Research: "Targeting MEX3A/RIG-I axis: innovative perspectives for new multi-targeting approaches in the treatment of glioblastoma"
Personal data:
Name and Surname: Gennaro Adabbo
Date and place of birth: 24/11/1998, Avellino (AV), Italy
Nationality: Italian
Work address: Laboratory of Molecular Oncology (Department of Molecular Medicine),
Viale Regina Elena 291, 00161 Rome, Italy
Phone number: +39 3487017239
Mail address: gennaro.adabbo@uniroma1.it
Education:
October 2022 – Master degree in Genetics and Molecular Biology at Sapienza University, Rome (Italy).
Score: 110/110 cum laude.
Thesis title: “The cytoskeleton in the regulation of Hedgehog signaling and in the Hedgehog-dependent medulloblastoma: study of the role of inverted formin 2, INF2”.
Supervisor: Prof.ssa Paola Infante – Dept. of Molecular Medicine, Sapienza University, Rome (Italy)
September 2020 – Bachelor degree in Biotechnology at University of Sannio, Benevento (Italy).
Score: 110/110 cum laude
Thesis title: “The functional deficiency of the BCS1L chaperone protein is the cause of the onset of GRACILE syndrome”
Supervisor: Prof. Angelo Lupo– Dept. of Science and Technology, University of Sannio, Benevento (Italy).
Other certifications:
January 2018: English IELTS, Europass Level B1
Research experience:
November 2022– Present:PhD Student in Molecular Medicine, Dept. of Molecular Medicine, Sapienza University, Rome (Italy). Tutor: Prof.ssa Lucia Di Marcotullio. Field of interest: Molecular basis and therapeutic approaches in brain tumors.
October 2021 – October 2022: Trainee at Dept. of Molecular Medicine, Sapienza University, Rome (Italy).
May 2020– July 2020:Trainee in Laboratory of Biochemistry and Molecular Biology, Dept. of Science and Technology, University of Sannio, Benevento (Italy). Tutor: Prof. Angelo Lupo
AWARDS
2020 Winner Scholarship "Wanted the best", Sapienza (Rome, RM)
Technical skills and competences:
Molecular Biology techniques: Plasmidic and genomic DNA extraction, RNA extraction, cloning, DNA mutagenesis, reverse transcription, PCR, quantitative real time PCR, luciferase reporter assays.
Analysis of proteins: Protein extraction and western blot analysis, protein post-translational modifications analysis; immunoprecipitation assays.
Cellular biology: cell culture techniques (animal cells), DNA and siRNA transfection/transduction, cell treatments, BrdU assay, production and use of lentiviral vectors.
Histology and histopathology techniques: immunofluorescence, histochemical and immuno-histochemical techniques.
IT Skills:
Office suite; Adobe Photoshop; Image J; Image Lab; GraphPad.
Use of various DataBases and tools: NCBI, PDB, BLAST, GenScript, OncoMX, Uniprot, Biorender, STRING
ORAL AND POSTER PRESENTATION
-BraYn 6th Research Assembly for Young Neuroscientists- Napoli, Italy (27-29 Sept.2023) – Poster
presentation (“The cytoskeleton regulator inverted formin INF2 regulates the SHH pathway and is involved in medulloblastoma tumorigenesis”)
PUBLICATIONS
Quaglio D, Infante P, Cammarone S, Lamelza L, Conenna M, Ghirga F, Adabbo G, Pisano L, Di Marcotullio
L, Botta B, Mori M. Exploring the Potential of Anthraquinone-Based Hybrids for Identifying a Novel
Generation of Antagonists for the Smoothened Receptor in HH-Dependent Tumour. Chemistry. 2023 Nov
8;29(62):e202302237. doi: 10.1002/chem.202302237. Epub 2023 Sep 25. PMID: 37565343