GINEVRA D'OTTAVIO

PhD Graduate

PhD program:: XXXVI


supervisor: Daniele Caprioli

Thesis title: Translating human drug use patterns into rat models: exploring interindividual differences via refined drug self-administration procedures

Drug users instrumentalize the drug dosing-timing relationship (i.e. preferred drug dose in the preferred time) to produce their desired effects (i.e. euphoria, withdrawal avoidance, etc.). This is achieved by harnessing drug type, dosage, route, and frequency of drug taking. Yet, preclinical addiction research often employs self-administration and choice procedures based on discrete, as opposed to continuous dimension strategies, characterized by pre-selected experimenter-imposed unit-doses spaced by timeouts. This approach imposes constraints on the dose-time relationship voluntary harnessed by individuals with drug-addiction in real-world. This dissertation is devoted to the refinement of animal models of drug addiction. The considerations for the refinements stem from a detailed analysis of naturalistic patterns of drug taking in humans and are based on a strict pharmacokinetics and pharmacodynamics analysis of the drugs being investigated. The ambition is to guide preclinical researchers toward the self-administration procedure for neuropharmacological studies, tailored to the specific drug being investigated and is largely motivated by the limited advancements in available treatment options stemming from preclinical insights. This dissertation is devoted to the refinement of animal models of drug addiction. The considerations for the refinements stem from a detailed analysis of naturalistic patterns of drug-taking in humans and are based on a strict pharmacokinetics and pharmacodynamics analysis of the drugs being investigated. The ambition is to guide preclinical researchers toward the optimal self-administration procedure for neuropharmacological studies, tailored to the specific drug being investigated and is largely motivated by the limited advancements in available treatment options stemming from preclinical insights.

Research products

11573/1692453 - 2023 - The impact of discrete versus continuous dimensions strategies in heroin and cocaine self-administration on drug-taking patterns and social interaction.
D’Ottavio, Ginevra; Pezza, Sara; Reverte, Ingrid; Marchetti, Claudia; Filippo Zenoni, Soami; Maftei, Daniela; Fabrizio, Carlo; Termine, Andrea; Stanislaw Milella, Michele; Ragozzino, Davide; Venniro, Marco; Badiani, Aldo; Boix, Fernando; Caprioli, Daniele - 04f Poster
conference: Neuroscience 2023 (Washington DC)
book: Neuroscience 2023 - ()

11573/1600585 - 2023 - Increased heroin intake and relapse vulnerability in intermittent relative to continuous self‐administration: sex differences in rats
D’Ottavio, Ginevra; Reverte, Ingrid; Ragozzino, Davide; Meringolo, Maria; Stanislaw Milella, Michele; Boix, Fernando; Venniro, Marco; Badiani, Aldo; Caprioli, Daniele - 01a Articolo in rivista
paper: BRITISH JOURNAL OF PHARMACOLOGY (Basingstoke: Nature Publishing Group London: Macmillan, 1968-) pp. 910-926 - issn: 0007-1188 - wos: WOS:000753266300001 (17) - scopus: 2-s2.0-85124728510 (19)

11573/1677557 - 2023 - Heroin and its metabolites: relevance to heroin use disorder
Milella, Michele Stanislaw; D’Ottavio, Ginevra; De Pirro, Silvana; Barra, Massimo; Caprioli, Daniele; Badiani, Aldo - 01a Articolo in rivista
paper: TRANSLATIONAL PSYCHIATRY (New York, NY : Nature Pub. Group-Springer Nature) pp. 120- - issn: 2158-3188 - wos: WOS:000966781900005 (13) - scopus: 2-s2.0-85151937095 (11)

11573/1651258 - 2022 - Evidence for heroin-induced social isolation in the rat
D'ottavio, Ginevra; Micheli, Chiara; Stanislaw Milella, Michele; Fabrizio, Carlo; Termine, Andrea; Reverte, Ingrid; Boix, Fernando; Venniro, Marco; Caprioli, Daniele - 04f Poster
conference: International Narcotics Research Conference (INRC) (Valencia)
book: N/A - ()

11573/1634725 - 2022 - Sex differences in the immune system: Implications for cocaine relapse
Reverte, Ingrid; D'ottavio, Ginevra; Stanislaw Milella, Michele; Caprioli, Daniele - 01b Commento, Erratum, Replica e simili
paper: BRAIN BEHAVIOR AND IMMUNITY (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 29-30 - issn: 0889-1591 - wos: WOS:000813496800005 (1) - scopus: 2-s2.0-85130869941 (1)

11573/1621109 - 2022 - Targeting chemokines and chemokine GPCRs to enhance strong opioid efficacy in neuropathic pain
Vincenzi, Martina; Milella, Michele Stanislaw; D'ottavio, Ginevra; Caprioli, Daniele; Reverte, Ingrid; Maftei, Daniela - 01g Articolo di rassegna (Review)
paper: LIFE (Basel: MDPI) pp. 1-22 - issn: 2075-1729 - wos: WOS:000775133800001 (7) - scopus: 2-s2.0-85126534951 (7)

11573/1566339 - 2021 - Intermittent access heroin self-administration increases drug intake in both sexes and relapse vulnerability in female rats
D’Ottavio, Ginevra; Reverte, I.; Ragozzino, D.; Meringolo, M.; Milella, M. S.; Boix, F.; Venniro, M.; Badiani, A.; Caprioli, D. - 04f Poster
conference: 49th Meeting of the European Brain and Behaviour Society (Lausanne (CH))
book: European Brain and Behaviour Society - ()

11573/1561868 - 2021 - Intermittent access heroin self-administration increases drug intake in both sexes and relapse vulnerability in female rats
D’Ottavio, Ginevra; Reverte, Ingrid; Ragozzino, Davide; Meringolo, Maria; Milella, Michele S.; Boix, Fernando; Venniro, Marco; Badiani, Aldo; Caprioli, Daniele - 04f Poster
conference: EBPS Biennal Meeting 2021 (Maastricht)
book: European Behavioural Pharmacology Society - ()

11573/1572919 - 2021 - Factors modulating the incubation of drug and non-drug craving and their clinical implications
Venniro, Marco; Reverte Soler, Ingrid; Ramsey, Leslie A.; Papastrat, Kimberly M.; D'ottavio, Ginevra; Stanislaw Milella, Michele; Li, Xuan; Grimm, Jeffrey W.; Caprioli, Daniele - 01a Articolo in rivista
paper: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 847-864 - issn: 0149-7634 - wos: WOS:000712076600001 (27) - scopus: 2-s2.0-85122489742 (31)

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