GIANLUCA CIARLEGLIO

Dottore di ricerca

ciclo: XXXVII

supervisore: Prof.ssa Mariagabriella Santonicola

Titolo della tesi: Smart electrospun and electrosprayed materials based on biocompatible polymers for use in healthcare technologies

This doctoral thesis investigates the design, synthesis, and optimization of advanced biomaterials using electrospinning and electrospraying techniques, targeting applications in controlled drug delivery, wound healing, and implantable device coatings. The key objectives include the fabrication of nanofibres and microspheres with specific mechanical, thermal, and morphological properties using tailor-made biocompatible polymers for biomedical applications. Electrospray was used to produce pH- and thermo-responsive microspheres, enabling controlled drug release in targeted physiological environments. Specifically, two types of electrosprayed microspheres were developed: pH-responsive microspheres and dual-responsive microspheres based on alginate and poly(N-isopropylacrylamide) (PNIPAM), responsive to both pH and temperature variations. Electrospinning was employed to create nanofiber mats with high surface area and tunable porosity. Polyvinyl alcohol and hyaluronic acid (PVA/HA) nanofiber mats were fabricated through electrospinning for bioactive wound dressings, with enhanced stability achieved through citric acid crosslinking. Additionally, poly(lactic acid) and nano-hydroxyapatite (PLA/nHAp) composite nanofibers were developed as coatings for titanium implants, designed to improve biocompatibility, promote osseointegration, and enhance corrosion resistance. Through a multidisciplinary approach that combines material synthesis, characterization, and application-focused testing, this research advances the design of responsive, high-performance biomaterials for modern healthcare technologies.

Produzione scientifica

11573/1711667 - 2024 - Bioactive wound dressings based on polymer nanofibers fabricated by electrospinning

Ciarleglio, Gianluca; Capuccilli, Nicholas; Toto, Elisa; Laurenzi, Susanna; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: XIV Convegno INSTM sulla Scienza e Tecnologia dei Materiali (Cagliari)

libro: Book of Abstract - XIV Convegno INSTM sulla Scienza e Tecnologia dei Materiali - ()

11573/1714144 - 2024 - Crosslinked PVA/HA Nanofibers Fabricated via Electrospinning for Potential Advanced Wound Management

Ciarleglio, Gianluca; Capuccilli, Nicholas; Toto, Elisa; Laurenzi, Susanna; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: Second symposium for young chemists -SYNC2024 (Roma)

libro: Book of Abstract - Second symposium for young chemists -SYNC2024 - ()

11573/1715710 - 2024 - Nanofiber-based wound dressings for bioactive healing applications

Ciarleglio, Gianluca; Capuccilli, Nicholas; Toto, Elisa; Laurenzi, Susanna; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: Annual Meeting of the Italian Society for Biomaterials (SIB 2024) (Faenza)

libro: ABSTRACT BOOK - Annual Meeting of the Italian Society for Biomaterials (SIB 2024) - ()

11573/1715837 - 2024 - Fabrication of pH-responsive multilayer hydrogel patches for enhanced burn wound treatment

Ciarleglio, Gianluca; Clarizia, Virginia; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: 1st International Online Conference on Functional Biomaterials (IOCFB2024) (Online)

libro: Book of Abstract - 1st International Online Conference on Functional Biomaterials - ()

11573/1720202 - 2024 - pH-Responsive Multilayer Hydrogel Patches for Improved Burn Wound Healing

Ciarleglio, Gianluca; Clarizia, Virginia; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: AMYC BIOMED 2024 - Autumn Meeting for Young Chemists in Biomedical Sciences 5th Edition (Roma)

libro: Book of Abstract - AMYC BIOMED 2024 5th Edition - ()

11573/1723176 - 2024 - Dual-Responsive Alginate/PNIPAM Microspheres Fabricated by Microemulsion-Based Electrospray

Ciarleglio, Gianluca; Placido, Monica; Toto, Elisa; Santonicola, Maria Gabriella - 01a Articolo in rivista

rivista: POLYMERS (Basel : Molecular Diversity Preservation International) pp. 1-17 - issn: 2073-4360 - wos: WOS:001332595400001 (0) - scopus: 2-s2.0-85206497744 (0)

11573/1699906 - 2024 - Fabrication of Alginate/Ozoile Gel Microspheres by Electrospray Process

Ciarleglio, Gianluca; Russo, Tiziana; Toto, Elisa; Santonicola, Maria Gabriella - 01a Articolo in rivista

rivista: GELS (Basel : MDPI) pp. 1-16 - issn: 2310-2861 - wos: WOS:001148952000001 (7) - scopus: 2-s2.0-85183400766 (8)

11573/1717796 - 2024 - Electrospray fabrication of pH‐responsive microspheres for the delivery of Ozoile

Ciarleglio, Gianluca; Russo, Tiziana; Vella, Serena; Toto, Elisa; Santonicola, Maria Gabriella - 01a Articolo in rivista

rivista: MACROMOLECULAR SYMPOSIA (Huethig & Wepf Verlag:Auf dem Wolf 4, CH 4018 Basel Switzerland:011 41 61 3179410, Fax: 011 41 61 3179411) pp. 1-3 - issn: 1022-1360 - wos: WOS:001293226800052 (1) - scopus: 2-s2.0-85201430183 (1)

11573/1719988 - 2024 - Reconstruction of the permittivity of ex vivo animal tissues in the frequency range 1–20 GHz using a water-based dielectric model

Liporace, Flavia; Ciarleglio, Gianluca; Santonicola, Maria Gabriella; Cavagnaro, Marta - 01a Articolo in rivista

rivista: SENSORS (Basel : Molecular Diversity Preservation International (MDPI), 2001-) pp. - - issn: 1424-8220 - wos: WOS:001305476800001 (0) - scopus: 2-s2.0-85202437351 (0)

11573/1714463 - 2024 - Dielectric characterization of biological tissues at microwave frequencies based on water content

Liporace, Flavia; Ciarleglio, Gianluca; Santonicola, Mariagabriella; Cavagnaro, Marta - 04b Atto di convegno in volume

11573/1717798 - 2024 - The effect of crosslinking density on the dynamic behavior of thermo‐responsive poly(N‐isopropylacrylamide) hydrogels

Toto, Elisa; Franco, Eleonora; Ciarleglio, Gianluca; Santonicola, Maria Gabriella - 01a Articolo in rivista

rivista: MACROMOLECULAR SYMPOSIA (Huethig & Wepf Verlag:Auf dem Wolf 4, CH 4018 Basel Switzerland:011 41 61 3179410, Fax: 011 41 61 3179411) pp. 1-3 - issn: 1022-1360 - wos: (0) - scopus: 2-s2.0-85201260463 (1)

11573/1687550 - 2023 - Synthesis and characterization of alginate gel beads with embedded zeolite structures as carriers of hydrophobic curcumin

Ciarleglio, Gianluca; Cinti, Federica; Toto, Elisa; Santonicola, Mariagabriella - 01a Articolo in rivista

rivista: GELS (Basel : MDPI) pp. 1-16 - issn: 2310-2861 - wos: WOS:001071789900001 (11) - scopus: 2-s2.0-85172235242 (14)

11573/1678014 - 2023 - Book of abstracts Chimici per le Biotecnologie 2023

Ciarleglio, Gianluca; Montesano, Domenico; Vella, Serena; Benevento, Gilda; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: 5° Workshop "I chimici per le biotecnologie" (Napoli)

libro: Book of abstracts Chimici per le Biotecnologie 2023 - ()

11573/1684106 - 2023 - Electrospray Fabrication of pH-Responsive Microspheres for the Delivery of Ozoile

Ciarleglio, Gianluca; Russo, Tiziana; Vella, Serena; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: TOP 11TH INTERNATIONAL CONFERENCE (Ischia)

libro: Book of abstracts TOP 11TH INTERNATIONAL CONFERENCE - ()

11573/1670566 - 2023 - Conductive and thermo-responsive composite hydrogels with poly(N-isopropylacrylamide) and carbon nanotubes fabricated by two-step photopolymerization

Ciarleglio, Gianluca; Toto, Elisa; Santonicola, Mariagabriella - 01a Articolo in rivista

rivista: POLYMERS (Basel : Molecular Diversity Preservation International) pp. - - issn: 2073-4360 - wos: WOS:000941855400001 (19) - scopus: 2-s2.0-85149036970 (22)

11573/1689151 - 2023 - pH-Responsive Hydrogel Vectors with Nanostructures: Innovative Approaches for the Efficient Delivery of Lipophilic Drugs

Ciarleglio, Gianluca; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: NanoInnovation Conference & Exhibition 2023 (Roma)

libro: Programme book - NanoInnovation Conference & Exhibition 2023 - ()

11573/1662568 - 2023 - Emulsion-based multi-responsive microspheres for the delivery of lipophilic ozoile

Ciarleglio, Gianluca; Vella, Serena; Toto, Elisa; Santonicola, Mariagabriella - 01a Articolo in rivista

rivista: CERAMICS INTERNATIONAL (Oxford, United Kingdom: Elsevier Science Ltd) pp. 24517-24524 - issn: 0272-8842 - wos: WOS:001018288800001 (9) - scopus: 2-s2.0-85144548423 (11)

11573/1691936 - 2023 - Stimuli-responsive emulsion-based hydrogels integrated with anti-inflammatory Ozoile molecules

Ciarleglio, Gianluca; Vella, Serena; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: Merck Young Chemists’ Symposium XXII edition (Rimini)

libro: Proceedings of the Merck Young Chemists’ Symposium XXII edition - (978-88-94952-44-5)

11573/1684107 - 2023 - The Effect of Crosslinking Density on the Dynamic Behaviour of Thermo-Responsive Poly(N-Isopropylacrylamide) Hydrogels

Toto, Elisa; Franco, Eleonora; Ciarleglio, Gianluca; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: TOP 11TH INTERNATIONAL CONFERENCE (Ischia)

libro: Book of abstracts TOP 11TH INTERNATIONAL CONFERENCE - ()

11573/1649156 - 2022 - N-Isopropylacrylamide-based composite hydrogels containing carbon nanotubes: synthesis by two-step photopolymerization and characterization

Ciarleglio, Gianluca; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: Polymers 2022 - New Trends in Polymer Science: Health of the Planet, Health of the People (Turin)

libro: Conference Book - Polymers 2022 - New Trends in Polymer Science: Health of the Planet, Health of the People - ()

11573/1649157 - 2022 - Stimuli responsive emulsion-based micro/nanospheres for the delivery of lipophilic therapeutics

Ciarleglio, Gianluca; Vella, Serena; Toto, Elisa; Santonicola, Mariagabriella - 04f Poster

congresso: School of Nanomedicine 2022 (Roma)

libro: School of nanomedicine 2022 - ()

11573/1657538 - 2022 - Multi-responsive hydrogel microspheres for the controlled release of ozoile

Ciarleglio, Gianluca; Vella, Serena; Toto, Elisa; Santonicola, Mariagabriella - 04d Abstract in atti di convegno

congresso: CIMTEC 2022 9th Forum on New Materials (Perugia)

libro: Programme book - 9th Forum on New Materials - ()

11573/1657540 - 2022 - Ozoile-alginate microspheres for the therapeutic management of Crohn's disease

Ciarleglio, Gianluca; Vella, Serena; Toto, Elisa; Santonicola, Mariagabriella - 04b Atto di convegno in volume

congresso: BIOMAH - Biomaterials and novel technologies for healthcare. 3rd biennal International Conference (Roma; Italia)

libro: Biomaterials and novel technologies for healthcare. 3rd biennal International Conference BIOMAH - (978 88 8080 500 7)