Phd in LIFE SCIENCE

email: gianni.cenci@uniroma1.it
phone: +390649912477
building: CU022
room: 3-07

My lab is interested on the comprehension of molecular mechanisms underlying the maintenance of chromosome integrity in the model organism, Drosophila melanogaster. The specific aims of our research deal with three major issues:
a) the genetic and molecular regulation of telomere capping. In particular, we are addressing the role of ubiquitination at chromosome ends and unraveling unanticipated functions of centromeric factors in telomere homeostasis;
b) the involvement of intra-cellular metabolism in the maintenance of genome stability. More specifically, we are investigating how the mitochondrial-mediated flux of metabolites controls cell proliferation and chromosome integrity;
c) the biological effects of low dose radiation/low dose rate on Drosophila genome stability. In particular we are studying the genetic and molecular bases that underlie the radioadaptive response using fruit flies as an in vivo model.
Owing the high level of protein homology between Drosophila and humans, these studies will be instrumental for the identification of new players and pathways in human chromosome stability. Our research is currently supported by Fondazione Cenci Bolognetti, FERMI Institute, Pasteur Institute (France) and The French Muscular Dystrophy Association (AFM-Telethon)-

ORCID.ORG/0000-0002-9628-1411
https://scholar.google.co.uk/citations?user=7B7vx3kAAAAJ&hl=en&oi=ao