Research: Towards a novel docking algorithm: development of new computational methods for the investigation of the molecular mechanisms underlying the interaction among proteins
EDUCATION:
- PhD student in Life Science. University La Sapienza, in collaboration with the Center for Life Nanoscience & Neuro-Science, Fondazione Istituto Italiano di Tecnologia Viale Regina Elena 291, 00161 Rome, Italy (Rome, starting from November 2021).
- Master degree (English courses) in Applied Physics. University of Bologna, 110/110 cum laude (Bologna, September 2021).
Master degree thesis: A novel computational strategy for defining the minimal protein molecular surface representation.
Advisors: Prof. G.Ruocco, Prof. A.Bazzani. Co-advisors: Dr. E.Milanetti.
(Bologna University, Center for Life Nano-science & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy).
- Bachelor’s degree in Physics. University of Trieste, 104/110 (Trieste, September 2019).
Bachelor’s degree thesis: Causalità di Wiener-Granger applicata a serie temporali estratte da C. elegans.
Supervisors: Prof. E.Milotti, Prof. L.Rigon and Dr. V.Folli.
(Trieste University, Center for Life Nano-science & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy).
PUBLISHED PAPERS:
- Grassmann G, Miotto M, Di Rienzo L, Gosti G, Ruocco G, Milanetti E. A novel computational strategy for defining the minimal protein molecular surface representation. Plos ONE. 2022 April. https://doi.org/10.1371/journal.pone.0266004
- Grassmann G, Miotto M, Di Rienzo L, Salaris F, Silvestri B, Zacco E, Rosa A, Tartaglia GG, Ruocco G, Milanetti E. A Computational Approach to Investigate TDP-43 RNA-Recognition Motif 2 C-Terminal Fragments Aggregation in Amyotrophic Lateral Sclerosis. Biomolecules. 2021 Dec 19;11(12):1905. doi: 10.3390/biom11121905. PMID: 34944548; PMCID: PMC8699346.
- Grassmann G. Letter to the editor of Heliyon re: "New considerations on the validity of the Wiener-Granger causality test." Heliyon. 2020; 6(10): e05208
- Grassmann G. New considerations on the validity of the Wiener-Granger causality test. Heliyon, Volume 6, Issue 10 (2020).
https://doi.org/10.1016/j.heliyon.2020.e05208
SUBMITTED PAPERS:
- Miotto M, Di Rienzo L, Grassmann G, Desantis F, Gosti G, Leonetti M, Ruocco G, Milanetti E. Differences in the organization of interface residues tunes the stability of the SARS-CoV-2 spike-ACE2 complex.
(Under submission to Frontiers in Bioscience-Landmark)
- Di Rienzo L, Miotto M, Desantis F, Grassmann G, Ruocco G, Milanetti E. Dynamical Changes of SARS-Cov-2 Spike Variants in the Highly Immunogenic Regions Impact the Viral Antibodies Escaping.
(Under submission to Proteins: Structure, Function and Bioinformatics)
- Grassmann G, Miotto M, Di Rienzo L, Gosti G, Leonetti M, Ruocco G, Milanetti E. Electrostatic complementarity at the interface drives transient protein-protein interactions. arXiv:2208.09871
(Under submission to Scientific Reports)
OBTAINED FOUNDS:
- Progetti di Ricerca (Piccoli, Medi) - Progetti Piccoli (3000.00 €)
The role of the electrostatic contribution to the interface of protein complexes: a Zernike polynomial based method.
Milanetti E (PI), Grassmann G (December 2022)
TALK:
- Workshop on New Frontiers in Molecular Crowding: A computational approach to investigate TDP-43 RNA-Recognition Motif 2 C-Terminal fragments aggregation in Amyotrophic Lateral Sclerosis (ESRF Grenoble, June 2022)
POSTERS:
- XVI International Workshop on Complex Systems: Electrostatic complementarity evaluation at the protein interfaces: prediction of transient protein-protein interactions (Andalo, March 2023)
- Second DiSVA-MaSBiC Annual Symposium - Protein Structure and Function in Biology, Medicine and Nanotechnology: A computational approach for biomolecular binding characterization: TDP-43 C-terminal fragment aggregation in ALS (Ancona, October 2022)
- Workshop on New Frontiers in Molecular Crowding: A computational approach for biomolecular binding characterization: TDP-43 C-terminal fragment aggregation in ALS (ESRF Grenoble, June 2022)
- The I MASBIC-DISVA annual symposium: A computational approach to investigate TDP-43 C-terminal fragments aggregation in Amyotrophic Lateral Sclerosis (ALS). (Ancona, September 2021).
PROGRAMMING SKILLS:
- Matlab
- Python
- C++
LANGUAGES:
- English: IELTS certificate: overall band score: 8.0. CEFR level: C1. (Bologna, December 2020).
- German: basic.