FRANCESCA PAOLINI

PhD Student

PhD program:: XXXVIII
email: francesca.paolini@uniroma1.it
phone: 0652666959




supervisor: Aldo Venuti
advisor: Fabio Di Domenico

Francesca Paolini
Date of birth: 05th April 1979
Place of birth: Rome-Italy
Citizenship: Italian
Work address: Regina Elena Cancer Institute Via Elio Chianesi 53 00144
Phone number and e-mail address: +390652666959 francesca.paolini@ifo.it
Education: she received her Clinical Pathology specialisation on June 2014 at the “La Sapienza” University of Rome, the title of thesis was “Diagnosi biomolecolare della presenza di HPV in campioni clinici della cavità orale: confronto fra popolazione sana e pazienti affetti da lesioni precancerose e tumori della cavità orale”. She graduated on May 2006 in Molecular Biology at the “La Sapienza” University of Rome, by discussing a thesis entitled: “Stress ossidativo e modulazione di cellule epiteliali trasformate da Human Papilloma Virus tipo 16”. She received her technician’s diploma in chemistry and biology in Julie 1998.
Research experiences: Since 2006 she is working in the Laboratory of Virology of the Regina Elena Cancer Institute (IRE), as co.co.co in several Projects sponsored by Lega Italiana Lotta Tumori and Ministry of Health. In particular, she was in chief of a workpackage on the study of beta genus HPVs within a collaborative Project with Hospital San Carlo-IDI on “HPV in the carcinogenesis of the oropharynx area” and as Co-P.I. on Erb receptor family in an internal Grant of IRE. At present she is co.co.co in the UOSD Tumor Immunology and Immunotherapy at the Regina Elena National Cancer Institute following a project on HPV immunotherapy and she is in charge to use the Luminex (Bio-Rad platform) to study cytokine and chemokine in pre-clinical model and in Human.
Technical skills and competences: She has extensive competences in molecular biology in particular with several assays about Polymerase chain reaction (PCR), Reverse PCR, Real time PCR, identification of protein as Western-blot and Immuprecipitation method. In addition, she is working in animal house for vaccine research for HPV associated cancer.

Research products

11573/1726434 - 2024 - Circulating tumor HPV DNA in the management of HPV+ oropharyngeal cancer and its correlation with MRI
Campo, Flaminia; Paolini, Francesca; Manciocco, Valentina; Moretto, Silvia; Pichi, Barbara; Moretti, Claudio; Blandino, Giovanni; De Pascale, Valentina; Benevolo, Maria; Pimpinelli, Fulvia; Vidiri, Antonello; Marzi, Simona; Ruggiero, Sergio; Terrenato, Irene; Iocca, Oreste; Venuti, Aldo; Pellini, Raul - 01a Articolo in rivista
paper: HEAD & NECK ([New York, NY] : Wiley Periodicals, Inc., c1989-) pp. - - issn: 1097-0347 - wos: WOS:001265560000001 (2) - scopus: 2-s2.0-85197744627 (1)

11573/1697539 - 2023 - It is time to improve the diagnostic workup of oropharyngeal cancer with circulating tumor HPV DNA: systematic review and meta‐analysis
Paolini, Francesca; Campo, Flaminia; Iocca, Oreste; Manciocco, Valentina; De Virgilio, Armando; De Pascale, Valentina; Moretto, Silvia; Dalfino, Gianluca; Vidiri, Antonello; Blandino, Giovanni; Pimpinelli, Fulvia; Venuti, Aldo; Pellini, Raul - 01g Articolo di rassegna (Review)
paper: HEAD & NECK (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 2945-2954 - issn: 1043-3074 - wos: WOS:001067687100001 (5) - scopus: 2-s2.0-85171298818 (4)

11573/1725333 - 2023 - Targeting tumor-stroma communication by blocking endothelin-1 receptors sensitizes high-grade serous ovarian cancer to PARP inhibition
Tocci, Piera; Roman, Celia; Sestito, Rosanna; Di Castro, Valeriana; Sacconi, Andrea; Molineris, Ivan; Paolini, Francesca; Carosi, Mariantonia; Tonon, Giovanni; Blandino, Giovanni; Bagnato, Anna - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. 1-14 - issn: 2041-4889 - wos: WOS:000909496000001 (8) - scopus: 2-s2.0-85145645475 (7)

11573/1634885 - 2022 - Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients
Bruschini, Sara; Pallocca, Matteo; Sperandio, Eleonora; D'ambrosio, Lorenzo; Ascenzi, Francesca; De Vitis, Claudia; Salvati, Valentina; Esposito, Antonella; Di Martino, Simona; De Nicola, Francesca; Paolini, Francesca; Fattore, Luigi; Alessandrini, Gabriele; Facciolo, Francesco; Foddai, Maria Laura; Bassi, Massimiliano; Venuta, Federico; D'ascanio, Michela; Ricci, Alberto; D' Andrilli, Antonio; Napoli, Christian; Aurisicchio, Luigi; Fanciulli, Maurizio; Rendina, Erino Angelo; Ciliberto, Gennaro; Mancini, Rita - 01a Articolo in rivista
paper: JOURNAL FOR IMMUNOTHERAPY OF CANCER ([London] : BioMed Central) pp. - - issn: 2051-1426 - wos: WOS:000798224600002 (7) - scopus: 2-s2.0-85130301591 (8)

11573/1697607 - 2022 - Modifying Anthocyanins Biosynthesis in Tomato Hairy Roots: A Test Bed for Plant Resistance to Ionizing Radiation and Antioxidant Properties in Space
Massa, Silvia; Pagliarello, Riccardo; Cemmi, Alessia; Di Sarcina, Ilaria; Bombarely, Aureliano; Demurtas, Olivia Costantina; Diretto, Gianfranco; Paolini, Francesca; Petzold, H Earl; Bliek, Mattijs; Bennici, Elisabetta; Del Fiore, Antonella; De Rossi, Patrizia; Spelt, Cornelis; Koes, Ronald; Quattrocchio, Francesca; Benvenuto, Eugenio - 01a Articolo in rivista
paper: FRONTIERS IN PLANT SCIENCE (Lausanne : Frontiers Research Foundation, 2010-) pp. 1-30 - issn: 1664-462X - wos: WOS:000770628600001 (4) - scopus: 2-s2.0-85126199998 (5)

11573/1697611 - 2021 - HPV Infection in Middle Ear Squamous Cell Carcinoma: Prevalence, Genotyping and Prognostic Impact
Cristalli, Giovanni; Venuti, Aldo; Giudici, Fabiola; Paolini, Francesca; Ferreli, Fabio; Mercante, Giuseppe; Spriano, Giuseppe; Boscolo Nata, Francesca - 01a Articolo in rivista
paper: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. 1-9 - issn: 2077-0383 - wos: WOS:000624007400001 (3) - scopus: 2-s2.0-85114083312 (3)

11573/1696104 - 2021 - EPCL electrospun microfibrous layers for Immune assays. Sensitive Elisa for the detection of serum antibodies against HPV16 E7 oncoprotein
Falcucci, S; Paolini, F; Mileo, Am; Franconi, R; Massa, S; Rinaldi, A; Venuti, A - 01a Articolo in rivista
paper: ACS OMEGA (Washington, D.C. : American Chemical Society, 2016-) pp. 8778-8783 - issn: 2470-1343 - wos: WOS:000638986700006 (1) - scopus: 2-s2.0-85106122853 (0)

11573/1584779 - 2021 - Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients
Sacconi, A.; De Vitis, C.; De Latouliere, L.; Di Martino, S.; De Nicola, F.; Goeman, F.; Mottini, C.; Paolini, F.; D'ascanio, M.; Ricci, A.; Tafuri, A.; Marchetti, P.; Di Napoli, A.; De Biase, L.; Negro, A.; Napoli, C.; Anibaldi, P.; Salvati, V.; Duffy, D.; Terrier, B.; Fanciulli, M.; Capalbo, C.; Sciacchitano, S.; Blandino, G.; Piaggio, G.; Mancini, R.; Ciliberto, G. - 01a Articolo in rivista
paper: CELL DEATH & DISEASE (Nature Group) pp. 1-14 - issn: 2041-4889 - wos: WOS:000712879100008 (3) - scopus: 2-s2.0-85118432604 (3)

11573/1697612 - 2021 - Construction of a recombinant avipoxvirus expressing the env gene of Zika virus as a novel putative preventive vaccine
Zanotto, Carlo; Paolini, Francesca; Radaelli, Antonia; De Giuli Morghen, Carlo - 01a Articolo in rivista
paper: VIROLOGY JOURNAL (London : Biomed Central) pp. 1-14 - issn: 1743-422X - wos: WOS:000625540000001 (2) - scopus: 2-s2.0-85102006899 (3)

11573/872993 - 2016 - Targeting immune response with therapeutic vaccines in premalignant lesions and cervical cancer: hope or reality from clinical studies
Vici, P; Pizzuti, L; Mariani, L; Zampa, G; Santini, D; Di Lauro, L; Gamucci, T; Natoli, C; Barba, M; Maugeri Saccà, M; Sergi, D; Tomao, Federica; Vizza, E; Di Filippo, S; Paolini, F; Corrado, G; Michelotti, A; Sanguineti, G; Giordano, A; De Maria, R; Venuti, A.; Marchetti, Paolo; Curzio, G - 01a Articolo in rivista
paper: EXPERT REVIEW OF VACCINES ("Future Drugs Ltd, Unitec House, 3rd Floor, 2 Albert Place, Finchley Central, London, N3 1QB, UK) pp. 1327-1336 - issn: 1476-0584 - wos: WOS:000384322000010 (64) - scopus: 2-s2.0-84987790585 (74)

11573/670416 - 2015 - Bach1 overexpression in down syndrome correlates with the alteration of the ho-1/bvr-a system: insights for transition to Alzheimer's disease
Di Domenico, Fabio; Pupo, Gilda; Mancuso, C; Barone, Eugenio; Paolini, F; Arena, Andrea; Blarzino, Carla; Schmitt, Fa; Head, E; Butterfield, Da; Perluigi, Marzia - 01a Articolo in rivista
paper: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. - - issn: 1387-2877 - wos: WOS:000350001000007 (50) - scopus: 2-s2.0-84923270517 (58)

11573/687252 - 2014 - Immunologic treatments for precancerous lesions and uterine cervical cancer
Patrizia, Vici; Luciano, Mariani; Laura, Pizzuti; Domenico, Sergi; Luigi Di, Lauro; Enrico, Vizza; Tomao, Federica; Tomao, Silverio; Claudia, Cavallotti; Francesca, Paolini; Aldo, Venuti - 01a Articolo in rivista
paper: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 29- - issn: 1756-9966 - wos: WOS:000334695200001 (35) - scopus: 2-s2.0-84902261184 (43)

11573/542905 - 2010 - Predictors of human papilloma virus (HPV) infection in Italian women
M. C., Cercato; L., Mariani; A., Vocaturo; Carrone, Angela; I., Terrenato; Morano, Giuseppina; M., Benevolo; F., Rollo; C., Germelli; F., Paolini; A., Venuti - 01a Articolo in rivista
paper: JOURNAL OF MEDICAL VIROLOGY (-Hoboken, NJ : John Wiley & Sons Incorporated -[New York] Alan R. Liss, 1977-) pp. 1921-1927 - issn: 0146-6615 - wos: WOS:000282266900016 (8) - scopus: 2-s2.0-79952117067 (9)

11573/216873 - 2006 - MODULATION OF MELANOSOMAL FUNCTION IN MELANOMA CELLS: EXPRESSION OF THE E5 ONCOGENE RESTORES TYROSINASE ACTIVITY
Di Domenico, Fabio; Foppoli, C; Perluigi, Marzia; Blarzino, Carla; Coccia, Raffaella; Paolini, F; De Marco, F. - 04a Atto di comunicazione a congresso
book: Congresso nazionale Società Italiana di Cancerologia - ()

11573/218404 - 2006 - “Expression of HPV-16 E5 gene in melanoma cells regulates endo-melanosomal pH and restore tyrosinase activity”
Di Domenico, Fabio; Foppoli, C; Perluigi, Marzia; Blarzino, Carla; Coccia, Raffaella; Paolini, F; De Marco, F. - 04a Atto di comunicazione a congresso
book: 23rd International Papillomavirus Conference - ()

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