Phd in MOLECULAR MEDICINE

email: gianluca.canettieri@uniroma1.it
phone: 06/49255130
building: Regina Elena Edificio B (RM110)
room: 219

PRESENT POSITION

Full Professor, General Pathology, MED/04
Department of Molecular Medicine
Sapienza University of Rome
Viale Regina Elena 291 - 00161 Roma



ADDITIONAL POSITIONS

- Head of Epigenetics, Metabolism and Cancer Unit, Department of Molecular Medicine, Sapienza University of Rome
- PI - Nutrition and Cancer Research (NACRe) European Consortium
- Secretary of the Board of Full Professors SSD Med/04
- Secretary-Treasurer of the Italian Society of Pathology and Translational Medicine (SIPMeT)



EDUCATION AND CAREER

2019- today: Full Professor, General Pathology (SSD MED/04), Dept. Molecular Medicine, University La Sapienza.
2008 – 2019: Associate Professor, General Pathology (SSD MED/04), Dept. Molecular Medicine, University La Sapienza
2005-2008: Assistant Professor of Pathology c/o Department of Experimental Medicine and Pathology. Programma Rientro dei Cervelli - MIUR - University of Rome “La Sapienza”
2000-2005 Research Associate, Salk Institute for Biological Studies, Peptide Biology laboratories, La Jolla, CA.
1996-2000: PhD in Endocrinology and Metabolic Sciences at the University “La Sapienza”, Rome
1996: Visiting fellow at the Geriatric Division of the Johns Hopkins University, Baltimore MD USA.
1996: Board certification for medical practice
1995: Medical Doctor degree, Graduation cum laude

MOST RELEVANT RESEARCH LINES

1. Energy and redox alterations in cancer (colorectal and medulloblastoma) and their targeting with metabolic drugs and diet.
2. Polyamine metabolism and hypusination pathway in cancer and muscle disease.
3. Molecular mechanisms regulating MYC in colorectal cancer and their targeting
4. Discovery of novel compounds targeting WNT pathway, epigenetic and metabolic alterations in colorectal cancer and medulloblastoma

COLLABORATIONS:

Salk Institute for Biological Studies, La Jolla, CA; The Burnham Institute, La Jolla, CA; Scripps Research institute, San Diego, CA; University of Toronto, Canada; University of Florida, FL; Harvard Medical School, Boston, MA; Whitehead Institute for Biomedical Research, Cambridge, MA; University of Illinois College of Medicine, Chicago, IL; Osaka University, Osaka, Japan; Johns Hopkins University, Baltimore, MD; University of Maryland, Baltimore, MD; University of Warzav, Poland; École Polytechnique Fédérale de Lausanne, Switzerland; University of Leeds, UK; McMaster University, Canada; Michigan State University, MI, USA
Università di Palermo; Università di Bari; Università di Pisa, Università di Messina; Università di Siena, Università di Roma Tor Vergata; Università Cattolica del Sacro Cuore, Roma; Consiglio Nazionale delle Ricerche, Roma e Napoli, Italian Institute of Tecnology, Rome, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Cancer Genetics Laboratory, IRCCS S. de Bellis, Castellana Grotte; IRBM-Merck Research Laboratories Rome; Ente Per Le Nuove Technologie, l'Energia e l'Ambiente (ENEA), Centro Ricerche Casaccia, Casaccia, Roma; Neuromed Institute Pozzilli, Isernia; Istituto Nazionale della Nutrizione, Roma



FIVE SELECTED PUBLICATIONS

Coni S, Falconio FA, Marzullo M, Munafò M, Zuliani B, Mosti F, Fatica A, Ianniello Z, Bordone R, Macone A, Agostinelli E, Perna A, Matkovic T, Sigrist S, Silvestri G, Canettieri G*, Ciapponi L*. Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function. Elife. 2021 Sep 14;10:e69269. doi: 10.7554/eLife.69269. PMID: 34517941 Free PMC article.

Di Magno L, Manni S, Di Pastena F, Coni S, Macone A, Cairoli S, Sambucci M, Infante P, Moretti M, Petroni M, Nicoletti C, Capalbo C, De Smaele E, Di Marcotullio L, Giannini G, Battistini L, Goffredo BM, Iorio E, Agostinelli E, Maroder M, Canettieri G. Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module. Cell Rep. 2020 Feb 11;30(6):1735-1752.e7. doi: 10.1016/j.celrep.2020.01.024.

Coni S, Serrao SM, Yurtsever ZN, Di Magno L, Bordone R, Bertani C, Licursi V, Ianniello Z, Infante P, Moretti M, Petroni M, Guerrieri F, Fatica A, Macone A, De Smaele E, Di Marcotullio L, Giannini G, Maroder M, Agostinelli E, Canettieri G Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation. Cell Death Dis. 2020 Dec 10;11(12):1045. doi: 10.1038/s41419-020-03174

Coni S, Mancuso AB, Di Magno L, Sdruscia G, Manni S, Serrao S, Rotili D, Spiombi E, Bufalieri F, Petroni ML, Kusio-Kobialka M, De Smaele E, Ferretti E, Capalbo C, Mai A, Niewiadomski P, Screpanti I, Di Marcotullio L and Canettieri G Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma Sci Rep. 2017 Mar 9;7:44079. doi: 10.1038/srep44079.

D'Amico D, Antonucci L, Di Magno L, Coni S, Sdruscia G, Macone A, Miele E, Infante P, Di Marcotullio L, De Smaele E, Ferretti E, Ciapponi L, Giangaspero F, Yates JR 3rd, Agostinelli E, Cardinali B, Screpanti I, Gulino A, Canettieri G. Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth. Dev Cell. 2015 Oct 12;35(1):21-35. doi: 10.1016/j.devcel.2015.09.008.