GIULIA POMATI

Dottoressa di ricerca

ciclo: XXXV


supervisore: Prof.ssa Silvia Mezi
relatore: Prof. Giulia D'Amati

Titolo della tesi: The predictive role of immune profile in patients with solid tumours in treatment with immunotherapy: a network analysis of efficacy and toxicity

Background: Despite immunotherapy has deeply changed the treatment landscape and prognosis of several cancers, only a small percentage of patients achieve long-term benefit in terms of overall survival (OS). In addition, ICIs have particular immune-related adverse events (irAEs). Soluble immune profiles, resulting from the combined evaluation of circulating checkpoints, adhesion and inflammatory molecules, rather than the evaluation of individual marker, could be considered as a portrait of the immune system fitness of each patient at the baseline, which affects the response to treatment and the development of toxicities. The aim of this study was to define an immune profile predicting outocomes to ICIs and irAE development. Methods: A prospective, multicenter study evaluating the immune profile of patients with advanced cancer, treated with ICIs was performed. The immune profile was studied evaluating circulating concentration of 12 cytokines, 5 chemokines, 13 soluble immune checkpoints (sIC), 3 adhesion molecules and indoleamine 2,3-dioxygenase (IDO) at the baseline (T0) through a multiplex assay. Four connectivity heat maps and networks were obtained by calculating the Spearman correlation coefficients, according to the response to immunotherapy and onset of cumulative toxicity: responder patients without toxicity, non-responder with toxicity, responder with toxicity, non-responder without toxicity. Then, connectivity heat maps were defined for OS and progression-free survival (PFS) using the median values as cut-off. Results: Immune profile of 53 patients with advanced solid tumours treated with ICIs was evaluated at T0. Cumulative toxicity occurred in 18 patients (34%). A subgroup of non-small cell lung cancer (NSCLC) patients with high cytokine/chemokine concentrations was identified in non-responder patients without toxicity. A statistically significant up-regulation of IL17A and all the adhesion molecules in non-responder patients with toxicity with respect to the other ones was detected. CTLA4 was significantly higher in non-responders with toxicity compared to both responders and non-responders without toxicity, as well as sCD80 compared to both non-responders without toxicity and responders with toxicity. Four connectivity maps in responder and non-responder patients with and without toxicity were defined. In patients with toxicity, we observed a clearly different connectivity patterns with a loss of connectivity of mostly of sICs and cytokines correlations. In non-responder patients with toxicity, an inversion of the correlation for some adhesion molecules was observed (from positive or null correlation became negative). Four corresponding connectivity networks were built. Only 14 connections among the four networks were common, while connections specifically observed for each group of patients were: 26 in responder with toxicity, 38 in responder without toxicity, 80 in non-responder with toxicity, 31 in non-responder without toxicity. IL10, IL8, IL4, IL6, INFgamma, INFalpha, TNFalpha, GM-CSF, MIP-1alpha, IL13, sLAG3, sTIM3, sCD27, sCD28, sCD 137 and sPDL-2 showed a statistically significant down-regulation in patients with a longer OS. IL10, IL12p70, GM-CFS and sCD27 were statistically significant down-regulated in patients with longer PFS. No connectivity differences were instead observed when we compared the correlations maps between patients with OS and PFS above and below the respective median values. Conclusions: The combined evaluation of soluble molecules, rather than a single circulating factor, may be more suitable to represent the fitness of the immune system status in each patient and could allow to identify different prognostic and predictive outcome profiles. A specific connectivity model for each of the 4 clinical situation patterns, based on response to immunotherapy and irAE onset, was defined by a network analysis. Moreover, an organ-dependent immunity has also been highlighted. In patients who develop irAEs and in patients with the worst prognosis (non-responders who will develop toxicity), peculiar connectivity network of immune dysregulation was defined, which could facilitate their early and timely identification. The detection of these specific immune profiles before treatment, if confirmed in a larger patient population, could lead to the design of a personalized treatment approach fit to the peculiar characteristic of patient immune status, to improve outcomes and preventing avoidable irAEs.

Produzione scientifica

11573/1703913 - 2024 - PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey
Cerbelli, Bruna; Cirillo, Alessio; Pomati, Giulia; Pernazza, Angelina; Ascione, Andrea; Pisegna, Simona; Pisano, Annalinda; Leopizzi, Martina; Pignataro, Maria Gemma; Costarelli, Leopoldo; Mulè, Antonino; Vecchione, Andrea; Catalano, Piera; Coppola, Luigi; Perrone, Giuseppe; Perracchio, Letizia; Anemona, Lucia; Mastracchio, Antonio; Nardi, Stefano; Reitano, Renato; Massari, Annalisa; Grillo, Lucia Rosalba; Liberati, Fabrizio; Della Rocca, Carlo; Marchetti, Paolo; Botticelli, Andrea; D’Amati, Giulia - 01a Articolo in rivista
rivista: TUMORI (-Roma: Il Pensiero Scientifico Editore srl -Milano: Istituto nazionale per to studio e la cura dei tumori -Milan Italy: Casa Editrice Ambrosiana) pp. 44-48 - issn: 0300-8916 - wos: WOS:001068844400001 (0) - scopus: 2-s2.0-85171568459 (0)

11573/1674348 - 2023 - Immune-related toxicity and soluble profile in patients affected by solid tumors: a network approach
Botticelli, Andrea; Cirillo, Alessio; Pomati, Giulia; Cortesi, Enrico; Rossi, Ernesto; Schinzari, Giovanni; Tortora, Giampaolo; Tomao, Silverio; Fiscon, Giulia; Farina, Lorenzo; Scagnoli, Simone; Pisegna, Simona; Ciurluini, Fabio; Chiavassa, Antonella; Amirhassankhani, Sasan; Ceccarelli, Fulvia; Conti, Fabrizio; Di Filippo, Alessandra; Zizzari, Ilaria Grazia; Napoletano, Chiara; Rughetti, Aurelia; Nuti, Marianna; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: CANCER IMMUNOLOGY, IMMUNOTHERAPY (Heidelberg; Berlin: Springer) pp. - - issn: 1432-0851 - wos: WOS:000943090400001 (2) - scopus: 2-s2.0-85149261068 (2)

11573/1693735 - 2023 - PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey
Cerbelli, Bruna; Cirillo, Alessio; Pomati, Giulia; Pernazza, Angelina; Ascione, Andrea; Pisegna, Simona; Pisano, Annalinda; Leopizzi, Martina; Pignataro, Maria Gemma; Costarelli, Leopoldo; Mulè, Antonino; Vecchione, Andrea; Catalano, Piera; Coppola, Luigi; Perrone, Giuseppe; Perracchio, Letizia; Anemona, Lucia; Mastracchio, Antonio; Nardi, Stefano; Reitano, Renato; Massari, Annalisa; Grillo, Lucia Rosalba; Liberati, Fabrizio; Della Rocca, Carlo; Marchetti, Paolo; Botticelli, Andrea; D'amati, Giulia - 01a Articolo in rivista
rivista: TUMORI (Roma : Il Pensiero Scientifico Editore) pp. 3008916231196781- - issn: 2038-2529 - wos: WOS:001068844400001 (0) - scopus: 2-s2.0-85171568459 (0)

11573/1689340 - 2023 - The impact of drug–drug Interactions on the toxicity profile of combined treatment with BRAF and MEK Inhibitors in patients with BRAF-mutated metastatic melanoma
Mezi, Silvia; Botticelli, Andrea; Scagnoli, Simone; Pomati, Giulia; Fiscon, Giulia; De Galitiis, Federica; Romana Di Pietro, Francesca; Verkhovskaia, Sofia; Amirhassankhani, Sasan; Pisegna, Simona; Gentile, Giovanna; Simmaco, Maurizio; Gohlke, Bjoern; Preissner, Robert; Marchetti, Paolo - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:001075924700001 (0) - scopus: 2-s2.0-85172778786 (0)

11573/1685883 - 2023 - A network approach to define the predictive role of immune profile on tumor response and toxicity of anti PD-1 single agent immunotherapy in patients with solid tumors
Mezi, Silvia; Pomati, Giulia; Fiscon, Giulia; Amirhassankhani, Sasan; Zizzari, Ilaria Grazia; Napoletano, Chiara; Rughetti, Aurelia; Rossi, Ernesto; Schinzari, Giovanni; Tortora, Giampaolo; Lanzetta, Gaetano; D'amati, Giulia; Nuti, Marianna; Santini, Daniele; Botticelli, Andrea - 01a Articolo in rivista
rivista: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-3224 - wos: WOS:001030189500001 (0) - scopus: 2-s2.0-85165554864 (0)

11573/1688013 - 2023 - Network approach in liquidomics landscape
Santini, Daniele; Botticelli, Andrea; Galvano, Antonio; Iuliani, Michele; Incorvaia, Lorena; Gristina, Valerio; Taffon, Chiara; Foderaro, Simone; Paccagnella, Elisa; Simonetti, Sonia; Fazio, Federico; Scagnoli, Simone; Pomati, Giulia; Pantano, Francesco; Perrone, Giuseppe; De Falco, Elena; Russo, Antonio; Spinelli, Gian Paolo - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. - - issn: 1756-9966 - wos: WOS:001042534000001 (7) - scopus: 2-s2.0-85166598273 (8)

11573/1664405 - 2023 - Molecular profiling of male breast cancer by multigene panel testing: Implications for precision oncology
Valentini, Virginia; Silvestri, Valentina; Bucalo, Agostino; Conti, Giulia; Karimi, Mina; Di Francesco, Linda; Pomati, Giulia; Mezi, Silvia; Cerbelli, Bruna; Pignataro, Maria Gemma; Nicolussi, Arianna; Coppa, Anna; D’Amati, Giulia; Giannini, Giuseppe; Ottini, Laura - 01a Articolo in rivista
rivista: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. - - issn: 2234-943X - wos: WOS:000916823700001 (4) - scopus: 2-s2.0-85146553102 (4)

11573/1661193 - 2022 - The role of immune profile in predicting outcomes in cancer patients treated with immunotherapy
Botticelli, A.; Pomati, G.; Cirillo, A.; Scagnoli, S.; Pisegna, S.; Chiavassa, A.; Rossi, E.; Schinzari, G.; Tortora, G.; Di Pietro, F. R.; Cerbelli, B.; Di Filippo, A.; Amirhassankhani, S.; Scala, A.; Zizzari, I. G.; Cortesi, E.; Tomao, S.; Nuti, M.; Mezi, S.; Marchetti, P. - 01a Articolo in rivista
rivista: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. - - issn: 1664-3224 - wos: WOS:000888273100001 (8) - scopus: 2-s2.0-85142215079 (8)

11573/1659852 - 2022 - Network analysis to determine association between immuno-related toxicities and immune soluble profile in patients treated with anti-PD-1
Botticelli, A; Cirillo, A; Pomati, G; Cortesi, E; Rossi, E; Schinzari, G; Tortora, G; Tomao, S; Nuti, M; Fiscon, G; Farina, L; Pisegna, S; Ciurluini, F; Chiavassa, A; Amirhassankhani, S; Di Filippo, A; Zizzari, I; Mezi, S; Marchetti, P - 04f Poster
rivista: JOURNAL OF CLINICAL ONCOLOGY (editori attuale: -American Society of Clinical Oncology. , 330 JOHN CARLYLE ST, STE 300, ALEXANDRIA, USA, VA, 22314 precedente: -W B Saunders Company:Fulfillment Department, The Curtis Center, Independence Square West:Philadelphia, PA 19106:(800)654-2452, (215)238-7800, EMAIL: wbspcs@harcourt.com, INTERNET: http://elsevierhealth.com, Fax: (215)238-6445) pp. - - issn: 0732-183X - wos: WOS:000863680300776 (0) - scopus: (0)
congresso: 2022 ASCO Annual Meeting I (Chicago)
libro: Journal of clinical oncology - ()

11573/1660536 - 2022 - Genomic and immune approach in platinum refractory HPV-negative head and neck squamous cell carcinoma patients treated with Immunotherapy: a novel combined profile
Mezi, Silvia; Pomati, Giulia; Zizzari, Ilaria Grazia; Di Filippo, Alessandra; Cerbelli, Bruna; Cirillo, Alessio; Fiscon, Giulia; Amirhassankhani, Sasan; Valentini, Valentino; De Vincentiis, Marco; Corsi, Alessandro; Di Gioia, Cira Rosaria Tiziana; Tombolini, Vincenzo; Della Rocca, Carlo; Polimeni, Antonella; Nuti, Marianna; Marchetti, Paolo; Botticelli, Andrea - 01a Articolo in rivista
rivista: BIOMEDICINES (Basel : MDPI) pp. - - issn: 2227-9059 - wos: WOS:000880889000001 (3) - scopus: 2-s2.0-85141779736 (3)

11573/1669227 - 2022 - Antibiotics, the microbiome and gastrointestinal cancers: a causal interference?
Ramai, Daryl; Salati, Massimiliano; Pomati, Giulia; Amoroso, Chiara; Facciorusso, Antonio; Botticelli, Andrea; Ghidini, Michele - 01g Articolo di rassegna (Review)
rivista: CURRENT OPINION IN PHARMACOLOGY (Oxford: Elsevier) pp. - - issn: 1471-4973 - wos: WOS:000926493100004 (2) - scopus: 2-s2.0-85141255117 (2)

11573/1529260 - 2021 - The role of opioids in cancer response to immunotherapy
Botticelli, Andrea; Cirillo, Alessio; Pomati, Giulia; Cerbelli, Bruna; Scagnoli, Simone; Roberto, Michela; Gelibter, Alain; Mammone, Giulia; Calandrella, Maria Letizia; Cerbelli, Edoardo; Di Pietro, Francesca Romana; De Galitiis, Federica; Lanzetta, Gaetano; Cortesi, Enrico; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central, London) pp. - - issn: 1479-5876 - wos: WOS:000634783000001 (22) - scopus: 2-s2.0-85103161618 (23)

11573/1562486 - 2021 - Weekly chemotherapy as first line treatment in frail head and neck cancer patients in the immunotherapy era
Botticelli, Andrea; Pomati, Giulia; Cirillo, Alessio; Mammone, Giulia; Ciurluini, Fabio; Cerbelli, Bruna; Sciattella, Paolo; Ralli, Massimo; Romeo, Umberto; De Felice, Francesca; Catalano, Carlo; Vullo, Francesco; Della Monaca, Marco; Amirhassankhani, Sasan; Tomao, Silverio; Valentini, Valentino; De Vincentiis, Marco; Tombolini, Vincenzo; Della Rocca, Carlo; Polimeni, Antonella; Di Gioia, Cira; Corsi, Alessandro; D'amati, Giulia; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: JOURNAL OF TRANSLATIONAL MEDICINE (London: BioMed Central, London) pp. - - issn: 1479-5876 - wos: WOS:000674445600002 (1) - scopus: 2-s2.0-85109717512 (2)

11573/1562092 - 2021 - The role of soluble LAG3 and soluble immune checkpoints profile in advanced head and neck cancer: a pilot study
Botticelli, Andrea; Zizzari, Ilaria Grazia; Scagnoli, Simone; Pomati, Giulia; Strigari, Lidia; Cirillo, Alessio; Cerbelli, Bruna; Di Filippo, Alessandra; Napoletano, Chiara; Scirocchi, Fabio; Rughetti, Aurelia; Nuti, Marianna; Mezi, Silvia; Marchetti, Paolo - 01a Articolo in rivista
rivista: JOURNAL OF PERSONALIZED MEDICINE (Basel: MDPI AG, 2011-) pp. - - issn: 2075-4426 - wos: WOS:000677382600001 (27) - scopus: 2-s2.0-85110848603 (30)

11573/1530366 - 2021 - Standard of care and promising new agents for the treatment of mesenchymal triple-negative breast cancer
Mezi, S.; Botticelli, A.; Pomati, G.; Cerbelli, B.; Scagnoli, S.; Amirhassankhani, S.; D'amati, G.; Marchetti, P. - 01g Articolo di rassegna (Review)
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000627934600001 (9) - scopus: 2-s2.0-85101843049 (10)

11573/1434713 - 2020 - Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1
Botticelli, A.; Mezi, S.; Pomati, G.; Cerbelli, B.; Cerbelli, E.; Roberto, M.; Giusti, R.; Cortellini, A.; Lionetto, L.; Scagnoli, S.; Zizzari, I. G.; Nuti, M.; Simmaco, M.; Marchetti, P. - 01a Articolo in rivista
rivista: FRONTIERS IN IMMUNOLOGY (Lausanne : Frontiers Research Foundation, 2010-) pp. 1-13 - issn: 1664-3224 - wos: WOS:000553414800001 (26) - scopus: 2-s2.0-85088439843 (27)

11573/1429330 - 2020 - The 5-Ws of immunotherapy in head and neck cancer
Botticelli, Andrea; Mezi, Silvia; Pomati, Giulia; Cerbelli, Bruna; Di Rocco, Christiana; Amirhassankhani, Sasan; Sirgiovanni, Grazia; Occhipinti, Mario; Napoli, Valerio; Emiliani, Alessandra; Mazzuca, Federica; Tomao, Silverio; Nuti, Marianna; Marchetti, Paolo - 01g Articolo di rassegna (Review)
rivista: CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY (Amsterdam : Elsevier) pp. - - issn: 1879-0461 - wos: WOS:000572848600011 (11) - scopus: 2-s2.0-85087344326 (12)

11573/1387452 - 2020 - The impact of locoregional treatment on response to Nivolumab in advanced platinum refractory head and neck cancer: the NEED TRIAL
Botticelli, Andrea; Mezi, Silvia; Pomati, Giulia; Sciattella, Paolo; Cerbelli, Bruna; Roberto, Michela; Mammone, Giulia; Cirillo, Alessio; Cassano, Alessandra; Di Dio, Carmela; Cortellini, Alessio; Pizzuti, Laura; Ronzino, Graziana; Salati, Massimiliano; Vici, Patrizia; Polimeni, Antonella; Carlo Merlano, Marco; Nuti, Marianna; Marchetti, Paolo - 01a Articolo in rivista
rivista: VACCINES (Basel: MDPI) pp. - - issn: 2076-393X - wos: WOS:000553554200001 (8) - scopus: 2-s2.0-85083830456 (9)

11573/1481391 - 2020 - Primary squamous cell carcinoma of major salivary gland: “Sapienza Head and Neck Unit” clinical recommendations
Mezi, S.; Pomati, G.; Botticelli, A.; De Felice, F.; Musio, D.; Della Monaca, M.; Amirhassankhani, S.; Vullo, F.; Cerbelli, B.; Carletti, R.; Di Gioia, C.; Catalano, C.; Valentini, V.; Tombolini, V.; Della Rocca, C.; Marchetti, P. - 01a Articolo in rivista
rivista: RARE TUMORS (Pavia : PagePress Publications) pp. 1-10 - issn: 2036-3605 - wos: WOS:000593564900001 (6) - scopus: 2-s2.0-85096533132 (8)

11573/1440797 - 2020 - Induction chemotherapy in nonlaryngeal human papilloma virus-negative high-risk head and neck cancer: a real-world experience
Mezi, Silvia; Pomati, Giulia; Botticelli, Andrea; Roberto, Michela; Cerbelli, Bruna; Cirillo, Alessio; Di Gioia, Cira; Corsi, Alessandro; Vullo, Francesco; De Vincentiis, Marco; Polimeni, Antonella; Tombolini, Vincenzo; Valentini, Valentino; Marchetti, Paolo - 01a Articolo in rivista
rivista: ANTI-CANCER DRUGS (London: Lippincott Williams & Wilkins Oxford UK: Rapid Communications of Oxford, [1990]-) pp. 1-10 - issn: 0959-4973 - wos: WOS:000580389200011 (1) - scopus: 2-s2.0-85093706069 (1)

11573/1437796 - 2020 - Exploratory pilot study of circulating biomarkers in metastatic renal cell carcinoma
Zizzari, Ilaria Grazia; Napoletano, Chiara; Di Filippo, Alessandra; Botticelli, Andrea; Gelibter, Alain Jonathan; Calabro', Fabio; Rossi, Ernesto; Schinzari, Giovanni; Urbano, Federica; Pomati, Giulia; Scagnoli, Simone; Rughetti, Aurelia; Caponnetto, Salvatore; Marchetti, Paolo; Nuti, Marianna - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. - - issn: 2072-6694 - wos: WOS:000581372600001 (21) - scopus: 2-s2.0-85090828527 (22)

11573/1275290 - 2019 - Palbociclib plus endocrine therapy in HER2 negative, hormonal receptor-positive, advanced breast cancer: a real-world experience
Pizzuti, Laura; Giordano, Antonio; Michelotti, Andrea; Mazzotta, Marco; Natoli, Clara; Gamucci, Teresa; De Angelis, Claudia; Landucci, Elisabetta; Diodati, Lucrezia; Iezzi, Laura; Mentuccia, Lucia; Fabbri, Agnese; Barba, Maddalena; Sanguineti, Giuseppe; Marchetti, Paolo; Tomao, Silverio; Mariani, Luciano; Paris, Ida; Lorusso, Vito; Vallarelli, Simona; Cassano, Alessandra; Airoldi, Francesca; Orlandi, Armando; Moscetti, Luca; Sergi, Domenico; Sarobba, Maria Giuseppina; Tonini, Giuseppe; Santini, Daniele; Sini, Valentina; Veltri, Enzo; Vaccaro, Angela; Ferrari, Laura; De Tursi, Michele; Tinari, Nicola; Grassadonia, Antonino; Greco, Filippo; Botticelli, Andrea; La Verde, Nicla; Zamagni, Claudio; Rubino, Daniela; Cortesi, Enrico; Magri, Valentina; Pomati, Giulia; Scagnoli, Simone; Capomolla, Elisabetta; Kayal, Ramy; Scinto, Angelo Fedele; Corsi, Domenico; Cazzaniga, Marina; Laudadio, Lucio; Forciniti, Samantha; Mancini, Maria; Carbognin, Luisa; Seminara, Patrizia; Barni, Sandro; Samaritani, Riccardo; Roselli, Mario; Portarena, Ilaria; Russo, Antonio; Ficorella, Corrado; Cannita, Katia; Carpano, Silvia; Pistelli, Mirco; Berardi, Rossana; De Maria, Ruggero; Sperduti, Isabella; Ciliberto, Gennaro; Vici, Patrizia - 01a Articolo in rivista
rivista: JOURNAL OF CELLULAR PHYSIOLOGY (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 7708-7717 - issn: 0021-9541 - wos: WOS:000459314500004 (19) - scopus: 2-s2.0-85058158145 (20)

11573/1650247 - 2017 - Comparative effects of Folfirinox and Gemcitabine/nab-paclitaxel as first and second line chemotherapy for metastatic pancreatic cancer: single choice or sequence
Caponnetto, S.; Gelibter, A.; Mosillo, C.; Magri, V.; Scagnoli, S.; Pomati, G.; Piesco, G.; Verkhovskaya, S.; Pisegna, S.; Sirgiovanni, G.; Napoli, V.; Buscicchio, D.; Iannantuono, G. M.; Marinelli, D.; Mammone, G.; Pannunzio, S.; Nicolo', E.; Stefani, A.; Astorino, V.; Mancini, M.; Cortesi, E. - 01h Abstract in rivista
rivista: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. vi51- - issn: 0923-7534 - wos: WOS:000414493900166 (3) - scopus: (0)

11573/1070785 - 2017 - Management of salivary gland malignant tumor: the Policlinico Umberto I, "Sapienza" University of Rome Head and Neck Unit clinical recommendations
De Felice, Francesca; De Vincentiis, Marco; Valentini, Valentino; Musio, Daniela; Mezi, Silvia; Lo Mele, Luigi; Della Monaca, Marco; D'aguanno, Vittorio; Terenzi, Valentina; Di Brino, Martina; Brauner, Edoardo; Bulzonetti, Nadia; Tenore, Gianluca; Pomati, Giulia; Cassoni, Andrea; Tombolini, Mario; Battisti, Andrea; Greco, Antonio; Pompa, Giorgio; Minni, Antonio; Romeo, Umberto; Cortesi, Enrico; Polimeni, Antonella; Tombolini, Vincenzo - 01g Articolo di rassegna (Review)
rivista: CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (-NEW YORK, USA, NY: ELSEVIER SCIENCE INC -Boca Raton, Fla.: CRC Press.) pp. 93-97 - issn: 1040-8428 - wos: WOS:000418980100011 (18) - scopus: 2-s2.0-85033552529 (21)

11573/1018172 - 2017 - Burned-out testicular cancer: really a different history?
Mosillo, Claudia; Scagnoli, Simone; Pomati, Giulia; Caponnetto, Salvatore; Mancini, Maria Laura; Bezzi, Mario; Cortesi, Enrico; Gelibter, Alain - 01i Case report
rivista: CASE REPORTS IN ONCOLOGY (Basel : Karger) pp. 846-850 - issn: 1662-6575 - wos: WOS:000418467200009 (17) - scopus: 2-s2.0-85029753356 (18)

11573/1280087 - 2016 - Prolactin as a potential negative predictive factor in metastatic non-small cell lung cancers (NSCLC) patients in treatment with Nivolumab (NIVO)
Caponnetto, S.; Mancini, M.; Manai, C.; Magri, V.; Iannantuono, G. M.; Pellegrino, D.; Mosillo, C.; Piesco, G.; Pomati, G.; Scagnoli, S.; Urbano, F.; Verkhovskaya, S.; Barchiesi, G.; Zancla, S.; Cortesi, E. - 01h Abstract in rivista
rivista: ANNALS OF ONCOLOGY (London; Dordrecht; Boston: Kluwer Academic Publishers) pp. - - issn: 0923-7534 - wos: WOS:000393913000185 (0) - scopus: (0)

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