FEDERICA MARRAFFA

PhD Graduate

PhD program:: XXXVIII



Thesis title: Emangiomi Infantili: utilizzo del propranololo sistemico e valutazione dei risultati a distanza

Infantile Hemangiomas (IH) are the most common benign vascular tumors in childhood and can be challenging to manage when located in critical areas. Systemic propranolol, established as first-line therapy since 2016, has revolutionized treatment, although long-term evaluation remains complex. This study assessed the clinical and instrumental efficacy of propranolol in 20 pediatric patients treated and followed for up to four years. Clinical, ultrasound, and specific scoring systems (HAS, HSS) were used, along with cutaneous Optical Coherence Tomography (OCT) in eight cases. Ninety-five percent of patients achieved complete remission without clinical relapse. The single partial responder benefited sufficiently to undergo optimal corrective surgery. OCT revealed a significant correlation between residual vascular density and lesion persistence. Statistical analysis confirmed OCT as a reliable objective marker. Propranolol proved safe and effective even in complex cases. The integration of OCT and dynamic scoring supports a personalized, long-term, and multidisciplinary approach to IH management.

Research products

11573/1734970 - 2025 - Multidisciplinary, multicenter consensus for the care of patients affected with Sturge–Weber syndrome
El Hachem, May; Diociaiuti, Andrea; Galeotti, Angela; Grussu, Francesca; Gusson, Elena; Ferretti, Alessandro; Marras, Carlo Efisio; Vecchio, Davide; Cappelletti, Simona; Severino, Mariasavina; Gandolfo, Carlo; Reali, Simone; Longo, Rosa; D'amore, Carmen; Gariazzo, Lodovica; Marraffa, Federica; Ciofi Degli Atti, Marta Luisa; Mancardi, Maria Margherita; Null, Null; Aristei, Francesco; Biolcati Rinaldi, Alessandra; Brisca, Giacomo; Cantalupo, Gaetano; Consales, Alessandro; De Palma, Luca; Federici, Matteo; Fontana, Elena; Giacomini, Thea; Laffi, Nicola; Longaretti, Laura; Marchini, Giorgio; Nobili, Lino; Occella, Corrado; Pedrazzoli, Eleonora; Priolo, Enrico; Ricciardi, Giuseppe Kenneth; Rigotti, Erika; Schena, Donatella; Trevisiol, Lorenzo; Urbani, Urbano; Vigevano, Federico - 01a Articolo in rivista
paper: ORPHANET JOURNAL OF RARE DISEASES (London : BioMed Central) pp. - - issn: 1750-1172 - wos: WOS:001397778800002 (9) - scopus: 2-s2.0-85216058311 (9)

11573/1688962 - 2023 - A case of Psoriatic Disease and Hidradenitis Suppurativa in a child with Chromosome 17q21.31 Microduplication Syndrome
Tolino, E.; Skroza, N.; Del Giudice, E.; Maddalena, P.; Bernardini, N.; Proietti, I.; Mambrin, A.; Marraffa, F.; Rossi, G.; Lubrano, R.; Potenza, C. - 01i Case report
paper: CHILDREN (Basel: MDPI AG, 2014-) pp. - - issn: 2227-9067 - wos: WOS:001014318800001 (1) - scopus: 2-s2.0-85163601324 (1)

11573/1701331 - 2022 - Long term efficacy, safety, and tolerability of tildrakizumab in epileptic patient with psoriasis and eczema
Bernardini, N.; Skroza, N.; Rossi, G.; Mambrin, A.; Tolino, E.; Marraffa, F.; Caviglia, M.; Di Guardo, A.; Volpe, S.; Proietti, I.; Potenza, C. - 01i Case report
paper: DERMATOLOGY REPORTS (Pavia : PagePress Publications) pp. - - issn: 2036-7392 - wos: WOS:000890343700001 (3) - scopus: 2-s2.0-85143205297 (3)

11573/1692517 - 2022 - Herpes zoster ophthalmicus in two women after Pfizer-BioNTech (BNT162b2) vaccine
Bernardini, Nicoletta; Skroza, Nevena; Mambrin, Alessandra; Proietti, Ilaria; Marchesiello, Anna; Marraffa, Federica; Rossi, Giovanni; Volpe, Salvatore; Tolino, Ersilia; Potenza, Concetta - 01f Lettera, Nota
paper: JOURNAL OF MEDICAL VIROLOGY (New York, NY : Wiley-Liss) pp. 817-818 - issn: 1096-9071 - wos: WOS:000704292700001 (3) - scopus: 2-s2.0-85116451063 (3)

11573/1699157 - 2022 - Psoriatic patients with a history of cancer: a real-life experience with Apremilast treatment for 104 weeks
Bernardini, Nicoletta; Skroza, Nevena; Marchesiello, Anna; Mambrin, Alessandra; Proietti, Ilaria; Tolino, Ersilia; Maddalena, Patrizia; Marraffa, Federica; Rossi, Giovanni; Volpe, Salvatore; Potenza, Concetta - 01a Articolo in rivista
paper: DERMATOLOGIC THERAPY (Malden, MA: Blackwell Science Incorporated Copenhagen: Munksgaard) pp. - - issn: 1396-0296 - wos: WOS:000839463700001 (7) - scopus: 2-s2.0-85135851838 (10)

11573/1652943 - 2022 - A case of twins affected by psoriasis, psoriatic arthritis and autism: five years of efficacious and safe treatment with Secukinumab
Bernardini, Nicoletta; Skroza, Nevena; Marraffa, Federica; Prevete, Elisabeth; Mambrin, Alessandra; Proietti, Ilaria; Tolino, Ersilia; Caviglia, Martina; Di Guardo, Antonio; Rossi, Giovanni; Volpe, Salvatore; Bersani, Giuseppe; Potenza, Concetta - 01i Case report
paper: DERMATOLOGIC THERAPY (-Malden, MA : John Wiley & Sons -Oxford, England] : Blackwell Science) pp. - - issn: 1529-8019 - wos: WOS:000790584200001 (3) - scopus: 2-s2.0-85129304039 (4)

11573/1652945 - 2022 - Guselkumab for the treatment of severe plaque psoriasis in a schizophrenia patient. A case report
Bernardini, Nicoletta; Skroza, Nevena; Prevete, Elisabeth; Marraffa, Federica; Proietti, Ilaria; Tolino, Ersilia; Mambrin, Alessandra; Rossi, Giovanni; Volpe, Salvatore; Bersani, Giuseppe; Potenza, Concetta - 01i Case report
paper: DERMATOLOGY REPORTS (Pavia PagePress Publications) pp. 1-2 - issn: 2036-7406 - wos: (0) - scopus: 2-s2.0-85152210717 (6)

11573/1651571 - 2022 - Non-invasive instrumental examinations of cutaneous, adnexal and mucosal manifestations after sars-cov-2 infection in adult and children
Proietti, I.; Tolino, E.; Mambrin, A.; Skroza, N.; Bernardini, N.; Marchesiello, A.; Marraffa, F.; Michelini, S.; Rossi, G.; Volpe, S.; Del Giudice, E.; Lubrano, R.; Potenza, C. - 01f Lettera, Nota
paper: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. e169-e170 - issn: 0926-9959 - wos: WOS:000727450300001 (0) - scopus: 2-s2.0-85120648265 (0)

11573/1701861 - 2022 - PSSD and biologic therapy: real-life data in 417 patients with moderate to severe psoriasis
Proietti, Ilaria; Bernardini, Nicoletta; Skroza, Nevena; Mambrin, Alessandra; Tolino, Ersilia; Marchesiello, Anna; Marraffa, Federica; Rossi, Giovanni; Volpe, Salvatore; Potenza, Concetta - 01a Articolo in rivista
paper: REVIEWS ON RECENT CLINICAL TRIALS (Netherlands Hilversum : Bentham Science Publishers) pp. 171-176 - issn: 1574-8871 - wos: WOS:000899571800003 (2) - scopus: 2-s2.0-85143276237 (3)

11573/1701176 - 2022 - Adverse skin reactions to personal protective equipment during COVID-19 pandemic in Italian health care workers
Proietti, Ilaria; Borrelli, Ivan; Skroza, Nevena; Santoro, Paolo Emilio; Gualano, Maria Rosaria; Bernardini, Nicoletta; Mambrin, Alessandra; Tolino, Ersilia; Marchesiello, Anna; Marraffa, Federica; Michelini, Simone; Rossi, Giovanni; Volpe, Salvatore; Ricciardi, Walter; Moscato, Umberto; Potenza, Concetta - 01a Articolo in rivista
paper: DERMATOLOGIC THERAPY (-Malden, MA : John Wiley & Sons -Oxford, England] : Blackwell Science) pp. - - issn: 1529-8019 - wos: WOS:000772146700001 (13) - scopus: 2-s2.0-85126907203 (12)

11573/1657631 - 2022 - A possible link between gut microbiome composition and cardiovascular comorbidities in psoriatic patients
Valentini, Virginia; Silvestri, Valentina; Bucalo, Agostino; Marraffa, Federica; Risicato, Maria; Grassi, Sara; Pellacani, Giovanni; Ottini, Laura; Richetta, Antonio Giovanni - 01a Articolo in rivista
paper: JOURNAL OF PERSONALIZED MEDICINE (Basel: MDPI AG, 2011-) pp. - - issn: 2075-4426 - wos: WOS:000833804400001 (10) - scopus: 2-s2.0-85137220471 (10)

11573/1570174 - 2021 - Long-term maintained response to selective internal radiation therapy in an oligometastatic uveal melanoma patient treated with concomitant Anti-PD-1 therapy
Proietti, Ilaria; Skroza, Nevena; Filippi, Luca; Bernardini, Nicoletta; Mambrin, Alessandra; Tolino, Ersilia; Rossi, Giovanna; Marchesiello, Anna; Marraffa, Federica; Volpe, Salvatore; Bagni, Oreste; Potenza, Concetta - 01i Case report
paper: LIFE (Basel: MDPI) pp. - - issn: 2075-1729 - wos: WOS:000676171800001 (2) - scopus: 2-s2.0-85111118448 (2)

11573/1700992 - 2021 - Aesthetic treatments in cancer patients
Proietti, Ilaria; Skroza, Nevena; Mambrin, Alessandra; Marraffa, Federica; Tolino, Ersilia; Bernardini, Nicoletta; Marchesiello, Anna; Rossi, Giovanni; Volpe, Salvatore; Potenza, Concetta - 01a Articolo in rivista
paper: CLINICAL, COSMETIC AND INVESTIGATIONAL DERMATOLOGY ([Auckland, N.Z.] : Dove Medical Press, c2008-) pp. 1831-1837 - issn: 1178-7015 - wos: WOS:000729072800003 (14) - scopus: 2-s2.0-85120772913 (13)

11573/1583161 - 2021 - Ustekinumab for the treatment of moderate-to-severe plaque psoriasis in a solid organ transplanted recipient: a case report
Richetta, A.; Marraffa, F.; Grassi, S.; Aquila, E.; Dybala, A.; Aprile, F.; Merli, M. - 01f Lettera, Nota
paper: AUSTRALASIAN JOURNAL OF DERMATOLOGY (Blackwell Science Asia Party Limited:550 Swanston Street, Carlton VIC 3053 Australia:011 61 3 83591011, EMAIL: info@blackwell-science-asia.com, INTERNET: http://www.blackwell-science.com, Fax: 011 61 3 83591120) pp. e442-e443 - issn: 0004-8380 - wos: WOS:000621800000001 (3) - scopus: 2-s2.0-85101609353 (3)

11573/1570362 - 2021 - Safety and impact of anti-COVID-19 vaccines in psoriatic patients treated with biologics. A real life experience
Skroza, N.; Bernardini, N.; Tolino, E.; Proietti, I.; Mambrin, A.; Marchesiello, A.; Marraffa, F.; Rossi, G.; Volpe, S.; Potenza, C - 01a Articolo in rivista
paper: JOURNAL OF CLINICAL MEDICINE (Salerno : Momento Medico) pp. 1-4 - issn: 2240-0109 - wos: WOS:000682049000001 (17) - scopus: 2-s2.0-85114073866 (18)

11573/1701002 - 2021 - Advantages of tailored isotretinoin treatment in moderate to severe acne: real-life data
Skroza, N; Tolino, E; Balduzzi, V; Bernardini, N; Mambrin, A; Marchesiello, A; Marraffa, F; Rossi, G; Volpe, S; Proietti, I; Potenza, C. - 01a Articolo in rivista
paper: FRONTIERS IN PHARMACOLOGY (Lausanne: Frontiers Media S.A., 2010-) pp. - - issn: 1663-9812 - wos: WOS:000733902500001 (8) - scopus: 2-s2.0-85120667421 (8)

11573/1500906 - 2021 - Gut microbiome profile in psoriatic patients treated and untreated with biologic therapy
Valentini, V.; Silvestri, V.; Marraffa, F.; Greco, G.; Bucalo, A.; Grassi, S.; Gagliardi, A.; Mazzotta, A.; Ottini, L.; Richetta, A. G. - 01a Articolo in rivista
paper: JOURNAL OF DERMATOLOGY (Nihon Hifuka Gakkai:(Japanese Dermatological Association), Taisei Building, 3-14-10 Hongo, Bunkyoku Tokyo 113 Japan) pp. - - issn: 0385-2407 - wos: WOS:000612550800001 (18) - scopus: 2-s2.0-85099821795 (21)

11573/1450800 - 2020 - Paradoxical psoriasis induced by Anti-TNFα treatment: Evaluation of disease-specific clinical and genetic markers
Bucalo, A.; Rega, F.; Zangrilli, A.; Silvestri, V.; Valentini, V.; Scafetta, G.; Marraffa, F.; Grassi, S.; Rogante, E.; Piccolo, A.; Cucchiara, S.; Viola, F.; Bianchi, L.; Ottini, L.; Richetta, A. - 01a Articolo in rivista
paper: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000588902800001 (26) - scopus: 2-s2.0-85093960459 (30)

11573/1151375 - 2018 - Metastases risk in thin cutaneous melanoma: Prognostic value of clinical-pathologic characteristics and mutation profile
Richetta, Antonio G.; Valentini, Virginia; Marraffa, Federica; Paolino, Giovanni; Rizzolo, Piera; Silvestri, Valentina; Zelli, Veronica; Carbone, Anna; Mattia, Cinzia Di; Calvieri, Stefano; Frascione, Pasquale; Donati, Pietro; Ottini, Laura - 01a Articolo in rivista
paper: ONCOTARGET (Albany, N.Y. : Impact Journals) pp. 32173-32181 - issn: 1949-2553 - wos: (0) - scopus: 2-s2.0-85051601714 (14)

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