FABIO DI DOMENICO

Professore ordinario


email: fabio.didomenico@uniroma1.it
telefono: 06 49910900
edificio: CU027
stanza: 314

INDICI BIIBLIOMETRICI
Articoli scientifici: 106
Capitoli di libro: 5
Fattore di impatto totale: ≈ 490
Citazioni totali: 10402
Indice H: 45

ISTRUZIONE E FORMAZIONE
Dottorato in Scienze Biochimiche presso l'Università La Sapienza di Roma
Laurea in Scienze Biologiche presso l'Università La Sapienza di Roma

ESPERIENZA LAVORATIVA
2021 – oggi Professore Ordinario presso il Dipartimento di Scienze Biochimiche dell'Università La Sapienza di Roma
2015 – 2021 Professore Associato presso il Dipartimento di Scienze Biochimiche dell'Università La Sapienza di Roma
2010 – 2015 Ricercatore (Professore Aggregato) presso il Dipartimento di Scienze Biochimiche dell'Università La Sapienza di Roma
2009 – 2010 Assegnista di ricerca post-dottorale (dall'Istituto Pasteur – Fondazione Cenci Bolognetti) presso il Dipartimento di Chimica dell'Università del Kentucky
2007 – 2008 Studente straniero del dottorato presso il Dipartimento di Chimica dell'Università del Kentucky
2005 – 2008 Studente di dottorato presso il Dipartimento di Scienze Biochimiche dell'Università La Sapienza di Roma

ATTIVITÀ DI RICERCA
Parole chiave: Malattia di Alzheimer, sindrome di Down, proteomica, stress ossidativo, neurodegenerazione, omeostasi proteica
Dichiarazione personale: La mia ricerca è attualmente incentrata sulla comprensione del ruolo della proteostasi difettosa nello sviluppo di una demenza simile a quella di Alzheimer, al fine di proporre nuovi approcci terapeutici efficaci che possano migliorare il declino cognitivo. A partire dal 2005, ho dedicato la mia ricerca allo studio del ruolo dello stress ossidativo nello sviluppo delle malattie neurodegenerative. Grazie alla mia esperienza presso l'Università del Kentucky nel laboratorio del prof. D. Allan Butterfield, sono stato coinvolto nell'implementazione di approcci proteomici, compresi quelli della redox proteomica. Attraverso l'uso di queste tecniche, i miei progetti di ricerca successivi hanno contribuito a evidenziare il ruolo dello stress ossidativo aumentato e dei sistemi disfunzionali di degradazione proteica nella patogenesi e progressione della demenza simile a quella di Alzheimer. Abbiamo dimostrato che la modificazione ossidativa (carboidratazione, legame proteico HNE e nitrazione) di proteine appartenenti a diversi sistemi di degradazione (proteasoma e autofagia) compromette la loro funzionalità e contribuisce alla progressione del processo neurodegenerativo. I dati raccolti hanno suggerito che la proteostasi aberrante, osservata sia nei pazienti affetti da Alzheimer che in quelli affetti da sindrome di Down, è strettamente associata all'aumento dei danni ossidativi come risultato di una risposta antiossidante compromessa e di sistemi proteolitici difettosi. Studi recenti hanno rivelato che l'induzione cronica della risposta della proteina non ripiegata svolge un ruolo prominente nello sviluppo della demenza simile a quella di Alzheimer nel cervello di persone con sindrome di Down. In effetti, il recupero farmacologico della funzione della risposta della proteina non ripiegata porta alla riduzione delle caratteristiche neuropatologiche e alla diminuzione dell'ossidazione proteica in un meccanismo che coinvolge la risposta antiossidante Nrf2. I risultati ottenuti hanno portato alla pubblicazione di diversi articoli su riviste scientifiche e, sulla base di questi, abbiamo iniziato a testare una serie di composti per il trattamento e la prevenzione del declino cognitivo nei topi affetti da sindrome di Down.

Interessi di ricerca:
• Ruolo dello stress ossidativo e dell'ossidazione proteica nella malattia di Alzheimer, malattia di Parkinson e sindrome di Down.
• Ruolo della glicosilazione proteica (N-Gly e O-Gly) nello sviluppo e nella progressione della malattia di Alzheimer.
• Ruolo della "risposta allo shock termico" durante la progressione della lieve compromissione cognitiva alla malattia di Alzheimer.
• Studio dei meccanismi molecolari controllati da STAT3 coinvolti nel processo neurodegenerativo di ischemia/riperfusione.
• Analisi dell'implicazione della crosstalk mutato tra LRRK2 e tau nello sviluppo della malattia di Parkinson.
• Analisi del liquido cerebrospinale e del plasma di pazienti affetti da malattia di Alzheimer e compromissione cognitiva lieve alla ricerca di biomarcatori diagnostici.
• Analisi delle funzioni del percorso HO-1/BVR-A durante la progressione della compromissione cognitiva lieve e della malattia di Alzheimer.

FINANZIAMENTI
2024 Responsabile Scientifico del progetto #2280 - GRT-2023B dal titolo “Nutrient-dependent alteration of the Unfolded Protein Response in Down syndrome brain: tackling the diet/cognition axis” Finanzianto dalla Jerome Lejeune Foundation con 80.000,00 Euro
2023 Responsabile scientifico del progetto prot. 2022KP5LKS dal titolo "The noxious crosstalk between protein O-GlcNAcylation and S-palmitoylation under metabolic stress: from their biochemical interaction to the development of neuropathological hallmarks", finanziato dal programma PRIN 2022 del Ministero dell'Università e della Ricerca con 204.550,00 Euro.
2022 Co-responsabile del progetto MA12218162A911A3 dal titolo MUMAD: Multimode detection platform to Unravel molecular Mechanisms of Age-associated degenerative Disorders" finanziato su progetti di Ateneo" dell'Università La Sapienza di Roma con 48.036,00 Euro.
2022 Responsabile scientifico del progetto RG12218162AE202C dal titolo "The noxious crosstalk between protein O-GlcNAcylation and S-palmitoylation under metabolic stress: from their biochemical interaction to the development of neuropathological hallmarks", finanziato dal programma "progetti di Ateneo" dell'Università La Sapienza di Roma con 73.890,00 Euro.
2021 Responsabile scientifico del progetto RM12117A2EC1C9E4 dal titolo "Deciphering the the interplay between the unfolded protein response and insulin resistance in Down syndrome brain", finanziato dal programma "progetti di Ateneo" dell'Università La Sapienza di Roma con 10.000,00 Euro.
2019 Responsabile scientifico di un progetto dal titolo "The sweet link between brain dys-metabolism and cognitive decline: A novel role for protein O-GlcNAcylation", finanziato dall'Istituto Pasteur - Fondazione Cenci Bolognetti nell'ambito del programma "Progetto di ricerca biennale riservato a giovani ricercatori sotto i 45 anni" con 40.000,00 Euro.
2019 Co-responsabile del progetto GR-2018-12366381 dal titolo "Aberrant protein palmitoylation: a novel biomarker and therapeutic target in Alzheimer's disease", finanziato dal Ministero della Salute nell'ambito del bando RICERCA FINALIZZATA 2018 con 422.000,00 Euro.
2018 Responsabile scientifico del progetto RG1181642744DF59 dal titolo "The sweet link between aberrant brain metabolism and cognitive decline: A novel role for altered protein O-GlcNAcylation", finanziato dal programma "progetti di Ateneo" dell'Università La Sapienza di Roma con 32.000,00 Euro.
2017 Responsabile scientifico del progetto RM11715C773949E3 dal titolo "Inhibition of PERK pathway for the early treatment of Alzheimer Disease-like cognitive decline in Down Syndrome", finanziato dal programma "progetti di Ateneo" dell'Università La Sapienza di Roma con 31.750,00 Euro.
2016 Responsabile scientifico del progetto RG116154C9214D1A dal titolo "Brain insulin resistance in age-related cognitive decline: molecular mechanisms and novel therapeutic approaches", finanziato dal programma "progetti di Ateneo" dell'Università La Sapienza di Roma con 34.000,00 Euro.
2016 Co-responsabile di un progetto dal titolo "Novel therapeutic strategies for the prevention of Alzheimer Disease", finanziato dalla Banca d'Italia con 50.000,00 Euro.
2016 Co-responsabile di un progetto dal titolo "Intranasal rapamycin administration to prevent Alzheimer-like dementia in Down Syndrome", finanziato dalla fondazione Jerome Lejeune con 26.000,00 Euro.
2015 Responsabile scientifico di un progetto di Ricerca Scientifica Indipendente (SIR) del Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) Protocollo #RBSI144MTL dal titolo "Cross-talk between insulin signalling and oxidative stress in Alzheimer disease: A new paradigm" con 169.938,00 Euro.
2013 Co-responsabile di una sovvenzione Marie Curie con il progetto "Biliverdin Reductase-A in brain insulin signaling and oxidative stress-mediated neurodegeneration" con 180.000,00 Euro.
2012 Responsabile scientifico di una borsa di studio di un anno per assumere un collaboratore come uno dei migliori giovani ricercatori "sotto i 40 anni" della facoltà di farmacia e medicina dell'Università La Sapienza di Roma con il progetto "Role of oxidative stress in the mechanisms of neurodegeneration" con 22.800,00 Euro.

ISCRIZIONE A SOCIETÀ, PREMI E ONORIFICENZE

2020 - oggi Membro del comitato editoriale della rivista MDPI "NeuroSci" (ISSN 2673-4087)
2020 - oggi Editore ospite invitato per un numero speciale su "Feature paper in sezione Molecular Pathology" per "Biomolecules" (ISSN 2218-273X)
2019 - oggi Membro del comitato editoriale della rivista MDPI "Biomolecules" (ISSN 2218-273X) nella sezione di Molecular Pathology
2015 Premio Giovane alla 12a Conferenza Internazionale su Malattia di Alzheimer e Malattia di Parkinson (APDP 2015)
2013 - oggi Membro della società di ricerca sulla Trisomia 21 (T21RS)
2012 - oggi Membro della Società Europea di Ricerca sui Radicali Liberi (SFRRE)
2013 Co-editore della rivista Journal of Alzheimer Disease - IOS press
2012 Selezionato tra i migliori giovani ricercatori "sotto i 40 anni" della facoltà di farmacia e medicina dell'Università La Sapienza di Roma
2008 - oggi Membro della Società Italiana di Biochimica e Biologia Molecolare (SIB)

Lista delle Pubblicazioni

Capitoli su Libri
[1] F. Di Domenico, C. Lanzillotta. The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerative disorders. Advances in Protein Chemistry and Structural Biology, Academic Press, 2022, ISSN 1876-1623,
[2] M. Perluigi, F. Di Domenico. D. A. Butterfield. Oxidative stress and mTOR in Down syndrome brain: link to Alzheimer’s dysmetabolism, neuropathology and possible therapies. The neurobiology of aging and Alzheimer disease in Down syndrome. Academic Press. pp 75-96. ISBN 978-0-12-818845-3
[3] V. Calabrese, M. Perluigi, C. Cornelius, R. Coccia, F. Di Domenico, et al. (2009) Phenolics in aging and neurodegenerative disorders. Plant phenolics and human health. Wiley-IUBMB Series on Biochemistry and Molecular Biology. 427- 451
[4] F. Di Domenico, M. Perluigi. Peripheral Biomarkers of Oxidative Stress in Alzheimer’s Disease. Studies on Alzheimer's Disease. Humana Press, Editors: Domenico Praticὸ, Patrizia Mecocci, pp.185-199, DOI:10.1007/978-1-62703-598-9_13 ISBN: 978-1-62703-598-9
[5] F. Di Domenico, M. Perluigi, D.A. Butterfield. Redox proteomics in human biofluids: Sample preparation, separation and immunochemical tagging for analysis of protein oxidation. System Biology of Alzheimer’s Disease, pubs. August 02, 2015, pp. 391-403

Riviste Internazionali

[1] C. Urbinati, C. Lanzillotta, L. Cosentino, D. Valenti, M.C. Quattrini, L. Di Crescenzo, F. Prestia, D. Pietraforte, M. Perluigi, F. Di Domenico, R.A. Vacca, B. De Filippis, Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome, Neuropharmacology 224 (2023) 109350.
[2] A. Tramutola, S. Lanzillotta, G. Aceto, S. Pagnotta, G. Ruffolo, P. Cifelli, F. Marini, C. Ripoli, E. Palma, C. Grassi, F. Di Domenico, M. Perluigi, E. Barone, Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome, Antioxidants (Basel) 12(1) (2023).
[3] F. Di Domenico, C. Lanzillotta, The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerative disorders, Adv Protein Chem Struct Biol 132 (2022) 49-87.
[4] S. Pagnotta, A. Tramutola, E. Barone, F. Di Domenico, V. Pittalà, L. Salerno, V. Folgiero, M. Caforio, F. Locatelli, S. Petrini, D.A. Butterfield,M. Perluigi, CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome Free Radical Biology and Medicine, 2022 in press
[5] M. Perluigi, A. Picca, E. Montanari, R. Calvani, F. Marini, R. Matassa, A. Tramutola, A.Villani, G. Familiari, F. Di Domenico, D.A. Butterfield, K.J. Oh, E. Marzetti, D. Valentini, E. Barone, Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles Alzheimer's and Dementia 2021 1-13.
[6] I. Zuliani, C. Lanzillotta, A. Tramutola, A. Francioso, S. Pagnotta, E. Barone, M. Perluigi, F. Di Domenico, The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome, Neurotherapeutics 18(1) (2021) 340-363.
[7] I. Zuliani, C. Lanzillotta, A. Tramutola, E. Barone, M. Perluigi, S. Rinaldo, A. Paone, F. Cutruzzola, F. Bellanti, M. Spinelli, F. Natale, S. Fusco, C. Grassi, F. Di Domenico, High-Fat Diet Leads to Reduced Protein O-GlcNAcylation and Mitochondrial Defects Promoting the Development of Alzheimer's Disease Signatures, Int J Mol Sci 22(7) (2021).
[8] M. Perluigi, F. Di Domenico, E. Barone, D.A. Butterfield, mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder, Free Radic Biol Med 169 (2021) 382-396.
[9] C. Lanzillotta, I. Zuliani, A. Tramutola, E. Barone, C. Blarzino, V. Folgiero, M. Caforio, D. Valentini, A. Villani, F. Locatelli, D.A. Butterfield, E. Head, M. Perluigi, J.F. Abisambra, F. Di Domenico, Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention, Prog Neurobiol 196 (2021) 101892.
[10] C. Lanzillotta, A. Tramutola, G. Di Giacomo, F. Marini, D.A. Butterfield, F. Di Domenico, M. Perluigi, E. Barone, Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome, Free Radic Biol Med 165 (2021) 152-170.
[11] C. Lanzillotta, F. Di Domenico, Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules, Biomolecules 11(2) (2021).
[12] S.A. Koren, M.J. Hamm, R. Cloyd, S.N. Fontaine, E. Chishti, C. Lanzillotta, J. Rodriguez-Rivera, A. Ingram, M. Bell, S.M. Galvis-Escobar, N. Zulia, F. Di Domenico, D. Duong, N.T. Seyfried, D. Powell, M. Vandsburger, T. Frolinger, A.M.S. Hartz, J. Koren, 3rd, J.M. Axten, N.J. Laping, J.F. Abisambra, Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy, Int J Mol Sci 22(3) (2021).
[13] D.J. Klionsky et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)(1), Autophagy 17(1) (2021) 1-382.
[14] E. Barone, F. Di Domenico, M. Perluigi, D.A. Butterfield, The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease, Free Radic Biol Med 176 (2021) 16-33.
[15] I. Zuliani, C. Urbinati, D. Valenti, M.C. Quattrini, V. Medici, L. Cosentino, D. Pietraforte, F. Di Domenico, M. Perluigi, R.A. Vacca, B. De Filippis, The Anti-Diabetic Drug Metformin Rescues Aberrant Mitochondrial Activity and Restrains Oxidative Stress in a Female Mouse Model of Rett Syndrome, J Clin Med 9(6) (2020).
[16] A. Tramutola, C. Lanzillotta, F. Di Domenico, E. Head, D.A. Butterfield, M. Perluigi, E. Barone, Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome, Neurobiol Dis 137 (2020) 104772.
[17] A. Tramutola, S. Falcucci, U. Brocco, F. Triani, C. Lanzillotta, M. Donati, C. Panetta, F. Luzi, F. Iavarone, F. Vincenzoni, M. Castagnola, M. Perluigi, F. Di Domenico, F. Marco, Protein Oxidative Damage in UV-Related Skin Cancer and Dysplastic Lesions Contributes to Neoplastic Promotion and Progression, Cancers (Basel) 12(1) (2020).
[18] V. Protto, A. Tramutola, M. Fabiani, M.E. Marcocci, G. Napoletani, F. Iavarone, F. Vincenzoni, M. Castagnola, M. Perluigi, F. Di Domenico, G. De Chiara, A.T. Palamara, Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer's Disease Progression, Microorganisms 8(7) (2020).
[19] C. Lanzillotta, I. Zuliani, C. Vasavda, S.H. Snyder, B.D. Paul, M. Perluigi, F. Di Domenico, E. Barone, BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration, Antioxidants (Basel) 9(8) (2020).
[20] C. Lanzillotta, V. Greco, D. Valentini, A. Villani, V. Folgiero, M. Caforio, F. Locatelli, S. Pagnotta, E. Barone, A. Urbani, F. Di Domenico, M. Perluigi, Proteomics Study of Peripheral Blood Mononuclear Cells in Down Syndrome Children, Antioxidants (Basel) 9(11) (2020).
[21] N. Sharma, A. Tramutola, C. Lanzillotta, A. Arena, C. Blarzino, T. Cassano, D.A. Butterfield, F. Di Domenico, M. Perluigi, E. Barone, Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease, Neurobiol Dis 125 (2019) 176-189.
[22] C. Lanzillotta, F. Di Domenico, M. Perluigi, D.A. Butterfield, Targeting Mitochondria in Alzheimer Disease: Rationale and Perspectives, CNS Drugs 33(10) (2019) 957-969.
[23] F. Di Domenico, I. Zuliani, A. Tramutola, Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses, Expert Rev Proteomics 16(11-12) (2019) 951-964.
[24] F. Di Domenico, A. Tramutola, E. Barone, C. Lanzillotta, O. Defever, A. Arena, I. Zuliani, C. Foppoli, F. Iavarone, F. Vincenzoni, M. Castagnola, D.A. Butterfield, M. Perluigi, Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome, Redox Biol 23 (2019) 101162.
[25] F. Di Domenico, C. Lanzillotta, A. Tramutola, Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies, Expert Rev Neurother 19(1) (2019) 1-3.
[26] F.A. Cimini, A. Arena, I. Barchetta, A. Tramutola, V. Ceccarelli, C. Lanzillotta, M. Fontana, L. Bertoccini, F. Leonetti, D. Capoccia, G. Silecchia, C. Di Cristofano, C. Chiappetta, F. Di Domenico, M.G. Baroni, M. Perluigi, M.G. Cavallo, E. Barone, Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity, Biochim Biophys Acta Mol Basis Dis 1865(6) (2019) 1490-1501.
[27] E. Barone, A. Tramutola, F. Triani, S. Calcagnini, F. Di Domenico, C. Ripoli, S. Gaetani, C. Grassi, D.A. Butterfield, T. Cassano, M. Perluigi, Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease, Mol Neurobiol 56(4) (2019) 2922-2943.
[28] F. Triani, A. Tramutola, F. Di Domenico, N. Sharma, D.A. Butterfield, E. Head, M. Perluigi, E. Barone, Biliverdin reductase-A impairment links brain insulin resistance with increased Abeta production in an animal model of aging: Implications for Alzheimer disease, Biochim Biophys Acta Mol Basis Dis 1864(10) (2018) 3181-3194.
[29] A. Tramutola, F. Triani, F. Di Domenico, E. Barone, J. Cai, J.B. Klein, M. Perluigi, D.A. Butterfield, Poly-ubiquitin profile in Alzheimer disease brain, Neurobiol Dis 118 (2018) 129-141.
[30] A. Tramutola, N. Sharma, E. Barone, C. Lanzillotta, A. Castellani, F. Iavarone, F. Vincenzoni, M. Castagnola, D.A. Butterfield, S. Gaetani, T. Cassano, M. Perluigi, F. Di Domenico, Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease, Biochim Biophys Acta Mol Basis Dis 1864(10) (2018) 3309-3321.
[31] A. Tramutola, C. Lanzillotta, E. Barone, A. Arena, I. Zuliani, L. Mosca, C. Blarzino, D.A. Butterfield, M. Perluigi, F. Di Domenico, Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome, Transl Neurodegener 7 (2018) 28.
[32] A. Tramutola, G. Abate, C. Lanzillotta, F. Triani, E. Barone, F. Iavarone, F. Vincenzoni, M. Castagnola, M. Marziano, M. Memo, E. Garrafa, D.A. Butterfield, M. Perluigi, F. Di Domenico, D. Uberti, Protein nitration profile of CD3(+) lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection, Free Radic Biol Med 129 (2018) 430-439.
[33] C. Lanzillotta, A. Tramutola, S. Meier, F. Schmitt, E. Barone, M. Perluigi, F. Di Domenico, J.F. Abisambra, Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models, J Alzheimers Dis 62(1) (2018) 347-359.
[34] F. Di Domenico, A. Tramutola, C. Foppoli, E. Head, M. Perluigi, D.A. Butterfield, mTOR in Down syndrome: Role in Ass and tau neuropathology and transition to Alzheimer disease-like dementia, Free Radic Biol Med 114 (2018) 94-101.
[35] A. Tramutola, C. Lanzillotta, F. Di Domenico, Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies, Expert Rev Neurother 17(1) (2017) 33-45.
[36] A. Tramutola, F. Di Domenico, E. Barone, A. Arena, A. Giorgi, L. di Francesco, M.E. Schinina, R. Coccia, E. Head, D.A. Butterfield, M. Perluigi, Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology, Antioxid Redox Signal 26(7) (2017) 280-298.
[37] S.N. Fontaine, A. Ingram, R.A. Cloyd, S.E. Meier, E. Miller, D. Lyons, G.K. Nation, E. Mechas, B. Weiss, C. Lanzillotta, F. Di Domenico, F. Schmitt, D.K. Powell, M. Vandsburger, J.F. Abisambra, Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach, Neurobiol Aging 56 (2017) 78-86.
[38] F. Di Domenico, A. Tramutola, D.A. Butterfield, Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of alzheimer disease and other selected age-related neurodegenerative disorders, Free Radic Biol Med 111 (2017) 253-261.
[39] F. Di Domenico, E. Barone, M. Perluigi, D.A. Butterfield, The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics, Antioxid Redox Signal 26(8) (2017) 364-387.
[40] A. Tramutola, G. Pupo, F. Di Domenico, E. Barone, A. Arena, C. Lanzillotta, D. Brokeaart, C. Blarzino, E. Head, D.A. Butterfield, M. Perluigi, Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype, J Alzheimers Dis 52(1) (2016) 359-371.
[41] A. Tramutola, C. Lanzillotta, A. Arena, E. Barone, M. Perluigi, F. Di Domenico, Increased Mammalian Target of Rapamycin Signaling Contributes to the Accumulation of Protein Oxidative Damage in a Mouse Model of Down's Syndrome, Neurodegener Dis 16(1-2) (2016) 62-8.
[42] A. Tramutola, F. Di Domenico, E. Barone, M. Perluigi, D.A. Butterfield, It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease, Oxid Med Cell Longev 2016 (2016) 2756068.
[43] C. Spadaccio, F. Nappi, N. Al-Attar, R. Coccia, M. Perluigi, F. Di Domenico, CURRENT DEVELOPMENTS IN DRUG ELUTING DEVICES: Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis, Drug Target Insights 10(Suppl 1) (2016) 15-19.
[44] C. Spadaccio, R. Coccia, M. Perluigi, G. Pupo, M.E. Schinina, A. Giorgi, C. Blarzino, F. Nappi, F.W. Sutherland, M. Chello, F. Di Domenico, Redox proteomic analysis of serum from aortic anerurysm patients: insights on oxidation of specific protein target, Mol Biosyst 12(7) (2016) 2168-77.
[45] M. Perluigi, E. Barone, F. Di Domenico, D.A. Butterfield, Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways, Biochim Biophys Acta 1862(10) (2016) 1871-82.
[46] D.J. Klionsky et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy 12(1) (2016) 1-222.
[47] F. Di Domenico, A. Tramutola, M. Perluigi, Cathepsin D as a therapeutic target in Alzheimer's disease, Expert Opin Ther Targets 20(12) (2016) 1393-1395.
[48] F. Di Domenico, G. Pupo, E. Giraldo, A. Lloret, M.C. Badia, M.E. Schinina, A. Giorgi, D.A. Butterfield, J. Vina, M. Perluigi, Autoantibodies Profile in Matching CSF and Serum from AD and aMCI patients: Potential Pathogenic Role and Link to Oxidative Damage, Curr Alzheimer Res 13(2) (2016) 112-22.
[49] F. Di Domenico, G. Pupo, E. Giraldo, M.C. Badia, P. Monllor, A. Lloret, M.E. Schinina, A. Giorgi, C. Cini, A. Tramutola, D.A. Butterfield, J. Vina, M. Perluigi, Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients, Free Radic Biol Med 91 (2016) 1-9.
[50] F. Di Domenico, M. Perluigi, D.A. Butterfield, Redox Proteomics in Human Biofluids: Sample Preparation, Separation and Immunochemical Tagging for Analysis of Protein Oxidation, Methods Mol Biol 1303 (2016) 391-403.
[51] E. Barone, F. Di Domenico, T. Cassano, A. Arena, A. Tramutola, M.A. Lavecchia, R. Coccia, D.A. Butterfield, M. Perluigi, Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm, Free Radic Biol Med 91 (2016) 127-42.
[52] A. Tramutola, J.C. Triplett, F. Di Domenico, D.M. Niedowicz, M.P. Murphy, R. Coccia, M. Perluigi, D.A. Butterfield, Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD, J Neurochem 133(5) (2015) 739-49.
[53] M. Perluigi, F. Di Domenico, D.A. Butterfield, mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy, Neurobiol Dis 84 (2015) 39-49.
[54] A. Nenna, F. Nappi, S.S. Avtaar Singh, F.W. Sutherland, F. Di Domenico, M. Chello, C. Spadaccio, Pharmacologic Approaches Against Advanced Glycation End Products (AGEs) in Diabetic Cardiovascular Disease, Res Cardiovasc Med 4(2) (2015) e26949.
[55] F. Di Domenico, G. Pupo, C. Mancuso, E. Barone, F. Paolini, A. Arena, C. Blarzino, F.A. Schmitt, E. Head, D.A. Butterfield, M. Perluigi, Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease, J Alzheimers Dis 44(4) (2015) 1107-20.
[56] F. Di Domenico, E. Barone, M. Perluigi, D.A. Butterfield, Strategy to reduce free radical species in Alzheimer's disease: an update of selected antioxidants, Expert Rev Neurother 15(1) (2015) 19-40.
[57] G. Bedse, F. Di Domenico, G. Serviddio, T. Cassano, Aberrant insulin signaling in Alzheimer's disease: current knowledge, Front Neurosci 9 (2015) 204.
[58] E. Barone, G. Cenini, F. Di Domenico, T. Noel, C. Wang, M. Perluigi, D.K. St Clair, D.A. Butterfield, Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53, J Neurosci Res 93(11) (2015) 1728-39.
[59] C. Spadaccio, F. De Marco, F. Di Domenico, R. Coccia, M. Lusini, R. Barbato, E. Covino, M. Chello, Simvastatin attenuates the endothelial pro-thrombotic shift in saphenous vein grafts induced by Advanced glycation endproducts, Thromb Res 133(3) (2014) 418-25.
[60] M. Perluigi, G. Pupo, A. Tramutola, C. Cini, R. Coccia, E. Barone, E. Head, D.A. Butterfield, F. Di Domenico, Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain, Biochim Biophys Acta 1842(7) (2014) 1144-53.
[61] M. Perluigi, F. Di Domenico, D.A. Buttterfield, Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics, Proteomics Clin Appl 8(1-2) (2014) 73-85.
[62] F. Di Domenico, G. Pupo, A. Tramutola, A. Giorgi, M.E. Schinina, R. Coccia, E. Head, D.A. Butterfield, M. Perluigi, Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease, Free Radic Biol Med 71 (2014) 270-280.
[63] D.A. Butterfield, L. Gu, F. Di Domenico, R.A. Robinson, Mass spectrometry and redox proteomics: applications in disease, Mass Spectrom Rev 33(4) (2014) 277-301.
[64] D.A. Butterfield, F. Di Domenico, A.M. Swomley, E. Head, M. Perluigi, Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain, Biochem J 463(2) (2014) 177-89.
[65] D.A. Butterfield, F. Di Domenico, E. Barone, Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain, Biochim Biophys Acta 1842(9) (2014) 1693-706.
[66] E. Barone, F. Di Domenico, C. Mancuso, D.A. Butterfield, The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation, Neurobiol Dis 62 (2014) 144-59.
[67] E. Barone, F. Di Domenico, D.A. Butterfield, Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets, Biochem Pharmacol 88(4) (2014) 605-16.
[68] C. Spadaccio, G. Patti, F. De Marco, R. Coccia, F. Di Domenico, F. Pollari, R. Zanzonico, M. Pettinari, M. Lusini, G. Di Sciascio, E. Covino, M. Chello, Usefulness of preprocedural levels of advanced glycation end products to predict restenosis in patients with controlled diabetes mellitus undergoing drug-eluting stent implantation for stable angina pectoris (from the Prospective ARMYDA-AGEs Study), Am J Cardiol 112(1) (2013) 21-6.
[69] A. Fiorini, T. Koudriavtseva, E. Bucaj, R. Coccia, C. Foppoli, A. Giorgi, M.E. Schinina, F. Di Domenico, F. De Marco, M. Perluigi, Involvement of oxidative stress in occurrence of relapses in multiple sclerosis: the spectrum of oxidatively modified serum proteins detected by proteomics and redox proteomics analysis, PLoS One 8(6) (2013) e65184.
[70] F. Di Domenico, M. Perluigi, E. Barone, Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain, Neural Regen Res 8(21) (2013) 1925-37.
[71] F. Di Domenico, F. De Marco, M. Perluigi, Proteomics strategies to analyze HPV-transformed cells: relevance to cervical cancer, Expert Rev Proteomics 10(5) (2013) 461-72.
[72] F. Di Domenico, R. Coccia, A. Cocciolo, M.P. Murphy, G. Cenini, E. Head, D.A. Butterfield, A. Giorgi, M.E. Schinina, C. Mancuso, C. Cini, M. Perluigi, Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain, Biochim Biophys Acta 1832(8) (2013) 1249-59.
[73] C. Spadaccio, F. Di Domenico, M. Perluigi, M. Lusini, A. Giorgi, M.E. Schinina, C. Blarzino, E. Covino, M. Chello, R. Coccia, Serum proteomics in patients with diagnosis of abdominal aortic aneurysm, Cardiovasc Pathol 21(4) (2012) 283-90.
[74] C. Mancuso, E. Barone, P. Guido, F. Miceli, F. Di Domenico, M. Perluigi, R. Santangelo, P. Preziosi, Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro, Neurosci Lett 518(2) (2012) 101-5.
[75] F. Di Domenico, R. Sultana, A. Ferree, K. Smith, E. Barone, M. Perluigi, R. Coccia, W. Pierce, J. Cai, C. Mancuso, R. Squillace, M. Wiengele, I. Dalle-Donne, B. Wolozin, D.A. Butterfield, Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease, Antioxid Redox Signal 17(11) (2012) 1490-506.
[76] F. Di Domenico, C. Foppoli, R. Coccia, M. Perluigi, Antioxidants in cervical cancer: chemopreventive and chemotherapeutic effects of polyphenols, Biochim Biophys Acta 1822(5) (2012) 737-47.
[77] F. Di Domenico, G. Casalena, J. Jia, R. Sultana, E. Barone, J. Cai, W.M. Pierce, C. Cini, C. Mancuso, M. Perluigi, C.M. Davis, N.J. Alkayed, D.A. Butterfield, Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion, J Neurochem 121(4) (2012) 680-92.
[78] F. Di Domenico, E. Barone, C. Mancuso, M. Perluigi, A. Cocciolo, P. Mecocci, D.A. Butterfield, R. Coccia, HO-1/BVR-a system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: a potential biochemical marker for the prediction of the disease, J Alzheimers Dis 32(2) (2012) 277-89.
[79] F. De Marco, E. Bucaj, C. Foppoli, A. Fiorini, C. Blarzino, K. Filipi, A. Giorgi, M.E. Schinina, F. Di Domenico, R. Coccia, D.A. Butterfield, M. Perluigi, Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues, PLoS One 7(3) (2012) e34366.
[80] A. Cocciolo, F. Di Domenico, R. Coccia, A. Fiorini, J. Cai, W.M. Pierce, P. Mecocci, D.A. Butterfield, M. Perluigi, Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics, Free Radic Biol Med 53(10) (2012) 1868-76.
[81] D.A. Butterfield, E. Barone, F. Di Domenico, G. Cenini, R. Sultana, M.P. Murphy, C. Mancuso, E. Head, Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain, Int J Neuropsychopharmacol 15(7) (2012) 981-7.
[82] E. Barone, C. Mancuso, F. Di Domenico, R. Sultana, M.P. Murphy, E. Head, D.A. Butterfield, Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease, J Neurochem 120(1) (2012) 135-46.
[83] E. Barone, F. Di Domenico, R. Sultana, R. Coccia, C. Mancuso, M. Perluigi, D.A. Butterfield, Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment, Free Radic Biol Med 52(11-12) (2012) 2292-301.
[84] E. Barone, G. Cenini, R. Sultana, F. Di Domenico, A. Fiorini, M. Perluigi, T. Noel, C. Wang, C. Mancuso, D.K. St Clair, D.A. Butterfield, Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B, Antioxid Redox Signal 16(12) (2012) 1407-20.
[85] R. Sultana, R.A. Robinson, F. Di Domenico, H.M. Abdul, D.K. St Clair, W.R. Markesbery, J. Cai, W.M. Pierce, D.A. Butterfield, Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age, J Proteomics 74(11) (2011) 2430-40.
[86] M. Perluigi, F. di Domenico, A. Fiorini, A. Cocciolo, A. Giorgi, C. Foppoli, D.A. Butterfield, M. Giorlandino, C. Giorlandino, M.E. Schinina, R. Coccia, Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid, Proteomics Clin Appl 5(3-4) (2011) 167-78.
[87] F. Di Domenico, R. Sultana, E. Barone, M. Perluigi, C. Cini, C. Mancuso, J. Cai, W.M. Pierce, D.A. Butterfield, Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects, J Proteomics 74(7) (2011) 1091-103.
[88] F. Di Domenico, R. Coccia, D.A. Butterfield, M. Perluigi, Circulating biomarkers of protein oxidation for Alzheimer disease: expectations within limits, Biochim Biophys Acta 1814(12) (2011) 1785-95.
[89] E. Barone, F. Di Domenico, G. Cenini, R. Sultana, R. Coccia, P. Preziosi, M. Perluigi, C. Mancuso, D.A. Butterfield, Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment, J Alzheimers Dis 25(4) (2011) 623-33.
[90] E. Barone, F. Di Domenico, G. Cenini, R. Sultana, C. Cini, P. Preziosi, M. Perluigi, C. Mancuso, D.A. Butterfield, Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment, Biochim Biophys Acta 1812(4) (2011) 480-7.
[91] E. Barone, G. Cenini, F. Di Domenico, S. Martin, R. Sultana, C. Mancuso, M.P. Murphy, E. Head, D.A. Butterfield, Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action, Pharmacol Res 63(3) (2011) 172-80.
[92] R. Sultana, F. Di Domenico, M. Tseng, J. Cai, T. Noel, R.L. Chelvarajan, W.D. Pierce, C. Cini, S. Bondada, D.K. St Clair, D.A. Butterfield, Doxorubicin-induced thymus senescence, J Proteome Res 9(12) (2010) 6232-41.
[93] M. Perluigi, F. Di Domenico, A. Giorgi, M.E. Schinina, R. Coccia, C. Cini, F. Bellia, M.T. Cambria, C. Cornelius, D.A. Butterfield, V. Calabrese, Redox proteomics in aging rat brain: involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process, J Neurosci Res 88(16) (2010) 3498-507.
[94] M. Perluigi, F. Di Domenico, C. Blarzino, C. Foppoli, C. Cini, A. Giorgi, C. Grillo, F. De Marco, D.A. Butterfield, M.E. Schinina, R. Coccia, Effects of UVB-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach, Proteome Sci 8 (2010) 13.
[95] F. Di Domenico, R. Sultana, G.F. Tiu, N.N. Scheff, M. Perluigi, C. Cini, D.A. Butterfield, Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: an investigation on the role of cellular stress response in the progression of Alzheimer disease, Brain Res 1333 (2010) 72-81.
[96] F. Di Domenico, M. Perluigi, D.A. Butterfield, C. Cornelius, V. Calabrese, Oxidative damage in rat brain during aging: interplay between energy and metabolic key target proteins, Neurochem Res 35(12) (2010) 2184-92.
[97] F. Di Domenico, J.B. Owen, R. Sultana, R.A. Sowell, M. Perluigi, C. Cini, J. Cai, W.M. Pierce, D.A. Butterfield, The wheat germ agglutinin-fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression, J Neurosci Res 88(16) (2010) 3566-77.
[98] F. Di Domenico, G. Casalena, R. Sultana, J. Cai, W.M. Pierce, M. Perluigi, C. Cini, A. Baracca, G. Solaini, G. Lenaz, J. Jia, S. Dziennis, S.J. Murphy, N.J. Alkayed, D.A. Butterfield, Involvement of Stat3 in mouse brain development and sexual dimorphism: a proteomics approach, Brain Res 1362 (2010) 1-12.
[99] M. Perluigi, R. Sultana, G. Cenini, F. Di Domenico, M. Memo, W.M. Pierce, R. Coccia, D.A. Butterfield, Redox proteomics identification of 4-hydroxynonenal-modified brain proteins in Alzheimer's disease: Role of lipid peroxidation in Alzheimer's disease pathogenesis, Proteomics Clin Appl 3(6) (2009) 682-693.
[100] M. Perluigi, A. Giorgi, C. Blarzino, F. De Marco, C. Foppoli, F. Di Domenico, D.A. Butterfield, M.E. Schinina, C. Cini, R. Coccia, Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation, J Cell Mol Med 13(8B) (2009) 1809-1822.
[101] M. Perluigi, F. Di Domenico, C. Cini, R. Coccia, F.R. Giorlandino, M. Giorlandino, P. Cignini, A. Mesoraca, C. Giorlandino, Proteomic analysis for the study of amniotic fluid protein composition, J Prenat Med 3(3) (2009) 39-41.
[102] J.B. Owen, F. Di Domenico, R. Sultana, M. Perluigi, C. Cini, W.M. Pierce, D.A. Butterfield, Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD, J Proteome Res 8(2) (2009) 471-82.
[103] F. Di Domenico, M. Perluigi, C. Foppoli, C. Blarzino, R. Coccia, F. De Marco, D.A. Butterfield, C. Cini, Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes, Free Radic Res 43(4) (2009) 365-75.
[104] F. Di Domenico, C. Foppoli, C. Blarzino, M. Perluigi, F. Paolini, S. Morici, R. Coccia, C. Cini, F. De Marco, Expression of human papilloma virus type 16 E5 protein in amelanotic melanoma cells regulates endo-cellular pH and restores tyrosinase activity, J Exp Clin Cancer Res 28 (2009) 4.
[105] F. Di Domenico, G. Cenini, R. Sultana, M. Perluigi, D. Uberti, M. Memo, D.A. Butterfield, Glutathionylation of the pro-apoptotic protein p53 in Alzheimer's disease brain: implications for AD pathogenesis, Neurochem Res 34(4) (2009) 727-33.
[106] M. Chello, C. Spadaccio, M. Lusini, E. Covino, C. Blarzino, F. De Marco, F. Di Domenico, R. Coccia, Advanced glycation end products in diabetic patients with optimized glycaemic control and their effects on endothelial reactivity: possible implications in venous graft failure, Diabetes Metab Res Rev 25(5) (2009) 420-6.


Produzione scientifica

11573/1708399 - 2024 - Redox imbalance and metabolic defects in the context of Alzheimer disease
Di Domenico, F.; Lanzillotta, C.; Perluigi, M. - 01g Articolo di rassegna (Review)
rivista: FEBS LETTERS (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1-20 - issn: 0014-5793 - wos: WOS:001183461800001 (0) - scopus: 2-s2.0-85187458858 (0)

11573/1709575 - 2024 - Shaping down syndrome brain cognitive and molecular changes due to aging using adult animals from the Ts66Yah murine model
Lanzillotta, Chiara; Baniowska, Monika Rataj; Prestia, Francesca; Sette, Chiara; Nalesso, Valérie; Perluigi, Marzia; Barone, Eugenio; Duchon, Arnaud; Tramutola, Antonella; Herault, Yann; Di Domenico, Fabio - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 1-22 - issn: 0969-9961 - wos: WOS:001239384700001 (0) - scopus: 2-s2.0-85192167129 (0)

11573/1711799 - 2024 - Biliverdin reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β
Lanzillotta, Chiara; Tramutola, Antonella; Lanzillotta, Simona; Greco, Viviana; Pagnotta, Sara; Sanchini, Caterina; Di Angelantonio, Silvia; Forte, Elena; Rinaldo, Serena; Paone, Alessio; Cutruzzolà, Francesca; Cimini, Flavia Agata; Barchetta, Ilaria; Cavallo, Maria Gisella; Urbani, Andrea; Butterfield, D Allan; Di Domenico, Fabio; Paul, Bindu D; Perluigi, Marzia; Duarte, Joao M N; Barone, Eugenio - 01a Articolo in rivista
rivista: REDOX BIOLOGY (Amsterdam : Elsevier) pp. - - issn: 2213-2317 - wos: (0) - scopus: 2-s2.0-85195097821 (0)

11573/1708400 - 2024 - Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
Perluigi, Marzia; Di Domenico, Fabio; Butterfield, D. Allan - 01a Articolo in rivista
rivista: PHYSIOLOGICAL REVIEWS (American Physiological Society:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7180, EMAIL: subscrip@the-aps.org, INTERNET: http://www.the-aps.org, Fax: (301)571-8313) pp. 103-197 - issn: 0031-9333 - wos: (0) - scopus: 2-s2.0-85175584736 (15)

11573/1666748 - 2023 - Intranasal administration of KYCCSRK peptide rescues brain insulin signaling activation and reduces Alzheimer’s disease-like neuropathology in a mouse model for Down syndrome
Tramutola, Antonella; Lanzillotta, Simona; Aceto, Giuseppe; Pagnotta, Sara; Ruffolo, Gabriele; Cifelli, Pierangelo; Marini, Federico; Ripoli, Cristian; Palma, Eleonora; Grassi, Claudio; Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio - 01a Articolo in rivista
rivista: ANTIOXIDANTS (Basel: MDPI) pp. 111- - issn: 2076-3921 - wos: WOS:000916695100001 (11) - scopus: 2-s2.0-85146816588 (13)

11573/1669730 - 2023 - Chronic treatment with the anti-diabetic drug metformin rescues impaired brain mitochondrial activity and selectively ameliorates defective cognitive flexibility in a female mouse model of Rett syndrome
Urbinati, Chiara; Lanzillotta, Chiara; Cosentino, Livia; Valenti, Daniela; Quattrini, Maria Cristina; Di Crescenzo, Livia; Prestia, Francesca; Pietraforte, Donatella; Perluigi, Marzia; Di Domenico, Fabio; Vacca, Rosa Anna; De Filippis, Bianca - 01a Articolo in rivista
rivista: NEUROPHARMACOLOGY ([Oxford] : Elsevier Ltd.) pp. 109350- - issn: 1873-7064 - wos: WOS:000895904100001 (3) - scopus: 2-s2.0-85143870753 (3)

11573/1659637 - 2022 - The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerative disorders
Di Domenico, Fabio; Di Domenico, F; Lanzillotta, C - 01a Articolo in rivista
rivista: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY (Amsterdam : Elsevier) pp. 49-87 - issn: 1876-1623 - wos: (0) - scopus: 2-s2.0-85132226955 (9)

11573/1634188 - 2022 - CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down syndrome
Pagnotta, S.; Tramutola, A.; Barone, E.; Di Domenico, F.; Pittala, V.; Salerno, L.; Folgiero, V.; Caforio, M.; Locatelli, F.; Petrini, S.; Butterfield, D. A.; Perluigi, M. - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-13 - issn: 0891-5849 - wos: WOS:000790734500001 (7) - scopus: 2-s2.0-85126271579 (11)

11573/1612865 - 2022 - Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles
Perluigi, M.; Picca, A.; Montanari, E.; Calvani, R.; Marini, F.; Matassa, R.; Tramutola, A.; Villani, A.; Familiari, G.; Domenico, F. D.; Butterfield, D. A.; Oh, K. J.; Marzetti, E.; Valentini, D.; Barone, E. - 01a Articolo in rivista
rivista: ALZHEIMER'S & DEMENTIA (New York : Elsevier, c2005-) pp. 1498-1510 - issn: 1552-5260 - wos: WOS:000721478900001 (16) - scopus: 2-s2.0-85119666649 (17)

11573/1610949 - 2021 - The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease
Barone, E.; Di Domenico, F.; Perluigi, M.; Butterfield, D. A. - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 16-33 - issn: 0891-5849 - wos: WOS:000709495400002 (49) - scopus: 2-s2.0-85114802429 (67)

11573/1486108 - 2021 - Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Dj; Abdel-Aziz, Ak; Abdelfatah, S; Abdellatif, M; Abdoli, A; Abel, S; Abeliovich, H; Abildgaard, Mh; Abudu, Yp; Acevedo-Arozena, A; Adamopoulos, Ie; Adeli, K; Adolph, Te; Adornetto, A; Aflaki, E; Agam, G; Agarwal, A; Aggarwal, Bb; Agnello, M; Agostinis, P; Agrewala, Jn; Agrotis, A; Aguilar, Pv; Ahmad, St; Ahmed, Zm; Ahumada-Castro, U; Aits, S; Aizawa, S; Akkoc, Y; Akoumianaki, T; Akpinar, Ha; Al-Abd, Am; Al-Akra, L; Al-Gharaibeh, A; Alaoui-Jamali, Ma; Alberti, S; Alcocer-Gómez, E; Alessandri, C; Ali, M; Alim Al-Bari, Ma; Aliwaini, S; Alizadeh, J; Almacellas, E; Almasan, A; Alonso, A; Alonso, Gd; Altan-Bonnet, N; Altieri, Dc; Álvarez, Émc; Alves, S; Alves Da Costa, C; Alzaharna, Mm; Amadio, M; Amantini, C; Amaral, C; Ambrosio, S; Amer, Ao; Ammanathan, V; An, Z; Andersen, Su; Andrabi, Sa; Andrade-Silva, M; Andres, Am; Angelini, S; Ann, D; Anozie, Uc; Ansari, My; Antas, P; Antebi, A; Antón, Z; Anwar, T; Apetoh, L; Apostolova, N; Araki, T; Araki, Y; Arasaki, K; Araújo, Wl; Araya, J; Arden, C; Arévalo, Ma; Arguelles, S; Arias, E; Arikkath, J; Arimoto, H; Ariosa, Ar; Armstrong-James, D; Arnauné-Pelloquin, L; Aroca, A; Arroyo, Ds; Arsov, I; Artero, R; Asaro, Dml; Aschner, M; Ashrafizadeh, M; Ashur-Fabian, O; Atanasov, Ag; Au, Ak; Auberger, P; Auner, Hw; Aurelian, L; Autelli, R; Avagliano, L; Ávalos, Y; Aveic, S; Aveleira, Ca; Avin-Wittenberg, T; Aydin, Y; Ayton, S; Ayyadevara, S; Azzopardi, M; Baba, M; Backer, Jm; Backues, Sk; Bae, Dh; Bae, On; Bae, Sh; Baehrecke, Eh; Baek, A; Baek, Sh; Baek, Sh; Bagetta, G; Bagniewska-Zadworna, A; Bai, H; Bai, J; Bai, X; Bai, Y; Bairagi, N; Baksi, S; Balbi, T; Baldari, Ct; Balduini, W; Ballabio, A; Ballester, M; Balazadeh, S; Balzan, R; Bandopadhyay, R; Banerjee, S; Banerjee, S; Bánréti, Á; Bao, Y; Baptista, Ms; Baracca, A; Barbati, C; Bargiela, A; Barilà, D; Barlow, Pg; Barmada, Sj; Barreiro, E; Barreto, Ge; Bartek, J; Bartel, B; Bartolome, A; Barve, Gr; Basagoudanavar, Sh; Bassham, Dc; Bast Rc, Jr; Basu, A; Batoko, H; Batten, I; Baulieu, Ee; Baumgarner, Bl; Bayry, J; Beale, R; Beau, I; Beaumatin, F; Bechara, Lrg; Beck Gr, Jr; Beers, Mf; Begun, J; Behrends, C; Behrens, Gmn; Bei, R; Bejarano, E; Bel, S; Behl, C; Belaid, A; Belgareh-Touzé, N; Bellarosa, C; Belleudi, F; Belló Pérez, M; Bello-Morales, R; Beltran, Jso; Beltran, S; Benbrook, Dm; Bendorius, M; Benitez, Ba; Benito-Cuesta, I; Bensalem, J; Berchtold, Mw; Berezowska, S; Bergamaschi, D; Bergami, M; Bergmann, A; Berliocchi, L; Berlioz-Torrent, C; Bernard, A; Berthoux, L; Besirli, Cg; Besteiro, S; Betin, Vm; Beyaert, R; Bezbradica, Js; Bhaskar, K; Bhatia-Kissova, I; Bhattacharya, R; Bhattacharya, S; Bhattacharyya, S; Bhuiyan, Ms; Bhutia, Sk; Bi, L; Bi, X; Biden, Tj; Bijian, K; Billes, Va; Binart, N; Bincoletto, C; Birgisdottir, Ab; Bjorkoy, G; Blanco, G; Blas-Garcia, A; Blasiak, J; Blomgran, R; Blomgren, K; Blum, Js; Boada-Romero, E; Boban, M; Boesze-Battaglia, K; Boeuf, P; Boland, B; Bomont, P; Bonaldo, P; Bonam, Sr; Bonfili, L; Bonifacino, Js; Boone, Ba; Bootman, Md; Bordi, M; Borner, C; Bornhauser, Bc; Borthakur, G; Bosch, J; Bose, S; Botana, Lm; Botas, J; Boulanger, Cm; Boulton, Me; Bourdenx, M; Bourgeois, B; Bourke, Nm; Bousquet, G; Boya, P; Bozhkov, Pv; Bozi, Lhm; Bozkurt, To; Brackney, De; Brandts, Ch; Braun, Rj; Braus, Gh; Bravo-Sagua, R; Bravo-San Pedro, Jm; Brest, P; Bringer, Ma; Briones-Herrera, A; Broaddus, Vc; Brodersen, P; Brodsky, Jl; Brody, Sl; Bronson, Pg; Bronstein, Jm; Brown, Cn; Brown, Re; Brum, Pc; Brumell, Jh; Brunetti-Pierri, N; Bruno, D; Bryson-Richardson, Rj; Bucci, C; Buchrieser, C; Bueno, M; Buitrago-Molina, Le; Buraschi, S; Buch, S; Buchan, Jr; Buckingham, Em; Budak, H; Budini, M; Bultynck, G; Burada, F; Burgoyne, Jr; Burón, Mi; Bustos, V; Büttner, S; Butturini, E; Byrd, A; Cabas, I; Cabrera-Benitez, S; Cadwell, K; Cai, J; Cai, L; Cai, Q; Cairó, M; Calbet, Ja; Caldwell, Ga; Caldwell, Ka; Call, Ja; Calvani, R; Calvo, Ac; Calvo-Rubio Barrera, M; Camara, No; Cam - 01g Articolo di rassegna (Review)
rivista: AUTOPHAGY (Landes Bioscience Georgetown TX 78628) pp. 1-382 - issn: 1554-8627 - wos: WOS:000636121800001 (913) - scopus: 2-s2.0-85102619204 (1430)

11573/1610953 - 2021 - Broad kinase inhibition mitigates early neuronal dysfunction in tauopathy
Koren, Shon A; Hamm, Matthew J; Cloyd, Ryan; Fontaine, Sarah N; Chishti, Emad; Lanzillotta, Chiara; Rodriguez-Rivera, Jennifer; Ingram, Alexandria; Bell, Michelle; Galvis-Escobar, Sara M; Zulia, Nicholas; Di Domenico, Fabio; Duong, Duc; Seyfried, Nicholas T; Powell, David; Vandsburger, Moriel; Frolinger, Tal; Hartz, Anika M S; Koren, John; Axten, Jeffrey M; Laping, Nicholas J; Abisambra, Jose F - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel: MDPI Center) pp. - - issn: 1422-0067 - wos: WOS:000615342000001 (5) - scopus: 2-s2.0-85099949284 (5)

11573/1502715 - 2021 - Stress responses in down syndrome neurodegeneration: State of the art and therapeutic molecules
Lanzillotta, C.; Di Domenico, F. - 01a Articolo in rivista
rivista: BIOMOLECULES (Basel: MDPI) pp. 1-34 - issn: 2218-273X - wos: WOS:000622164800001 (17) - scopus: 2-s2.0-85100693795 (18)

11573/1456191 - 2021 - Chronic perk induction promotes alzheimer-like neuropathology in down syndrome: Insights for therapeutic intervention
Lanzillotta, C.; Zuliani, I.; Tramutola, A.; Barone, E.; Blarzino, C.; Folgiero, V.; Caforio, M.; Valentini, D.; Villani, A.; Locatelli, F.; Butterfield, D. A.; Head, E.; Perluigi, M.; Abisambra, J. F.; Di Domenico, F. - 01a Articolo in rivista
rivista: PROGRESS IN NEUROBIOLOGY (-Oxford:PERGAMON-ELSEVIER SCIENCE LTD, -Oxford; New York; Toronto; Rushcutters Bay; Braunschweig: Pergamon Press Vieweg & Sohn.) pp. 1-17 - issn: 0301-0082 - wos: WOS:000604785900004 (17) - scopus: 2-s2.0-85089501564 (24)

11573/1487153 - 2021 - Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in down syndrome
Lanzillotta, Chiara; Tramutola, Antonella; Di Giacomo, Graziella; Marini, Federico; Butterfield, D Allan; Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 152-170 - issn: 0891-5849 - wos: WOS:000631946000004 (27) - scopus: 2-s2.0-85100251745 (29)

11573/1610951 - 2021 - mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder
Perluigi, M.; Di Domenico, F.; Barone, E.; Butterfield, D. A. - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 382-396 - issn: 0891-5849 - wos: WOS:000653018200002 (55) - scopus: 2-s2.0-85105070584 (63)

11573/1659636 - 2021 - Oxidative stress and mTOR in Down syndrome brain: link to Alzheimer’s dysmetabolism, neuropathology, and possible therapies
Perluigi, M.; Di Domenico, F.; Butterfield, D. A. - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 75-96 - issn: 0891-5849 - wos: (0) - scopus: 2-s2.0-85129094977 (0)

11573/1532739 - 2021 - High-fat diet leads to reduced protein o-glcnacylation and mitochondrial defects promoting the development of Alzheimer’s disease signatures
Zuliani, I.; Lanzillotta, C.; Tramutola, A.; Barone, E.; Perluigi, M.; Rinaldo, S.; Paone, A.; Cutruzzola', F.; Bellanti, F.; Spinelli, M.; Natale, F.; Fusco, S.; Grassi, C.; Di Domenico, F. - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (Basel (Matthaeustrasse 11) : Molecular Diversity Preservation International MDPI) pp. - - issn: 1661-6596 - wos: WOS:000638633700001 (18) - scopus: 2-s2.0-85103489586 (19)

11573/1474740 - 2021 - The dysregulation of OGT/OGA cycle mediates Tau and APP neuropathology in down syndrome
Zuliani, I.; Lanzillotta, C.; Tramutola, A.; Francioso, A.; Pagnotta, S.; Barone, E.; Perluigi, M.; Di Domenico, F. - 01a Articolo in rivista
rivista: NEUROTHERAPEUTICS (Orlando, FL: Elsevier, c2007-) pp. 340-363 - issn: 1933-7213 - wos: WOS:000594792400002 (11) - scopus: 2-s2.0-85096999977 (10)

11573/1474752 - 2020 - Proteomics study of peripheral blood mononuclear cells in down syndrome children
Lanzillotta, C.; Greco, V.; Valentini, D.; Villani, A.; Folgiero, V.; Caforio, M.; Locatelli, F.; Pagnotta, S.; Barone, E.; Urbani, A.; Domenico, F. D.; Perluigi, M. - 01a Articolo in rivista
rivista: ANTIOXIDANTS (Basel: MDPI) pp. 1-27 - issn: 2076-3921 - wos: WOS:000592837500001 (3) - scopus: 2-s2.0-85095984917 (5)

11573/1474757 - 2020 - BVR-A deficiency leads to autophagy impairment through the dysregulation of AMPK/mTOR axis in the brain—Implications for neurodegeneration
Lanzillotta, C.; Zuliani, I.; Vasavda, C.; Snyder, S.; Paul, B.; Perluigi, M.; Di Domenico, F.; Barone, E. - 01a Articolo in rivista
rivista: ANTIOXIDANTS (Basel: MDPI) pp. 1-20 - issn: 2076-3921 - wos: WOS:000564629100001 (15) - scopus: 2-s2.0-85088956309 (18)

11573/1425664 - 2020 - Multiple Herpes simplex virus-1 (HSV-1) reactivations induce protein oxidative damage in mouse brain. Novel mechanisms for Alzheimer’s disease progression
Protto, Virginia; Tramutola, Antonella; Fabiani, Marco; Marcocci, Maria Elena; Napoletani, Giorgia; Iavarone, Federica; Vincenzoni, Federica; Castagnola, Massimo; Perluigi, Marzia; Di Domenico, Fabio; De Chiara, Giovanna; Palamara, Anna Teresa - 01a Articolo in rivista
rivista: MICROORGANISMS (Basel : MDPI) pp. 1-21 - issn: 2076-2607 - wos: WOS:000554284200001 (15) - scopus: 2-s2.0-85087114145 (16)

11573/1381380 - 2020 - Protein oxidative damage in UV-related skin cancer and dysplastic lesions contributes to neoplastic promotion and progression
Tramutola, A.; Falcucci, S.; Brocco, U.; Triani, F.; Lanzillotta, C.; Donati, M.; Panetta, C.; Luzi, F.; Iavarone, F.; Vincenzoni, F.; Castagnola, M.; Perluigi, M.; Di Domenico, F.; De Marco, F. - 01a Articolo in rivista
rivista: CANCERS (Basel: MDPI) pp. 1-25 - issn: 2072-6694 - wos: WOS:000516826700110 (8) - scopus: 2-s2.0-85077526078 (8)

11573/1381801 - 2020 - Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome
Tramutola, A.; Lanzillotta, C.; Di Domenico, F.; Head, E.; Butterfield, D. A.; Perluigi, M.; Barone, E. - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 104772- - issn: 0969-9961 - wos: WOS:000518709300017 (47) - scopus: 2-s2.0-85078670491 (50)

11573/1406171 - 2020 - Potential therapeutic value of the anti-diabetic drug metformin in a mouse model of Rett syndrome: a preclinical study
Urbinati, Chiara; Zuliani, Ilaria; Valenti, Daniela; Cristina Quattrini, Maria; Cosentino, Livia; Medici, Vanessa; Pietraforte, Donatella; Di Domenico, Fabio; Perluigi, Marzia; Anna Vacca, Rosa; De Filippis, Bianca - 04d Abstract in atti di convegno
congresso: FENS 2020 virtual forum (virtual)
libro: FENS 2020 virtual forum - ()

11573/1406139 - 2020 - The anti-diabetic drug metformin rescues aberrant mitochondrial activity and restrains oxidative stress in a female mouse model of rett syndrome
Zuliani, Ilaria; Urbinati, Chiara; Valenti, Daniela; Cristina Quattrini, Maria; Medici, Vanessa; Cosentino, Livia; Pietraforte, Donatella; Di Domenico, Fabio; Perluigi, Marzia; Anna Vacca, Rosa; De Filippis, Bianca - 01a Articolo in rivista
rivista: JOURNAL OF CLINICAL MEDICINE (MDPI Publishing, Basel, Switzerland) pp. - - issn: 2077-0383 - wos: WOS:000549226700001 (16) - scopus: 2-s2.0-85102223213 (16)

11573/1175653 - 2019 - Biliverdin reductase-A mediates the beneficial effects of intranasal insulin in Alzheimer disease
Barone, E; Tramutola, A; Triani, F; Calcagnini, S; Di Domenico, F; Ripoli, C; Gaetani, S; Grassi, C; Butterfield, Da; Cassano, T; Perluigi, M - 01a Articolo in rivista
rivista: MOLECULAR NEUROBIOLOGY (Humana Press Incorporated:999 Riverview Drive, Suite 208:Totowa, NJ 07512:(973)256-1699, EMAIL: lglasner@humanapr.com, INTERNET: http://www.humanapress.com, Fax: (973)256-8341) pp. 2922-2943 - issn: 0893-7648 - wos: WOS:000465498200050 (62) - scopus: 2-s2.0-85051645596 (68)

11573/1244127 - 2019 - Reduced biliverdin reductase-a levels are associated with early alterations of insulin signaling in obesity
Cimini, Flavia Agata; Arena, Andrea; Barchetta, Ilaria; Tramutola, Antonella; Ceccarelli, Valentina; Lanzillotta, Chiara; Fontana, Mario; Bertoccini, Laura; Leonetti, Frida; Capoccia, Danila; Silecchia, Gianfranco; Di Cristofano, Claudio; Chiappetta, Caterina; Di Domenico, Fabio; Baroni, Marco Giorgio; Perluigi, Marzia; Cavallo, Maria Gisella; Barone, Eugenio - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. - - issn: 0925-4439 - wos: WOS:000468708200039 (27) - scopus: 2-s2.0-85062273097 (30)

11573/1335755 - 2019 - Shining a light on defective autophagy by proteomics approaches: implications for neurodegenerative illnesses
Di Domenico, F.; Zuliani, I.; Tramutola, A. - 01a Articolo in rivista
rivista: EXPERT REVIEW OF PROTEOMICS (--London : Expert Reviews Ltd, London : Future Drugs, 2004-) pp. 1-14 - issn: 1478-9450 - wos: WOS:000496385600001 (8) - scopus: 2-s2.0-85075138357 (10)

11573/1273664 - 2019 - Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome
Di Domenico, Fabio; Tramutola, Antonella; Barone, Eugenio; Lanzillotta, Chiara; Defever, Olivia; Arena, Andrea; Zuliani, Ilaria; Foppoli, Cesira; Iavarone, Federica; Vincenzoni, Federica; Castagnola, Massimo; Butterfield, D Allan; Perluigi, Marzia - 01a Articolo in rivista
rivista: REDOX BIOLOGY (Amsterdam : Elsevier) pp. 101162- - issn: 2213-2317 - wos: WOS:000498848200015 (45) - scopus: 2-s2.0-85062690014 (49)

11573/1335759 - 2019 - Targeting mitochondria in Alzheimer disease: rationale and perspectives
Lanzillotta, C.; Di Domenico, F.; Perluigi, M.; Butterfield, D. A. - 01g Articolo di rassegna (Review)
rivista: CNS DRUGS (Adis International Limited:Private Bag 65901, Mairangi Bay, Auckland 1311 New Zealand:011 64 9 4770741, EMAIL: subs@adis.com, david.herrick@adis.co.nz, INTERNET: http://www.adis.com, Fax: 011 64 9 4770766) pp. 957-969 - issn: 1172-7047 - wos: WOS:000493655900001 (43) - scopus: 2-s2.0-85071187006 (44)

11573/1244121 - 2019 - Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease
Sharma, Nidhi; Tramutola, Antonella; Lanzillotta, Chiara; Arena, Andrea; Blarzino, Carla; Cassano, Tommaso; Butterfield, D. Allan; Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 176-189 - issn: 0969-9961 - wos: WOS:000461406000017 (46) - scopus: 2-s2.0-85061254683 (48)

11573/1348640 - 2019 - Metformin treatment rescues aberrant mitochondrial activity and oxidative stress status in the brain of female mouse model of Rett syndrome
Urbinati, Chiara; Zuliani, Ilaria; Valenti, Daniela; Medici, Vanessa; Cosentino, Livia; Vigli, Daniele; Di Domenico, Fabio; Perluigi, Marzia; Anna Vacca, Rosa; De Filippis, Bianca - 04d Abstract in atti di convegno
congresso: 6th European Conference on Behaviour and Cognition, (Padova)
libro: 6th European Conference on Behaviour and Cognition - ()

11573/1178992 - 2018 - Therapeutic potential of rescuing protein O-GlcNAcylation in tau-related pathologies
Di Domenico, Fabio; Lanzillotta, Chiara; Tramutola, Antonella - 01a Articolo in rivista
rivista: EXPERT REVIEW OF NEUROTHERAPEUTICS (-London, United Kingdom: Expert Reviews Ltd -London, United Kingdom: Future Drugs Limited) pp. - - issn: 1473-7175 - wos: WOS:000454507900001 (12) - scopus: 2-s2.0-85055744358 (13)

11573/1456215 - 2018 - mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia
Di Domenico, Fabio; Tramutola, Antonella; Foppoli, Cesira; Head, Elizabeth; Perluigi, Marzia; Butterfield, D. Allan - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 94-101 - issn: 0891-5849 - wos: WOS:000418889700011 (63) - scopus: 2-s2.0-85027579851 (68)

11573/1071360 - 2018 - Early and selective activation and subsequent alterations to the unfolded protein response in down syndrome mouse models
Lanzillotta, Chiara; Tramutola, Antonella; Meier, Shelby; Schmitt, Frederick; Barone, Eugenio; Perluigi, Marzia; Di Domenico, Fabio; Abisambra, Jose F - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 347-359 - issn: 1387-2877 - wos: WOS:000424245200026 (16) - scopus: 2-s2.0-85047973196 (18)

11573/1175590 - 2018 - Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease
Tramutola, A; Sharma, N; Barone, E; Lanzillotta, C; Castellani, A; Iavarone, F; Vincenzoni, F; Castagnola, M; Butterfield, Da; Gaetani, S; Cassano, T; Perluigi, M; Di Domenico, F. - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 3309-3321 - issn: 0925-4439 - wos: WOS:000445312000018 (29) - scopus: 2-s2.0-85050225026 (31)

11573/1175577 - 2018 - Poly-ubiquitin profile in Alzheimer disease brain
Tramutola, A; Triani, F; Di Domenico, F; Barone, E; Cai, J; Klein, Jb; Perluigi, M; Butterfield, Da. - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 129-141 - issn: 0969-9961 - wos: WOS:000442193400011 (26) - scopus: 2-s2.0-85049878421 (31)

11573/1178983 - 2018 - Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: novel hints on immunosenescence and biomarker detection
Tramutola, Antonella; Abate, Giulia; Lanzillotta, Chiara; Triani, Francesca; Barone, Eugenio; Iavarone, Federica; Vincenzoni, Federica; Castagnola, Massimo; Marziano, Mariagrazia; Memo, Maurizio; Garrafa, Emirena; Butterfield, D Allan; Perluigi, Marzia; Di Domenico, Fabio; Uberti, Daniela - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 430-439 - issn: 0891-5849 - wos: WOS:000450298400039 (19) - scopus: 2-s2.0-85055168925 (20)

11573/1199021 - 2018 - Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
Tramutola, Antonella; Lanzillotta, Chiara; Barone, Eugenio; Arena, Andrea; Zuliani, Ilaria; Mosca, Luciana; Blarzino, Carla; Butterfield, D. Allan; Perluigi, Marzia; Di Domenico, Fabio - 01a Articolo in rivista
rivista: TRANSLATIONAL NEURODEGENERATION (London : BioMed Central) pp. 1-28 - issn: 2047-9158 - wos: WOS:000449479100001 (67) - scopus: 2-s2.0-85056084092 (74)

11573/1175667 - 2018 - Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: implications for Alzheimer disease
Triani, F; Tramutola, A; Di Domenico, F; Sharma, N; Butterfield, Da; Head, E; Perluigi, M; Barone, E - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 3181-3194 - issn: 0925-4439 - wos: WOS:000445312000007 (37) - scopus: 2-s2.0-85049953122 (38)

11573/1180249 - 2017 - Metodi alternativi alla sperimentazione animale
Amorosino, Sandro; Campanaro, Carla; De Angelis, Isabella; Di Domenico, Fabio; Ferroni, Maria Vittoria; Hartung, Thomas; Parodi, Barbara; Penco, Susanna; Perluigi, Marzia; Picozza, Eugenio; Rovida, Maria Costanza; Santucci, Ugo; Scuccimarra, Luca; Vincelli, Claudio; Vitale, Augusto - 06a Curatela

11573/1612903 - 2017 - From redox proteomics to clinical practice: Search for therapeutic targets
Di Domenico, F.; Cini, C.; Perluigi, M. - 01a Articolo in rivista
rivista: JOURNAL OF GERONTOLOGY AND GERIATRICS (Pisa: Pacini) pp. 101-109 - issn: 2499-6564 - wos: WOS:000407094400003 (0) - scopus: 2-s2.0-85022036566 (0)

11573/935434 - 2017 - The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein homeostasis revealed by redox proteomics
Di Domenico, Fabio; Barone, Eugenio; Perluigi, Marzia; Butterfield, D. Allan - 01a Articolo in rivista
rivista: ANTIOXIDANTS & REDOX SIGNALING (Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688) pp. - - issn: 1523-0864 - wos: WOS:000395554300002 (86) - scopus: 2-s2.0-85014561567 (94)

11573/935431 - 2017 - Role of 4-hydroxy-2-nonenal (HNE) in the pathogenesis of Alzheimer disease and other selected age-related neurodegenerative disorders
Di Domenico, Fabio; Tramutola, Antonella; Butterfield, D. Allan - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 253-261 - issn: 0891-5849 - wos: WOS:000406049900022 (173) - scopus: 2-s2.0-85006067115 (188)

11573/1167280 - 2017 - Multiple Herpes Simplex Virus-1 (HSV-1) reactivations induce neurodegenerative and oxidative damages in mouse brains
Fabiani, Marco; Tramutola, Antonella; Napoletani, Giorgia; Perluigi, Marzia; Di Domenico, Fabio; Palamara, Anna Teresa; De Chiara, Giovanna - 04f Poster
congresso: Congresso Nazionale SIM 2017 (Genova)
libro: Congresso Nazionale SIM 2017 – Genova - ()

11573/959955 - 2017 - Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach
Fontaine, Sn; Ingram, A; Cloyd, Ra; Meier, Se; Miller, E; Lyons, D; Nation, Gk; Mechas, E; Weiss, B; Lanzillotta, Chiara; Di Domenico, Fabio; Schmitt, F; Powell, Dk; Vandsburger, M; Abisambra, J. F. 8. - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF AGING (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 78-86 - issn: 0197-4580 - wos: WOS:000405463300009 (20) - scopus: 2-s2.0-85019051591 (20)

11573/968244 - 2017 - I principi europei sui metodi alternativi alla sperimentazione animale
Scuccimarra, Luca; Ferroni, Maria Vittoria; Campanaro, Carla; Perluigi, Marzia; Di Domenico, Fabio; Picozza, Eugenio; Hartung, Thomas; Rovida, Costanza; Penco, Susanna; Parodi, Barbara; Amorosino, Sandro; Vitale, Augusto; De Angelis, Isabella; Santucci, Ugo; Vincelli, Claudio - 02a Capitolo o Articolo
libro: Metodi alternativi alla sperimentazione animale - (9788892105812)

11573/935420 - 2017 - Introductory editorial: drug-eluting stents or drug-eluting grafts? insights from proteomic analysis
Spadaccio, Cristiano; Nappi, Francesco; Al Attar, Nawwar; Coccia, Raffaella; Perluigi, Marzia; Di Domenico, Fabio - 01a Articolo in rivista
rivista: DRUG TARGET INSIGHTS (Auckland, N.Z. : Libertas Academica, [2006]-) pp. 15-19 - issn: 1177-3928 - wos: WOS:000395306000001 (7) - scopus: 2-s2.0-85012293425 (8)

11573/935436 - 2017 - Polyubiquitinylation profile in down syndrome brain before and after the development of Alzheimer neuropathology
Tramutola, Antonella; Di Domenico, Fabio; Barone, Eugenio; Arena, Andrea; Giorgi, Alessandra; Di Francesco, Laura; Schinina', Maria Eugenia; Coccia, Raffaella; Head, Elizabeth; Butterfield, D. Allan; Perluigi, Marzia - 01a Articolo in rivista
rivista: ANTIOXIDANTS & REDOX SIGNALING (Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688) pp. 280-298 - issn: 1523-0864 - wos: WOS:000394334400002 (32) - scopus: 2-s2.0-85013434336 (36)

11573/930567 - 2017 - Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies
Tramutola, Antonella; Lanzillotta, Chiara; Di Domenico, Fabio - 01a Articolo in rivista
rivista: EXPERT REVIEW OF NEUROTHERAPEUTICS (-London, United Kingdom: Expert Reviews Ltd -London, United Kingdom: Future Drugs Limited) pp. 33-45 - issn: 1473-7175 - wos: WOS:000390241300005 (19) - scopus: 2-s2.0-85004065396 (55)

11573/846243 - 2016 - Impairment of biliverdin reductase-a promotes brain insulin resistance in Alzheimer disease: a new paradigm
Barone, Eugenio; Di Domenico, Fabio; Cassano, Tommaso; Arena, Andrea; Tramutola, Antonella; Lavecchia, Michele Angelo; Coccia, Raffaella; Butterfield, D. Allan; Perluigi, Marzia - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 127-142 - issn: 0891-5849 - wos: WOS:000370181400012 (88) - scopus: 2-s2.0-84950335909 (91)

11573/1023555 - 2016 - Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients
Di Domenico, Fabio; Pupo, Gilda; Giraldo, Esther; Badã¬A, Mari-Carmen; Monllor, Paloma; Lloret, Ana; Eugenia Schininã&Nbsp;, Maria; Giorgi, Alessandra; Cini, Chiara; Tramutola, Antonella; Butterfield, D. Allan; Viã±A, Josã©; Perluigi, Marzia - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1-9 - issn: 0891-5849 - wos: WOS:000370181400001 (72) - scopus: 2-s2.0-84949509857 (74)

11573/948284 - 2016 - Autoantibodies profile in matching CSF and serum from AD and aMCI patients: potential pathogenic role and link to oxidative damage
Di Domenico, Fabio; Pupo, Gilda; Giraldo, Esther; Lloret, Ana; Badia, Mari Carmen; Schinina', Maria Eugenia; Giorgi, Alessandra; Butterfield, D. Allan; Vina, Jose; Perluigi, Marzia - 01a Articolo in rivista
rivista: CURRENT ALZHEIMER RESEARCH (BENTHAM SCIENCE PUBL LTD,) pp. 112-22- - issn: 1567-2050 - wos: WOS:000372101800002 (17) - scopus: 2-s2.0-84959329508 (17)

11573/935430 - 2016 - Cathepsin D as a therapeutic target in Alzheimer’s disease
Di Domenico, Fabio; Tramutola, Antonella; Perluigi, Marzia - 01a Articolo in rivista
rivista: EXPERT OPINION ON THERAPEUTIC TARGETS (--London United Kingdom:Informa Healthcare -London : Ashley, 2002-.) pp. 1393-1395 - issn: 1472-8222 - wos: WOS:000388696200001 (37) - scopus: 2-s2.0-84994085585 (39)

11573/849606 - 2016 - Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; Adams, Christopher M; Adams, Peter D; Adeli, Khosrow; Adhihetty, Peter J; Adler, Sharon G; Agam, Galila; Agarwal, Rajesh; Aghi, Manish K; Agnello, Maria; Agostinis, Patrizia; Aguilar, Patricia V; Aguirre Ghiso, Julio; Airoldi, Edoardo M; Ait Si Ali, Slimane; Akematsu, Takahiko; Akporiaye, Emmanuel T; Al Rubeai, Mohamed; Albaiceta, Guillermo M; Albanese, Chris; Albani, Diego; Albert, Matthew L; Aldudo, Jesus; Algül, Hana; Alirezaei, Mehrdad; Alloza, Iraide; Almasan, Alexandru; Almonte Beceril, Maylin; Alnemri, Emad S; Alonso, Covadonga; Altan Bonnet, Nihal; Altieri, Dario C; Alvarez, Silvia; Alvarez Erviti, Lydia; Alves, Sandro; Amadoro, Giuseppina; Amano, Atsuo; Amantini, Consuelo; Ambrosio, Santiago; Amelio, Ivano; Amer, Amal O; Amessou, Mohamed; Amon, Angelika; An, Zhenyi; Anania, Frank A; Andersen, Stig U; Andley, Usha P; Andreadi, Catherine K; Andrieu Abadie, Nathalie; Anel, Alberto; Ann, David K; Anoopkumar Dukie, Shailendra; Antonioli, Manuela; Aoki, Hiroshi; Apostolova, Nadezda; Aquila, Saveria; Aquilano, Katia; Araki, Koichi; Arama, Eli; Aranda, Agustin; Araya, Jun; Arcaro, Alexandre; Arias, Esperanza; Arimoto, Hirokazu; Ariosa, Aileen R; Armstrong, Jane L; Arnould, Thierry; Arsov, Ivica; Asanuma, Katsuhiko; Askanas, Valerie; Asselin, Eric; Atarashi, Ryuichiro; Atherton, Sally S; Atkin, Julie D; Attardi, Laura D; Auberger, Patrick; Auburger, Georg; Aurelian, Laure; Autelli, Riccardo; Avagliano, Laura; Avantaggiati, Maria Laura; Avrahami, Limor; Awale, Suresh; Azad, Neelam; Bachetti, Tiziana; Backer, Jonathan M; Bae, Dong Hun; Bae, Jae Sung; Bae, Ok Nam; Bae, Soo Han; Baehrecke, Eric H; Baek, Seung Hoon; Baghdiguian, Stephen; Bagniewska Zadworna, Agnieszka; Bai, Hua; Bai, Jie; Bai, Xue Yuan; Bailly, Yannick; Balaji, Kithiganahalli Narayanaswamy; Balduini, Walter; Ballabio, Andrea; Balzan, Rena; Banerjee, Rajkumar; Bánhegyi, Gábor; Bao, Haijun; Barbeau, Benoit; Barrachina, Maria D; Barreiro, Esther; Bartel, Bonnie; Bartolomé, Alberto; Bassham, Diane C; Bassi, Maria Teresa; Bast, Robert C; Basu, Alakananda; Batista, Maria Teresa; Batoko, Henri; Battino, Maurizio; Bauckman, Kyle; Baumgarner, Bradley L; Bayer, K. Ulrich; Beale, Rupert; Beaulieu, Jean François; Beck, George R; Becker, Christoph; Beckham, J. David; Bédard, Pierre André; Bednarski, Patrick J; Begley, Thomas J; Behl, Christian; Behrends, Christian; Behrens, Georg Mn; Behrns, Kevin E; Bejarano, Eloy; Belaid, Amine; Belleudi, Francesca; Bénard, Giovanni; Berchem, Guy; Bergamaschi, Daniele; Bergami, Matteo; Berkhout, Ben; Berliocchi, Laura; Bernard, Amélie; Bernard, Monique; Bernassola, Francesca; Bertolotti, Anne; Bess, Amanda S; Besteiro, Sébastien; Bettuzzi, Saverio; Bhalla, Savita; Bhattacharyya, Shalmoli; Bhutia, Sujit K; Biagosch, Caroline; Bianchi, Michele Wolfe; Biard Piechaczyk, Martine; Billes, Viktor; Bincoletto, Claudia; Bingol, Baris; Bird, Sara W; Bitoun, Marc; Bjedov, Ivana; Blackstone, Craig; Blanc, Lionel; Blanco, Guillermo A; Blomhoff, Heidi Kiil; Boada Romero, Emilio; Böckler, Stefan; Boes, Marianne; Boesze Battaglia, Kathleen; Boise, Lawrence H; Bolino, Alessandra; Boman, Andrea; Bonaldo, Paolo; Bordi, Matteo; Bosch, Jürgen; Botana, Luis M; Botti, Joelle; Bou, German; Bouche', Marina; Bouchecareilh, Marion; Boucher, Marie Josée; Boulton, Michael E; Bouret, Sebastien G; Boya, Patricia; Boyer Guittaut, Michaël; Bozhkov, Peter V; Brady, Nathan; Braga, Vania Mm; Brancolini, Claudio; Braus, Gerhard H; Bravo San Pedro, José M; Brennan, Lisa A; Bresnick, Emery H; Brest, Patrick; Bridges, Dave; Bringer, Marie Agnès; Brini, Marisa; Brito, Glauber C; Brodin, Bertha; Brookes, Paul S; Brown, Eric J; Brown, Karen; Broxmeyer, Hal E; Bruhat, Alain; Brum, Patricia Chakur; Brumell, John H; Brunetti Pierri, Nicola; Bryson Richardson, Robert J; Buch, Shilpa; Buchan, Alastair M; Buda - 01g Articolo di rassegna (Review)
rivista: AUTOPHAGY (Landes Bioscience Georgetown TX 78628) pp. 1-222 - issn: 1554-8627 - wos: WOS:000373595400001 (3691) - scopus: 2-s2.0-85013763791 (4320)

11573/947023 - 2016 - Aberrant protein phosphorylation in Alzheimer disease brain disturbs pro-survival and cell death pathways
Perluigi, Marzia; Barone, Eugenio; Di Domenico, Fabio; Butterfield, D. A. - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1871-1882 - issn: 0925-4439 - wos: WOS:000382413300003 (60) - scopus: 2-s2.0-84979620769 (65)

11573/867885 - 2016 - Redox proteomic analysis of serum from aortic anerurysm patients: insights on oxidation of specific protein target
Spadaccio, Cristiano; Coccia, Raffaella; Perluigi, Marzia; Pupo, Gilda; Schinina', Maria Eugenia; Giorgi, Alessandra; Blarzino, Carla; Nappi, Francesco; Sutherland, Fraser W; Chello, Massimo; Di Domenico, Fabio - 01a Articolo in rivista
rivista: MOLECULAR BIOSYSTEMS (Cambridge : Royal Society of Chemistry, 2005-) pp. - - issn: 1742-206X - wos: WOS:000378395000015 (4) - scopus: 2-s2.0-84975883320 (4)

11573/871573 - 2016 - It is all about (U)biquitin: role of altered ubiquitin-proteasome system and UCHL1 in Alzheimer disease
Tramutola, Antonella; Di Domenico, Fabio; Barone, Eugenio; Perluigi, Marzia; Butterfield, David Allan - 01a Articolo in rivista
rivista: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (London: Hindawi AUSTIN, USA, TX: LANDES BIOSCIENCE) pp. - - issn: 1942-0900 - wos: WOS:000372640600001 (78) - scopus: 2-s2.0-84961344015 (80)

11573/840612 - 2016 - Increased mammalian target of rapamycin signaling contributes to the accumulation of protein oxidative damage in a mouse model of down's syndrome
Tramutola, Antonella; Lanzillotta, Chiara; Arena, Andrea; Barone, Eugenio; Perluigi, Marzia; Di Domenico, Fabio - 01a Articolo in rivista
rivista: NEURODEGENERATIVE DISEASES (Basel [etc.]: S. Karger 2004-) pp. 62-68 - issn: 1660-2854 - wos: WOS:000369778000010 (33) - scopus: 2-s2.0-84958063630 (35)

11573/867882 - 2016 - Activation of p53 in down syndrome and in the ts65dn mouse brain is associated with a pro-apoptotic phenotype
Tramutola, Antonella; Pupo, Gilda; Di Domenico, Fabio; Barone, Eugenio; Arena, Andrea; Lanzillotta, Chiara; Broekaart, Diede; Blarzino, Carla; Head, Elizabeth; Butterfield, D. Allan; Perluigi, Marzia - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 359-71-371 - issn: 1387-2877 - wos: WOS:000375008500030 (26) - scopus: 2-s2.0-84973143959 (30)

11573/796560 - 2015 - Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53
Barone, Eugenio; Cenini, Giovanna; Di Domenico, Fabio; Noel, Teresa; Wang, Chi; Perluigi, Marzia; Daret K., S. T. Clair; Butterfield, D. Allan - 01a Articolo in rivista
rivista: JOURNAL OF NEUROSCIENCE RESEARCH (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 1728-39-1739 - issn: 0360-4012 - wos: WOS:000362831800011 (17) - scopus: 2-s2.0-84941994540 (18)

11573/796562 - 2015 - Aberrant insulin signaling in Alzheimer's disease: current knowledge
Bedse, Gaurav; Di Domenico, Fabio; Serviddio, Gaetano; Cassano, Tommaso - 01a Articolo in rivista
rivista: FRONTIERS IN NEUROSCIENCE (Lausanne (PO Box 110, 1015) : Frontiers Research Foundation, 2007-) pp. - - issn: 1662-4548 - wos: WOS:000362003500002 (219) - scopus: 2-s2.0-84931271345 (225)

11573/670428 - 2015 - Strategy to reduce free radical species in Alzheimer's disease: an update of selected antioxidants
Di Domenico, Fabio; Barone, Eugenio; Perluigi, Marzia; Butterfield, Da - 01a Articolo in rivista
rivista: EXPERT REVIEW OF NEUROTHERAPEUTICS (-London, United Kingdom: Expert Reviews Ltd -London, United Kingdom: Future Drugs Limited) pp. - - issn: 1473-7175 - wos: WOS:000347802800004 (77) - scopus: 2-s2.0-84920840714 (92)

11573/796561 - 2015 - Redox proteomics in human biofluids: sample preparation, separation and immunochemical tagging for analysis of protein oxidation
Di Domenico, Fabio; Perluigi, Marzia; Butterfield, D. Allan - 02a Capitolo o Articolo
libro: Systems Biology of Alzheimer's Disease - (978-1-4939-2626-8; 978-1-4939-2627-5; 978-1-4939-2626-8; 978-1-4939-2627-5)

11573/670416 - 2015 - Bach1 overexpression in down syndrome correlates with the alteration of the ho-1/bvr-a system: insights for transition to Alzheimer's disease
Di Domenico, Fabio; Pupo, Gilda; Mancuso, C; Barone, Eugenio; Paolini, F; Arena, Andrea; Blarzino, Carla; Schmitt, Fa; Head, E; Butterfield, Da; Perluigi, Marzia - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. - - issn: 1387-2877 - wos: WOS:000350001000007 (50) - scopus: 2-s2.0-84923270517 (56)

11573/796559 - 2015 - Pharmacologic approaches against advanced glycation end products (ages) in diabetic cardiovascular disease
Nenna, Antonio; Nappi, Francesco; Avtaar Singh, Sanjeet Singh; Sutherland, Fraser W; Di Domenico, Fabio; Chello, Massimo; Spadaccio, Cristiano - 01a Articolo in rivista
rivista: RESEARCH IN CARDIOVASCULAR MEDICINE (Tehran: Kowsar Corporation; Rajaie Cardiovascular, Medical and Research Center.) pp. e26949- - issn: 2251-9572 - wos: (0) - scopus: (0)

11573/796565 - 2015 - MTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy
Perluigi, Marzia; Di Domenico, Fabio; Butterfield, D. Allan - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. - - issn: 0969-9961 - wos: WOS:000367029300004 (218) - scopus: 2-s2.0-84925436842 (252)

11573/796567 - 2015 - Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD
Tramutola, Antonella; Triplett, Judy C.; Di Domenico, Fabio; Niedowicz, Dana M.; Murphy, Michael P.; Coccia, Raffaella; Perluigi, Marzia; Butterfield, D. Allan - 01a Articolo in rivista
rivista: JOURNAL OF NEUROCHEMISTRY (Editore attuale:BLACKWELL PUBLISHING LTD, 9600 GARSINGTON RD, OXFORD, ENGLAND, OXON, OX4 2DG Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 739-749 - issn: 0022-3042 - wos: WOS:000353570500012 (236) - scopus: 2-s2.0-84928012290 (255)

11573/784064 - 2014 - The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation
Barone, Eugenio; Di Domenico, Fabio; C., Mancuso; D., Butterfield - 01a Articolo in rivista
rivista: NEUROBIOLOGY OF DISEASE (Academic Press Incorporated:6277 Sea Harbor Drive:Orlando, FL 32887:(800)543-9534, (407)345-4100, EMAIL: ap@acad.com, INTERNET: http://www.idealibrary.com, Fax: (407)352-3445) pp. 144-159 - issn: 0969-9961 - wos: WOS:000330553600014 (108) - scopus: 2-s2.0-84886872345 (112)

11573/556360 - 2014 - Statins more than cholesterol lowering agents in Alzheimer disease: Their pleiotropic functions as potential therapeutic targets.
Barone, Eugenio; Di Domenico, Fabio; D. A., Butterfield - 01a Articolo in rivista
rivista: BIOCHEMICAL PHARMACOLOGY (-Oxford, United Kingdom: Elsevier Science Limited -London ; New York : Pergamon Press, 1958-) pp. 605-616 - issn: 0006-2952 - wos: WOS:000334977400019 (78) - scopus: 2-s2.0-84897954198 (84)

11573/670432 - 2014 - Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain
Butterfield, Da; Di Domenico, Fabio; Barone, Eugenio - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1693-1706 - issn: 0925-4439 - wos: WOS:000340975400041 (281) - scopus: 2-s2.0-84904113244 (298)

11573/670430 - 2014 - Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain.
Butterfield, Da; Di Domenico, Fabio; Swomley, Am; Head, E; Perluigi, Marzia - 01a Articolo in rivista
rivista: BIOCHEMICAL JOURNAL (London: Portland Press Limited London: Biochemical Society, 1984-) pp. 177-189 - issn: 0264-6021 - wos: WOS:000342267500002 (87) - scopus: 2-s2.0-84907196714 (89)

11573/670433 - 2014 - Mass spectrometry and redox proteomics: applications in disease.
Butterfield, Da; Gu, L; Di Domenico, Fabio; Robinson, Ra - 01a Articolo in rivista
rivista: MASS SPECTROMETRY REVIEWS (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 277-301 - issn: 0277-7037 - wos: WOS:000340469600002 (92) - scopus: 2-s2.0-84902361638 (96)

11573/556362 - 2014 - Simvastatin attenuates the endothelial pro-thrombotic shift in saphenous vein grafts induced by Advanced glycation endproducts.
C., Spadaccio; F., De Marco; Di Domenico, Fabio; Coccia, Raffaella; M., Lusini; R., Barbato; E., Covino; M., Chello - 01a Articolo in rivista
rivista: THROMBOSIS RESEARCH (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 418-425 - issn: 0049-3848 - wos: WOS:000331540400021 (10) - scopus: 2-s2.0-84893963782 (10)

11573/1612901 - 2014 - Oxidative stress and proteostasis network: culprit and casualty of Alzheimer’s-like neurodegeneration
Di Domenico, Fabio; Head, Elizabeth; Allan Butterfield, D.; Perluigi, Marzia - 01a Articolo in rivista
rivista: ADVANCES IN GERIATRICS (Cairo : Hindawi Publishing Corporation) pp. 1-14 - issn: 2314-7679 - wos: (0) - scopus: (0)

11573/556923 - 2014 - Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease.
Di Domenico, Fabio; Pupo, Gilda; Tramutola, Antonella; Giorgi, Alessandra; Schinina', Maria Eugenia; Coccia, Raffaella; E., Head; D. A., Butterfield; Perluigi, Marzia - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 270-280 - issn: 0891-5849 - wos: WOS:000336891100024 (81) - scopus: 2-s2.0-84898812067 (87)

11573/556354 - 2014 - Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics.
Perluigi, Marzia; Di Domenico, Fabio; D. A., Buttterfield - 01a Articolo in rivista
rivista: PROTEOMICS. CLINICAL APPLICATIONS (Weinheim : Wiley-VCH-Verl.) pp. 73-85 - issn: 1862-8354 - wos: WOS:000331953400007 (45) - scopus: 2-s2.0-84893509799 (47)

11573/556926 - 2014 - Neuropathological role of pi3k/akt/mtor axis in Down syndrome brain
Perluigi, Marzia; Pupo, Gilda; Tramutola, Antonella; Cini, Chiara; Coccia, Raffaella; Barone, Eugenio; E., Head; D. A., Butterfield; Di Domenico, Fabio - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1144-1153 - issn: 0925-4439 - wos: WOS:000336698400027 (121) - scopus: 2-s2.0-84899787783 (128)

11573/524902 - 2013 - Involvement of Oxidative Stress in Occurrence of Relapses in Multiple Sclerosis: The Spectrum of Oxidatively Modified Serum Proteins Detected by Proteomics and Redox Proteomics Analysis
Ada, Fiorini; Tatiana, Koudriavtseva; Elona, Bucaj; Coccia, Raffaella; Cesira, Foppoli; Giorgi, Alessandra; Schinina', Maria Eugenia; Di Domenico, Fabio; Federico De, Marco; Perluigi, Marzia - 01a Articolo in rivista
rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e65184- - issn: 1932-6203 - wos: WOS:000321094800023 (73) - scopus: 2-s2.0-84878752933 (74)

11573/558039 - 2013 - Usefulness of preprocedural levels of advanced glycation end products to predict restenosis in patients with controlled diabetes mellitus undergoing drug-eluting stent implantation for stable angina pectoris (from the Prospective ARMYDA-AGEs Study).
C., Spadaccio; G., Patti; F., De Marco; Coccia, Raffaella; Di Domenico, Fabio; Pollari, Francesco; R., Zanzonico; M., Pettinari; M., Lusini; G. D., Sciascio; E., Covino; M., Chello - 01a Articolo in rivista
rivista: THE AMERICAN JOURNAL OF CARDIOLOGY (NY : Elsevier Science Incorporated / NY; EXCERPTA MEDICA INC) pp. 21-26 - issn: 0002-9149 - wos: WOS:000321677200004 (19) - scopus: 2-s2.0-84879099031 (21)

11573/514827 - 2013 - Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: Redox proteomics analysis of human brain
Di Domenico, Fabio; Coccia, Raffaella; Cocciolo, Annalisa; M., Paul Murphy; Giovanna, Cenini; Elizabeth, Head; D., Allan Butterfield; Giorgi, Alessandra; Schinina', Maria Eugenia; Cesare, Mancuso; Cini, Chiara; Perluigi, Marzia - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 1249-1259 - issn: 0925-4439 - wos: WOS:000321081300015 (97) - scopus: 2-s2.0-84877315419 (104)

11573/556350 - 2013 - Proteomics strategies to analyze HPV-transformed cells: relevance to cervical cancer.
Di Domenico, Fabio; F., De Marco; Perluigi, Marzia - 01a Articolo in rivista
rivista: EXPERT REVIEW OF PROTEOMICS (--London : Expert Reviews Ltd, London : Future Drugs, 2004-) pp. 461-472 - issn: 1478-9450 - wos: WOS:000330534800012 (9) - scopus: 2-s2.0-84885983778 (14)

11573/670470 - 2013 - Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain.
Di Domenico, Fabio; Perluigi, Marzia; Barone, Eugenio - 01a Articolo in rivista
rivista: NEURAL REGENERATION RESEARCH (Shenyang : Publishing House of Neural Regeneration Research.) pp. 1925-1937 - issn: 1673-5374 - wos: WOS:000325239400008 (0) - scopus: 2-s2.0-84886903907 (13)

11573/463583 - 2012 - Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease
Barone, Eugenio; C., Mancuso; Di Domenico, Fabio; R., Sultana; M. P., Murphy; E., Head; D. A., Butterfield - 01a Articolo in rivista
rivista: JOURNAL OF NEUROCHEMISTRY (Editore attuale:BLACKWELL PUBLISHING LTD, 9600 GARSINGTON RD, OXFORD, ENGLAND, OXON, OX4 2DG Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 135-146 - issn: 0022-3042 - wos: WOS:000298060500014 (62) - scopus: 2-s2.0-83755221773 (65)

11573/460535 - 2012 - Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment
Barone, Eugenio; Di Domenico, Fabio; Rukhsana, Sultana; Coccia, Raffaella; Cesare, Mancuso; Perluigi, Marzia; D., Allan Butterfield - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 2292-2301 - issn: 0891-5849 - wos: WOS:000305857300015 (103) - scopus: 2-s2.0-84861601576 (107)

11573/441034 - 2012 - Lack of p53 Decreases Basal Oxidative Stress Levels in the Brain Through Upregulation of Thioredoxin-1, Biliverdin Reductase-A, Manganese Superoxide Dismutase, and Nuclear Factor Kappa-B
Barone, Eugenio; Giovanna, Cenini; Rukhsana, Sultana; Di Domenico, Fabio; Fiorini, Ada; Perluigi, Marzia; Teresa, Noel; Chi, Wang; Cesare, Mancuso; D. K., St; D., Allan Butterfield - 01a Articolo in rivista
rivista: ANTIOXIDANTS & REDOX SIGNALING (Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688) pp. 1407-1420 - issn: 1523-0864 - wos: WOS:000303047100004 (27) - scopus: 2-s2.0-84860206827 (28)

11573/460488 - 2012 - Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro
Cesare, Mancuso; Barone, Eugenio; Pina, Guido; Fiorella, Miceli; Di Domenico, Fabio; Perluigi, Marzia; Rosaria, Santangelo; Paolo, Preziosi - 01a Articolo in rivista
rivista: NEUROSCIENCE LETTERS (Limerick Ireland: Elsevier Science Ireland Limited) pp. 101-105 - issn: 0304-3940 - wos: WOS:000305713200007 (70) - scopus: 2-s2.0-84861682913 (73)

11573/494056 - 2012 - Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics
Cocciolo, Annalisa; Di Domenico, Fabio; Coccia, Raffaella; Fiorini, Ada; J., Cai; W. M., Pierce; P., Mecocci; D. A., Butterfield; Perluigi, Marzia - 01a Articolo in rivista
rivista: FREE RADICAL BIOLOGY & MEDICINE (Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 1868-1876 - issn: 0891-5849 - wos: WOS:000311328300006 (60) - scopus: 2-s2.0-84867392697 (61)

11573/440843 - 2012 - Serum proteomics in patients with diagnosis of abdominal aortic aneurysm
Cristiano, Spadaccio; Di Domenico, Fabio; Perluigi, Marzia; Mario, Lusini; Giorgi, Alessandra; Schinina', Maria Eugenia; Blarzino, Carla; Elvio, Covino; Massimo, Chello; Coccia, Raffaella - 01a Articolo in rivista
rivista: CARDIOVASCULAR PATHOLOGY (Elsevier Science Incorporated / NY Journals:Madison Square Station, PO Box 882:New York, NY 10159:(212)633-3730, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: (212)633-3680) pp. 283-290 - issn: 1054-8807 - wos: WOS:000306778600005 (14) - scopus: 2-s2.0-84863728818 (14)

11573/784051 - 2012 - Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain
D., Butterfield; Barone, Eugenio; Di Domenico, Fabio; G., Cenini; R., Sultana; M., Murphy; C., Mancuso; E., Head - 01a Articolo in rivista
rivista: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (Cambridge University Press / New York:40 West 20th Street:New York, NY 10011:(800)872-7423, (212)924-3900, EMAIL: journals_subscriptions@cup.org, INTERNET: http://www.journals.cambridge.org, Fax: (212)691-3239) pp. 981-987 - issn: 1461-1457 - wos: WOS:000307187400011 (62) - scopus: 2-s2.0-84864349775 (65)

11573/468362 - 2012 - HO-1/BVR-A system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: A potential biochemical marker for the prediction of the disease
Di Domenico, Fabio; Barone, Eugenio; C., Mancuso; Perluigi, Marzia; Cocciolo, Annalisa; P., Mecocci; D. A., Butterfield; Coccia, Raffaella - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 277-289 - issn: 1387-2877 - wos: WOS:000309977800004 (45) - scopus: 2-s2.0-84867489401 (46)

11573/441038 - 2012 - Antioxidants in cervical cancer: Chemopreventive and chemotherapeutic effects of polyphenols
Di Domenico, Fabio; C., Foppoli; Coccia, Raffaella; Perluigi, Marzia - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 737-747 - issn: 0925-4439 - wos: WOS:000302486400014 (95) - scopus: 2-s2.0-84858149475 (117)

11573/441036 - 2012 - Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia/reperfusion.
Di Domenico, Fabio; G., Casalena; J., Jia; R., Sultana; Barone, Eugenio; J., Cai; W. M., Pierce; Cini, Chiara; C., Mancuso; Perluigi, Marzia; C. M., Davis; N. J., Alkayed; A. D., Butterfield - 01a Articolo in rivista
rivista: JOURNAL OF NEUROCHEMISTRY (Editore attuale:BLACKWELL PUBLISHING LTD, 9600 GARSINGTON RD, OXFORD, ENGLAND, OXON, OX4 2DG Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320) pp. 680-692 - issn: 0022-3042 - wos: WOS:000302721400018 (29) - scopus: 2-s2.0-84859747516 (27)

11573/441035 - 2012 - Redox Proteomics Analyses of the Influence of Co-Expression of Wild-Type or Mutated LRRK2 and Tau on C. elegans Protein Expression and Oxidative Modification: Relevance to Parkinson Disease
Di Domenico, Fabio; Rukhsana, Sultana; Andrew, Ferree; Katelyn, Smith; Barone, Eugenio; Perluigi, Marzia; Coccia, Raffaella; William, Pierce; Jian, Cai; Cesare, Mancuso; Rachel, Squillace; Manfred, Wiengele; Isabella Dalle, Donne; Benjamin, Wolozin; D., Allan Butterfield - 01a Articolo in rivista
rivista: ANTIOXIDANTS & REDOX SIGNALING (Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: info@liebertpub.com, swilliams@liebertpub.com, INTERNET: http://www.liebertpub.com, Fax: (914)834-3688) pp. 1490-1506 - issn: 1523-0864 - wos: WOS:000309509200002 (42) - scopus: 2-s2.0-84866663422 (42)

11573/462229 - 2012 - Oxidative Stress in HPV-Driven Viral Carcinogenesis: Redox Proteomics Analysis of HPV-16 Dysplastic and Neoplastic Tissues
Federico De, Marco; Elona, Bucaj; Cesira, Foppoli; Fiorini, Ada; Blarzino, Carla; Kozeta, Filipi; Giorgi, Alessandra; Schinina', Maria Eugenia; Di Domenico, Fabio; Coccia, Raffaella; D., Allan Butterfield; Perluigi, Marzia - 01a Articolo in rivista
rivista: PLOS ONE (San Francisco, CA : Public Library of Science) pp. e34366- - issn: 1932-6203 - wos: WOS:000304489000101 (55) - scopus: 2-s2.0-84859020443 (66)

11573/375942 - 2011 - Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment
Barone, Eugenio; Di Domenico, Fabio; Cenini, G; Sultana, R; Cini, Chiara; Preziosi, P; Perluigi, Marzia; Mancuso, C; Butterfield, Da - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE (Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: nlinfo-f@elsevier.nl, INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598) pp. 480-487 - issn: 0925-4439 - wos: WOS:000288301500007 (85) - scopus: 2-s2.0-79551569963 (84)

11573/366160 - 2011 - Oxidative and Nitrosative Modifications of Biliverdin Reductase-A in the Brain of Subjects with Alzheimer’s Disease and Amnestic Mild Cognitive Impairment
Barone, Eugenio; Di Domenico, Fabio; Cenini, G; Sultana, R; Coccia, Raffaella; Preziosi, P; Perluigi, Marzia; Mancuso, C; Butterfield, Da - 01a Articolo in rivista
rivista: JOURNAL OF ALZHEIMER'S DISEASE (Netherlands: IOS Press) pp. 623-633 - issn: 1387-2877 - wos: WOS:000293595400005 (82) - scopus: 2-s2.0-80052829260 (83)

11573/354281 - 2011 - Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action
Barone, Eugenio; Giovanna, Cenini; Di Domenico, Fabio; Sarah, Martin; Rukhsana, Sultana; Cesare, Mancuso; Michael Paul, Murphy; Elizabeth, Head; D., Allan Butterfield - 01a Articolo in rivista
rivista: PHARMACOLOGICAL RESEARCH (Attuale:ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON, ENGLAND, NW1 7DX Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: asianfo@elsevier.com, tcb@elsevier.co.UK, INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010) pp. 162-180 - issn: 1043-6618 - wos: WOS:000288041400003 (80) - scopus: 2-s2.0-79751532850 (80)

11573/432618 - 2011 - Circulating biomarkers of protein oxidation for Alzheimer disease: Expectations within limits
Di Domenico, Fabio; Coccia, Raffaella; D., Allan Butterfield; Perluigi, Marzia - 01a Articolo in rivista
rivista: BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (Tokyo ; Oxford ; New York ; London ; Amsterdam ; Shannon ; Paris : Elsevier) pp. 1785-1795 - issn: 1570-9639 - wos: WOS:000298363200022 (57) - scopus: 2-s2.0-80054978676 (55)

11573/354278 - 2011 - Quantitative proteomics analysis of phosphorylated proteins in the hippocampus of Alzheimer's disease subjects
Di Domenico, Fabio; Rukhsana, Sultana; Barone, Eugenio; Perluigi, Marzia; Cini, Chiara; Cesare, Mancuso; Jian, Cai; William M., Pierce; D., Allan Butterfield - 01a Articolo in rivista
rivista: JOURNAL OF PROTEOMICS () pp. 1091-1103 - issn: 1874-3919 - wos: WOS:000292440400019 (80) - scopus: 2-s2.0-79957644804 (85)

11573/354279 - 2011 - Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid
Perluigi, Marzia; Di Domenico, Fabio; Fiorini, Ada; Cocciolo, Annalisa; Giorgi, Alessandra; Cesira, Foppoli; D., Allan Butterfield; Maurizio, Giorlandino; Claudio, Giorlandino; Schinina', Maria Eugenia; Coccia, Raffaella - 01a Articolo in rivista
rivista: PROTEOMICS. CLINICAL APPLICATIONS (Weinheim : Wiley-VCH-Verl.) pp. 167-178 - issn: 1862-8346 - wos: WOS:000288947700007 (86) - scopus: 2-s2.0-79953120069 (92)

11573/385773 - 2011 - Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh)×PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age.
Sultana, R; Robinson, Ra; Di Domenico, Fabio; Abdul, Hm; Clair, Dk; Markesbery, Wr; Cai, J; Pierce, Wm; Butterfield, Da - 01a Articolo in rivista
rivista: JOURNAL OF PROTEOMICS () pp. 2430-2440 - issn: 1874-3919 - wos: WOS:000296994900017 (33) - scopus: 2-s2.0-80054871710 (35)

11573/363298 - 2010 - Involvement of stat3 in mouse brain development and sexual dimorphism: A proteomics approach
Di Domenico, Fabio; Gabriella, Casalena; Rukhsana, Sultana; C. A. I., Jian; William M., Pierce; Perluigi, Marzia; Cini, Chiara; Alessandra, Baracca; Giancarlo, Solaini; Giorgio, Lenaz; J. I. A., Jia; Suzan, Dziennis; Stephanie J., Murphy; J., Alkayed Nabil; D., Allan Butterfield - 01a Articolo in rivista
rivista: BRAIN RESEARCH (Amsterdam; Lausanne; New York; Oxford; Shannon; Tokyo: Elsevier) pp. 1-12 - issn: 0006-8993 - wos: WOS:000284667400001 (15) - scopus: 2-s2.0-78149358608 (17)

11573/362351 - 2010 - The Wheat Germ Agglutinin-Fractionated Proteome of Subjects With Alzheimer's Disease and Mild Cognitive Impairment Hippocampus and Inferior Parietal Lobule: Implications for Disease Pathogenesis and Progression
Di Domenico, Fabio; Joshua B., Owen; Rukhsana, Sultana; Rena A., Sowell; Perluigi, Marzia; Cini, Chiara; Jian, Cai; William M., Pierce; D., Allan Butterfield - 01a Articolo in rivista
rivista: JOURNAL OF NEUROSCIENCE RESEARCH (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 3566-3577 - issn: 0360-4012 - wos: WOS:000284191200015 (37) - scopus: 2-s2.0-78049431249 (36)

11573/361025 - 2010 - Oxidative Damage in Rat Brain During Aging: Interplay Between Energy and Metabolic Key Target Proteins
Di Domenico, Fabio; Perluigi, Marzia; D. A., Butterfield; C., Cornelius; V., Calabrese - 01a Articolo in rivista
rivista: NEUROCHEMICAL RESEARCH (Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047) pp. 2184-2192 - issn: 0364-3190 - wos: WOS:000285364900036 (32) - scopus: 2-s2.0-78651283063 (37)

11573/360962 - 2010 - Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: An investigation on the role of cellular stress response in the progression of Alzheimer disease
Di Domenico, Fabio; Rukhsana, Sultana; Georgianne F., Tiu; Nicole N., Scheff; Perluigi, Marzia; Cini, Chiara; D., Allan Butterfield - 01a Articolo in rivista
rivista: BRAIN RESEARCH (Amsterdam; Lausanne; New York; Oxford; Shannon; Tokyo: Elsevier) pp. 72-81 - issn: 0006-8993 - wos: WOS:000278668100008 (91) - scopus: 2-s2.0-77952107755 (95)

11573/363065 - 2010 - Effects of uvb-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach.
Perluigi, Marzia; Di Domenico, Fabio; Blarzino, Carla; Foppoli, C; Cini, Chiara; Giorgi, Alessandra; Grillo, Caterina; De Marco, F; Butterfield, Da; Schinina', Maria Eugenia; Coccia, Raffaella - 01a Articolo in rivista
rivista: PROTEOME SCIENCE (BioMed Central Ltd.) pp. 1-13 - issn: 1477-5956 - wos: WOS:000276740800001 (65) - scopus: 2-s2.0-77952922104 (67)

11573/360963 - 2010 - Redox Proteomics in Aging Rat Brain: Involvement of Mitochondrial Reduced Glutathione Status and Mitochondrial Protein Oxidation in the Aging Process
Perluigi, Marzia; Di Domenico, Fabio; Giorgi, Alessandra; Schinina', Maria Eugenia; Coccia, Raffaella; Cini, Chiara; F., Bellia; M. T., Cambria; C., Cornelius; D. A., Butterfield; V., Calabrese - 01a Articolo in rivista
rivista: JOURNAL OF NEUROSCIENCE RESEARCH (John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: societyinfo@wiley.com, INTERNET: http://www.wiley.com, Fax: (212)748-6551) pp. 3498-3507 - issn: 0360-4012 - wos: WOS:000284191200008 (92) - scopus: 2-s2.0-78049423686 (98)

11573/354276 - 2010 - Doxorubicin-Induced Thymus Senescence
Rukhsana, Sultana; Di Domenico, Fabio; Michael, Tseng; Jian, Cai; Teresa, Noel; R., Lakshman Chelvarajan; William D., Pierce; Cini, Chiara; Subbarao, Bondada; Clair, Daret K. S. T.; And D., Allan Butterfield - 01a Articolo in rivista
rivista: JOURNAL OF PROTEOME RESEARCH (Washington, D.C. : American Chemical Society, c2002-) pp. 6232-6241 - issn: 1535-3893 - wos: WOS:000284856200013 (20) - scopus: 2-s2.0-78649867546 (24)

11573/230453 - 2009 - Glutathionylation of p53 Pro-apoptotic Protein in Alzheimer Brain: Possible implication in AD pathogenesis
Di Domenico, Fabio; Cenini, G; Sultana, R; Perluigi, Marzia; Uberti, D; Memo, M.; Butterfield, D. A. - 01a Articolo in rivista
rivista: NEUROCHEMICAL RESEARCH (Plenum Press:Book Customer Service, 233 Spring Street:New York, NY 10013:(212)620-8471, (212)620-8000, EMAIL: info@plenum.com, INTERNET: http://www.plenum.com, Fax: (212)807-1047) pp. 727-733 - issn: 0364-3190 - wos: WOS:000263979200013 (65) - scopus: 2-s2.0-62349084020 (73)

11573/135717 - 2009 - Expression of human Papilloma virus type 16 E5 gene in amelanotic melanoma cells regulates endo-melanosomal pH and restores tyrosinase activity
Di Domenico, Fabio; Foppoli, C; Blarzino, Carla; Perluigi, Marzia; De Marco, F; Cini, Chiara; Coccia, Raffaella - 01a Articolo in rivista
rivista: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (London : BioMed Central) pp. 1-12 - issn: 1756-9966 - wos: WOS:000264472900001 (11) - scopus: 2-s2.0-62149129576 (13)

11573/229051 - 2009 - Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes
Di Domenico, Fabio; Perluigi, Marzia; C., Foppoli; Blarzino, Carla; Coccia, Raffaella; F., De Marco; D. A., Butterfield; Cini, Chiara - 01a Articolo in rivista
rivista: FREE RADICAL RESEARCH (Taylor & Francis Limited:Rankine Road, Basingstoke RG24 8PR United Kingdom:011 44 1256 813035, EMAIL: madeline.sims@tandf.co.uk, info@tandf.co.uk, INTERNET: http://www.tandf.co.uk, Fax: 011 44 1256 330245) pp. 365-375 - issn: 1071-5762 - wos: WOS:000264749200005 (33) - scopus: 2-s2.0-67650121024 (39)

11573/361709 - 2009 - Advanced glycation end products in diabetic patients with optimized glycaemic control and their effects on endothelial reactivity: possible implications in venous graft failure
Massimo, Chello; Cristiano, Spadaccio; Mario, Lusini; Elvio, Covino; Blarzino, Carla; Federico De, Marco; Di Domenico, Fabio; Coccia, Raffaella - 01a Articolo in rivista
rivista: DIABETES/METABOLISM RESEARCH AND REVIEWS (John Wiley & Sons Limited:1 Oldlands Way, Bognor Regis, P022 9SA United Kingdom:011 44 1243 779777, EMAIL: cs-journals@wiley.co.uk, INTERNET: http://www.wiley.co.uk, Fax: 011 44 1243 843232) pp. 420-426 - issn: 1520-7552 - wos: WOS:000268418900005 (12) - scopus: 2-s2.0-70350639458 (14)

11573/229705 - 2009 - Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: Implications for pregression of AD
Owen, J; Di Domenico, Fabio; Sultana, R; Perluigi, Marzia; Cini, Chiara; Pierce, W; Butterfield, D. A. - 01a Articolo in rivista
rivista: JOURNAL OF PROTEOME RESEARCH (Washington, D.C. : American Chemical Society, c2002-) pp. 471-482 - issn: 1535-3893 - wos: WOS:000263193300008 (86) - scopus: 2-s2.0-61849168093 (95)

11573/135947 - 2009 - Proteomic analysis for the study of amniotic fluid protein composition.
Perluigi, Marzia; Coccia, Raffaella; P., Cignini; Di Domenico, Fabio; L., D'emidio; M., Giorlandino; A., Mesoraca; Cini, Chiara; L., Mangiafico; A., Girgenti; L., Mobili; C., Giorlandino - 01a Articolo in rivista
rivista: JOURNAL OF PRENATAL MEDICINE (Roma : CIC Edizioni internazionali) pp. 39-41 - issn: 1971-3282 - wos: (0) - scopus: (0)

11573/230526 - 2009 - Proteomics analysis of protein expression and specific protein oxidation in human papillomavirus transformed keratinocytes upon UVB irradiation.
Perluigi, Marzia; Giorgi, Alessandra; Blarzino, Carla; De Marco, F; Foppoli, C; Di Domenico, Fabio; Butterfield D., A; Schinina', Maria Eugenia; Cini, Chiara; Coccia, Raffaella - 01a Articolo in rivista
rivista: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (Bucharest : Foundation for Cellular and Molecular Medicine.) pp. 1809-1822 - issn: 1582-1838 - wos: WOS:000272190800018 (20) - scopus: 2-s2.0-72949108915 (23)

11573/226914 - 2009 - Redox proteomics identification of4-hydroxinonenal-modified brain proteins in Alzheimer’s disease: role of lipid peroxidation in Alzheimer's Disease pathogenesis
Perluigi, Marzia; Sultana, R; Di Domenico, Fabio; Cenini, G; Memo, M; Pierce W., M; Coccia, Raffaella; Butterfield, D. A. - 01a Articolo in rivista
rivista: PROTEOMICS. CLINICAL APPLICATIONS (Weinheim : Wiley-VCH-Verl.) pp. 682-693 - issn: 1862-8346 - wos: WOS:000267915300005 (162) - scopus: 2-s2.0-70350089195 (173)

11573/176026 - 2009 - Phenolics in aging and neurodegenerative disorders
Perluigi, Marzia; Vittorio, Calabrese; Carolin, Cornelius; Coccia, Raffaella; Di Domenico, Fabio; Giovanni, Pennisi; Cini, Chiara; Albena T., Dinkova Kostova - 02a Capitolo o Articolo
libro: Phenolic Compounds of Plant Origin and Health: The Biochemistry behind their Nutritional and Pharmacological Value - (9780470287217; 9780470531792)

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma