11573/1767592 - 2026 -
A synergistic interaction between PRMT5 and LSD1 inhibitors in AML Param, Nesteene Joy; Arceci, Elisa; Fiorentino, Francesco; Pignata, Luca; Torre, Denis; Gutiérrez-Trejo, Nayeli; Fong, Jia Yi; Goy, Pierre-Alexis; Han, Brenda Y; Lambona, Chiara; Di Bello, Elisabetta; Castiello, Carola; Barone, Marco; Schwarz, Megan; Arrowsmith, Cheryl; Ito, Koichi; Scherle, Peggy; Wee, Dave Keng Boon; Ndoye, Steven; Tabaglio, Tommaso; Jeyasekharan, Anand D; Lakshmanan, Manikandan; Cirilli, Roberto; Habisch, Hansjörg; Madl, Tobias; Mattevi, Andrea; Valente, Sergio; Mai, Antonello; Guccione, Ernesto - 01a Articolo in rivista
rivista: SCIENCE ADVANCES (Washington, DC : American Association for the Advancement of Science, 2015-) pp. 1-15 - issn: 2375-2548 - wos: WOS:001727101900005 (0) - scopus: 2-s2.0-105034601668 (0)
11573/1775149 - 2026 -
Exploring the role of conformational restriction in 5-alkyl-6-benzyl-2-{[(methylthio)methyl]thio}pyrimidin-4(3H)-ones. Effects in HIV-1 infected cells and reverse transcriptase enzymes Degtyarenko, Egor; Hailu, Gebremedhin Solomon; Fabbrizi, Emanuele; Golovina, Anastasia; Voronkov, Andrey; Astolfi, Roberta; Giuliani, Lidia; Mancini, Andrea; Nawrozkij, Maxim B; Chernyshov, Vladimir; Pupillo, Clarissa; Cirilli, Roberto; Bavagnoli, Laura; Ragno, Rino; Esté, José A; Crespan, Emmanuele; Fiorentino, Francesco; Ivanov, Roman; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ([Paris] : Elsevier, [198?]-) pp. 1-18 - issn: 1768-3254 - wos: WOS:001875392200001 (0) - scopus: 2-s2.0-105049199102 (0)
11573/1775143 - 2026 -
Development of High-Affinity CHD1 Chromodomain Inhibitors Greschik, Holger; Friedrich, Florian; Seifert, Ludwig; Mousavizadeh, Farnoush; Fiorentino, Francesco; Walz, Johannes; Zhang, Lin; Li, Jianyu; Fabbrizi, Emanuele; Tomassi, Stefano; Panahi, Farhad; Papenkordt, Niklas; Wurnig, Silas L.; Osterroth, Johannes; Strasser, Anna M.; Ruprecht, Jan; Moumbock, Aurélien F. A.; Hügle, Martin; Sum, Manuela; Peng, Ling; Wang, Sheng; Baniahmad, Adina A.; Pulido-Cortés, Laura; Marc Timmers, H. Th.; Flaig, Ralf; Metzger, Eric; Breit, Bernhard; Einsle, Oliver; Günther, Stefan; Rotili, Dante; Mai, Antonello; Schüle, Roland; Jung, Manfred - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 12020-12047 - issn: 1520-4804 - wos: WOS:001757284300001 (0) - scopus: 2-s2.0-105040723838 (0)
11573/1775144 - 2026 -
METTL1/WDR4 Complex: A Novel Epitranscriptomic Target at the Crossroads of RNA Methylation and Drug Discovery Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Mancini, Andrea; Mai, Antonello; Fiorentino, Francesco; Rotili, Dante - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 17736-17769 - issn: 1520-4804 - wos: WOS:001825578700001 (0) - scopus: 2-s2.0-105047215837 (0)
11573/1775146 - 2026 -
Native Mass Spectrometry of Soluble Proteins with Sodium Chloride Enabled by a Dendritic Detergent Fiorentino, Francesco; Hiller, Wolf; Urner, Leonhard H. - 01a Articolo in rivista
rivista: ACS MEASUREMENT SCIENCE AU (Washington DC: American Chemical Society, [2021]-) pp. 1038-1048 - issn: 2694-250X - wos: WOS:001788376900001 (0) - scopus: 2-s2.0-105048824627 (0)
11573/1775148 - 2026 -
Deubiquitinase-targeting chimeras (DUBTACs). A game-changing approach for targeted protein stabilization in drug discovery Hailu, Gebremedhin Solomon; Fabbrizi, Emanuele; Mancini, Andrea; Fiorentino, Francesco; Mai, Antonello; Rotili, Dante - 01g Articolo di rassegna (Review)
rivista: DRUG DISCOVERY TODAY (Amsterdam: Elsevier) pp. 1-20 - issn: 1878-5832 - wos: WOS:001861197500001 (0) - scopus: 2-s2.0-105048164104 (0)
11573/1775150 - 2026 -
Systematic structure–activity relationship investigation on novel 5-alkyl-6-benzyl-2-{[(methylthio/phenylthio)alkyl]thio}-pyrimidin-4(3H)-ones endowed with potent anti-hiv-1 activity Hailu, Gebremedhin Solomon; Degtyarenko, Egor; Fabbrizi, Emanuele; Golovina, Anastasia; Voronkov, Andrey; Mancini, Andrea; Nawrozkij, Maxim B.; Chernyshov, Vladimir; Bavagnoli, Laura; Bianchi, Elena; Astolfi, Roberta; Ragno, Rino; Esté, José A.; Crespan, Emmanuele; Fiorentino, Francesco; Ivanov, Roman; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
rivista: ACS OMEGA (Washington, D.C. : American Chemical Society, 2016-) pp. 1-18 - issn: 2470-1343 - wos: WOS:001877209400001 (0) - scopus: (0)
11573/1767594 - 2026 -
The ATC12 small molecule inhibits the Aurora-A/TPX2 interaction and impairs the proliferation of breast cancer cells Boi, Dalila; Fianco, Giulia; Polverino, Federica; Fiorentino, Francesco; Mastrangelo, Anna; Rossi, Simone; Rubini, Elisabetta; Rosignoli, Serena; Troilo, Francesca; Antonelli, Maria Rosaria; Tarquini, Dalila; Cervoni, Laura; Rinaldo, Serena; Tramonti, Angela; Scarpone, Eleonora Kristina; Naro, Chiara; Sette, Claudio; Stagni, Venturina; Colotti, Gianni; Rotili, Dante; Paiardini, Alessandro; Guarguaglini, Giulia; Asteriti, Italia Anna - 01a Articolo in rivista
rivista: CELL DEATH & DISEASE (London: Nature Group-Springer
London: Nature Publishing Group, 2001-) pp. - - issn: 2041-4889 - wos: WOS:001730449000001 (1) - scopus: 2-s2.0-105034685392 (1)
11573/1767644 - 2026 -
Development of biphenyl-substituted uracil-based hydroxamic acids (UBHAs) as potent HDAC inhibitors with pro-apoptotic activity in leukemia and prostate cancer cells Fiorentino, Francesco; Bontempi, Giulio; Michetti, Federica; Pecci, Valeria; Fabbrizi, Emanuele; Passeri, Daniela; Corsetti, Letizia; Farini, Valentina; Casano, Fabrizio; Gioiello, Antimo; Di Sotto, Antonella; Pellicciari, Roberto; Bufalo, Donatella Del; Trisciuoglio, Daniela; Nanni, Simona; Strippoli, Raffaele; Mai, Antonello; Rotili, Dante - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. - - issn: 0022-2623 - wos: WOS:001753924400001 (0) - scopus: (0)
11573/1777613 - 2026 -
METTL3–METTL14 heterodimer assembly enables multivalent RNA engagement and is tuned by interface-targeting peptides Fiorentino, Francesco; Xiao, Boyi; Cesaro, Bianca; Venezia, Sara; Zhou, Jujun; Fabbrizi, Emanuele; Casano, Fabrizio; Hailu, Gebremedhin Solomon; Cheng, Xiaodong; Corey, Robin A.; Fatica, Alessandro; Mai, Antonello; Tomassi, Stefano; Rotili, Dante - 01a Articolo in rivista
rivista: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY ([Washington, USA: American Chemical Society] 1879-) pp. - - issn: 0002-7863 - wos: (0) - scopus: (0)
11573/1767195 - 2025 -
Correction. Sennato et al. Optimization of Lipoplexes functionalized with a sialic acid mimetic (F9-PEG) to target the C1858T PTPN22 variant for preclinical assessment of a novel immunotherapy in endocrine autoimmunity. Pharmaceutics 2025, 17, 710 Sennato, Simona; Paldino, Giorgia; Bombelli, Cecilia; Mezzani, Irene; Petrini, Stefania; Belcastro, Eugenia; Vittorio Delfino, Domenico; Fiorentino, Francesco; Marianecci, Carlotta; Ciogli, Alessia; Rotili, Dante; Ceccacci, Francesca; Fierabracci, Alessandra - 01b Commento, Erratum, Replica e simili
rivista: PHARMACEUTICS (Basel: MDPI, 2009-) pp. 1-2 - issn: 1999-4923 - wos: WOS:001648266200001 (0) - scopus: 2-s2.0-105026459246 (0)
11573/1747195 - 2025 -
Native mass spectrometry for proximity-inducing compounds: a new opportunity for studying chemical-induced protein modulation Fabbrizi, Emanuele; Fiorentino, Francesco; Casano, Fabrizio; Mai, Antonello; Rotili, Dante - 01g Articolo di rassegna (Review)
rivista: EXPERT OPINION ON DRUG DISCOVERY (First or current publisher [London] : Informa Healthcare, 2006-
Current or last publisher [London] : [Taylor & Francis]) pp. 643-657 - issn: 1746-045X - wos: WOS:001461316100001 (3) - scopus: 2-s2.0-105002576152 (3)
11573/1747193 - 2025 -
An amazing 30-year journey around the DABO family. A medicinal chemistry lesson on a versatile class of non-nucleoside HIV-1 reverse transcriptase inhibitors Fabbrizi, Emanuele; Chernyshov, Vladimir V.; Fiorentino, Francesco; Sbardella, Gianluca; Ragno, Rino; Nawrozkij, Maxim; Ivanov, Roman; Rotili, Dante; Mai, Antonello - 01g Articolo di rassegna (Review)
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 5993-6026 - issn: 0022-2623 - wos: WOS:001440408700001 (6) - scopus: 2-s2.0-86000539361 (5)
11573/1767141 - 2025 -
Structural snapshots of Pseudomonas aeruginosa LptB2FG and LptB2FGC reveal insights into lipopolysaccharide recognition and transport Fiorentino, Francesco; Cervoni, Matteo; Wang, Yi; Urner, Leonhard H.; Sauer, Joshua B.; Tran, Anh; Corey, Robin A.; Rotili, Dante; Mai, Antonello; Stansfeld, Phillip J.; Imperi, Francesco; Yu, Edward W.; Su, Chih-Chia; Robinson, Carol V.; Bolla, Jani R. - 01a Articolo in rivista
rivista: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. 1-14 - issn: 2041-1723 - wos: WOS:001647742800004 (2) - scopus: 2-s2.0-105025801869 (2)
11573/1754713 - 2025 -
Sirtuin modulators: a review of patents from 2020 to 2024 Fabbrizi, Emanuele; Fiorentino, Francesco; Mai, Antonello; Rotili, Dante - 01g Articolo di rassegna (Review)
rivista: EXPERT OPINION ON THERAPEUTIC PATENTS (--London United Kingdom:Informa Healthcare
-London, United Kingdom: Ashley Publications Limited) pp. 1-23 - issn: 1354-3776 - wos: WOS:001609146000001 (6) - scopus: 2-s2.0-105021101395 (6)
11573/1746317 - 2025 -
Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor Noce, Beatrice; Marchese, Sara; Massari, Marta; Lambona, Chiara; Reis, Joana; Fiorentino, Francesco; Raucci, Alessia; Fioravanti, Rossella; Castelôa, Mariana; Mormino, Alessandro; Garofalo, Stefano; Limatola, Cristina; Basile, Lorenzo; Gottinger, Andrea; Binda, Claudia; Mattevi, Andrea; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington DC : ACS Publications) pp. 6292-6311 - issn: 1520-4804 - wos: WOS:001437973800001 (13) - scopus: 2-s2.0-86000188474 (14)
11573/1730586 - 2025 -
GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis Cocozza, Germana; Busdraghi, Ludovica Maria; Chece, Giuseppina; Menini, Antonio; Ceccanti, Marco; Libonati, Laura; Cambieri, Chiara; Fiorentino, Francesco; Rotili, Dante; Scavizzi, Ferdinando; Raspa, Marcello; Aronica, Eleonora; Inghilleri, Maurizio; Garofalo, Stefano; Limatola, Cristina - 01a Articolo in rivista
rivista: BRAIN, BEHAVIOR, AND IMMUNITY (Orlando, Fla. : Academic Press) pp. 280-293 - issn: 1090-2139 - wos: WOS:001389522200001 (10) - scopus: 2-s2.0-85211752412 (9)
11573/1747191 - 2025 -
Development of C646‐based proteolysis targeting chimeras degraders of the lysine acetyltransferases CBP and p300 Fiorentino, Francesco; Spriano, Filippo; Tomaselli, Daniela; Risi, Giorgia; Fabbrizi, Emanuele; Pecci, Valeria; Nanni, Simona; Bertoni, Francesco; Rotili, Dante; Mai, Antonello - 01a Articolo in rivista
rivista: CHEMMEDCHEM (Weinheim : Wiley-VCH-Verl..) pp. - - issn: 1860-7179 - wos: WOS:001463791500001 (5) - scopus: 2-s2.0-105002391129 (4)
11573/1744500 - 2025 -
A C3‐Symmetric Diphenylethylendiamine‐Based Catalyst in the Asymmetric Michael Addition of α,β‐Unsaturated Ketones with 4‐Hydroxycoumarin and 4‐Hydroxyquinolin‐2‐One Oljira, Shilashi Badasa; De Angelis, Martina; Manetto, Simone; Fiorentino, Francesco; Rotili, Dante; Mosca, Luciana; Di Risola, Daniel; Mattioli, Roberto; Pierini, Marco; Mazzoccanti, Giulia; Ciogli, Alessia - 01a Articolo in rivista
rivista: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (Wiley-VCH Verlag GmBH:PO Box 101161, D 69451 Weinheim Germany:011 49 6201 606147, EMAIL: service@wiley-vch.de, INTERNET: http://www.wiley-vch.de, Fax: 011 49 6201 606328) pp. 1-8 - issn: 1434-193X - wos: WOS:001548536200001 (1) - scopus: 2-s2.0-105012933260 (1)
11573/1756562 - 2025 -
Quinoline-based DNA methyltransferase inhibitors featuring basic side chains: design, synthesis, and insight in biochemical and anticancer cell properties Zwergel, Clemens; Lambona, Chiara; Fioravanti, Rossella; Raucci, Alessia; Fiorentino, Francesco; Nchugoua Tchieh, Guilaine; Jallet, Corinne; Lacroix, Laurent; Pierrettori, Michela; Pellegrini, Francesca Romana; Xiong, Yan; Jin, Jian; Arimondo, Paola; Trisciuoglio, Daniela; Mai, Antonello; Valente, Sergio - 01a Articolo in rivista
rivista: JOURNAL OF MEDICINAL CHEMISTRY (Washington, DC: American Chemical Society) pp. 23886-23909 - issn: 0022-2623 - wos: WOS:001612302100001 (3) - scopus: 2-s2.0-105023168579 (4)
11573/1746681 - 2025 -
Optimization of lipoplexes functionalized with a Sialic Acid Mimetic (f9-peg) to target the c1858t ptpn22 variant for preclinical assessment of a novel immunotherapy in endocrine autoimmunity Sennato, Simona; Paldino, Giorgia; Bombelli, Cecilia; Mezzani, Irene; Petrini, Stefania; Delfino, Domenico Vittorio; Fiorentino, Francesco; Marianecci, Carlotta; Ciogli, Alessia; Rotili, Dante; Ceccacci, Francesca; Fierabracci, Alessandra - 01a Articolo in rivista
rivista: PHARMACEUTICS (Basel: MDPI, 2009-) pp. 1-14 - issn: 1999-4923 - wos: WOS:001514902500001 (2) - scopus: 2-s2.0-105009166163 (2)
11573/1767593 - 2025 -
Structural characterisation of the fungal Pmt4 homodimer Mcdowell, Melanie A; Wild, Klemens; Fiorentino, Francesco; Bausewein, Daniela; Metschies, Anke; Chiapparino, Antonella; Hackmann, Yvonne; Bilsing, Florestan L; Brenske, David; Mortensen, Sofia; Wu, Di; Robinson, Carol V; Strahl, Sabine; Sinning, Irmgard - 01a Articolo in rivista
rivista: NATURE COMMUNICATIONS (London: Nature Publishing Group-Springer Nature) pp. 1-14 - issn: 2041-1723 - wos: WOS:001639412100001 (1) - scopus: 2-s2.0-105024825849 (1)