Gianno Francesca

Dottoressa di ricerca

ciclo: XXXIII


supervisore: Prof. Felice Giangaspero

Titolo della tesi: “MicroRNAs expression profile In Meningioma 1 (MN1) gene altered astroblastoma”

Astroblastoma is an uncommon glial brain tumour arising more frequently in young patients (median age 15 years), with a female predominance and unclear clinical behaviour and outcome. Histological aspects are common to other brain tumours, but the diagnostic molecular alteration is the rearrangement of meningioma 1 (MN1) gene. We collected a cohort of 14 tumour samples histologically defined as astroblastoma. The DNA methylation analysis of this group showed that only 8 cases harboured the MN1 rearrangement characteristic of astroblastoma. The 6 remaining samples were 1 ependymoma RELA fusion positive, 1 glioblastoma mesenchymal subtype, 1 diffuse midline glioma H3 K27M mutant, 1 pleomorphic xanthoastrocytoma / advanced stage ganglioglioma, 1 CNS high grade neuroepithelial tumour with BCOR alteration, 1 glioblastoma RTK II subtype. Considering the importance of microRNAs (miRNAs) as regulators of gene expression and their implication in several biological processes, the expression pattern of miRNAs in the class of MN1-altered astroblastoma was determined employing Nanostring technology. The results identified 39 deregulated miRNAs in our cohort respect to normal brain tissue. In order to understand whether epigenetic factors are responsible for the aberrant expression of miRNAs, the methylation status of the promoters of 32/39 deregulated miRNAs was analysed. An epigenetic regulation on 14/32 miRNAs was observed. Concerning the hypothesis of a genomic alteration as a reason for the abnormal expression of the remaining 18/32 deregulated miRNAs, the Copy Number Variation (CNV) of tumour samples was analysed. No alteration was found on chromosome locus where miRNAs were mapped. Finally validated targets of the 32 deregulated miRNAs were identified using R open-source software. Gene Ontology (GO) enrichment analysis for the Biological Processes (BPs) category and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways provided a correlation between miRNA target genes and MN1-altered astroblastomas. A relationship between pathways of deregulated miRNAs and clinical and pathological characteristics of MN1-altered astroblastomas was hypothesized. Notably, these findings might offer therapeutic targets and prognostic indications for patient survival.

Produzione scientifica

  • 11573/851689 - 2017 - Alveolar ridge preservation with nc-HA and d-PTFE membrane: a clinical, histologic, and histomorphometric study (01a Articolo in rivista)
    LAURITO, DOMENICA; LOLLOBRIGIDA, MARCO; GIANNO, FRANCESCA; BOSCO, SANDRO; LAMAZZA, LUCA; DE BIASE, ALBERTO
  • 11573/810276 - 2014 - Lobular capillary hemangioma and external auditory canal (01a Articolo in rivista)
    MAGLIULO, GIUSEPPE; IANNELLA, GIANNICOLA; GIANNO, FRANCESCA; RE, MASSIMO
  • 11573/1676424 - 2022 - A microRNA prognostic signature in patients with diffuse intrinsic pontine gliomas through non-invasive liquid biopsy (01a Articolo in rivista)
    GASPARINI, PAOLO; GIANNO, FRANCESCA; GIANGASPERO, FELICE
  • 11573/1680490 - 2023 - Case report of a pediatric medulloblastoma with concurrent MYC and MYCN subclonal amplification in distinct populations of neoplastic cells (01i Case report)
    MINASI, SIMONE; GIANNO, FRANCESCA; BARGIACCHI, LAVINIA; ANTONELLI, MANILA; BUTTARELLI, FRANCESCA ROMANA
  • 11573/1676445 - 2021 - Notch1 switches progenitor competence in inducing medulloblastoma (01a Articolo in rivista)
    GIANNO, FRANCESCA; GIANGASPERO, FELICE
  • 11573/1652654 - 2022 - Immunotherapy for Aggressive and Metastatic Pituitary Neuroendocrine Tumors (PitNETs): State-of-the Art (01g Articolo di rassegna (Review))
    FEOLA, TIZIANA; VERRICO, MONICA; GIANNO, FRANCESCA; COLONNESE, CLAUDIO; ARCELLA, ANTONIETTA; DE ALCUBIERRE, DARIO; TOMAO, SILVERIO; ESPOSITO, VINCENZO; GIANGASPERO, FELICE; MINNITI, GIUSEPPE
  • 11573/1046765 - 2019 - Role of immunohistochemistry in the identification of supratentorial C11ORF95-RELA fused ependymoma in routine neuropathology (01a Articolo in rivista)
    ELEFANTE, GRAZIA MARIA; GIANNO, FRANCESCA; BUTTARELLI, FRANCESCA ROMANA; ARCELLA, ANTONIETTA; GIANGASPERO, FELICE; ANTONELLI, MANILA
  • 11573/1676247 - 2020 - Dural-based atypical teratoid/rhabdoid tumor in an adult: DNA methylation profiling as a tool for the diagnosis (01i Case report)
    GIANNO, FRANCESCA; GIANGASPERO, FELICE; MIELE, EVELINA; ANTONELLI, MANILA
  • 11573/1681031 - 2023 - Role of 1p/19q Codeletion in Diffuse Low-grade Glioma Tumour Prognosis (01a Articolo in rivista)
    FAMILIARI, PIETRO; LAPOLLA, PIERFRANCESCO; PICOTTI, VERONICA; PALMIERI, MAURO; PESCE, ALESSANDRO; CAROSI, GIULIA; RELUCENTI, MICHELA; NOTTOLA, STEFANIA ANNARITA; GIANNO, FRANCESCA; MINASI, SIMONE; ANTONELLI, MANILA; FRATI, ALESSANDRO; SANTORO, ANTONIO; BRUZZANITI, PLACIDO; LA PIRA, BIAGIA
  • 11573/1676240 - 2021 - Diffuse midline glioma H3 K27M-mutant in adults: a report of six cases and literature review (01g Articolo di rassegna (Review))
    GIANGASPERO, FELICE; ANTONELLI, MANILA; GIANNO, FRANCESCA
  • 11573/1670081 - 2022 - Embryonal tumors in the WHO CNS5 classification: a review (01g Articolo di rassegna (Review))
    GIANNO, FRANCESCA; MIELE, EVELINA; ANTONELLI, MANILA; GIANGASPERO, FELICE
  • 11573/1670061 - 2018 - BK-virus progressive multifocal leukoencephalitis in a patient with systemic lupus erythematosus (01i Case report)
    BADIALI, MANUELA; GIANNO, FRANCESCA
  • 11573/1679458 - 2022 - Newly recognised tumour types in glioneuronal tumours according to the 5th edition of the CNS WHO classification (01g Articolo di rassegna (Review))
    GIANNO, FRANCESCA
  • 11573/1679459 - 2022 - Expanding the spectrum of "mesenchymal" tumors of the central nervous system (01g Articolo di rassegna (Review))
    GIANNO, FRANCESCA
  • 11573/1676268 - 2020 - Secreting Germ Cell Tumors of the Central Nervous System: A Long-Term Follow-up Experience (01a Articolo in rivista)
    FERRARI, ANDREA; PALLOTTI, FEDERICA; GIANNO, FRANCESCA
  • 11573/948909 - 2017 - Plaque-Like Myofibroblastic Tumor of Infancy: A New Case Report and Literature Review (01a Articolo in rivista)
    ALESINI, FRANCESCO; SODA, GIUSEPPE; GIANNO, FRANCESCA; BOSCO, SANDRO
  • 11573/763901 - 2016 - Socket preservation with d-PTFE membrane: histologic analysis of the newly formed matrix at membrane removal (01a Articolo in rivista)
    LAURITO, DOMENICA; CUGNETTO, RICCARDO; LOLLOBRIGIDA, MARCO; GUERRA, FABRIZIO; VESTRI, ANNA RITA; GIANNO, FRANCESCA; BOSCO, SANDRO; LAMAZZA, LUCA; DE BIASE, ALBERTO
  • 11573/1677448 - 2022 - Atypical teratoid/rhabdoid tumor in adults: a systematic review of the literature with meta‑analysis and additional reports of 4 cases (01g Articolo di rassegna (Review))
    GIANNO, FRANCESCA; GIANGASPERO, FELICE; ANTONELLI, MANILA
  • 11573/1174165 - 2018 - Sonic hedgehog medulloblastoma cancer stem cells mirnome and transcriptome highlight novel functional networks (01a Articolo in rivista)
    PO, AGNESE; ABBALLE, LUANA; SABATO, CLAUDIA; GIANNO, FRANCESCA; CHIACCHIARINI, MARTINA; CATANZARO, GIUSEPPINA; DE SMAELE, ENRICO; GIANGASPERO, FELICE; FERRETTI, ELISABETTA; MIELE, EVELINA; BESHARAT, ZEIN MERSINI
  • 11573/1206786 - 2018 - Low expression of miR-466f-3p sustains epithelial to mesenchymal transition in sonic hedgehog medulloblastoma stem cells through Vegfa-Nrp2 signaling pathway (01a Articolo in rivista)
    BESHARAT, ZEIN MERSINI; SABATO, CLAUDIA; PO, AGNESE; GIANNO, FRANCESCA; ABBALLE, LUANA; NAPOLITANO, MADDALENA; MIELE, EVELINA; GIANGASPERO, FELICE; VACCA, ALESSANDRA; CATANZARO, GIUSEPPINA; FERRETTI, ELISABETTA
  • 11573/1682746 - 2023 - Circulating miR-26b-5p and miR-451a as diagnostic biomarkers in medullary thyroid carcinoma patients (01a Articolo in rivista)
    BESHARAT, ZEIN MERSINI; TROCCHIANESI, SOFIA; VERRIENTI, ANTONELLA; SABATO, CLAUDIA; PO, AGNESE; CITARELLA, ANNA; GIANNO, FRANCESCA; CARPINO, GUIDO; GAUDIO, EUGENIO; CHIACCHIARINI, MARTINA; MASUELLI, LAURA; SPONZIELLO, MARIALUISA; PECCE, VALERIA; DURANTE, COSIMO; FERRETTI, ELISABETTA
  • 11573/928117 - 2014 - FSTL5 expression is a marker of Group C metastatic medulloblastomas (01h Abstract in rivista)
    BALDI, CATERINA; MINASI, SIMONE; GIANNO, FRANCESCA; GIANGASPERO, FELICE; BUTTARELLI, FRANCESCA ROMANA
  • 11573/1683867 - 2023 - Optimizing reirradiation for relapsed medulloblastoma: identifying the ideal patient and tumor profiles (01a Articolo in rivista)
    BUTTARELLI, FRANCESCA ROMANA; ANTONELLI, MANILA; MINASI, SIMONE; GIANNO, FRANCESCA
  • 11573/650065 - 2014 - Is CRX protein a useful marker in differential diagnosis of tumors of the pineal region? (01a Articolo in rivista)
    ANTONELLI, MANILA; BUTTARELLI, FRANCESCA ROMANA; GIANGASPERO, FELICE; GIANNO, FRANCESCA
  • 11573/1334335 - 2019 - Telomere Length Maintenance in Pediatric High-Grade Gliomas (04d Abstract in atti di convegno)
    BUTTARELLI, FRANCESCA ROMANA; MINASI, SIMONE; GIANNO, FRANCESCA; ANTONELLI, MANILA; GIANGASPERO, FELICE
  • 11573/1317224 - 2018 - Nanoscale mechanics of brain abscess: An atomic force microscopy study (01a Articolo in rivista)
    MINELLI, ELEONORA; SASSUN, TANYA ENNY; PAPI, MASSIMILIANO; PALERMO, FRANCESCA; ANTONELLI, MANILA; GIANNO, FRANCESCA; CIASCA, GABRIELE
  • 11573/1361000 - 2019 - Truncated BRPF1 cooperates with smoothened to promote adult shh medulloblastoma (01a Articolo in rivista)
    GIANNO, FRANCESCA; GIANGASPERO, FELICE
  • 11573/1428374 - 2021 - Alternative lengthening of telomeres in molecular subgroups of paediatric high-grade glioma (01a Articolo in rivista)
    MINASI, SIMONE; BALDI, CATERINA; GIANNO, FRANCESCA; ANTONELLI, MANILA; BUTTARELLI, FRANCESCA ROMANA
  • 11573/1414685 - 2020 - Modeling medulloblastoma in vivo and with human cerebellar organoids (01a Articolo in rivista)
    MIELE, EVELINA; GIANNO, FRANCESCA; CIOLFI, ANDREA; LOCATELLI, FRANCO; FERRETTI, ELISABETTA; GIANGASPERO, FELICE
  • 11573/1436012 - 2020 - Uterine adenosarcoma admixed with a primitive neuroectodermal tumour (PNET): a case report and review of the literature (01i Case report)
    PECORELLA, IRENE; ALESINI, FRANCESCO; GIANNO, FRANCESCA; TORNESE, ANDREA; COLAGIOVANNI, VANESSA; MONTI, MARCO
  • 11573/1444589 - 2020 - Sporadic high-grade malignant peripheral nerve sheath tumor of the hypoglossal nerve (01i Case report)
    COLIZZA, ANDREA; D'AGUANNO, VITTORIO; GRECO, ANTONIO; GIANNO, FRANCESCA; RIMINUCCI, MARA; DE VINCENTIIS, MARCO; CORSI, ALESSANDRO
  • 11573/1444376 - 2020 - Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells (01a Articolo in rivista)
    PO, AGNESE; CITARELLA, ANNA; CATANZARO, GIUSEPPINA; BESHARAT, ZEIN MERSINI; TROCCHIANESI, SOFIA; GIANNO, FRANCESCA; SABATO, CLAUDIA; MORETTI, MARTA; DE SMAELE, ENRICO; VACCA, ALESSANDRA; FERRETTI, ELISABETTA
  • 11573/1444803 - 2020 - Mechanisms of telomere maintenance in pediatric brain tumors: promising targets for therapy – a narrative review (01g Articolo di rassegna (Review))
    MINASI, SIMONE; GIANNO, FRANCESCA; ANTONELLI, MANILA; GIANGASPERO, FELICE; BUTTARELLI, FRANCESCA ROMANA
  • 11573/1444904 - 2018 - Pediatric high-grade glioma: a heterogeneous group of neoplasms with different molecular drivers (01g Articolo di rassegna (Review))
    GIANNO, FRANCESCA; ANTONELLI, MANILA; FERRETTI, ELISABETTA; ARCELLA, ANTONIETTA; GIANGASPERO, FELICE
  • 11573/1431133 - 2021 - Correlation between immunohistochemistry and sequencing in H3G34-mutant gliomas (01a Articolo in rivista)
    GIANNO, FRANCESCA; ANTONELLI, MANILA; DI DIO, TIZIANO; MINASI, SIMONE; GIANGASPERO, FELICE; BUTTARELLI, FRANCESCA ROMANA
  • 11573/1550455 - 2021 - Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review (01g Articolo di rassegna (Review))
    FEOLA, TIZIANA; GIANNO, FRANCESCA; COLONNESE, CLAUDIO; ESPOSITO, VINCENZO; GIANGASPERO, FELICE
  • 11573/1605509 - 2022 - Cerebellar liponeurocytoma: clinical, histopathological and molecular features of a series of three cases, including one recurrent tumor (01a Articolo in rivista)
    GIANNO, FRANCESCA; ANTONELLI, MANILA; MINASI, SIMONE; MIELE, EVELINA; GIANGASPERO, FELICE
  • 11573/1627437 - 2022 - A custom {DNA}-Based {NGS} panel for the molecular characterization of patients with diffuse gliomas: diagnostic and therapeutic applications (01a Articolo in rivista)
    MINASI, SIMONE; GIANNO, FRANCESCA; ANTONELLI, MANILA; BUTTARELLI, FRANCESCA ROMANA; GIANGASPERO, FELICE
  • 11573/1641130 - 2022 - HGG-09. MicroRNAs expression profile in Meningioma 1 (MN1) gene altered astroblastoma (01h Abstract in rivista)
    ANTONELLI, MANILA; BUTTARELLI, FRANCESCA ROMANA; MINASI, SIMONE; GIANGASPERO, FELICE; GIANNO, FRANCESCA
  • 11573/872491 - 2015 - Proven Epstein-Barr encephalitis with negative EBV-DNA load in cerebrospinal fluid after allogeneic hematopoietic stem cell transplantation in a child with acute lymphoblastic leukemia (01a Articolo in rivista)
    BARBERI, WALTER; PERRONE, SALVATORE; IORI, ANNA PAOLA; TESTI, ANNA MARIA; CEGLIE, TERESA; PAPOFF, PAOLA; ANTONELLI, MANILA; GIANNO, FRANCESCA; GIANGASPERO, FELICE; GENTILE, GIUSEPPE
  • 11573/1670072 - 2022 - Diffuse intrinsic pontine gliomas: Re-irradiation response correlated to clinical-morphological and molecular features (01h Abstract in rivista)
    GIANNO, FRANCESCA
  • 11573/1670077 - 2022 - Pediatric high grade glioma with YAP1-MAML2 fusion: A report of two cases (01h Abstract in rivista)
    GIANNO, FRANCESCA
  • 11573/1626286 - 2021 - Melanotic neuroectodermal tumor of infancy (Mnti) and pineal anlage tumor (pat) harbor a medulloblastoma signature by dna methylation profiling (01a Articolo in rivista)
    ALAGGIO, RITA; GIANNO, FRANCESCA
  • 11573/1649691 - 2022 - MiR-1248: a new prognostic biomarker able to identify supratentorial hemispheric pediatric low-grade gliomas patients associated with progression (01a Articolo in rivista)
    CATANZARO, GIUSEPPINA; BESHARAT, ZEIN MERSINI; SPLENDIANI, ELENA; PO, AGNESE; CHIACCHIARINI, MARTINA; CITARELLA, ANNA; GIANNO, FRANCESCA; CACCHIONE, ANTONELLA; MIELE, EVELINA; LOCATELLI, FRANCO; GIANGASPERO, FELICE; FERRETTI, ELISABETTA
  • 11573/1392386 - 2015 - Primary cutaneous alk positive anaplastic large cell lymphoma in a melanoma patient (01i Case report)
    PAOLINO, GIOVANNI; GIANNO, FRANCESCA; SODA, GIUSEPPE; CANTISANI, CARMEN; RICHETTA, ANTONIO GIOVANNI
  • 11573/1663588 - 2022 - Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification (01g Articolo di rassegna (Review))
    GIANNO, FRANCESCA; MINASI, SIMONE; BUTTARELLI, FRANCESCA ROMANA; ANTONELLI, MANILA; ALAGGIO, RITA; GIANGASPERO, FELICE
  • 11573/1663589 - 2022 - NSD1 mutations and pediatric high-grade gliomas: a comparative genomic study in primary and recurrent tumors (01a Articolo in rivista)
    NICOLUSSI, ARIANNA; GIANNO, FRANCESCA; BUTTARELLI, FRANCESCA ROMANA; MINASI, SIMONE; COPPA, ANNA; GIANGASPERO, FELICE; ANTONELLI, MANILA
  • 11573/1673002 - 2023 - Hyaline Protoplasmic Astrocytopathy in the Setting of Epilepsy (01a Articolo in rivista)
    GIANNO, FRANCESCA; GIANGASPERO, FELICE; ANTONELLI, MANILA
  • 11573/1601150 - 2022 - Alternative lengthening of telomeres (ALT) and telomerase reverse transcriptase promoter methylation in recurrent adult and primary pediatric pituitary neuroendocrine tumors (01a Articolo in rivista)
    MINASI, SIMONE; GIANNO, FRANCESCA; ANTONELLI, MANILA; BELARDINILLI, FRANCESCA; GIANGASPERO, FELICE; BUTTARELLI, FRANCESCA ROMANA

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