GIUSEPPE PROCOPIO

Dottore di ricerca

ciclo: XXXV


supervisore: prof. Massimiliano Giona

Titolo della tesi: Hydrodynamic characterization of finite-sized particle transport in confined microfluidic systems, Brownian motion and stochastic modeling of particle transport at microscale.

In this thesis the peculiar effects of the hydrodynamic confinement on the dynamic of a colloid in Stokes regime has been addressed theoretically. Practical expressions, useful to investigate transport of particles in complex geometries, have been provided for force, torque and higher order moments on the particle and the disturbed velocity field of the fluid. To begin with, a new formulation of the Stokesian singularity method is developed by introducing a bitensorial distributional formalism. This formalism overcomes the ambiguities of the classical hydrodynamic formulation of the singularity method that limit its application in confined problems. The formalism proposed permits naturally to distinguish between poles and field points of tensorial singular fields and to clearly define each singularity from its associated Stokes problem, connecting singularities each other. As a consequence of this approach an explicit expression for the singularity operator is provided, giving the disturbance field due to a body once applied to an ambient flow of the fluid. The operator is expressed in terms of the volume moments and its expression is valid regardless the boundary conditions applied to the surface of the body. The dualism between the singularity operator giving the disturbance flow of a n-th order ambient flow and the n-th order Faxén operator has been investigated. It has been found that this dualism, referred to as the Hinch-Kim dualism, holds only if the boundary conditions satisfy a property that is referred to as the Boundary-Condition reciprocity (BC-reciprocity, for short). If this property is fulfilled, the Faxén operators can be expressed in terms of (m, n)-th order geometrical moments of volume forces (defined in the Chapter 3). In addition, it is shown that in these cases, the hydromechanics of the fluid-body system is completely determined by the entire system of the Faxén operators. Classical boundary conditions of hydrodynamic practice (involving slippage, fluid-fluid interfaces, porous materials, etc.) are investigated in the light of this property. It is found the analytical expression for the 0-th, 1-st and 2-nd Faxén operators for a sphere with Navier-slip boundary conditions. These results are applied in order to express the hydrodynamics of particles in confined fluids in terms of quantities related to the geometry of the particle and the geometry of the confinement separately using the reflection method. Specifically, closed-form results and practical expressions for the velocity field of the fluid and for the functional form of force and torque acting on a particle are derived in terms of: (i) the Faxén operators of the body of the particle (given by its unbounded geometrical moments) and (ii) the multi-poles in the domain of the confinement. The convergence of the reflection method is examined and it is found that the expressions obtained are also valid for distance between particle and walls of the confinement of the same magnitude order, failing only in the limit case of the lubrication range. The reflection solutions obtained with the present theory, approximated to the order O(lb /ld )^5 , are compared with the exact solution of a sphere near a planar wall, and the expressions for forces and torques considering the more general situation of Navier-slip boundary conditions on the body are provided. A general formulation of the fluctuation-dissipation relations in confined geome- tries, the paradoxes associated with no-slip boundary conditions close to a solid boundary, and the modal representation of the inertial kernels for complex fluids complete the present dissertation.

Produzione scientifica

11573/1705086 - 2024 - Initial management approach for localized/locally advanced disease is critical to guide metastatic castration-resistant prostate cancer care
Conteduca, Vincenza; Di Tullio, Piergiorgio; Allamprese, Rossana; Bruno, Giuseppina; Lolli, Cristian; Schepisi, Giuseppe; Rosano, Aldo; Giordano, Guido; Garofoli, Marianna; Chiuri, Vincenzo Emanuele; Fratino, Lucia; Zanardi, Elisa; Galli, Luca; Massari, Francesco; Falagario, Ugo; Rescigno, Pasquale; Fornarini, Giuseppe; Sanguedolce, Francesca; Santini, Daniele; Procopio, Giuseppe; Caffo, Orazio; Carrieri, Giuseppe; Landriscina, Matteo; De Giorgi, Ugo - 01a Articolo in rivista
rivista: PROSTATE CANCER AND PROSTATIC DISEASES (-LONDON:NATURE PUBLISHING GROUP. -Basingstoke: Stockton Press.) pp. - - issn: 1365-7852 - wos: WOS:001161055500002 (1) - scopus: 2-s2.0-85184928462 (1)

11573/1700983 - 2024 - Another normality is possible. Distributive transformations and emergent Gaussianity
Giona, Massimiliano; Pezzotti, Chiara; Procopio, Giuseppe - 01a Articolo in rivista
rivista: PHYSICA. A (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0378-4371 - wos: WOS:001147767500001 (1) - scopus: 2-s2.0-85180534735 (1)

11573/1724164 - 2024 - On the Hinch–Kim dualism between singularity and Faxén operators in the hydromechanics of arbitrary bodies in Stokes flows
Procopio, Giuseppe; Giona, Massimiliano - 01a Articolo in rivista
rivista: PHYSICS OF FLUIDS (American Institute of Physics:2 Huntington Quadrangle, Suite 1NO1:Melville, NY 11747:(800)344-6902, (631)576-2287, EMAIL: subs@aip.org, INTERNET: http://www.aip.org, Fax: (516)349-9704) pp. - - issn: 1070-6631 - wos: WOS:001182753500025 (0) - scopus: 2-s2.0-85187959850 (0)

11573/1724166 - 2024 - Thermodynamics of Irreversible Processes: Fundamental Constraints, Representations, and Formulation of Boundary Conditions
Procopio, Giuseppe; Pezzotti, Chiara; Cocco, Davide; Giona, Massimiliano - 01a Articolo in rivista
rivista: PHYSICS (Basel: MDPI, [2018]-) pp. 801-827 - issn: 2624-8174 - wos: (0) - scopus: (0)

11573/1674390 - 2023 - The fourfold way to Gaussianity. Physical Interactions, distributional models and monadic transformations
Giona, Massimiliano; Pezzotti, Chiara; Procopio, Giuseppe - 01a Articolo in rivista
rivista: AXIOMS (Basel : MDPI) pp. - - issn: 2075-1680 - wos: WOS:000954077800001 (2) - scopus: 2-s2.0-85151149611 (3)

11573/1663502 - 2023 - New formulation of the Navier–Stokes equations for liquid flows
Giona, Massimiliano; Procopio, Giuseppe; Adrover, Alessandra; Mauri, Roberto - 01a Articolo in rivista
rivista: JOURNAL OF NON-EQUILIBRIUM THERMODYNAMICS (Walter de Gruyter and Company:Genthinerstrasse 13, D 10785 Berlin Germany:011 49 30 260050, EMAIL: customerservice@deguyter.de, INTERNET: http://www.degruyter.de/, Fax: 011 49 30 26005338) pp. - - issn: 0340-0204 - wos: WOS:000898090600001 (4) - scopus: 2-s2.0-85144769728 (4)

11573/1673088 - 2023 - Modal representation of inertial effects in fluid–particle interactions and the regularity of the memory kernels
Procopio, Giuseppe; Giona, Massimiliano - 01a Articolo in rivista
rivista: FLUIDS (Basel: MDPI AG, 2016-) pp. - - issn: 2311-5521 - wos: WOS:000959970200001 (4) - scopus: 2-s2.0-85151147775 (4)

11573/1622165 - 2022 - Hydrodynamic Green functions. Paradoxes in unsteady Stokes conditions and infinite propagation velocity in incompressible viscous models
Giona, Massimiliano; Procopio, Giuseppe; Mauri, Roberto - 01a Articolo in rivista
rivista: MECCANICA (Berlin, New York: Springer London ; Dordrecht ; Boston : Kluwer Academic Publishers Milano : Tamburini Milano : AIMETA) pp. - - issn: 0025-6455 - wos: WOS:000769835500001 (3) - scopus: 2-s2.0-85126380322 (3)

11573/1620522 - 2022 - Stochastic modeling of particle transport in confined geometries. Problems and peculiarities
Procopio, Giuseppe; Giona, Massimiliano - 01a Articolo in rivista
rivista: FLUIDS (Basel: MDPI AG, 2016-) pp. - - issn: 2311-5521 - wos: WOS:000775507300001 (4) - scopus: 2-s2.0-85126943557 (5)

11573/1651830 - 2022 - Bitensorial formulation of the singularity method for Stokes flows
Procopio, Giuseppe; Giona, Massimiliano - 01a Articolo in rivista
rivista: MATHEMATICS IN ENGINEERING (Springfield Missouri: AIMS Press, 2018-) pp. 1-34 - issn: 2640-3501 - wos: WOS:000842875400001 (1) - scopus: 2-s2.0-85136939112 (1)

11573/1615982 - 2022 - Inertia-induced breakdown of acoustic sorting efficiency at high flow rates
Undvall, Eva; Garofalo, Fabio; Procopio, Giuseppe; Qiu, Wei; Lenshof, Andreas; Laurell, Thomas; Baasch, Thierry - 01a Articolo in rivista
rivista: PHYSICAL REVIEW APPLIED (College Park, MD : American Physical Society, [2014-]) pp. - - issn: 2331-7019 - wos: WOS:000767547400005 (4) - scopus: 2-s2.0-85126648999 (5)

11573/1628885 - 2022 - Comparison between one- and two-way coupling approaches for estimating effective transport properties of suspended particles undergoing Brownian sieving hydrodynamic chromatography
Venditti, Claudia; Cerbelli, Stefano; Procopio, Giuseppe; Adrover, Alessandra - 01a Articolo in rivista
rivista: PHYSICS OF FLUIDS (American Institute of Physics:2 Huntington Quadrangle, Suite 1NO1:Melville, NY 11747:(800)344-6902, (631)576-2287, EMAIL: subs@aip.org, INTERNET: http://www.aip.org, Fax: (516)349-9704) pp. - - issn: 1070-6631 - wos: WOS:000790490000002 (8) - scopus: 2-s2.0-85128822571 (8)

11573/1571242 - 2021 - Generalized reflection method for the stokes equation in confined geometries. Applications to microfluidics and particle transport
Procopio, G.; Adrover, A.; Giona, M. - 01a Articolo in rivista
rivista: CHEMICAL ENGINEERING TRANSACTIONS (Milano : Sauro Pierucci Milano : AIDIC) pp. 1153-1158 - issn: 2283-9216 - wos: (0) - scopus: 2-s2.0-85109493809 (0)

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