GIUSEPPE BARILARO

Dottore di ricerca

ciclo: XXXV


supervisore: Carlo della Rocca
relatore: Ricard Cervera Segura

Titolo della tesi: The role of antiphospholipid antibody pattern in the recurrence of thrombosis in patients with Antiphospholipid Syndrome

The antiphospholipid syndrome (APS) is a hypercoagulability condition of autoimmune origin clinically characterized by the development of arterial, venous and/or microvascular thrombosis and pregnancy complications (recurrent early miscarriages, fetal deaths after the 10th week of gestation and/or premature births) associated to the presence of antiphospholipid antibodies (aPL). It can occur either as an isolated condition (primary APS), or in the context of an underlying autoimmune disease, most commonly systemic lupus erythematosus (SLE). Three aPL are included in the current classification criteria: anti-cardiolipin IgG/IgM, anti-β2-glycoprotein I (β2GPI) IgG/IgM and lupus anticoagulant (LAC). Although several others have been identified, they are not tested in most laboratories. The standard of treatment is oral anticoagulation for thrombotic APS and prophylactic/therapeutic low molecular weight heparin plus low dose aspirin for obstetric APS. Nonetheless there is a high rate of recurrence of clinical manifestations in patients undergoing standard of care. Known risk factors for thrombotic recurrence are a previous arterial thrombosis, high risk aPL profiles such as triple aPL positivity and LA persistent positivity, association with SLE and presence of genetic and acquired risk factors for thrombosis. Moreover, aPL persistence over time seems to be associated with thrombotic recurrence, but data on the course of aPL tests over time are limited and mostly with a short follow-up. Recently a score system, named global APS score (GAPSS), that includes the three aPL plus anti-phosphatydilserine-prothrombin (aPS-PT) IgG/M, hypertension and dyslipidemia, has been proposed as a risk stratification tool for APS. Its “adjusted” (aGAPSS) does not include aPS-PT. Moreover, a score for measuring damage, named Damage Index for APS (DIAPS), has been devised. The aGAPSS is by its very nature dynamic, since both cardiovascular risk factors and aPL can change over time, and therefore needs to be monitored longitudinally at repeated time points. Furthermore, even though a disease activity index for APS is lacking, the aGAPSS, as a dynamic score that predispose to clinical manifestations, could be used a surrogate of disease activity and predictor of damage. Starting from these premises, the objective of my thesis has been to analyze the pattern of aPL persistence over time and its association with clinical manifestations and the role of longitudinal monitoring of the aGAPSS as a predictor of clinical recurrence and a surrogate of disease activity predicting damage accrual, in a cohort of patients with APS. In the first study we assessed the rate of aPL persistence in a cohort of 200 individuals with a diagnosis of APS. Median follow-up duration was 172.5 months (IQR 120-240). 56% of patients presented persistent aPL positivity, defined as positivity at medium-high titer in at least two thirds of total determinations. Higher aPL titers and multiple aPL positivity at baseline correlated with aPL persistence, while single aCL and LA positivity were associated with a transient aPL profile. Patients with persistent aPL presented a higher rate of recurrence of clinical manifestations (thrombosis and/or pregnancy morbidity) in comparison to patients with transient aPL (43.8% vs 23.9%) with an OR=2.48 (95% CI 1.34-4.58, p=0.003). The rate of thrombotic recurrence, analyzed separately, was also higher in patients with persistent aPL profile (40.2% vs 18.2%) with an OR=3.02 (95% CI 1.57-5.81, p<0.001). We therefore concluded that more than half of patients with APS maintained persistent aPL positivity over more than 14 years of follow-up. Multiple positivity at baseline increased the likelihood of aPL persistence in the follow-up. Persistent aPL increased the odds of thrombotic and thrombotic plus obstetric recurrence. In the second study we aimed to assess if the one-time aGAPSS measured at baseline, presented a different association with recurrence of thrombosis and/or pregnancy morbidity in comparison to the average aGAPSS over time, measured as a mean of up to 6 yearly measurements (in patients without recurrence) or up the event in patients with recurrence, and to the delta of the aGAPSS, computed as the difference between the aGAPSS before clinical recurrence (if present) or at the end of follow-up (in case of no clinical recurrence) and the basal aGAPSS. Only patients with at least three annual determinations of the aGAPSS were included. In more than half of patients under VKA therapy, we tested the percentage of time spent within the therapeutic range (TTR) to verify that there was no difference between patients with and without thrombotic recurrence. In our cohort of 200 APS patients, we found a higher baseline, mean and delta aGAPSS in patients with recurrence than patients without. Conversely, when comparing patients with thrombotic recurrence to patients with only obstetric recurrence, the baseline aGAPSS was not significantly different, while both the mean aGAPSS and the delta were significantly higher in the first group. The mean aGAPSS was higher in patients with arterial thrombotic recurrence than venous recurrence. TTR was similar in patients under VKA who did or did not present thrombotic recurrence. When performing a cox regression analysis to find the best cut-off value for predicting recurrence of clinical manifestations, a mean aGAPSS > 13 had the highest HR for the event. We therefore concluded that periodic, at least annual monitoring of aPL and cardiovascular risk factors gives a more realistic picture to stratify the risk of recurrence in APS patients and predispose preventive strategies. In the third study we tested if the mean aGAPSS over time, calculated in an identic fashion as the previous study, can be used as a predictor of damage accrual measured through DIAPS change during follow-up (calculated as the difference between the DIAPS at the end of follow-up and the basal DIAPS). aGAPSS showed a positive linear correlation with DIAPS change over time in the multivariate analysis. When comparing patients with high vs low damage accrual (setting a cut-off of 1 point of DIAPS increase during follow-up) we found that mean aGAPSS over time was higher in patients with high damage. Moreover, in the multivariate logistic regression analysis aGAPSS was a predictor of high damage accrual. Lastly, when analyzing the association between DIAPS and mortality, we found that baseline DIAPS correlated with increased odds of death during follow-up. We could therefore conclude that mean aGAPSS over time could serve as a predictor of damage accrual in APS patients. The overall conclusions of the present thesis are therefore that: 1. aPL persistence was associated with multiple positivity and higher aPL titers at baseline and correlated with recurrence of clinical manifestations. 2. aGAPSS longitudinal monitoring, assessed as a mean or delta, compared to one-time assessment of the score, better defined the risk for recurrence of clinical manifestations. A persistently high aGAPSS and an aGAPSS increasing over time were predictors of thrombotic recurrence. 3. Mean aGAPSS over time linearly correlated with DIAPS change and was associated with high damage. Considering its dynamic nature, it can be used as a surrogate of disease activity and a predictor of damage accrual in APS patients. 4. In light of our results results, periodic monitoring of aPL and cardiovascular risk factors is highly recommended in APS patients.

Produzione scientifica

11573/1675614 - 2023 - The adjusted global anti-phospholipid syndrome score as predictor of damage accrual measured by damage index for APS. A longitudinal study
Barilaro, G; Della Rocca, C; Esteves, A; Cervera, R; Espinosa, G - 01a Articolo in rivista
rivista: RHEUMATOLOGY (Oxford : Oxford University Press, 1999-) pp. 2211-2219 - issn: 1462-0324 - wos: WOS:000880341100001 (1) - scopus: 2-s2.0-85160970422 (1)

11573/1679175 - 2023 - Mortality and causes of death in systemic lupus erythematosus revisited
Barilaro, Giuseppe; Cervera, Ricard - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF INTERNAL MEDICINE (Amsterdam : Elsevier) pp. - - issn: 1879-0828 - wos: WOS:001018507400001 (0) - scopus: 2-s2.0-85152657989 (0)

11573/1671347 - 2023 - Predictive value of the adjusted global anti-phospholipida syndrome score on clinical recurrence in APS patients. A longitudinal study
Barilaro, Giuseppe; Esteves, Alexandra; Della Rocca, Carlo; Perez-Isidro, Albert; Araujo, Olga; Pires Da Rosa, Gilberto; Ruiz-Ortiz, Estibaliz; Tàssies Penella, Dolors; Viñas, Odette; Carles Reverter, Joan; Cervera, Ricard; Espinosa., Gerard - 01a Articolo in rivista
rivista: RHEUMATOLOGY (Oxford : Oxford University Press, 1999-) pp. 1576-1585 - issn: 1462-0324 - wos: WOS:000854225100001 (7) - scopus: 2-s2.0-85152156735 (6)

11573/1675609 - 2023 - Twelve-month clinical, functional, and radiological outcomes in patients hospitalized for SARS-CoV-2 pneumonia
Bongiovanni, Marco; Barilaro, Giuseppe; Bini, Francesco - 01a Articolo in rivista
rivista: JOURNAL OF MEDICAL VIROLOGY (New York, NY : Wiley-Liss) pp. - - issn: 1096-9071 - wos: WOS:001034949300065 (3) - scopus: 2-s2.0-85148609178 (3)

11573/1679176 - 2023 - Fluctuation of Anti-Domain 1 and Anti-β2 -Glycoprotein I Antibody Titers Over Time in Patients With Persistently Positive Antiphospholipid Antibodies
Chighizola, Cecilia B; Pregnolato, Francesca; Andrade, Danieli; Tektonidou, Maria; Pengo, Vittorio; Ruiz-Irastorza, Guillermo; Belmont, H Michael; Gerosa, Maria; Fortin, Paul; Branch, D Ware; Andreoli, Laura; Petri, Michelle A; Cervera, Ricard; Knight, Jason S; Willis, Rohan; Efthymiou, Maria; Cohen, Hannah; Erkan, Doruk; Bertolaccini, Maria Laura; Barilaro, Giuseppe. - 01a Articolo in rivista
rivista: ARTHRITIS & RHEUMATOLOGY (Malden, MA : John Wiley & Sons, [2014]-) pp. - - issn: 2326-5205 - wos: WOS:000962312600001 (4) - scopus: 2-s2.0-85152452844 (5)

11573/1675607 - 2023 - Anti-NET antibodies in antiphospholipid antibody-positive patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository
Zuo, Yu; Navaz, Sherwin; Tsodikov, Alex; Kmetova, Katarina; Kluge, Lyndsay; Ambati, Amala; K Hoy, Claire; Yalavarthi, Srilakshmi; De Andrade, Danieli; G Tektonidou, Maria; Sciascia, Savino; Pengo, Vittorio; Ruiz-Irastorza, Guillermo; Michael Belmont, H; Gerosa, Maria; R Fortin, Paul; Ramires De Jesus, Guilherme; Ware Branch, D; Andreoli, Laura; Rodriguez-Almaraz, Esther; Petri, Michelle; Cervera, Ricard; Willis, Rohan; R Karp, David; Li, Quan-Zhen; Cohen, Hannah; Laura Bertolaccini, Maria; Erkan, Doruk; S Knight, Jason; Barilaro, Giuseppe - 01a Articolo in rivista
rivista: ARTHRITIS & RHEUMATOLOGY (Malden, MA : John Wiley & Sons, [2014]-) pp. - - issn: 2326-5205 - wos: WOS:000992539300001 (18) - scopus: 2-s2.0-85159683587 (20)

11573/1436680 - 2022 - Sensitization to Gibberellin-regulated protein (Peamaclein) among Italian cypress pollen-sensitized patients
Asero, R; Abbadessa, S; Aruanno, A; Barilaro, G; Barzaghi, C; Bignardi, D; Bilò, M B; Borro, M; Bresciani, M; Busa, M; Buzzulini, F; Cavaliere, C; Cecchi, L; Ciccarelli, A; Cortellini, G; Cucinelli, F; Deleonardi, G; Emiliani, F; Farsi, A; Ferrarini, E; Franchini, M; Ingrassia, A; Lippolis, D; Losappio, L; Marra, A M; Martini, M; Masieri, S; Mauro, M; Mazzolini, M; Muratore, L; Murzilli, F; Nucera, E; Pastorello, E A; Pinter, E; Polillo, B R; Pravettoni, V; Quercia, O; Rizzi, A; Russello, M; Sacerdoti, C; Scala, E; Scala, G; Scarpa, A; Schroeder, J; Uasuf, G G; Villalta, D; Yang, B; Mistrello, G; Amato, S; Lidholm, J - 01a Articolo in rivista
rivista: JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY (Prous Science Publishers:Provenza 388, 08025 Barcelona Spain:011 34 3 4592220, EMAIL: service@prous.com, INTERNET: http://www.prous.com, Fax: 011 34 3 4581535) pp. 40-47 - issn: 1018-9068 - wos: WOS:000759630500005 (12) - scopus: 2-s2.0-85125013428 (15)

11573/1675634 - 2022 - Early Prediction of Adverse Pregnancy Outcome in Women with Systemic Lupus Erythematosus, Antiphospholipid Syndrome, or Non-Criteria Obstetric Antiphospholipid Syndrome
Baños, Núria; Susana Castellanos Gutierrez, Aleida; Barilaro, Giuseppe; Figueras, Francesc; Maria Lledo, Gema; Santana, Marta; Espinosa, Gerard - 01a Articolo in rivista
rivista: JOURNAL OF CLINICAL MEDICINE (Salerno : Momento Medico) pp. - - issn: 2240-0109 - wos: WOS:000887356700001 (0) - scopus: 2-s2.0-85142381775 (0)

11573/1675617 - 2022 - Systemic sclerosis and pregnancy outcomes. A retrospective study from a single center
Barilaro, G; Castellanos, A; Gomez-Ferreira, I; Lledó, Gm; Della Rocca, C; Fernandez-Blanco, L; Cervera, R; Baños, N; Figueras, F; Espinosa, G - 01a Articolo in rivista
rivista: ARTHRITIS RESEARCH & THERAPY (BioMed Central. London) pp. - - issn: 1478-6354 - wos: WOS:000788321300001 (1) - scopus: 2-s2.0-85128933025 (2)

11573/1675638 - 2022 - Persistence of antiphospholipid antibodies over time and its association with recurrence of clinical manifestation. A longitudinal study from a single centre
Barilaro, G; Coloma-Bazan, E; Chacur, A; Della Rocca, C; Perez-Isidro, A; Ruiz-Ortiz, E; Viñas, O; Tàssies Penella, D; Reverter, Jc; Molina Andujar, A; Cervera, Ricard Segura; Espinosa, G - 01g Articolo di rassegna (Review)
rivista: AUTOIMMUNITY REVIEWS (Amsterdam; London; New York; Oxford; Paris; Shannon; Tokyo: Elsevier Oxford: Elsevier Science) pp. - - issn: 1568-9972 - wos: WOS:000871020500001 (2) - scopus: 2-s2.0-85139278061 (2)

11573/1675615 - 2022 - Impact of the COVID-19 pandemic on multidrug-resistant hospital-acquired bacterial infections
Bongiovanni, M; Barilaro, G; Zanini, U; Giuliani, G - 01a Articolo in rivista
rivista: JOURNAL OF HOSPITAL INFECTION (London: Academic Press, c1980-) pp. 191-192 - issn: 1532-2939 - wos: WOS:000830108900031 (13) - scopus: 2-s2.0-85129285300 (14)

11573/1679173 - 2022 - The presence of non-criteria manifestations negatively affects the prognosis of seronegative antiphospholipid syndrome patients: a multicenter study
Da Rosa, Gilberto Pires; Sousa-Pinto, Bernardo; Ferreira, Ester; Araújo, Olga; Barilaro, Giuseppe; Bettencourt, Paulo; Cervera, Ricard; Espinosa, Gerard - 01a Articolo in rivista
rivista: ARTHRITIS RESEARCH & THERAPY (editore BioMed Central) pp. 9- - issn: 1478-6362 - wos: WOS:000737973800006 (4) - scopus: 2-s2.0-85122178947 (4)

11573/1675613 - 2022 - Immunosuppression use in primary antiphospholipid antibody-positive patients: Descriptive analysis of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ("Registry")
Erton, Zb; K Leaf, R; De Andrade, D; Clarke, Ae; Tektonidou, Mg; Pengo, V; Sciascia, S; Ugarte, A; Belmont, Hm; Gerosa, M; Fortin, Pr; Lopez-Pedrera, C; Atsumi, T; Zhouli, Z; Cohen, H; Ramires De Jesus, G; Branch, Dw; Wahl, D; Andreoli, L; Rodriguez-Almaraz, E; Petri, M; Barilaro, G; Erkan, D - 01a Articolo in rivista
rivista: LUPUS (Macmillan Magazines Limited:Porters South Crinian Street, London N1 9XW United Kingdom:011 44 207 8334000, 011 44 171 8434982, Fax: 011 44 207 812358) pp. - - issn: 0961-2033 - wos: WOS:000865139600001 (3) - scopus: 2-s2.0-85139506342 (3)

11573/1675687 - 2022 - FRAGILE-COLCOVID19: A Clinical Trial Based on Early Administration of an Oral Combination of Colchicine and Prednisone in Elderly Patients with COVID-19 in Geriatric Facilities
Hernández-Rodríguez, J; Durán-Sanclemente, J; Prieto-González, S; Araújo, O; Hospital-Vidal, T; Casanovas, G; Sapena, V; Blanco, Jl; López-Soto, A; Fragile-Colcovid19 Study, Group; Barilaro, G. - 01a Articolo in rivista
rivista: CLINICAL DRUG INVESTIGATION (Adis International Limited:Private Bag 65901, Mairangi Bay, Auckland 1311 New Zealand:011 64 9 4770741, EMAIL: subs@adis.com, david.herrick@adis.co.nz, INTERNET: http://www.adis.com, Fax: 011 64 9 4770766) pp. - - issn: 1173-2563 - wos: WOS:000863185700001 (0) - scopus: 2-s2.0-85139113674 (0)

11573/1585584 - 2021 - Obstetric outcomes in systemic sclerosis: looking inside the sealed box
Barilaro, G.; Della Rocca, C.; Espinosa, G. - 01f Lettera, Nota
rivista: RHEUMATOLOGY INTERNATIONAL (Berlin; Heidelberg: Springer.) pp. 921-922 - issn: 1437-160X - wos: WOS:000691960200001 (2) - scopus: 2-s2.0-85114020163 (2)

11573/1586201 - 2021 - Pre-exposure prophylaxis with hydroxychloroquine for COVID-19: a double-blind, placebo-controlled randomized clinical trial
Grau-Pujol, Berta; Camprubí-Ferrer, Daniel; Marti-Soler, Helena; Fernández-Pardos, Marc; Carreras-Abad, Clara; Andrés, Maria Velasco-De; Ferrer, Elisabet; Muelas-Fernandez, Magdalena; Jullien, Sophie; Barilaro, Giuseppe; Ajanovic, Sara; Vera, Isabel; Moreno, Laura; Gonzalez-Redondo, Eva; Cortes-Serra, Núria; Roldán, Montserrat; Arcos, Ana Artes-De; Mur, Isabel; Domingo, Pere; Garcia, Felipe; Guinovart, Caterina; Muñoz, Jose - 01l Trial clinico
rivista: TRIALS (London : BioMed Central) pp. - - issn: 1745-6215 - wos: WOS:000718825900001 (9) - scopus: 2-s2.0-85119080760 (10)

11573/1586205 - 2019 - Cooking influence in tolerance acquisition in egg-induced acute food protein enterocolitis syndrome
Miceli Sopo, S.; Romano, A.; Bersani, G.; Fantacci, C.; Badina, L.; Longo, G.; Monti, G.; Viola, S.; Tripodi, S.; Barilaro, G.; Iacono, I. D.; Caffarelli, C.; Mastrorilli, C.; Barni, S.; Mori, F.; Liotti, L.; Cuomo, B.; Franceschini, F.; Viggiano, D.; Monaco, S. - 01a Articolo in rivista
rivista: ALLERGOLOGIA ET IMMUNOPATHOLOGIA (Editorial Garsi SA:Ronda General Mitre 149-151, 08022 Barcelona Spain:011 34 3 2530517, Fax: 011 34 3 2530515) pp. 221-226 - issn: 0301-0546 - wos: WOS:000466999000004 (11) - scopus: 2-s2.0-85054463913 (15)

11573/1675611 - 2018 - Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review
Atzeni, F.; Gerardi, M. C.; Barilaro, G.; Masala, I. F.; Benucci, M.; Sarzi-Puttini, P. - 01a Articolo in rivista
rivista: EXPERT REVIEW OF CLINICAL IMMUNOLOGY (--London, United Kingdom: Expert Reviews Ltd -London : Future Drugs. 2005-) pp. 69-82 - issn: 1744-666X - wos: WOS:000426916800007 (54) - scopus: 2-s2.0-85037729900 (64)

11573/1675632 - 2018 - From autoinflammation to autoimmunity: old and recent findings
Caso, F.; Costa, L.; Nucera, V.; Barilaro, G.; Masala, I. F.; Talotta, R.; Caso, P.; Scarpa, R.; Sarzi-Puttini, P.; Atzeni, F. - 01a Articolo in rivista
rivista: CLINICAL RHEUMATOLOGY (-Heidelberg : Springer, -Brussels : Acta Medica Belgica, [1982-) pp. 2305-2321 - issn: 0770-3198 - wos: WOS:000441845200001 (31) - scopus: 2-s2.0-85049936200 (38)

11573/906828 - 2017 - In systemic sclerosis skin perfusion of hands is reduced and may predict the occurrence of new digital ulcers
Barbano, Biagio; Marra, Alessandro Maria; Quarta, Silvia; Gigante, Antonietta; Barilaro, Giuseppe; Gasperini, Maria Ludovica; Rosato, Edoardo - 01a Articolo in rivista
rivista: MICROVASCULAR RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 1-4 - issn: 0026-2862 - wos: WOS:000392560500001 (14) - scopus: 2-s2.0-84994700870 (13)

11573/1675635 - 2017 - The role of hyperbaric oxygen therapy in orthopedics and rheumatological diseases
Barilaro, G.; Masala, I. F.; Parracchini, R.; Iesu, C.; Caddia, G.; Sarzi-Puttini, P.; Atzeni, F. - 01a Articolo in rivista
rivista: ISRAEL MEDICAL ASSOCIATION JOURNAL (Ramat Gan, Israel : The Association, c1999) pp. 429-434 - issn: 1565-1088 - wos: WOS:000407870300008 (12) - scopus: 2-s2.0-85026834789 (12)

11573/926594 - 2016 - ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review
Barilaro, Giuseppe; Spaziani Testa, Claudia; Cacciani, Antonella; Donato, Giuseppe; Dimko, Mira; Mariotti, Amalia - 01a Articolo in rivista
rivista: IMMUNOLOGIC RESEARCH (Humana Press Incorporated:999 Riverview Drive, Suite 208:Totowa, NJ 07512:(973)256-1699, EMAIL: lglasner@humanapr.com, INTERNET: http://www.humanapress.com, Fax: (973)256-8341 Basel ; New York : S. Karger, [c1986-) pp. 1142-1149 - issn: 0257-277X - wos: WOS:000389191800004 (9) - scopus: 2-s2.0-84991288286 (19)

11573/1096288 - 2016 - "Delirium Day": a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool
Bellelli, Giuseppe; Morandi, Alessandro; Di Santo, Simona G.; Mazzone, Andrea; Cherubini, Antonio; Mossello, Enrico; Bo, Mario; Bianchetti, Angelo; Rozzini, Renzo; Zanetti, Ermellina; Musicco, Massimo; Ferrari, Alberto; Ferrara, Nicola; Trabucchi, Marco; Boffelli, Stefano; Stefano, Fabio Di; Filippi, Francesco De; Guerini, Fabio; Bertoletti, Erik; March, Albert; Margiotta, Alessandro; Mecocci, Patrizia; Addesi, Desireè; Fantò, Fausto; Dijik, Babette; Porrino, Paola; Cotroneo, Antonino Maria; Galli, Giovanni; Bruni, Amalia Cecilia; Bernardini, Bruno; Corsini, Carla; Cagnin, Annachiara; Zurlo, Amedeo; Barbagallo, Giuseppe; Lunardelli, Maria Lia; Martini, Emilio; Battaglia, Giuseppe; Latella, Raffaele; Petritola, Donatella; Sinforiani, Elena; Cester, Alberto; Formilan, Marino; Carbone, Pasqualina; Appollonio, Ildebrando; Cereda, Diletta; Tremolizzo, Lucio; Bottacchi, Edo; Lucchetti, Lucio; Mariani, Claudio; Rapazzini, Piero; Romanelli, Giuseppe; Marengoni, Alessandra; Zuliani, Giovanni; Bianchi, Lara; Suardi, Teresa; Muti, Ettore; Bottura, Renato; Sgrò, Giovanni; Mandas, Antonella; Serchisu, Luca; Crippa, Patrizia; Ivaldi, Claudio; Ungar, Andrea; Villani, Daniele; Raimondi, Clara; Mussi, Chiara; Isaia, Giancarlo; Provenzano, Giuseppe; Mari, Daniela; Odetti, Patrizio; Monacelli, Fiammetta; Incalzi, Raffaele Antonelli; Pluderi, Alice; Bellamoli, Claudio; Terranova, Luciano; Scarpini, Elio; D'amico, Ferdinando; Cavallini, Maria Chiara; Guerrini, Gianbattista; Scotuzzi, Anna Maria; Chiarello, Antonino; Pilotto, Alberto; Tognini, Sara; Dell'aquila, Giuseppina; Toigo, Gabriele; Ceschia, Giuliano; Piccinini, Maristella; Fabbo, Andrea; Zoli, Marco; Forti, Paola; Wenter, Christian; Basile, Giorgio; Lasagni, Anna; Padovani, Alessandro; Rozzini, Luca; Cottino, Maria; Vitali, Silvia; Tripi, Gabriele; Avanzi, Stefano; Annoni, Giorgio; Ruotolo, Giovanni; Boschi, Federica; Bonino, Paolo; Marchionni, Niccolo; Fascendini, Sara; Noro, Gabriele; Turco, Renato; Ubezio, Maria C.; Serrati, Carlo; Infante, Maria; Gentile, Simona; Pernigotti, Luigi M.; Biagini, Carlo A.; Canonico, Enzo; Bonati, Pietro; Gareri, Pietro; Caffarra, Paolo; Ceretti, Arcangelo; Castiglia, Rosanna; Gabelli, Carlo; Storto, Mario Lo; Putzu, Paolo; Santo, Simona Di; Malara, Alba; Spadea, Fausto; Di Cello, Serena; Ceravolo, Francesco; Fabiano, Francesco; Rispoli, Vincenzo; Chiaradia, Giuseppe; Gabriele, Amedeo; Settembrini, Vincenzo; Capomolla, Domenico; Citrino, Antonella; Scriva, Antonietta; Bruno, Irene; Secchi, Roberto; De Martino, Eugenio; Muccinelli, Roberto; Lupi, Gerardo; Paonessa, Patrizio; Fabbri, Andrea; Castellari, Sofia; Po, Andrea; Gaggioli, Guido; Varesi, Massimo; Moneti, Paolo; Capurso, Sebastiano; Latini, Vincenzo; Ghidotti, Stefano; Riccardelli, Francesco; Macchi, Maurizio; Boffelli, Stefano; Cassinadri, Angela; Tonini, Gabriele; Andreani, Laura; Coralli, Mirco; Balotta, Antonio; Cancelliere, Roberto; Strazzacapa, Mara; Cavallino, Pierangela; Fabio, Stefano; De Filippi, Francesco; Giudice, Chiara; Floris, Patrizia; Dentizzi, Cosimo; D’Elia, Katia; Azzini, Margherita; Cazzadori, Marco; Benati, Claudia; Tobaldini, Chiara; Antonioli, Angela; Guerini, Fabio; Mombelloni, Paolo; Fontanini, Fulvio; Oliverio, Martina; Del Grosso, Luciano; Giavedoni, Cristina; Bidoli, Giuliano; Mazzei, Bruno; Corsonello, Andrea; Fusco, Sergio; Vena, Silvio; De Vuono, Tommaso; Maiuri, Giorgio; Castegnaro, Eugenio; De Rosa, Salvatore; Sechi, Rossella Bazzano; Benvenuti, Enrico; Del Lungo, Ilaria; Giardini, Sante; Giulietti, Chiara; Bertoletti, Erik; D’Amico, Ferdinando; Caronzolo, Francesco; Grippa, Alessandro; Lombardo, Giuseppina; Pipicella, Tiziana; March, Albert; Nitti, Maria Teresa; Felici, Alessandro; Pavan, Silvia; Piazzani, Fabrizio; Lunelli, Alessandra; Dimori, Sergio; Magnani, Angelo; Margiotta, Alessandro; Soglia, Tiziano; Postacchini, Demetrio; Brunelli, Roberto; Santini, Silvia; Francavilla, Monia; Macchiati, Ilenia; Sorvillo, Fr - 01a Articolo in rivista
rivista: BMC MEDICINE (London : BioMed Central, 2003-) pp. - - issn: 1741-7015 - wos: WOS:000379738700001 (160) - scopus: 2-s2.0-84978827758 (175)

11573/899512 - 2016 - Serum uric acid as a marker of microvascular damage in systemic sclerosis patients
Gigante, Antonietta; Barbano, Biagio; Barilaro, Giuseppe; Quarta, Silvia; Gasperini, Maria Ludovica; Di Mario, Francesca; Romaniello, Antonella; Amoroso, Antonio; Cianci, Rosario; Rosato, Edoardo - 01a Articolo in rivista
rivista: MICROVASCULAR RESEARCH (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 39-43 - issn: 0026-2862 - wos: WOS:000376471900007 (20) - scopus: 2-s2.0-84961644368 (19)

11573/899592 - 2016 - Left ventricular mass and intrarenal arterial stiffness as early diagnostic markers in cardiorenal syndrome type 5 due to systemic sclerosis
Gigante, Antonietta; Barilaro, Giuseppe; Barbano, Biagio; Romaniello, Antonella; Di Mario, Francesca; Quarta, Silvia; Gasperini, Maria Ludovica; Di Lazzaro Giraldi, Gianluca; Laviano, Alessandro; Amoroso, Antonio; Cianci, Rosario; Rosato, Edoardo - 01a Articolo in rivista
rivista: CARDIORENAL MEDICINE (Basel : S. Karger, 2011-) pp. 135-142 - issn: 1664-3828 - wos: WOS:000371448600006 (3) - scopus: 2-s2.0-84974604664 (4)

11573/833234 - 2016 - In systemic sclerosis prolonged QTc interval is associated with reduced exercise tolerance.
Gigante, Antonietta; Rosato, Edoardo; Liberatori, Marta; Sardo, Liborio; Di Paolo, Marcello; Marinelli, Paolo; Barilaro, Giuseppe; Palange, Paolo; Amoroso, Antonio; Tubani, Luigi - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF CARDIOLOGY (Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114) pp. 570-572 - issn: 0167-5273 - wos: WOS:000367007200146 (3) - scopus: 2-s2.0-84952898747 (5)

11573/899526 - 2016 - Lung ultrasound in systemic sclerosis: correlation with high-resolution computed tomography, pulmonary function tests and clinical variables of disease
Gigante, Antonietta; Rossi Fanelli, Filippo; Lucci, Silvio; Barilaro, Giuseppe; Quarta, Silvia; Barbano, Biagio; Giovannetti, Antonello; Amoroso, Antonio; Rosato, Edoardo - 01a Articolo in rivista
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia Roma : CEPI) pp. 213-217 - issn: 1828-0447 - wos: WOS:000373634000008 (51) - scopus: 2-s2.0-84959861949 (59)

11573/808927 - 2015 - Eosinophilic granulomatosis with polyangiitis (EGPA) and PRES: a case-based review of literature in ANCA-associated vasculitides
Marra, Alessandro Maria; Barilaro, Giuseppe; Villella, Valeria; Granata, Massimo - 01a Articolo in rivista
rivista: RHEUMATOLOGY INTERNATIONAL (Heidelberg Germany: Springer Verlag Germany) pp. - - issn: 0172-8172 - wos: WOS:000359834200021 (4) - scopus: 2-s2.0-84939473865 (6)

11573/555549 - 2014 - Silicone-induced hypercalcemia in a patient who underwent sex reassignment surgery
Barilaro, Giuseppe; Cacciani, A; Spazioni Testa, C; Granata, Guido; Tenuta, Marta; Marra, Alessandro Maria; Villella, Valeria; Dimko, M; Mariotti, A; Granata, Massimo; Donato, Giuseppe - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia) pp. 34-34 - issn: 1970-9366 - wos: (0) - scopus: (0)
congresso: congresso SIMI (Roma)

11573/555552 - 2014 - Haart therapy and nephrotoxic agents, an issue not to be neglected!
Barilaro, Giuseppe; Granata, Guido; Tenuta, Marta; Marra, Alessandro Maria; Villella, Valeria; Leone, M; Cacciani, A; Granata, Massimo; Asllanaj, B; Mariotti, A; Donato, G. - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia) pp. 34-35 - issn: 1970-9366 - wos: (0) - scopus: (0)
congresso: congresso SIMI (Roma)

11573/555555 - 2014 - An immunodeficiency ….turning pale!
Granata, Guido; Tenuta, Marta; Barilaro, Giuseppe; Marra, Alessandro Maria; Villella, Valeria; Spaziani Testa, C; Leone, M; Granata, Massimo; Cacciani, A; Donato, Giuseppe - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia) pp. 121-121 - issn: 1970-9366 - wos: (0) - scopus: (0)
congresso: congresso SIMI (Roma)

11573/555558 - 2014 - Posterior reversibile encephalopathy syndrome
Marra, Alessandro Maria; Villella, Valeria; Barilaro, Giuseppe; Granata, Guido; Colantuono, Stefania; Cacciani, A; Donato, Giuseppe; Granata, Massimo - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia) pp. 126-126 - issn: 1970-9366 - wos: (0) - scopus: (0)
congresso: congresso SIMI (Roma)

11573/808929 - 2014 - A curious case of type 2 APS
Tenuta, Marta; Barilaro, Giuseppe; Granata, Guido; Marra, Alessandro Maria; Spaziani Testa, Claudia; Villella, Valeria; Molinaro, Ilenia; Colantuono, Stefania; Granata, Massimo - 04b Atto di convegno in volume
congresso: 115 th National Congress of the Italian Society of Internal Medicine, (Rome)
libro: Atti del 115 th National Congress of the Italian Society of Internal Medicine, - ()

11573/555560 - 2014 - When the imaging is …misleading.
Tenuta, Marta; Granata, Guido; Villella, Valeria; Marra, Alessandro Maria; Barilaro, Giuseppe; Leone, M; Spaziani Testa, Claudia; Granata, Massimo; Cacciani, A; Donato, Giuseppe - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia) pp. 140-140 - issn: 1970-9366 - wos: (0) - scopus: (0)
congresso: congresso SIMI (Roma)

11573/555561 - 2014 - Acute kidney injury: nsaids abuse or more?
Villella, Valeria; Marra, Alessandro Maria; Granata, Guido; Barilaro, Giuseppe; La Marra, Fabiola; Migliozzi, Elisa; Tenuta, Marta; Cacciani, A; Donato, Giuseppe; Granata, Massimo - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia) pp. 141-141 - issn: 1970-9366 - wos: (0) - scopus: (0)
congresso: Congresso SIMI (Roma)

11573/555562 - 2014 - A case of renal tubular acidosis in sjogren syndrome
Villella, Valeria; Marra, Alessandro Maria; Molinaro, Ilenia; Granata, Guido; Barilaro, Giuseppe; Tenuta, Marta; Cacciani, A; Donato, Giuseppe; Granata, Massimo - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia) pp. 141-142 - issn: 1970-9366 - wos: (0) - scopus: (0)
congresso: congresso SIMI (Roma)

11573/1675618 - 2011 - Acquired and Inherited Thrombophilia Disorders in Pregnancy
Pierangeli, S. S.; Leader, B.; Barilaro, G.; Willis, R.; Branch, D. W. - 01a Articolo in rivista
rivista: OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA (W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. 271-295 - issn: 0889-8545 - wos: (0) - scopus: 2-s2.0-79955966231 (20)

11573/494732 - 2010 - VASCULAR RISK FACTORS IN YOUNG PEOPLE: RESULTS FROM AN OBSERVATIONAL STUDY
Arturo, Consoli; L., Zeppilli; Di Mascio, Maria Teresa; Carbotta, Giovanni; Barilaro, Giuseppe; Lucchetti, Pietro; G., Causarano; Toni, Danilo; Sacchetti, Maria Luisa; S., Vidale - 04b Atto di convegno in volume
congresso: 78th Congress of the European-Atherosclerosis-Society (Hamburg, GERMANY)

11573/53407 - 2010 - BASILAR TYPE-MIGRAINE
Barilaro, Giuseppe; Sconci, Francesca Romana; Stifano, Giuseppina; Marra, Alessandro Maria; Granata, Guido; Granata, Massimo; Donato, Giuseppe - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia Roma : CEPI) pp. - - issn: 1828-0447 - wos: (0) - scopus: (0)
congresso: 111° Congresso Nazionale SIMI (Roma)
libro: Internal and Emergency Medicine - ()

11573/494726 - 2010 - Stroke awareness and vascular risk factors in youngsters: an observational study of the Italian Association against Stroke
Consoli, A; Zeppilli, L; Di Mascio, Mt; Carbotta, Giovanni; Barilaro, G; Lucchetti, P; Causarano, G; Toni, Danilo; Sacchetti, Maria Luisa; Vidale, S. - 04d Abstract in atti di convegno
rivista: JOURNAL OF NEUROLOGY (Heidelberg Germany: Springer Verlag) pp. 200-201 - issn: 0340-5354 - wos: WOS:000277955200586 (0) - scopus: (0)

11573/59775 - 2010 - ENDOCARDITIS AND LYMPHOMA: WHAT IS THE THERAPY ?
Stifano, Giuseppina; Granata, Guido; Feola, A; Marra, Alessandro Maria; Barilaro, Giuseppe; Donato, Giuseppe; Granata, Massimo - 04d Abstract in atti di convegno
rivista: INTERNAL AND EMERGENCY MEDICINE (Milano : Springer Verlag Italia Roma : CEPI) pp. - - issn: 1828-0447 - wos: (0) - scopus: (0)
congresso: 111° Congresso Nazionale SIMI (Roma)
libro: Internal And Emergency Medicine - ()

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