GIULIA FEDERICA MANCINI

PhD Graduate

PhD program:: XXXIII



Thesis title: RESILIENCE AND SUSCEPTIBILITY TO STRESS-RELATED DISORDERS: INSIGHTS FROM ANIMAL MODELS

Stressful experiences can produce both accurate or generalized memories, reflecting an interindividual differences in response to stress. Psychostimulants outcomes on memory enhancement are known from many years, but literature data also show their memory generalization effects. However, the mechanisms through which psychostimulants affect memory quality is still poor investigated. In Chapter 1 we explored the memory generalization effects induced by amphetamine and a new psychostimulant: the 3,4-methylenedioxypyrovalerone (MDPV), also called “bath salt”. Both psychostimulants share a similar, yet not identical mechanism of action, augmenting noradrenaline and dopamine levels in the synaptic cleft. Thus, in a second experiment we aimed at evaluating the different involvement of the noradrenergic and dopaminergic system in the effects on memory enhancement, and on memory generalization. Treatment with the anesthetic ketamine, a renowned drug of abuse, in trauma patients during emergency care aggravated early post-traumatic stress reaction which is highly predictive of PTSD development and severity. Based on the evidence that ketamine induces a robust central and peripheral adrenergic/noradrenergic potentiation and that activation of this system is essential for the formation of memory for stressful events, in Chapter 2 we explored the possibility that the strong sympathomimetic action of ketamine might underlie its memory enhancing effects. Given that PTSD is a chronic psychiatric disease, it is of critical importance to evaluate whether animal model of PTSD resemble the chronicity nature of this pathology. The single prolonged stress paradigm has been extensively shown to induce behavioral and endocrine effects resembling the hallmark symptoms observed in PTSD patients and, similarly to PTSD, the manifestation of these effects is time-dependent and requires a 1-2 weeks incubation period. Although women have a two-fold greater risk to develop PTSD, most preclinical studies have been carried out in males. In Chapter 3 we aimed at investigating whether SPS induced persistent PTSD-like behavioral alterations in rats long after trauma exposure and whether these effects are sex-dependent. Another important aspect of PTSD is the susceptibility to develop this pathology. Animal models are a useful tool to investigate this issue. However, in the sparse studies considering the individual variability in response to trauma, only the anxiety symptoms are used to discern between different PTSD-like phenotypes, without considering the cognitive aspects of PTSD. In Chapter 4 we aimed at the development of an animal model of PTSD, with translational value, able to predict the susceptibility and the resilience phenotype considering both the cognitive and emotional alterations long after trauma. For this purpose, we outstretched our previously validated animal model in order to identify susceptible and resilient rats in terms of over- consolidation, impaired extinction and social behavior alterations. Nowadays there are different hypotheses to explain the interindividual variability in response to stress. Different studies used the “two hit” stress model to investigate whether exposure to two different stressors at different ages may increase (or decrease) the risk to develop psychopathologies after experiencing the second stressor. However, how a social stress similar to bullying in humans experienced at adolescence may affect the reaction to additional stressor later in life are less investigated. Adolescence is a period of impressive brain maturation in which the structure of the brain is ever-changing. Thus, maintaining a correct balance between mediators that sustain synaptic plasticity is of utmost importance. In Chapter 5 we evaluated whether the exposure to social defeat stress, a highly validated animal model of bullying in rodents, at adolescence and/or single prolonged stress experienced at adulthood affect the later development of emotional and cognitive alterations and whether the behavioral alterations are linked to any modification of hippocampal brain derived neurotrophic factor (BDNF) expression and plasma corticosterone levels. While adolescent bullying occurs in a small subset of population, a more common social stressor is represented by the deprivation of social interactions with conspecifics which is able to induce profound behavioral changes in rodents. Social isolation stress paradigm is commonly used to reproduce schizophrenia in rodents and it is conducted chronically from weaning to adulthood. However, long-term effects induced by a briefer period of social isolation stress during adolescence, which is a critical window for brain development, are not investigated. Moreover, it is known that in mammals, females have greater risk to develop stress-related disorders than males. In Chapter 6 we firstly evaluated whether repeated brief periods of SIS may alter emotionality and cognitive functions in adult male rats. Secondly, we examined whether brief and repeated social isolation stress during at adolescence and/or single prolonged stress at adulthood affect the later development of alteration on emotionality and cognition. Further, we aimed at evaluating whether such effects are sex-dependent.

Research products

11573/1710028 - 2024 - Behavioral and molecular profiling of PTSD-like susceptible and resilient lines of rats.
Mancini, Giulia Federica; Morena, Maria; Di Cesare, Benedetta; Riccardi, Eleonora; Pisaneschi, Arianna; Meijer, Onno; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Global Stress Network – Stress and Resilience: Exploring New Horizons and in Science and Applications Meeting (Lausanne (Switzerland))
book: Abstract book - ()

11573/1702653 - 2024 - Evaluating vulnerability and resilience for post-traumatic stress disorder (PTSD) development in rats: behavioral and transcriptomic insights.
Mancini, Giulia Federica; Morena, Maria; Di Cesare, Benedetta; Riccardi, Eleonora; Virgilio, Anna; Meijer, Onno; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Steroids and Nervous System (SNS) 12th International Meeting (Torino (Italia))
book: Abstract book - ()

11573/1717456 - 2024 - Biomarkers of stress resilience. A review
Paribello, Pasquale; Branchi, Igor; Viglione, Aurelia; Mancini, Giulia Federica; Morena, Maria; Campolongo, Patrizia; Manchia, Mirko - 01g Articolo di rassegna (Review)
paper: NEUROSCIENCE APPLIED (Amsterdam: Elsevier B.V) pp. 1-25 - issn: 2772-4085 - wos: (0) - scopus: (0)

11573/1691712 - 2023 - Chronic intranasal administration of urb597 reverts short-term memory deficits in a rat model of metabolic syndrome
Di Cesare, Benedetta; Pisaneschi, Arianna; Somai, Martina; Mancini, Giulia Federica; Morena, Maria; Campolongo, Patrizia - 04f Poster
conference: 9th Mediterranean Neuroscience Society (MNS) Conference 2023 (Carthage; Tunis)
book: Abstract book - ()

11573/1691678 - 2023 - Chronic intranasal administration of URB597 reverts short-term memory deficits in a rat model of metabolic syndrome
Di Cesare, Benedetta; Pisaneschi, Arianna; Zannetti, Alessia; Mancini, Giulia Federica; Morena, Maria; Campolongo, Patrizia - 04f Poster
conference: XXV Conference of Young SIF Pharmacologists (Urbino; Italy)
book: Abstract book - ()

11573/1691718 - 2023 - Chronic intranasal administration of urb597 reverts short-term memory deficits in a rat model of metabolic syndrome
Di Cesare, Benedetta; Somai, Martina; Zannetti, Alessia; Mancini, Giulia Federica; Morena, Maria; Campolongo, Patrizia - 04f Poster
conference: Innovation in mental illness: from mechanisms to drug treatment and patient response (SIF) (Brescia; Italy)
book: Abstract book - ()

11573/1676778 - 2023 - Stress in adolescence as a first hit in stress-related disease development: timing and context are crucial
Mancini, Giulia F.; Meijer, Onno C.; Campolongo, Patrizia - 01a Articolo in rivista
paper: FRONTIERS IN NEUROENDOCRINOLOGY (Orlando, Fla.: Academic Press.) pp. 101065- - issn: 0091-3022 - wos: WOS:000967980500001 (2) - scopus: 2-s2.0-85151280838 (3)

11573/1691719 - 2023 - Stress at adolescence as a first hit in stress-related disease development: timing and context are crucial
Mancini, Giulia F.; Meijer, Onno C.; Campolongo, Patrizia - 01a Articolo in rivista
paper: FRONTIERS IN NEUROENDOCRINOLOGY (Orlando, Fla.: Academic Press.) pp. - - issn: 0091-3022 - wos: WOS:000967980500001 (2) - scopus: (0)

11573/1676913 - 2023 - Late glucocorticoid receptor antagonism normalizes the programming effects of brief and repeated periods of social isolation stress in adolescent rats.
Mancini, Giulia Federica; Di Cesare, Benedetta; Buurstede, Jacobus; Pisaneschi, Arianna; Meijer, Onno; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: FENS Regional Meeting (FRM) (Algarve (Portugal))
book: abstract book - ()

11573/1691717 - 2023 - Late treatment with RU486 normalizes the programming effects of brief and repeated periods of social isolation stress in adolescent rats
Mancini, Giulia Federica; Di Cesare, Benedetta; Fang, Zhou; Buurstede, Jacobus; Meijer, Onno; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: XXV Conference of Young Pharmacologists Società Italiana di Farmacologia (SIF) (Urbino)
book: Abstract book - ()

11573/1691713 - 2023 - Early-life stressful experiences in the susceptibility/resilience for psychiatric disorders development later in life
Mancini, Giulia Federica; Meijer, Onno C.; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Mediterranean Neuroscience Society (MNS) 9th Conference (Cartagine (Tunisia))
book: Abstract book - ()

11573/1691711 - 2023 - Vulnerability and resilience toward post-traumatic stress disorder (PTSD): behavioral and transcriptomic characterization of two unique PTSD rat lines
Mancini, Giulia Federica; Morena, Maria; Di Cesare, Benedetta; Masi, Fausto; Tofani, Rachele; Besombes-Galvez, Clara; Meijer, Onno C.; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Convegno Monotematico- Società Italiana di Farmacologia (SIF) in collaboration with Gruppo di Lavoro in Neuropsicofarmacologia (Brescia)
book: Abstract book - ()

11573/1691715 - 2023 - Post-traumatic stress disorder (PTSD) vulnerability and resilience: behavioral and transcriptomic characterization of two unique PTSD rat lines
Mancini, Giulia Federica; Morena, Maria; Di Cesare, Benedetta; Masi, Fausto; Tofani, Rachele; Meijer, Onno C.; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: National Congress of the Italian Society for Neuroscience (SINS) (Torino)
book: Abstract book - ()

11573/1662615 - 2023 - Enhancing Psychological Interventions for Post-Traumatic Stress Disorder (PTSD) Treatment with Memory Influencing Drugs
Marchetta, Enrico; Mancini, Giulia Federica; Morena, Maria; Campolongo, Patrizia - 01a Articolo in rivista
paper: CURRENT NEUROPHARMACOLOGY (Hilversum: Bentham Science Publishers) pp. - - issn: 1875-6190 - wos: WOS:001008218400017 (2) - scopus: 2-s2.0-85150849186 (3)

11573/1670107 - 2022 - Early life stress exposure: a pattern of adaptation or vulnerability to the development of stress-related psychopathologies?
Di Cesare, B.; Pisaneschi, Arianna; Gorga, Martina; Mancini, Giulia F.; Morena, Maria; Campolongo, Patrizia - 04f Poster
conference: 41° Congresso Nazionale della Società Italiana di Farmacologia (Roma)
book: Abstract book - ()

11573/1637309 - 2022 - Co-ultramicronized palmitoylethanolamide/luteolin restores oligodendrocyte homeostasis via peroxisome proliferator-activated receptor-α in an In vitro model of Alzheimer’s disease
Facchinetti, Roberta; Valenza, Marta; Gomiero, Chiara; Mancini, Giulia Federica; Steardo, Luca; Campolongo, Patrizia; Scuderi, Caterina - 01a Articolo in rivista
paper: BIOMEDICINES (Basel: MDPI) pp. 1-18 - issn: 2227-9059 - wos: WOS:000817622500001 (11) - scopus: 2-s2.0-85131534976 (9)

11573/1637436 - 2022 - Late glucocorticoid receptor antagonism counteracts the programming effects of brief and repeated social isolation stress in early-adolescent rats
Mancini, Giulia Federica; Buurstede, Jacobus C.; Di Cesare, Benedetta; Pisaneschi, Arianna; Campolongo, Patrizia; Meijer, Onno C. - 04d Abstract in atti di convegno
conference: Steroids and Nervous System (SNS) 2022 (web conference)
book: abstract book - ()

11573/1637437 - 2022 - Long-term effects of early-life adverse events: the role of sex differences
Mancini, Giulia Federica; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Mediterranean Neuroscience Society 8th Conference (Dubrovnik (Croazia))
book: abstract book - ()

11573/1652398 - 2022 - Late glucocorticoid receptor antagonism normalizes the programming effects of brief and repeated periods of social isolation stress in adolescent rats
Mancini, Giulia Federica; Di Cesare, Benedetta; Buurstede, J. C.; Pisaneschi, Arianna; Meijer, O. C.; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Society for Neuroscience Annual Meeting 2022 (San Diego, California (USA))
book: abstract book - ()

11573/1659924 - 2022 - Behavioral and molecular characterization of PTSD-like susceptible and resilient lines of rats
Morena, Maria; Mancini, Giulia Federica; Blasi, Eleonora; Riccardi, Eleonora; Pisaneschi, Arianna; Meijer, Onno; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Society for Neuroscience (SfN) 2022 (San Diego, California (USA))
book: Abstract book - ()

11573/1659925 - 2022 - Prediction of Susceptibility/Resilience Toward Animal Models of Post-traumatic Stress Disorder (PTSD)
Morena, Maria; Mancini, Giulia Federica; Campolongo, Patrizia - 02a Capitolo o Articolo
book: Psychiatric Vulnerability, Mood, and Anxiety Disorders pp 379–396 - ()

11573/1637435 - 2021 - Enduring effects of early life stressors: the role of sex-differences
Mancini, Giulia Federica; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: NEURO2021 (web conference)
book: abstract book - ()

11573/1637434 - 2021 - Late glucocorticoid receptor antagonism normalizes the enduring effects induced by brief and repeated periods of social isolation stress during early-adolescence
Mancini, Giulia Federica; Marchetta, Enrico; Colucci, Paola; Federica, Lucarella; Patrizia, Campolongo - 04d Abstract in atti di convegno
conference: Società Italiana di Farmacologia (SIF) 40th Conference (web meeting)
book: abstract in atto di convegno - ()

11573/1494552 - 2021 - Social Defeat Stress During Early Adolescence Confers Resilience Against a Single Episode of Prolonged Stress in Adult Rats
Mancini, Giulia Federica; Marchetta, Enrico; Pignani, Irene; Trezza, Viviana; Campolongo, Patrizia - 01a Articolo in rivista
paper: CELLS (Basel: mdpi-Molecular Diversity Preservation International) pp. - - issn: 2073-4409 - wos: WOS:000622388900001 (14) - scopus: 2-s2.0-85101460464 (16)

11573/1470681 - 2021 - Sex-divergent long-term effects of single prolonged stress in adult rats
Mancini, Giulia Federica; Marchetta, Enrico; Riccardi, Eleonora; Trezza, Viviana; Morena, Maria; Campolongo, Patrizia - 01a Articolo in rivista
paper: BEHAVIOURAL BRAIN RESEARCH (Amsterdam; London; New York NY; Tokyo: Elsevier) pp. 1-8 - issn: 0166-4328 - wos: WOS:000608605600007 (22) - scopus: 2-s2.0-85098185300 (23)

11573/1469574 - 2021 - Ketamine anesthesia enhances fear memory consolidation via noradrenergic activation in the basolateral amygdala
Morena, Maria; Colucci, Paola; Mancini, Giulia F; De Castro, Valentina; Peloso, Andrea; Schelling, Gustav; Campolongo, Patrizia - 01a Articolo in rivista
paper: NEUROBIOLOGY OF LEARNING AND MEMORY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. - - issn: 1074-7427 - wos: WOS:000619701900005 (5) - scopus: 2-s2.0-85098126470 (7)

11573/1431916 - 2020 - Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD)
Colucci, Paola; Marchetta, Enrico; Mancini, Giulia Federica; Alva, Phoebe; Chiarotti, Flavia; Hasan, Mazahir T.; Campolongo, Patrizia - 01a Articolo in rivista
paper: TRANSLATIONAL PSYCHIATRY (New York, NY : Nature Pub. Group-Springer Nature) pp. - - issn: 2158-3188 - wos: WOS:000553587600001 (20) - scopus: 2-s2.0-85088292252 (26)

11573/1333610 - 2019 - Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats
Colucci, Paola; Mancini, Giulia Federica; Santori, Alessia; Zwergel, Clemens; Mai, Antonello; Trezza, Viviana; Roozendaal, Benno; Campolongo, Patrizia - 01a Articolo in rivista
paper: FRONTIERS IN MOLECULAR NEUROSCIENCE (Lausanne: Frontiers Research Foundation, 2008-) pp. - - issn: 1662-5099 - wos: WOS:000502730100001 (11) - scopus: 2-s2.0-85076905906 (10)

11573/1231362 - 2019 - Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD)
Colucci, Paola; Marchetta, Enrico; Mancini, Giulia Federica; Federica, Marangio; Stefano Puglisi Allegra, ; Patrizia, Campolongo - 04d Abstract in atti di convegno
conference: 7th Mediterranean Neuroscience Conference (Marrakech, Marocco)
book: Abstract Book - ()

11573/1311127 - 2019 - Predicting susceptibility and resilience in an animal model of post-traumatic stress disorder (PTSD)
Colucci, Paola; Marchetta, Enrico; Mancini, Giulia Federica; Pasquale, Sementilli; Stefano Puglisi Allegra, ; Patrizia, Campolongo - 04d Abstract in atti di convegno
conference: ERA-NET NEURON Mid-Term Symposium (Lisbona, Portogallo)
book: Abstract Book - ()

11573/1275975 - 2019 - Enduring effects induced by brief and repeated periods of social isolation stress during early adolescence
Mancini, Giulia Federica; Marchetta, Enrico; Splendori, Marta; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: International Society of Psychoneuroendocrinology Conference (Milan, Italy)
book: Abstract book - ()

11573/1284416 - 2019 - Enduring behavioral effects of brief and repeated periods of social isolation stress during early adolescence
Mancini, Giulia Federica; Marchetta, Enrico; Splendori, Marta; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: 18th National Conference of the Italian Society for Neuroscience (SINS) (Perugia; Italy)
book: Abstract Book - ()

11573/1237579 - 2019 - Long-term behavioral effects of brief and repeated periods of social isolation stress during early adolescence
Mancini, Giulia Federica; Marchetta, Enrico; Splendori, Marta; Filosa, Marika; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: The 7th Mediterranean Neuroscience Conference (Marrakech, Morocco)
book: Abstract Book - ()

11573/1268665 - 2019 - Long-term effects of brief and repeated periods of brief social isolation stress during early adolescence
Mancini, Giulia Federica; Marchetta, Enrico; Splendori, Marta; Filosa, Marika; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: 39° Congresso Nazionale della Società Italiana di Farmacologia (SIF) (Firenze, Italia)
book: Abstract book - ()

11573/1240113 - 2019 - Social defeat stress during early adolescence affects susceptibility to stress-related disorders in adult rats
Marchetta, Enrico; Mancini, Giulia Federica; Splendori, Marta; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: The 7th Mediterranean Neuroscience Conference (Marrakech, Morocco)
book: abstract book - ()

11573/1299597 - 2019 - Anandamide modulation of circadian- and stress-dependent effects on rat short-term memory
Santori, A.; Colucci, P.; Mancini, G. F.; Morena, M.; Palmery, M.; Trezza, V.; Puglisi-Allegra, S.; Hill, M. N.; Campolongo, P. - 01a Articolo in rivista
paper: PSYCHONEUROENDOCRINOLOGY (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 155-162 - issn: 0306-4530 - wos: WOS:000484870800020 (15) - scopus: 2-s2.0-85068573630 (15)

11573/1231344 - 2019 - Endocannabinoid modulation of circadian- and stress-dependent effects on short-term memory in rats
Santori, Alessia; Colucci, Paola; Mancini, Giulia Federica; Ferrante, Pasqualino; Morena, Maria; Hill Matthew, N.; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: The 7th Mediterranean Neuroscience Conference (Marrakech, Morocco)
book: Abstract Book - ()

11573/1091955 - 2018 - Amphetamine and the “bath salt” 3,4-methylenedioxypyrovalerone (MDPV) differentially affect the accuracy of memory for emotional experiences in rats
Colucci, Paola; Mancini, Giulia Federica; Splendori, Marta; Roozendaal, Benno; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: The UC Irvine International Conference on Learning and Memory (Huntington Beach, California, USA)
book: Abstract Book - ()

11573/1119149 - 2018 - The psychostimulants amphetamine and the “bath salt” 3,4- methylenedioxypyrovalerone (MDPV) differentially affect the accuracy of memory in rats
Mancini, Giulia Federica; Colucci, Paola; Marta, Splendori; Benno, Roozendaal; Patrizia, Campolongo - 04d Abstract in atti di convegno
conference: FEDERATION OF EUROPEAN NEUROSCIENCE SOCIETIES (Berlino, Germania)
book: Abstract book - ()

11573/952572 - 2017 - Amphetamine and the “bath salt” 3,4-methylenedioxypyrovalerone (MDPV) alter accuracy of memory for emotional arousing experiences in rats
Colucci, Paola; Mancini, Giulia F.; Santori, Alessia; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: 38° Congresso Nazionale della Società Italiana di Farmacologia (SIF) (Rimini, Italia)
book: Abstract Book - ()

11573/952571 - 2017 - Amphetamine and the 'bath salt' MDPV enhance generalization of memory for emotional experiences in rats
Colucci, Paola; Mancini, Giulia F.; Santori, Alessia; Roozendaal, Benno; Campolongo, Patrizia - 04d Abstract in atti di convegno
conference: Mediterranean Neuroscience Society (MNS) (St Julian's, Malta)
book: Abstract Book - ()

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma