorganic processes. Dr. Fabrizi's work has been described in more than 160 scientific papers in professional journals and 3 patents. He has presented many talks throughout academia and industry and at numerous national and international meetings, and served as a frequent reviewer of a variety of international journals.