Dottorato in PSICOPATOLOGIA E FUNZIONAMENTO MENTALE: METODI DI
RICERCA IN AMBITO FORENSE

CURRICULUM VITAE

Francesca NARDECCHIA

CURRENT POSITION

15 July 2021 today Assistant Professor in Child and Adolescent Neurology and Psychiatry at Sapienza, University of Rome, Department of Human Neuroscience and medical director at Policlinico Umberto I, University Hospital, via dei Sabelli 108, 00181 Rome.

EDUCATION

Nov. 2017 February 2021 PhD Degree in Clinical/Experimental Neuroscience and Psychiatry, Department of Human Neuroscience, Child Neurology and Psychiatry Institute, Sapienza, University of Rome. Supervisor: Prof. Vincenzo Leuzzi

Nov. 2013 February 2017 PhD Degree in Pharmacology, Department of Physiology and Pharmacology, Sapienza, University of Rome. Supervisor: Prof. Ferdinando Nicoletti

July 2009 June 2014 Specialization in Child and Adolescent Neurology and Psychiatry at Sapienza, University of Rome, Department of Pediatrics and Child Neurology and Psychiatry - Policlinico Umberto I, University Hospital. Final grade: 70/70 summa cum laude. Graduation thesis: The role of biogenic amine/monoamine neurotransmitters in the physiopathology of phenylketonuria (PKU) . Advisor: Prof. Vincenzo Leuzzi

February 2009 Professional Qualification of Medical Doctor at Sapienza, University of Rome

September 2002 July 2008 Medical Doctor Degree at Sapienza, University of Rome. Final grade: 110/110 summa cum laude. Graduation thesis: The neurodevelopmental hypothesis of early onset schizophrenia: changes in Wnt/GSK-3 / -catenin cascade. Advisors: Prof. Teresa I. Carratelli, Prof. Ferdinando Nicoletti

PROFESSIONAL EXPERIENCE

March 2020 July 2021 Medical director in Child and Adolescent Neurology and Psychiatry at Policlinico Umberto I, University Hospital (Sapienza, University of Rome), via dei Sabelli 108, 00181 Rome (Permanent full-time employment).

May 2017 February 2020 Medical director in Child and Adolescent Neurology and Psychiatry at Policlinico Umberto I, University Hospital (Sapienza, University of Rome), Via dei Sabelli 108, 00181 Rome (Temporary full-time employment)

June 2016 April 2017 Freelance employment as consultant in Child and Adolescent Neurology and Psychiatry at Policlinico Umberto I, University Hospital (Sapienza, University of Rome), for the project New approaches in early diagnosis and treatment for children with neurogenetic and metabolic diseases , Via dei Sabelli 108, 00181 Rome (Full-time)

April 2015 April 2016 Freelance employment as consultant in Child and Adolescent Neurology and Psychiatry at ARMONIA, rehabilitation centre accredited and affiliated with the national health system, Via Piave Km. 69, 04100 Latina (40 h/month)

January 2015 March 2015 Freelance employment as consultant in Child and Adolescent Neurology and Psychiatry at Casa di Cura INI S.p.A. Unipersonale Divisione Medicus, rehabilitation centre accredited and affiliated with the national health system, P.le San Giovanni di Dio, snc 00019 Tivoli (RM) (10 h/month)

November 2014 March 2015 Freelance employment as consultant in Child and Adolescent Neurology and Psychiatry at VILLA ALBA, rehabilitation centre accredited and affiliated with the national health system, Via Nomentana 432, 00012 Fonte Nuova (RM) (40 h/month)

RESEARCH EXPERIENCE

Nov. 2013 February 2017 Study of metabotropic glutamate receptors in a mouse model of intellectual disability (PhD project). Department of Human Physiology and Pharmacology at Sapienza, University of Rome. Advisor: Prof. Ferdinando Nicoletti

Oct. 2015 September 2016 Research Fellowship on the effect of BH4 on biogenic amine peripheral metabolism and cognitive functions in Phenylketonuric patients. Department of Psychology, Sapienza, University of Rome. Advisor: Prof. Stefano Puglisi-Allegra

Oct. 2014 September 2015 Research Fellowship on the cognitive functions in early treated Phenylketonuric patients. Department of Pediatrics and Child Neurology and Psychiatry, Sapienza, University of Rome. Advisor: Prof. Vincenzo Leuzzi

Sept. 2011 August 2012 Molecular basis of the interallelic complementation of Phenylanaline Hydroxylase and its impact on phenotype-genotype correlation in Phenylketonuric patients. Department of Inborn Errors of Metabolism (Research Laboratory of Molecular Pediatrics) at Dr. von Hauner Children s Hospital, in Munich, Germany. Advisor: Prof. Ania C. Muntau

January 2006 July 2008 Molecular biology survey on nuclear, cytoplasmatic and serum molecular markers expressed in adolescents suffering from early onset schizophrenia (MD thesis project). Department of Human Physiology and Pharmacology at La Sapienza, University of Rome. Advisor: Prof. Ferdinando Nicoletti

CLINICAL TRIALS EXPERIENCE

January 2014 ongoing Merck Serono Protocoll EMR 700773-002: A Phase IV Open-Label, Single-Cohort Study of the Long-Term Neurocognitive Outcomes in 4 to 5 Year-old Children with Phenylkenonuria Treated with Sapropterin Dihydrochloride (Kuvan®) for 7 Years (KOGNITO)

August 2011 May 2017 Merck Serono Protocoll EMR700773-003: A Phase IIIb, Multicentre, Open-Label, Randomized, Controlled Study of the Efficacy, Safety, and Population Phamacokinetics of Sapropterin Dihydrochloride (Kuvan) in Phenylketonuria (PKU) Patients

November 2010 Nov. 2021 Observational Post-Authorization Safety Study (phase IV), EMR 700773-001, Kuvan® Adult Maternal Pediatric European Registry (KAMPER)

MEMBER:

Sub-representative of the European Reference Network for Hereditary Metabolic Disorders - MetabERN

International Working Group on Neurotransmitter Related Disorders (iNTDs), Patient Registry

International Parkinson and Movement Disorder Society (MDS)

Società Italiana per lo studio delle Malattie Metaboliche Ereditarie e lo Screening Neonatale (SIMMESN)

Società Italiana di Neuropsichiatria dell Infanzia e dell Adolescenza (SINPIA)