FRANCESCA AGNOLI

PhD Student

PhD program:: XXXIX
email: francesca.agnoli@uniroma1.it
phone: 0649255132
building: B (Dipartimento di Medicina Molecolare), Viale Regina Elena 291
room: 220

supervisor: Prof.ssa Marella Maroder
advisor: Prof.ssa Lucia Di Marcotullio
co-supervisor: Dott.ssa Francesca Bufalieri

Research: Role of MEX3A/RIG-I axis in Glioblastoma's pathogenesis

EDUCATION:
2018-2021: Bachelor degree in Agro-Industrial Biotechnology, La Sapienza University, Rome (Italia)
Score: 107/110
Thesis title: The role of vitamin B6 in epilpesy
Supervisor: Prof. Martino Luigi Di Salvo
2021-2023: Master degree in Medical Biotechnology, La Sapienza University, Rome (Italy)
Score: 110/110 cum laude
Thesis title: Defining the anti-cancer properties of a new inhibitor of the Endoplasmic Reticulum Aminoipeptidase 1 (ERAP1) in Hedgehog-dependent medulloblastoma
Supervisor: Prof.ssa Lucia Di Marcotullio

ACTUAL POSITION:
Novembre 2023- PhD student in Molecular Medicine, Dept. of Molecular Medicine, La Sapienza University, Rome (Italy)
Supervisor: Marella Maroder

SKILLS:
Molecular Biology techniques: Plasmidic and genomic DNA extraction, RNA extraction, cloning, DNA mutagenesis, reverse transcription, PCR, quantitative real time PCR, luciferase reporter assays.
Analysis of proteins: Protein extraction and western blot analysis, protein post-translational modifications analysis; immunoprecipitation assays.
Cellular biology: cell culture techniques (animal cells), DNA and siRNA transfection/transduction, cell treatments, BrdU assay, production and use of lentiviral vectors.
Histology and histopathology techniques: immunofluorescence, histochemical and immuno-histochemical techniques.
IT Skills:
Office suite; Adobe Photoshop; Image J; Image Lab; GraphPad.

Research products

11573/1765253 - 2026 - AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma

Basili, Irene; Bufalieri, Francesca; Conenna, Marilisa; Navacci, Shirin; Li, Yue-Ru; Torrejon, Jacob; Bernardi, Flavia; Lospinoso Severini, Ludovica; Marsaud, Veronique; Cancila, Gabriele; Bourmeau, Guillaume; Yu, Hua; Lo Re, Valentina; Talbot, Julie; Adabbo, Gennaro; Di Pinto, Alberico; Agnoli, Francesca; Giovannini, Daniela; Leonardi, Simona; Bordone, Rosa; Petroni, Marialaura; Souphron, Judith; Blauwblomme, Thomas; Beccaria, Kévin; Dufour, Christelle; D'angelo, Luca; De Smaele, Enrico; Canettieri, Gianluca; Giannini, Giuseppe; Fimia, Gian Maria; Maroder, Marella; Guardavaccaro, Daniele; Pazzaglia, Simonetta; Tsai, Jin-Wu; Infante, Paola; Ayrault, Olivier; Di Marcotullio, Lucia - 01a Articolo in rivista

paper: DEVELOPMENTAL CELL (Cell Press:1100 Massachusetts Avenue:Cambridge, MA 02138:(617)661-7057, EMAIL: subs@cell.com, INTERNET: http://www.cellpress.com, Fax: (617)397-2850) pp. - - issn: 1534-5807 - wos: (0) - scopus: (0)

11573/1753522 - 2025 - Discovery of a new selective Endoplasmic Reticulum Aminopeptidase 1 inhibitor for Hedgehog-dependent cancers treatment

Bufalieri, Francesca; Cucinotta, Antonino; Cammarone, Silvia; Agnoli, Francesca; Basili, Irene; Ferri, Giulia; Quaglio, Deborah; Caimano, Miriam; Capriotti, Anna Laura; Montone, Carmela Maria; Severini, Ludovica Lospinoso; Tempora, Patrizia; D'amico, Silvia; Juretich, Francesca; Semrau, Marta S.; Navacci, Shirin; Conenna, Marilisa; Bordone, Rosa; Spallotta, Francesco; Garavaglia, Silvia; Storici, Paola; Ghirga, Francesca; Laganà, Aldo; Locatelli, Franco; Ayrault, Olivier; Infante, Paola; Botta, Bruno; Mori, Mattia; Fruci, Doriana; Di Marcotullio, Lucia - 01a Articolo in rivista

paper: MOLECULAR THERAPY (New York: Elsevier Cell Press San Diego CA: Academic Press, 2000-) pp. - - issn: 1525-0016 - wos: WOS:001664314100001 (0) - scopus: 2-s2.0-105024998751 (1)

11573/1747506 - 2025 - MEX3A is a diagnostic, independent prognostic biomarker and a promising therapeutic target in glioblastoma

Bufalieri, Francesca; Armocida, Daniele; Cucinotta, Antonino; Familiari, Pietro; Di Magno, Laura; Serraino, Alessandra; Adabbo, Gennaro; Agnoli, Francesca; Lospinoso Severini, Ludovica; Antonelli, Manila; Frati, Alessandro; Canettieri, Gianluca; Infante, Paola; Santoro, Antonio; D'angelo, Luca; Di Marcotullio, Lucia - 01a Articolo in rivista

paper: FRONTIERS IN ONCOLOGY (Lausanne : Frontiers Editorial Office, 2011-) pp. 1-16 - issn: 2234-943X - wos: WOS:001572162600001 (0) - scopus: 2-s2.0-105016186914 (0)